The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
A practical guide to small angle X‐ray scattering (SAXS) of flexible and intrinsically disordered proteins
Open accessAbstract
Small‐angle X‐ray scattering (SAXS) is a biophysical method to study the overall shape and structural transitions of biological macromolecules in solution. SAXS provides low resolution information on the shape, conformation and assembly state of proteins, nucleic acids and various macromolecular complexes. The technique also offers powerful means for the quantitative analysis of flexible systems, including intrinsically disordered proteins (IDPs). Here, the basic principles of SAXS are presented, and profits and pitfalls of the characterization of multidomain flexible proteins and IDPs using SAXS are discussed from the practical point of view. Examples of the synergistic use of SAXS with high resolution methods like X‐ray crystallography and nuclear magnetic resonance (NMR), as well as other experimental and in silico techniques to characterize completely, or partially unstructured proteins, are presented.
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Cites
Intrinsically unstructured proteins and their functions
Dyson, H. J., & Wright, P. E. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1589 · Cited by 3,871
Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain
Wells, M., Tidow, H., Rutherford, T. J., Markwick, P., Jensen, M. R., Mylonas, E., Svergun, D. I., Blackledge, M., & Fersht, A. R. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801353105 · Cited by 434
Self-citationXLF regulates filament architecture of the XRCC4.ligase IV complex
Hammel, M., Yu, Y., Fang, S., Lees-Miller, S. P., & Tainer, J. A. (2010) · Structure · doi:10.1016/j.str.2010.09.009 · Cited by 116
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How multisite phosphorylation impacts the conformations of intrinsically disordered proteins
Jin, F., & Gräter, F. (2021) · PLOS Computational Biology · doi:10.1371/journal.pcbi.1008939 · Cited by 77
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Self-citationKeppel, T. R., Sarpong, K., Murray, E. M., Monsey, J., Zhu, J., & Bose, R. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.747485 · Cited by 29
The emerging role of physical modeling in the future of structure determination
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Metadata
- Authors
- Kikhney, A. G., & Svergun, D. I.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2015-08-29
- Volume
- 589
- Issue
- 19PartA
- Pages
- 2570-2577
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2170146374
- Cited by
- 693
- References
- 3
- FWCI
- 18.27
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Kikhney, A. G., & Svergun, D. I. (2015). A practical guide to small angle X‐ray scattering (SAXS) of flexible and intrinsically disordered proteins. FEBS Letters. https://doi.org/10.1016/j.febslet.2015.08.027
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