Cited by 122Renin-Angiotensin System StudiesEstrogen and related hormone effectsEicosanoids and Hypertension Pharmacology

Estrogen, natriuretic peptides and the renin-angiotensin system.

Kuroski de Bold, M·1999·Cardiovascular Research

Abstract

There are significant gender-specific differences in the incidence of hypertension and the clinical outcome of cardiovascular disease between premenopausal women and age-matched men, suggesting that sex hormones such as estrogen (E) might be responsible for the observed cardioprotective effects. This cardioprotective action of E is thought to involve lipoproteins. However, the effect of E on the lipid profile accounts for about 50% of the reduction in cardiovascular disease, indicating that there might be other mechanisms by which E exerts its cardioprotective effects. At present, the underlying mechanism of E action is poorly understood. In this review, the interplay between E, the natriuretic peptides (NP) and the renin-angiotensin system (RAS) is examined. It is hypothesized that E might, through endocrine and/or paracrine action, modulate cardiac NP in females by affecting the RAS either directly or indirectly.

Integrity signals

Registry

Crossref · 10.1016/s0008-6363(98)00324-1

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104 of 104 references verified0 citation errors · 0 not checkable

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  • Estradiol administration can activate the RAAS by increasing angiotensinogen synthesis, inhibiting angiotensin-converting enzyme activity, and raising plasma and tissue renin levels.

    “Conversely, others have shown that estradiol administration can activate the RAAS by enhancing angiotensinogen synthesis, inhibiting angiotensin-converting enzyme activity, and augmenting plasma and tissue levels of renin (15).”

    From Sex Hormone Effects on Body Fluid Regulation (2008) · cites this paper as [15]

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Authors
Kuroski de Bold, M.
Venue
Cardiovascular Research
Published
1999-03-01
Volume
41
Issue
3
Pages
524-531
ISSN
0008-6363 (ISSN-L)
OpenAlex
W2161506816
Cited by
122
References
104
Citations by year
2026: 2 · 2024: 6 · 2023: 4 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 2 · 2012: 3
FWCI
1.72
Type
journal article
Language
en
Open access
closed
Locations
  • Cardiovascular Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
Keywords
estrogen, natriuretic peptides, renin-angiotensin system, sex hormones, hypertension in women, cardiovascular disease, cardioprotection, premenopausal women, lipid profile, paracrine signaling
MeSH terms
Animals, Cardiovascular Diseases, Estrogens, Female, Homeostasis, Humans, Hypertension, Male, Middle Aged, Myocardium, Atrial Natriuretic Factor, Receptors, Estrogen, Renin-Angiotensin System, Testosterone, Natriuretic Peptide, Brain, Rats

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