Role of GnRH–GnRH receptor signaling at the maternal-fetal interface

Lee, Hee Joong; Snegovskikh, Victoria V.; Park, Joong Shin; Foyouzi, Nastaran; Han, Ku Taek; Hodgson, Eric J.; Guller, Seth; Norwitz, Errol R.

doi:10.1016/j.fertnstert.2010.03.016

Cited by 21Reproductive System and PregnancyHypothalamic control of reproductive hormonesPregnancy and preeclampsia studies

Role of GnRH–GnRH receptor signaling at the maternal-fetal interface

Open access

Lee, Hee Joong, Snegovskikh, Victoria V., Park, Joong Shin, Foyouzi, Nastaran, Han, Ku Taek, Hodgson, Eric J., Guller, Seth, Norwitz, Errol R.·2010·Fertility and Sterility

DOI 10.1016/j.fertnstert.2010.03.016

Open this paper in CoChat — free account Open PDF

Abstract

Objective To investigate the expression and function of GnRH and GnRH receptor (GnRHR) subtypes at the maternal-fetal interface.Design In vitro experiments using freshly isolated human trophoblast cells, decidual stromal cells (DSCs), and immortalized cell lines.Setting University teaching hospital.Patient(s) Placenta-fetal membranes from term deliveries.Intervention(s) Human trophoblast and DSCs were isolated, purified, and cultured.Main outcome measure(s) Expression of GnRH-I, GnRH-II, and GnRHR-I mRNA and protein in human trophoblast cell lines and tissues were evaluated by reverse-transcription polymerase chain reaction and Western blot. The effect of GnRH-I and -II on the production of select cytokines (hCG, interleukin [IL] 8, IL-6, matrix metalloproteinase 3, monocyte chemoattractant protein 1, vascular endothelial growth factor, soluble Fms-like tyrosine kinase 1, urokinase-type plasminogen activator, and plasminogen activator inhibitor 1) were measured by ELISA and normalized for protein content.Result(s) GnRH-I, GnRH-II, and GnRHR-I mRNA and protein were identified in trophoblasts and decidua. GnRH-I and -II stimulated hCG production by trophoblast and trophoblast-derived cell lines in a dose-dependent fashion (e.g., 2.8-fold, from 2.5 ± 0.5 to 7.0 ± 0.4 ng/mg protein per 24 h, for 1,000 nmol/L GnRH-I and 2.4-fold, from 2.5 ± 0.5 to 6.1 ± 0.6 ng/mg protein per 24 h, for 1,000 nmol/L GnRH-II) without affecting the production of other cytokines.Conclusion(s) Trophoblasts and decidua express GnRH-I, GnRH-II, and GnRHR-I mRNA and protein. GnRH-I and -II selectively stimulate hCG production by trophoblast cells without altering the production of select cytokines by trophoblasts or decidua. The role of GnRH-GnRHR signaling at the maternal-fetal interface therefore appears to be limited to the regulation of trophoblast hCG production.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.fertnstert.2010.03.016

Cites

57 of 57 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

GnRH and GnRHR have been detected in the placenta and decidua of several species.
“as GnRH and GnRHR have been detected in the placenta and decidua of several species23–28.”
From Conditional loss of ERK1 and ERK2 results in abnormal placentation and delayed parturition in the mouse (2019) · cites this paper as [23]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Purification, Characterization, andin vitroDifferentiation of Cytotrophoblasts from Human Term Placentae*
Kliman, H. J., Nestler, J. E., SERMASI, E., Sanger, J. M., & Strauss, J. F. (1986) · Endocrinology · doi:10.1210/endo-118-4-1567 · Cited by 1,572 · see citing works
Establishment and Characterization of First Trimester Human Trophoblast Cells with Extended Lifespan
Graham, C. H., Hawley, T. S., Hawley, R. G., MacDougall, J. R., Kerbel, R. S., Khoo, N. K. S., & Lala, P. K. (1993) · Experimental Cell Research · doi:10.1006/excr.1993.1139 · Cited by 1,056 · see citing works
Human Decidual Natural Killer Cells Are a Unique NK Cell Subset with Immunomodulatory Potential
Koopman, L. A., Kopcow, H. D., Rybalov, B., Boyson, J. E., Orange, J. S., Schatz, F., MASCH, R. J., Lockwood, C. J., Schachter, A. D., Park, P. J., et al. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030305 · Cited by 900 · see citing works
Second gene for gonadotropin-releasing hormone in humans
White, R. B., Eisen, J. A., Kasten, T. L., & Fernald, R. D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.1.305 · Cited by 405 · see citing works
A novel mammalian receptor for the evolutionarily conserved type II GnRH
Millar, R. P., Lowe, S., Conklin, D., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.141048498 · Cited by 314 · see citing works
GnRH II and type II GnRH receptors
Millar, R. P. (2003) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(02)00016-4 · Cited by 280 · see citing works
A Gonadotropin-Releasing Hormone (GnRH) Receptor Specific for GnRH II in Primates
Neill, J. D., Duck, L. W., Sellers, J. C., et al. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4678 · Cited by 240 · see citing works
Placental Luteinizing Hormone-Releasing Factor and Its Synthesis
Khodr, G. S., & Siler-Khodr, T. M. (1980) · Science · doi:10.1126/science.6985750 · Cited by 227 · see citing works
Disease-modifying activity of SB 242235, a selective inhibitor of p38 mitogen-activated protein kinase, in rat adjuvant-induced arthritis
Badger, A. M., Griswold, D. E., Kapadia, R. D., Blake, S. M., Swift, B. A., Hoffman, S. J., Stroup, G. B., Webb, E. F., Rieman, D. J., Gowen, M., et al. (2000) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200001)43:1 · Cited by 213 · see citing works
Minireview: GnRH and GnRH Receptor Genes in the Human Genome
Neill, J. D. (2002) · Endocrinology · doi:10.1210/endo.143.3.8705 · Cited by 187 · see citing works
Expression of Gonadotropin-Releasing Hormone II (GnRH-II) Receptor in Human Endometrial and Ovarian Cancer Cells and Effects of GnRH-II on Tumor Cell Proliferation
Gründker, C., Günthert, A. R., Millar, R. P., et al. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.3.8437 · Cited by 158 · see citing works
Three distinct types of GnRH receptor characterized in the bullfrog
Wang, L., Bogerd, J., Choi, H. S., Seong, J. Y., Soh, J. M., Chun, S. Y., Blomenröhr, M., Troskie, B. E., Millar, R. P., Yu, W. H., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.1.361 · Cited by 156 · see citing works
The nucleotide sequences of human GnRH receptors in breast and ovarian tumors are identical with that found in pituitary
Kakar, S. S., Grizzle, W. E., & Neill, J. D. (1994) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(94)90196-1 · Cited by 139 · see citing works
Human placental receptors for luteinizing hormone releasing hormone
Currie, A., Fraser, H. M., & Sharpe, R. M. (1981) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(81)91749-6 · Cited by 138 · see citing works
Content of luteinizing hormone-releasing factor in the human placenta
Siler-Khodr, T. M., & Khodr, G. S. (1978) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(78)90369-1 · Cited by 123 · see citing works
A Transcriptionally Active Human Type II Gonadotropin-Releasing Hormone Receptor Gene Homolog Overlaps Two Genes in the Antisense Orientation on Chromosome 1q.12
Morgan, K., Conklin, D., Pawson, A. J., Sellar, R., Ott, T. R., & Millar, R. P. (2003) · Endocrinology · doi:10.1210/en.2002-220622 · Cited by 123 · see citing works
Thrombin-enhanced matrix metalloproteinase-1 expression: a mechanism linking placental abruption with premature rupture of the membranes
Rosen, T., Schatz, F., Kuczynski, E., Lam, H., Koo, A. B., & Lockwood, C. J. (2002) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/jmf.11.1.11.17 · Cited by 119 · see citing works
Serum Gonadotropins Before, at the Inception of, and Following Human Pregnancy
Jaffe, R. B., LEE, P. A., & MIDGLEY, A. R. (1969) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-29-9-1281 · Cited by 113 · see citing works
Growth-Inhibitory Actions of Analogues of Luteinizing Hormone Releasing Hormone on Tumor Cells
Emons, G., Ortmann, O., Schulz, K.-D., et al. (1997) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(97)00155-0 · Cited by 106 · see citing works
Mechanisms of abruption-induced premature rupture of the fetal membranes: thrombin enhanced decidual matrix metalloproteinase-3 (stromelysin-1) expression
Mackenzie, A. P., Schatz, F., Krikun, G., Funai, E. F., Kadner, S., & Lockwood, C. J. (2004) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2004.08.003 · Cited by 95 · see citing works
Specific binding of luteinizing hormone releasing hormone to human luteal tissue
Popkin, R., Bramley, T. A., Currie, A., et al. (1983) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(83)90844-6 · Cited by 83 · see citing works
A novel human GnRH receptor homolog gene: abundant and wide tissue distribution of the antisense transcript
Millar, R. P., Conklin, D., Lofton–Day, C., Hutchinson, E., Troskie, B. E., Illing, N., Sealfon, S. C., & Hapgood, J. P. (1999) · Journal of Endocrinology · doi:10.1677/joe.0.1620117 · Cited by 79 · see citing works
Mutations Remote from the Human Gonadotropin-releasing Hormone (GnRH) Receptor-binding Sites Specifically Increase Binding Affinity for GnRH II but Not GnRH I
Lu, Z.-L., Gallagher, R., Sellar, R., Coetsee, M., & Millar, R. P. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413520200 · Cited by 67 · see citing works
Differential Effects of Gonadotropin-Releasing Hormone I and II on the Urokinase-Type Plasminogen Activator/Plasminogen Activator Inhibitor System in Human Decidual Stromal Cells in Vitro
Chou, C.-S., MacCalman, C. D., & Leung, P. C. K. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021955 · Cited by 66 · see citing works
The Genes Encoding the Type II Gonadotropin-Releasing Hormone Receptor and the Ribonucleoprotein RBM8A in Humans Overlap in Two Genomic Loci
Faurholm, B., Millar, R. P., & Katz, A. A. (2001) · Genomics · doi:10.1006/geno.2001.6650 · Cited by 64 · see citing works
Regulation of Gonadotropin-Releasing Hormone and Its Receptor Gene Expression by 17β-Estradiol in Cultured Human Granulosa-Luteal Cells*
Nathwani, P. S., Kang, S. K., Cheng, K. W., et al. (2000) · Endocrinology · doi:10.1210/endo.141.5.7447 · Cited by 57 · see citing works
Thrombin Regulates Soluble fms-Like Tyrosine Kinase-1 (sFlt-1) Expression in First Trimester Decidua
Lockwood, C. J., Toti, P., Arcuri, F., Norwitz, E. R., Funai, E. F., Huang, S.-T. J., Buchwalder, L. F., Krikun, G., & Schatz, F. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.060465 · Cited by 56 · see citing works
Self-citation
Structural Determinants for Ligand-Receptor Conformational Selection in a Peptide G Protein-coupled Receptor
Lu, Z.-L., Coetsee, M., White, C. D., & Millar, R. P. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610413200 · Cited by 56 · see citing works
Type II Gonadotropin-Releasing Hormone Receptor Transcripts in Human Sperm1
Biljon, W. V., Wykes, S. M., Scherer, S. D., et al. (2002) · Biology of Reproduction · doi:10.1095/biolreprod.101.002808 · Cited by 56 · see citing works
Independent Regulation of Matrix Metalloproteinase-9, Tissue Inhibitor of Metalloproteinase-1 (TIMP-1), and TIMP-3 in Human Endometrial Stromal Cells by Gonadotropin-Releasing Hormone: Implications in Early Human Implantation1
Raga, F., Casañ, E. M., Wen, Y., et al. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.2.5464 · Cited by 56 · see citing works
Action of Chicken II GnRH on the Human Placenta1
Siler-Khodr, T. M., & Grayson, M. H. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.2.7210 · Cited by 54 · see citing works
Regulatory Effects of Gonadotropin-Releasing Hormone (GnRH) I and GnRH II on the Levels of Matrix Metalloproteinase (MMP)-2, MMP-9, and Tissue Inhibitor of Metalloproteinases-1 in Primary Cultures of Human Extravillous Cytotrophoblasts
Chou, C.-S., Zhu, H., MacCalman, C. D., et al. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030659 · Cited by 52 · see citing works
Inhibition of Human Type I Gonadotropin-Releasing Hormone Receptor (GnRHR) Function by Expression of a Human Type II GnRHR Gene Fragment
Pawson, A. J., Maudsley, S. R., Morgan, K., Davidson, L., Naor, Z., & Millar, R. P. (2005) · Endocrinology · doi:10.1210/en.2005-0133 · Cited by 47 · see citing works
Steroid regulation of oncofetal fibronectin expression in human cytotrophoblasts
Guller, S. M., LaCroix, N. C., Kirkun, G., et al. (1993) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(93)90202-8 · Cited by 47 · see citing works
Self-citation
Hormonal regulation of human trophoblast differentiation: a possible role for 17β-estradiol and GnRH
Rama, S., Petrusz, P., & Rao, A. J. (2004) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2003.12.016 · Cited by 46 · see citing works
Human placental gonadotrophin-releasing hormone (GnRH) binding sites: I. Characterization, properties and ligand specificity
Bramley, T. A., McPhie, C. A., & Menzies, G. S. (1992) · Placenta · doi:10.1016/0143-4004(92)90020-t · Cited by 45 · see citing works
Luteinizing hormone‐releasing factor increases release of human chorionic gonadotrophin in isolated cell columns of normal and malignant trophoblasts
Bützow, R. C. (1982) · International Journal of Cancer · doi:10.1002/ijc.2910290103 · Cited by 40 · see citing works
Proteasome subunit LMP2 is required for matrix metalloproteinase‐2 and ‐9 expression and activities in human invasive extravillous trophoblast cell line
Wang, H., Wang, H., Wang, H., et al. (2005) · Journal of Cellular Physiology · doi:10.1002/jcp.20508 · Cited by 40 · see citing works
Conformational Constraint of Mammalian, Chicken, and Salmon GnRHs, But Not GnRH II, Enhances Binding at Mammalian and Nonmammalian Receptors: Evidence for Preconfiguration of GnRH II
Pfleger, K. D. G., Bogerd, J., & Millar, R. P. (2002) · Molecular Endocrinology · doi:10.1210/me.2002-0159 · Cited by 40 · see citing works
Dose-Dependent Effects of Gonadotropin Releasing Hormone on Matrix Metalloproteinase (MMP)-2, and MMP-9 and Tissue Specific Inhibitor of Metalloproteinases-1 Messenger Ribonucleic Acid Levels in Human Decidual Stromal Cellsin Vitro
Chou, C.-S., Tai, C., MacCalman, C. D., & Leung, P. C. K. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021277 · Cited by 40 · see citing works
The Effects of Gonadotropin-Releasing Hormone (GnRH) I and GnRH II on the Urokinase-Type Plasminogen Activator/Plasminogen Activator Inhibitor System in Human Extravillous Cytotrophoblastsin Vitro
Chou, C.-S., Zhu, H., Shalev, E., MacCalman, C. D., & Leung, P. C. K. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020883 · Cited by 36 · see citing works
Role of Hypoxia-Inducible Transcription Factors 1α and 2α in the Regulation of Plasminogen Activator Inhibitor-1 Expression in a Human Trophoblast Cell Line
Meade, E., Ma, Y., & Guller, S. M. (2007) · Placenta · doi:10.1016/j.placenta.2007.04.005 · Cited by 35 · see citing works
Self-citation
Changes in luteinizing hormone-releasing hormone in human placenta throughout pregnancy.
Miyake, A., Sakumoto, T., Aono, T., et al. (1982) · PubMed · Cited by 35 · see citing works
Comparison of the effects of GnRH-I and GnRH-II on HCG synthesis and secretion by first trimester trophoblast
Islami, D. (2001) · Molecular Human Reproduction · doi:10.1093/molehr/7.1.3 · Cited by 35 · see citing works
Action of Chicken II GnRH on the Human Placenta
Siler-Khodr, T. M. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.2.804 · Cited by 30 · see citing works
ORIGINAL ARTICLE: Supporting the Hypothesis of Pregnancy As a Tumor: Survivin Is Upregulated in Normal Pregnant Mice and Participates in Human Trophoblast Proliferation
Fest, S., Brachwitz, N., Schumacher, A., Zenclussen, M. L., Khan, F., Wafula, P. O., Casalis, P. A., Malfertheiner, S. F., Costa, S., Mor, G., et al. (2007) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.2007.00557.x · Cited by 27 · see citing works
Independent Regulation of Matrix Metalloproteinase-9, Tissue Inhibitor of Metalloproteinase-1 (TIMP-1), and TIMP-3 in Human Endometrial Stromal Cells by Gonadotropin-Releasing Hormone: Implications in Early Human Implantation
Raga, F. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.2.636 · Cited by 27 · see citing works
Intra-Amniotic Infection Upregulates Decidual Cell Vascular Endothelial Growth Factor (VEGF) and Neuropilin–1 and –2 Expression: Implications for Infection-Related Preterm Birth
Snegovskikh, V., Schatz, F., Arcuri, F., Toti, P., Kayisli, U. A., Murk, W. K., Luo, G., Lockwood, C. J., & Norwitz, E. R. (2009) · Reproductive Sciences · doi:10.1177/1933719109336623 · Cited by 25 · see citing works
Self-citation
Ca2+, but not Membrane Lipid Hydrolysis, Mediates Human Chorionic Gonadotropin Production by Luteinizing Hormone-Releasing Hormone in Human Term Placenta*
Bélisle, S., PETIT, A., Bellabarba, D., et al. (1989) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-69-1-117 · Cited by 25 · see citing works
Progestin inhibits and thrombin stimulates the plasminogen activator/inhibitor system in term decidual stromal cells: implications for parturition
Norwitz, E. R., Snegovskikh, V., Schatz, F., Foyouzi, N., Rahman, M. M., Buchwalder, L. F., Lee, H. J., Funai, E. F., Buhimschi, C. S., Buhimschi, I. A., et al. (2007) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2007.02.035 · Cited by 22 · see citing works
Self-citation
Integrin-Linked Kinase (ILK) Is Highly Expressed in First Trimester Human Chorionic Villi and Regulates Migration of a Human Cytotrophoblast-Derived Cell Line1
Elustondo, P. A., Hannigan, G. E., Caniggia, I., et al. (2006) · Biology of Reproduction · doi:10.1095/biolreprod.105.050419 · Cited by 22 · see citing works
Inflammatory Cytokine and Thrombin Regulation of Interleukin-8 and Intercellular Adhesion Molecule-1 Expression in First Trimester Human Decidua
Lockwood, C. J., Paidas, M. J., Krikun, G., et al. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-2528 · Cited by 21 · see citing works
Response of human chorionic gonadotrophin to luteinizing hormone-releasing hormone stimulation in the culture media of normal human placenta, choriocarcinoma cell lines, and in the serum of patients with gestational trophoblastic disease
Kim, S. J., Namkoong, S. E., Lee, J. W., Jung, J. K., Kang, B.-G., & Park, J. S. (1987) · Placenta · doi:10.1016/0143-4004(87)90049-x · Cited by 17 · see citing works
Self-citation
TGFB-responsive Human Trophoblast-derived Cell Lines
Lala, P. K., & Graham, C. G. (2001) · Placenta · doi:10.1053/plac.2001.0736 · Cited by 12 · see citing works
Salmon GnRH and its analogues bind the human placental receptor
Siler-Khodr, T. M. (2001) · Journal of the Society for Gynecologic Investigation · doi:10.1016/s1071-5576(01)00116-2 · Cited by 7 · see citing works
Salmon GnRH and Its Analogues Bind the Human Placental Receptor
Siler-Khodr, T. M., & Grayson, M. H. (2001) · Journal of the Society for Gynecologic Investigation · doi:10.1177/107155760100800408 · Cited by 3 · see citing works
[Effects of various agents on the proliferation and hCG secretion of choriocarcinoma cells in vitro].
Kaiho, T., Sekiya, S., Shirotake, S., et al. (1984) · PubMed · Cited by 2 · see citing works

Flagged first, then by citations

Research works printed but not linked: 4

Neill JD. GnRH and GnRH receptor genes in the hu- man genome. Endocrinology 2002;143:737-43.
Kakar SS, Grizzle WE, Neill JD. The nucleotide se- quences of human GnRH receptors in breast and ovar- ian tumors are identical with that found in the pituitary. Mol Cell Endocrinol 1994;106:145-9.
Di Simone N, Meroni PL, de Papa N, Raschi E, Caliandro D, De Carolis CS, et al. Antiphospholipid antibodies affect trophoblast gonadotropin secretion and invasiveness by binding directly and through ad- hered beta2-glycoprotein I. Arthritis Rheum 2000;43: 140-50.
Gr€ undker C, Gunthert AR, Millar RP, Emons G. Ex- pression of GnRH-II receptor in human endometrial and ovarian cancer cell lines and effects of GnRH-II on tumor cell proliferation. J Clin Endocrinol Metab 2002;87:1427-30.

Sorted by citations

Gonadotropin-releasing hormone and gonadotropin-releasing hormone receptor are expressed at tubal ectopic pregnancy implantation sites
Peng, B., Klausen, C., Campbell, L., Leung, P. C. K., Horne, A. W., & Bedaiwy, M. A. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2016.02.003 · Cited by 15 · see citing works
Conditional loss of ERK1 and ERK2 results in abnormal placentation and delayed parturition in the mouse
Brown, J. L., Sones, J. L., Angulo, C. N., Abbott, K., Miller, A. D., Boehm, U., & Roberson, M. S. (2019) · Scientific Reports · doi:10.1038/s41598-019-45997-0 · Cited by 13 · see citing works

Comparison of Immunosuppressive Properties of Hydatidiform Mole Decidua and Trophoblast Extracts
Bennett, W. A., Brackin, M. N., Long, C. A., et al. (1996) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.1996.tb00144.x · Cited by 4 · see citing works
Interaction of mouse ectoplacental cone trophoblast and uterine decidua in vitro
Babiarz, B., Romagnano, L., & Kurilla, G. (1992) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/bf02634133 · Cited by 23 · see citing works
Effects of a-momorcharin on human trophoblast and deciduacells in vitro
Han, W. (1991) · Zhongguo yaolixue yu dulixue zazhi
Tissue interactions in first trimester trophoblast-decidua co-cultures
Vićovac, L., Papic, N., & Aplin, J. (1993) · Placenta · doi:10.1016/s0143-4004(05)80296-6 · Cited by 13 · see citing works
The distribution of tissue inhibitor of metalloproteinases-2 (timp-2) in decidua and trophoblast of early human pregnancy
Ruck, P., Marzusch, K., Kröber, S. M., et al. (1997) · Placenta · doi:10.1016/s0143-4004(97)80083-5 · Cited by 6 · see citing works

Authors: Lee, H. J., Snegovskikh, V. V., Park, J. S., Foyouzi, N., Han, K. T., Hodgson, E. J., Guller, S., & Norwitz, E. R.
Affiliations: Catholic University of Korea (KR)
Yale University (US)
Seoul National University (KR)
Corresponding author: Norwitz, Errol R.
ORCID: Lee, Hee Joong
Park, Joong Shin
Guller, Seth
Norwitz, Errol R.
Venue: Fertility and Sterility
Publisher: Elsevier BV
Published: 2010-12
Volume: 94
Issue: 7
Pages: 2680-2687
ISSN: 0015-0282 (ISSN-L)
DOI: 10.1016/j.fertnstert.2010.03.016
OpenAlex: W2080194012
Cited by: 21
References: 57
Citations by year: 2025: 1 · 2024: 2 · 2022: 2 · 2021: 4 · 2020: 1 · 2019: 1 · 2016: 2 · 2014: 3 · 2013: 2 · 2012: 1
FWCI: 0.69
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4195 d)
Locations: Fertility and Sterility (publishedVersion)
PubMed (publishedVersion)
Seoul National University Open Repository (Seoul National University) (submittedVersion)
Funders: March of Dimes (21-FY05-1250)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Keywords: gonadotropin-releasing hormone, GnRH receptor, GnRH-I, GnRH-II, maternal-fetal interface, trophoblast, decidua, human chorionic gonadotropin, cytokines, matrix metalloproteinase-3, soluble fms-like tyrosine kinase-1, plasminogen activator inhibitor-1, placenta
MeSH terms: Animals, Cells, Cultured, Chlorocebus aethiops, Female, Extraembryonic Membranes, Chorionic Gonadotropin, Humans, Gonadotropin-Releasing Hormone, Placenta, Pregnancy, Pregnancy Trimester, First, Receptors, LHRH, Trophoblasts, Signal Transduction, Maternal-Fetal Relations, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Role of GnRH–GnRH receptor signaling at the maternal-fetal interface

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks