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Cited by 25Ovarian function and disordersDiabetes, Cardiovascular Risks, and LipoproteinsDiet, Metabolism, and Disease

Evaluation of insulin resistance and metabolic syndrome in patients with polycystic ovary syndrome

Lankarani, Mahnaz, Valizadeh, Neda, Heshmat, Ramin, Peimani, Maryam, Sohrabvand, Farnaz·2009·Gynecological Endocrinology
DOI 10.1080/09513590902972083
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Abstract

Mahnaz Lankarania, Neda Valizadeha*, Ramin Heshmata, Maryam Peimania & Farnaz Sohrabvandba Endocrinology and metabolism Research Center, Tehran University of Medical Sciences, Tehran, Iranb Obstetrics and Gynecology Department, Vallie-Asr Hospital, Imam Khomeini Medical Center, Tehran, Iran* Correspondence: Neda Valizadeh, Endocrinology and Metabolism Research Center, 5th floor, Shariati Hospital, North Kargar Avenue, Tehran, Iran +9821-88026902 +9821-88029399 neda_valizadeh2003@yahoo.comAim. Polycystic ovary syndrome (PCOS) is associated with the clustering of states including insulin resistance (IR), obesity, elevated blood pressure, and dyslipidemia that are termed as metabolic syndrome (MBS). This study was designed to assess the differences between homeostatic model assessment (HOMA) values in PCOS and healthy women.Methods. In a case–control study, 55 women with PCOS and 59 women with normal cycles (control group) aged 15–40 years old were evaluated. In all the subjects (after obtaining written informed consent), blood pressure, body weight, height, body mass index (BMI), waist /hip ratio(WHR) and fasting blood glucose (FBG), triglycerides (TG), HDL, C-peptide, insulin, HOMA Index, and FGIR (fasting glucose to insulin ratio) were measured.Results. In this study, the prevalence of MBS was significantly higher in PCOS group compared with the control group (p = 0.028). There were no significant differences in age, waist/hip ratio, fasting glucose, insulin, and C-peptide levels between patients with PCOS and control group. Furthermore, the prevalence of impaired fasting glucose (IFG) and the mean of HOMA and FGIR did not differ significantly between PCOS and control group.Conclusion. Criteria of MBS are frequently present in young women with PCOS and may be more useful as a prognostic factor than IR indexes in this age group. We suggest evaluation of IR in older age women with PCOS.

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Crossref · 10.1080/09513590902972083

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  • Skeletal muscle insulin resistance has been reported in association with normal ageing, dyslipidaemia, polycystic ovary syndrome, chronic kidney failure, heart failure, myotonic dystrophy, and lipodystrophy.

    “Insulin resistance in skeletal muscle also has been reported in association with the normal ageing process [37], dyslipidemia (increased plasma triglyceride/decreased HDL cholesterol) [4, 26], and in association with many disease states including polycystic ovary syndrome (PCOs) [38], chronic kidney failure [39], heart failure [40], myotonic dystrophy [41], and lipodystrophy [42].”

    From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [38]

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Authors
Lankarani, M., Valizadeh, N., Heshmat, R., Peimani, M., & Sohrabvand, F.
Affiliations
  • Tehran University of Medical Sciences (IR)
  • Imam Khomeini Hospital (IR)
Corresponding author
Valizadeh, Neda
ORCID
Venue
Gynecological Endocrinology
Publisher
Informa UK Limited
Published
2009-01
Volume
25
Issue
8
Pages
504-507
ISSN
  • 0951-3590 (ISSN-L)
  • 1473-0766
DOI
10.1080/09513590902972083
OpenAlex
W2025808981
Cited by
25
References
22
Citations by year
2026: 1 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 1 · 2012: 4
FWCI
1.97
Type
journal article
Language
en
Open access
closed
Locations
  • Gynecological Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords
polycystic ovary syndrome, insulin resistance, metabolic syndrome, HOMA index, fasting glucose to insulin ratio, impaired fasting glucose, C-peptide, insulin, young women, obesity, dyslipidemia
MeSH terms
Adolescent, Adult, Female, Homeostasis, Humans, Insulin Resistance, Polycystic Ovary Syndrome, Prognosis, Body Mass Index, Prevalence, Case-Control Studies, Metabolic Syndrome, Waist-Hip Ratio, Young Adult

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