Estrogen, natriuretic peptides and the renin-angiotensin system.
Abstract
There are significant gender-specific differences in the incidence of hypertension and the clinical outcome of cardiovascular disease between premenopausal women and age-matched men, suggesting that sex hormones such as estrogen (E) might be responsible for the observed cardioprotective effects. This cardioprotective action of E is thought to involve lipoproteins. However, the effect of E on the lipid profile accounts for about 50% of the reduction in cardiovascular disease, indicating that there might be other mechanisms by which E exerts its cardioprotective effects. At present, the underlying mechanism of E action is poorly understood. In this review, the interplay between E, the natriuretic peptides (NP) and the renin-angiotensin system (RAS) is examined. It is hypothesized that E might, through endocrine and/or paracrine action, modulate cardiac NP in females by affecting the RAS either directly or indirectly.
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Estradiol administration can activate the RAAS by increasing angiotensinogen synthesis, inhibiting angiotensin-converting enzyme activity, and raising plasma and tissue renin levels.
“Conversely, others have shown that estradiol administration can activate the RAAS by enhancing angiotensinogen synthesis, inhibiting angiotensin-converting enzyme activity, and augmenting plasma and tissue levels of renin (15).”
From Sex Hormone Effects on Body Fluid Regulation (2008) · cites this paper as [15]
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Sex differences in 123I-mIBG scintigraphy imaging techniques in patients with heart failure
Conte, M., Feo, M. S. D., Frantellizzi, V., Rocco, A. D., Farcomeni, A., Cristofaro, F. D., Ricci, M., Pisani, A. R., Rubini, G., & Vincentis, G. D. (2023) · Expert Review of Medical Devices · doi:10.1080/17434440.2023.2239139 · Cited by 3 · see citing works
- Authors
- Kuroski de Bold, M.
- Venue
- Cardiovascular Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-03-01
- Volume
- 41
- Issue
- 3
- Pages
- 524-531
- ISSN
- 0008-6363 (ISSN-L)
- OpenAlex
- W2161506816
- Cited by
- 122
- References
- 104
- Citations by year
- 2026: 2 · 2024: 6 · 2023: 4 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 2 · 2012: 3
- FWCI
- 1.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cardiovascular Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Keywords
- estrogen, natriuretic peptides, renin-angiotensin system, sex hormones, hypertension in women, cardiovascular disease, cardioprotection, premenopausal women, lipid profile, paracrine signaling
- MeSH terms
- Animals, Cardiovascular Diseases, Estrogens, Female, Homeostasis, Humans, Hypertension, Male, Middle Aged, Myocardium, Atrial Natriuretic Factor, Receptors, Estrogen, Renin-Angiotensin System, Testosterone, Natriuretic Peptide, Brain, Rats
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