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Cited by 210Ovarian function and disordersAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesMaternal Mental Health During Pregnancy and Postpartum

The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.

Increased prevalence of anxiety symptoms in women with polycystic ovary syndrome: systematic review and meta-analysis

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Dokras, Anuja, Clifton, Shari, Futterweit, Walter, Wild, Robert·2012·Fertility and Sterility
DOI 10.1016/j.fertnstert.2011.10.022
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Abstract

Objective To perform a systematic review and meta-analysis of studies that compared the prevalence of anxiety symptoms in women with polycystic ovary syndrome (PCOS) and control women. Design Meta-analysis and systematic review. Setting University practice. Patient(s) Cross-sectional studies comparing PCOS subjects and geographically matched clearly defined non-PCOS control subjects with data on age and body mass index (BMI). Intervention(s) Anxiety screening tool. Main outcome measure(s) The primary analysis contrasted prevalence of anxiety. Cochrane Review Manager 5.0.24 software was used to construct forest plots comparing frequency of anxiety symptoms in case and control subjects. Result(s) Of 613 screened articles, nine met our selection criteria for a systematic review and four were included in the meta-analysis. The prevalence of generalized anxiety symptoms was available in four studies and was significantly greater in PCOS subjects (42/206, 20.4%) compared to controls (8/204, 3.9%). The odds for anxiety symptoms were significantly greater in women with PCOS compared with control subjects (odds ratio 6.88, 95% confidence interval 2.5-18.9). The mean anxiety score was significantly increased in three of the remaining five studies. Other anxiety disorders, such as social phobia, panic attacks, and obsessive compulsive disorders, were assessed infrequently. Conclusion(s) Our systematic review suggests an increased odds of anxiety symptoms in women with PCOS, underscoring the importance of screening all women with PCOS for anxiety symptoms. Follow-up evaluation and treatment are essential, because generalized anxiety disorder is a chronic condition. Potential contributors for anxiety symptoms, such as hirsutism, obesity, and/or infertility may be specific to women with PCOS but need further investigation.

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Crossref · 10.1016/j.fertnstert.2011.10.022

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Metadata

Authors
Dokras, A., Clifton, S., Futterweit, W., & Wild, R.
Affiliations
  • University of Pennsylvania (US)
  • OU Health (US)
  • Icahn School of Medicine at Mount Sinai (US)
Corresponding author
Dokras, Anuja
ORCID
Venue
Fertility and Sterility
Publisher
Elsevier BV
Published
2012-01
Volume
97
Issue
1
Pages
225-230.e2
ISSN
0015-0282 (ISSN-L)
DOI
10.1016/j.fertnstert.2011.10.022
OpenAlex
W2161363718
Cited by
209
References
28
Citations by year
2026: 13 · 2025: 24 · 2024: 10 · 2023: 11 · 2022: 15 · 2021: 13 · 2020: 21 · 2019: 15 · 2018: 19 · 2017: 16 · 2016: 16 · 2015: 12 · 2014: 11 · 2013: 6 · 2012: 5
FWCI
1.17
Type
journal article
Language
en
Open access
Licence
Locations
  • Fertility and Sterility (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Keywords
polycystic ovary syndrome, anxiety symptoms, generalized anxiety disorder, prevalence, anxiety screening, women's mental health, hirsutism, obesity, infertility
MeSH terms
Anxiety Disorders, Female, Humans, Polycystic Ovary Syndrome, Prevalence

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