The DOI matches its Crossref record; 62 of the 63 references it cites were found in a registry or an index.
Reduced progesterone action during endometrial maturation: A potential risk factor for the development of endometriosis
Open accessAbstract
Objective To discuss the role that reduced endometrial responsiveness to progesterone (P) might play in the pathophysiology of endometriosis. Design A review of experimental evidence regarding the failure of P to regulate the expression of matrix metalloproteinases (MMPs) in the endometrium of patients with endometriosis. Conclusion(s) Progesterone and locally produced differentiation factors act cooperatively to reduce MMP expression by maternal endometrial cells within the pro-inflammatory micro-environment of early pregnancy. Our in vitro studies with normal human endometrium demonstrate that prior P exposure not only down-regulates MMP expression, but also limits the ability of locally produced proinflammatory cytokines to stimulate expression of these enzymes. In contrast, endometrial tissues from women with endometriosis demonstrate an altered response to P, allowing a continuous expression of MMPs throughout the secretory phase. Although the factors that influence the loss of P sensitivity in the endometrium of patients with endometriosis have not yet been defined, alterations in cell-cell communication seem to contribute to dysregulated MMP expression. Specifically, proinflammatory cytokines produced by epithelial cells oppose stromal cell responses to P, inhibiting production of key differentiation factors necessary for cell-specific MMP regulation. The resulting loss in normal MMP regulation enhances the invasive capacity of endometrial tissue, promoting ectopic establishment in an experimental model.
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“A reduction in progesterone action in endometrium, 'progesterone resistance', of women with endometriosis (Osteen et al., 2005; Table V) may play a key role in development of endometriosis and possibly with associated pain; use of progestagens may reverse these effects.”
From Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications (2011) · cites this paper as Osteen et al., 2005
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“Osteen et al. (2005) demonstrated that eutopic endometrium of women with endometriosis has reduced progesterone action during maturation or 'progesterone resistance', that, in turn, may enhance development of endometriosis.”
From Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications (2011) · cites this paper as Osteen et al., 2005
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Cites
Sampson, J. A. (1927) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(15)30003-x · Cited by 2,334
TISSUE CHANGES FOLLOWING DEPRIVATION OF FAT-SOLUBLE A VITAMIN
Wolbach, S., & Howe, P. R. (1925) · Journal of Experimental Medicine · doi:10.1084/jem.42.6.753 · Cited by 1,674
Global gene profiling in human endometrium during the window of implantation
Kao, L. C., Tulac, S., Lobo, S., Imani, B., Yang, J. P., Germeyer, A., Osteen, K., Taylor, R. N., Lessey, B. A., & Giudice, L. C. (2002) · Endocrinology · doi:10.1210/endo.143.6.8885 · Cited by 727
Self-citationKao, L. C., Germeyer, A., Tulac, S., Lobo, S., Yang, J. P., Taylor, R. N., Osteen, K., Lessey, B. A., & Giudice, L. C. (2003) · Endocrinology · doi:10.1210/en.2003-0043 · Cited by 696
Self-citationCurry, T. E., & Osteen, K. G. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0005 · Cited by 606
Self-citationGiguère, V. (1994) · Endocrine Reviews · doi:10.1210/edrv-15-1-61 · Cited by 522
Vitamin A and reproduction in rats
Thompson, J. N., Howell, J., & Pitt, G. A. (1964) · Proceedings of the Royal Society of London. Series B. Biological Sciences · doi:10.1098/rspb.1964.0017 · Cited by 381
Rodgers, W. H., Matrisian, L. M., Giudice, L. C., Dsupin, B. A., Cannon, P., Svitek, C., Gorstein, F., & Osteen, K. G. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117461 · Cited by 377
Self-citationThe Relation of Endometriosis to Menstrual Characteristics, Smoking, and Exercise
Cramer, D. W. (1986) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1986.03370140102032 · Cited by 367
Bruner‐Tran, K. L., Matrisian, L. M., Rodgers, W. H., Gorstein, F., & Osteen, K. G. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119478 · Cited by 283
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1 of the 63 references couldn’t be matched to a known paper.
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- Attia, 2000, Progesterone receptor isoform A but not B is expressed in endometriosis, J Clin Endocrinol Metab, 85, 2897
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Items 101–121 of 121
Developmental dioxin exposure and endometriosis
Nayyar, T., Bruner‐Tran, K. L., & Osteen, K. G. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-382032-7.10042-6 · Cited by 1
Self-citationRegulated expression of aggrecanases of ADAMTS family in endometrial physiology and pathology
Wen, J. (2010) · cIRcle (University of British Columbia) · doi:10.14288/1.0071568 · Cited by 1
Du, Y., Yan, L., Sun, M., Sheng, Y., Li, X., Feng, Z., & Tang, R. (2020) · doi:10.21203/rs.3.rs-15724/v1 · Cited by 1
Neue Aspekte zur Ätiologie und Pathogenese der Endometriose
Wölfler, M. M., Klein, P., Zalewski, M., & Maass, N. (2015) · Der Gynäkologe · doi:10.1007/s00129-014-3422-0
Endometriosis and Cancer: Is There an Association?
Vega, M. G., Soto, E., & Goldberg, J. M. (2015) · Springer eBooks · doi:10.1007/978-3-319-17849-3_5
Biberoglu, E. H., & Biberoglu, K. O. (2014) · Springer eBooks · doi:10.1007/978-4-431-54421-0_18
Neuroendocrine Aspects of Endometriosis‐Associated Pain
Stratton, P., & Berkley, K. J. (2011) · Wiley eBooks · doi:10.1002/9781444398519.ch22
Management del dolore pelvico cronico nelle pazienti con endometriosi
Calvino, I. G., Carletti, G. V., Panzeri, L., Paladini, L., Tonani, S., Gardella, B., & Spinillo, A. (2012) · Università degli Studi di Pavia · doi:10.6092/2039-1404.125.1136
Impact of endometriosis on IVF outcomes
Gafni‐Kane, A., Vitiello, D., & Arici, A. M. (2009) · Expert Review of Obstetrics & Gynecology · doi:10.1586/17474108.4.2.125
Rectovaginal endometriosis : pain treatment options
Tarjanne, S. (2016) · Työväentutkimus Vuosikirja
Laboratory Evaluation of Antisperm Antibodies
Centola, G. M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.64840-7
Wang, Y., Ye, C., Hu, C., Chen, P., Chen, C., & Wu, R. (2021) · Research Square · doi:10.21203/rs.3.rs-328521/v1
Endometriosis - Recent Advances, New Perspectives and Treatments
Gonçalves, G. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.95742 · Cited by 1
Endometriosis Research: From Bench to Bedside
Laganà, A. S., & La Rosa, V. L. (2022) · MDPI eBooks · doi:10.3390/books978-3-0365-2798-7
(2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-4217-4.00080-9
ANÁLISE HISTOLÓGICA DA ENDOMETRIOSE EM RATAS DURANTE AS FASES DO CICLO ESTRAL
da Conceição, A. P. M., Batista, A. P. C., de Araújo, A. C. C., Silva, F. C. A., Teixeira, V. W., & Teixeira, Á. A. C. (2005) · Arquivos do Instituto Biológico · doi:10.1590/1808-1657v72p4392005
O’Brien, K., & Bosak, C. (2025) · Springer eBooks · doi:10.1007/978-3-032-01737-6_5
Rostami, S., Aleyasin, A., Nekoonam, S., Shafie, A., Saedi, M., & Amidi, F. (2026) · Research Square · doi:10.21203/rs.3.rs-8971122/v1
The hidden impacts of endocrine-disrupting chemicals on endometrial and pregnancy health
Savin, S. J., Loveland, K. L., & Gurung, S. (2026) · Reproduction Fertility and Development · doi:10.1071/rd26173
Metadata
- Authors
- Osteen, K. G., Bruner-Tran, K. L., & Eisenberg, E.
- Affiliations
- Vanderbilt University (US)
- Corresponding author
- Osteen, Kevin G.
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2005-03
- Volume
- 83
- Issue
- 3
- Pages
- 529-537
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W1966049599
- Cited by
- 122
- References
- 63
- Citations by year
- 2026: 2 · 2025: 1 · 2023: 2 · 2022: 7 · 2021: 8 · 2020: 2 · 2019: 6 · 2018: 3 · 2017: 4 · 2016: 4 · 2015: 6 · 2014: 5 · 2013: 4 · 2012: 11
- FWCI
- 1.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Environmental Health Sciences (R21ES12298-01, R21ES012298)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (5K12HD43483, U54HD037321, U54 HD37321, K12HD043483)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Obstetrics and Gynecology › Ectopic Pregnancy Diagnosis and Management
- Keywords
- endometriosis, progesterone, endometrial maturation, matrix metalloproteinases, endometrial receptivity, inflammatory cytokines, endometrial invasion, luteal phase, intercellular communication, ectopic endometrium
- MeSH terms
- Endometriosis, Endometrium, Female, Humans, Pregnancy, Progesterone, Risk Factors
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