Effects of transdermal testosterone on natriuretic peptide levels in women: a randomized placebo-controlled pilot study
Open accessAbstract
Objective To investigate whether testosterone administration alters natriuretic peptide levels in women.Design Three-month, double-blind, randomized, placebo-controlled study.Setting Clinical research center.Patient(s) Fifty-one women with hypoandrogenemia due to hypopituitarism.Intervention(s) Transdermal testosterone (300 μg daily) or placebo patch.Main outcome measure(s) N-Terminal pro-B-type natriuretic peptide (NT-proBNP) levels.Result(s) NT-proBNP levels decreased in the transdermal testosterone group compared with placebo over three months. The difference between groups remained significant after controlling for baseline age, systolic blood pressure, body mass index, and homeostasis model assessment of insulin resistance. Change in NT-proBNP over 3 months was inversely associated with change in free testosterone levels.Conclusion(s) Testosterone administration to women results in decreased natriuretic peptide levels, suggesting that testosterone may be an inverse regulator of the natriuretic peptide system.Clinical trials registration number NCT00027430.
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The relatively low endogenous testosterone levels in women with PCOS compared with men do not seem to have any major influence on MR-proANP levels.
“Based on these findings, the relatively low endogenous testosterone levels in women with PCOS compared with men do not seem to have any major influence on MR-proANP levels.”
From Effect of liraglutide on atrial natriuretic peptide, adrenomedullin, and copeptin in PCOS (2018) · cites this paper as [42]
Studies in other populations and a study administering testosterone therapy in women with hypoandrogenemia point to an inverse correlation between NPs and testosterone.
“Regarding testosterone, studies in other populations and a study administering testosterone therapy in women with hypoandrogenemia point to an inverse correlation between NPs and testosterone (41, 42).”
From Effect of liraglutide on atrial natriuretic peptide, adrenomedullin, and copeptin in PCOS (2018) · cites this paper as [42]
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- Authors
- Lin, E., McCabe, E., Newton-Cheh, C., Bloch, K., Buys, E., Wang, T., & Miller, K. K.
- Affiliations
- Harvard University (US)
- Corresponding author
- Miller, Karen K.
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2012-02
- Volume
- 97
- Issue
- 2
- Pages
- 489-493
- ISSN
- 0015-0282 (ISSN-L)
- PMC
- PMC3269509
- OpenAlex
- W2091358616
- Cited by
- 12
- References
- 28
- Citations by year
- 2024: 1 · 2023: 2 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- Procter and Gamble
- National Institutes of Health
- U.S. Food and Drug Administration (FD-R-001981)
- National Heart, Lung, and Blood Institute (K24HL092902)
- National Institute of Diabetes and Digestive and Kidney Diseases (T32DK007028)
- National Center for Research Resources (M01RR001066, M01-RR01066)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Keywords
- transdermal testosterone, natriuretic peptides, NT-proBNP, women, hypopituitarism, free testosterone, natriuretic peptide system, insulin resistance, blood pressure
- MeSH terms
- Administration, Cutaneous, Adult, Analysis of Variance, Androgens, Boston, Double-Blind Method, Female, Humans, Hypopituitarism, Middle Aged, Peptide Fragments, Pilot Projects, Regression Analysis, Testosterone, Time Factors, Biomarkers, Down-Regulation, Treatment Outcome, Natriuretic Peptide, Brain, Hormone Replacement Therapy, Young Adult, Transdermal Patch
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