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Cited by 631Ovarian function and disordersEndometriosis Research and TreatmentMaternal Mental Health During Pregnancy and Postpartum

Increased risk of depressive disorders in women with polycystic ovary syndrome

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Hollinrake, Elizabeth, Abreu, Alison, Maifeld, Michelle, Van Voorhis, Bradley J., Dokras, Anuja·2007·Fertility and Sterility
DOI 10.1016/j.fertnstert.2006.11.039
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Abstract

Objective Polycystic ovary syndrome (PCOS) is associated with several metabolic complications. A few small studies have also suggested an increased risk of depression in women with PCOS. The goals of this study were to estimate the prevalence of depressive disorders in women with PCOS compared with controls and to evaluate the correlation between depression, hyperandrogenism, and other metabolic markers.Design Cohort study.Setting University Hospital.Patient(s) Women with PCOS (Rotterdam criteria; n = 103). Women without PCOS seen during the same time period for an annual exam were used as control subjects (n = 103).Intervention(s) Primary Care Evaluation of Mental Disorders Patient Health Questionnaire (PRIME-MD PHQ) and the Beck Depression Inventory.Main outcome measure(s) Depressive disorders.Result(s) Women with PCOS were at an increased risk for depressive disorders (new cases) compared with controls (21% vs. 3%; odds ratio 5.11 [95% confidence interval (CI) 1.26-20.69]; P<.03). The overall risk of depressive disorders in women with PCOS was 4.23 (95% CI 1.49-11.98; P<.01) independent of obesity and infertility. Compared with the nondepressed PCOS subjects, the depressed PCOS subjects had a higher body mass index (BMI) and evidence of insulin resistance (P<.02).Conclusion(s) We report a significantly increased risk of depressive disorders (as defined by the Diagnostic and Statistical Manual IV) in women with PCOS and recommend routine screening in this population.

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  • This is concerning given the established evidence of increased depression, anxiety, eating disorders and other mental illnesses in those affected with PCOS.

    “This is concerning given the established evidence of increased depression, anxiety, eating disorders and other mental illnesses in those affected with PCOS [3, 8, 57–59].”

    From Challenges in diagnosis and health care in polycystic ovary syndrome in Canada: a patient view to improve health care (2023) · cites this paper as [57]

    The Results report higher rates of depressive disorders, binge eating disorder, and risk for anxiety disorders in women with PCOS than in controls. The paper does not establish an increase in eating disorders beyond binge eating disorder or in the broader category of other mental illnesses. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • Women with PCOS are more likely to report fatigue than women without PCOS.

    “Women with PCOS are more likely to report fatigue than women without PCOS [59].”

    From Providing lifestyle advice to women with PCOS: an overview of practical issues affecting success (2021) · cites this paper as [59]

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2 of the 40 references couldn’t be matched to a known paper.

Research works printed but not linked: 3

  1. American Psychiatric Association. Diagnostic and statistical manual of mental disorders, fourth edition-text revision (DSM-IV-TR). Wash- ington, DC: American Psychiatric Association, 2000.
  2. Oddens BJ, den Tonkelaar I, Nieuwenhuyse H. Psychosocial experi- ences in women facing fertility problems-a comparative survey. Hum Reprod 1999;59:255-61.
  3. Spitzer RL, Kroenke K, Williams JBW. Validation and utility of a self-report version of PRIME-MD. JAMA 1999;282:1737-44.

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Authors
Hollinrake, E., Abreu, A., Maifeld, M., Van Voorhis, B. J., & Dokras, A.
Affiliations
University of Iowa (US)
Corresponding author
Dokras, Anuja
ORCID
Dokras, Anuja
Venue
Fertility and Sterility
Publisher
Elsevier BV
Published
2007-06
Volume
87
Issue
6
Pages
1369-1376
ISSN
0015-0282 (ISSN-L)
DOI
10.1016/j.fertnstert.2006.11.039
OpenAlex
W2150468895
Cited by
631
References
40
Citations by year
2026: 13 · 2025: 17 · 2024: 20 · 2023: 19 · 2022: 16 · 2021: 25 · 2020: 22 · 2019: 29 · 2018: 263 · 2017: 47 · 2016: 16 · 2015: 19 · 2014: 24 · 2013: 15 · 2012: 31
FWCI
12.84
Type
journal article
Language
en
Open access
Licence
Locations
  • Fertility and Sterility (publishedVersion)
  • PubMed (publishedVersion)
  • Iowa Research Online (The University of Iowa) (submittedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Keywords
polycystic ovary syndrome, depressive disorders, depression prevalence, hyperandrogenism, insulin resistance, body mass index, obesity, infertility, depression screening, women's mental health
MeSH terms
Adolescent, Adult, Depressive Disorder, Female, Humans, Interpersonal Relations, Middle Aged, Polycystic Ovary Syndrome, Surveys and Questionnaires, Risk Factors, Cohort Studies, Body Mass Index, Odds Ratio

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