Cited by 589Ovarian function and disordersDiabetes, Cardiovascular Risks, and LipoproteinsGenetic and Kidney Cyst Diseases

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Prevalence of insulin resistance in the polycystic ovary syndrome using the homeostasis model assessment

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DeUgarte, Catherine Marin, Bartolucci, Alfred A., Azziz, Ricardo·2005·Fertility and Sterility

DOI 10.1016/j.fertnstert.2004.11.070

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Abstract

Objective To determine the prevalence of insulin resistance (IR) in a large population of patients with the polycystic ovary syndrome (PCOS).Design Prospective, case-control.Setting University medical center.Patient(s) Two hundred seventy-one PCOS patients and 260 eumenorrheic, non-hirsute, control women.Intervention(s) History and physical examination and blood sampling.Main outcome measure(s) Total T, free T, DHEAS, sex hormone-binding globulin, and fasting glucose and insulin levels; homeostatic model assessment values for IR (HOMA-IR) and percent beta-cell function (HOMA-%beta-cell).Result(s) Patients with PCOS and controls differed significantly in all parameters studied, except fasting glucose. Because the HOMA-IR and HOMA-%beta-cell values were variably associated with race, age, and body mass index, the HOMA-IR and HOMA-%beta-cell values were then adjusted for these cofounders. After adjustment, 64.4% of PCOS patients were noted to be insulin resistant, and 2.6% had beta-cell dysfunction. Compared with PCOS patients without IR (n = 96), patients with IR (n = 174) were more obese and had higher beta-cell function.Conclusion(s) In patients with PCOS, the prevalence of IR was 64% according to the HOMA-IR measurement, after adjustment. Patients with IR were more clinically affected. Although IR is a common abnormality in PCOS, it does not seem to be a universal feature.

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Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man
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Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: Studies in subjects with various degrees of glucose tolerance and insulin sensitivity
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Self-citation

Authors: DeUgarte, C. M., Bartolucci, A. A., & Azziz, R.
Affiliations: Cedars-Sinai Medical Center (US)
University of Alabama at Birmingham (US)
Corresponding author: Azziz, Ricardo
ORCID: Bartolucci, Alfred A.
Azziz, Ricardo
Venue: Fertility and Sterility
Publisher: Elsevier BV
Published: 2005-05
Volume: 83
Issue: 5
Pages: 1454-1460
ISSN: 0015-0282 (ISSN-L)
DOI: 10.1016/j.fertnstert.2004.11.070
OpenAlex: W2117559317
Cited by: 589
References: 62
Citations by year: 2026: 14 · 2025: 23 · 2024: 24 · 2023: 30 · 2022: 41 · 2021: 32 · 2020: 33 · 2019: 33 · 2018: 23 · 2017: 28 · 2016: 32 · 2015: 37 · 2014: 33 · 2013: 48 · 2012: 21
FWCI: 23.24
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 6235 d)
Locations: Fertility and Sterility (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
Keywords: polycystic ovary syndrome, insulin resistance, HOMA-IR, beta-cell function, prevalence, obesity, sex hormones, insulin secretion
MeSH terms: Adult, Female, Homeostasis, Humans, Insulin Resistance, Middle Aged, Polycystic Ovary Syndrome, Prospective Studies, Prevalence, Chi-Square Distribution, Case-Control Studies

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Prevalence of insulin resistance in the polycystic ovary syndrome using the homeostasis model assessment

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