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Is PCOS an inflammatory process?
Open accessAbstract
PRO--PCOS is associated with low-grade systemic inflammation as evidenced by elevation of multiple markers of inflammation such as C-reactive protein, interleukin-18, monocyte chemoattractant protein-1 and white blood cell count as well as endothelial dysfunction and increased oxidative stress. CON--Current studies examining the evidence for low grade inflammation in PCOS are small, heterogeneous for the diagnosis, confounded by degree of adiposity and do not consistently demonstrate a clinically relevant increase in the above mentioned biomarkers.
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“However, hyperandrogenism in PCOS could worsen glucose tolerance by stimulating low-grade inflammation [17, 18].”
From From Prediabetes to Type 2 Diabetes Mellitus in Women with Polycystic Ovary Syndrome: Lifestyle and Pharmacological Management (2020) · cites this paper as [18]
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Metadata
- Authors
- Duleba, A. J., & Dokras, A.
- Affiliations
- University of Pennsylvania (US)
- ORCID
- Dokras, Anuja
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 97
- Issue
- 1
- Pages
- 7-12
- ISSN
- 0015-0282 (ISSN-L)
- PMC
- PMC3245829
- OpenAlex
- W2087004090
- Cited by
- 327
- References
- 68
- Citations by year
- 2026: 16 · 2025: 29 · 2024: 40 · 2023: 34 · 2022: 35 · 2021: 38 · 2020: 27 · 2019: 26 · 2018: 19 · 2017: 18 · 2016: 12 · 2015: 12 · 2014: 14 · 2013: 4 · 2012: 3
- FWCI
- 7.50
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD050656)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Keywords
- polycystic ovary syndrome, low-grade inflammation, C-reactive protein, IL-18, MCP-1, white blood cell count, endothelial dysfunction, oxidative stress, adiposity
- MeSH terms
- C-Reactive Protein, Female, Humans, Infections, Inflammation, Ovary, Polycystic Ovary Syndrome, Vasculitis, Biomarkers, Cytokines, Glycation End Products, Advanced, Oxidative Stress, Atherosclerosis
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