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Cited by 517

The DOI matches its Crossref record; 205 of the 205 references it cites were found in a registry or an index.

Circulating inflammatory markers in polycystic ovary syndrome: a systematic review and metaanalysis

Open access
Escobar-Morreale, Héctor F., Luque-Ramírez, Manuel, González, Frank·2011·Fertility and Sterility
DOI 10.1016/j.fertnstert.2010.11.036
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Abstract

Objective To review and meta-analyse the studies evaluating the status of serum inflammatory markers in women with Polycystic Ovary Syndrome (PCOS). Design Systematic review and meta-analysis of articles published in English before January 2010 and identified using the Entrez-PubMed engine. Setting Academic hospital Interventions Measurement of serum concentrations of inflammatory markers by high-sensitivity techniques. Main Outcome Measures Meta-analyses of the mean difference in serum C-reactive protein (CRP), interlekin-6 (IL-6) and tumor necrosis factor-α (TNF-α) concentrations among patients with PCOS and appropriate controls, applying random-effects models to limit interstudy variability, and using appropriate estimates of evidence dissemination bias. Results Meta-analysis of the 31 articles meeting inclusion criteria showed that circulating CRP was 96% higher in women with PCOS compared to controls (95% confidence interval 71% – 122%, z = 7.32, p < 0.0001) without evidence dissemination bias (Egger’s regression intercept 0.45, 95% confidence interval −2.30 – 3.21, P = 0.739). These findings persisted after excluding five studies with mismatches in body mass and/or frequency of obesity between women with PCOS and controls. Meta-analyses involving 10 studies of IL-6, and 9 studies of TNF-α revealed no statistically significant differences between PCOS and controls. Conclusion Women with PCOS exhibit elevation in circulating CRP that is independent of obesity. This finding corroborates existing molecular evidence of the chronic low-grade inflammation that may underpin the pathogenesis of this disorder.

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Metadata

Authors
Escobar-Morreale, H. F., Luque-Ramírez, M., & González, F.
Venue
Fertility and Sterility
Publisher
Elsevier BV
Published
2011-03
Volume
95
Issue
3
Pages
1048-1058.e2
ISSN
0015-0282 (ISSN-L)
DOI
10.1016/j.fertnstert.2010.11.036
OpenAlex
W1973239749
Cited by
517
References
205
FWCI
2.82
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Circulating inflammatory markers in polycystic ovary syndrome: a systematic review and metaanalysis. https://app.cochat.ai/papers/10.1016/j.fertnstert.2010.11.036
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Escobar-Morreale, H. F., Luque-Ramírez, M., & González, F. (2011). Circulating inflammatory markers in polycystic ovary syndrome: a systematic review and metaanalysis. Fertility and Sterility. https://doi.org/10.1016/j.fertnstert.2010.11.036

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.