Prenatal Testosterone Exposure Induces Insulin Resistance, Uterine Oxidative Stress and pro-Inflammatory Status in Rats
Abstract
Prenatal androgen excess is considered one of the main causes of the development of polycystic ovary syndrome. In this study, we investigated the effect of prenatal hyperandrogenization (PH) on the physiology of the adult uterine tissue using a murine model of fetal programming caused by androgen excess in adult female rats. Pregnant rats were hyperandrogenized with testosterone and female offspring were studied when adult. Our results showed that PH leads to hyperglycemia and hyperinsulinemia. Consequently, PH developed insulin resistance and a systemic inflammatory state reflected by increased C-reactive protein. In the uterine tissue, levels of PPAR gamma-an important metabolic sensor in the endometrium-were found to be impaired. Moreover, PH induced a pro-inflammatory and an unbalanced oxidative state in the uterus reflected by increased COX-2, lipid peroxidation, and NF-κB. In summary, our results revealed that PH leads to a compromised metabolic state likely consequence of fetal reprogramming.
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Prenatal exposure to high levels of androgens can probably lead to the development of insulin resistance and PCOS.
“Moreover, prenatal exposure to high levels of androgens can probably lead to the development of IR and PCOS [53,54,55].”
From The Role of Glp-1 Receptor Agonists in Insulin Resistance with Concomitant Obesity Treatment in Polycystic Ovary Syndrome (2022) · cites this paper as [55]
Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860 · see citing works
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502 · see citing works
Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases
Barnes, P. J., & Karin, M. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704103361506 · Cited by 4,622 · see citing works
Kamata, H., Honda, S.-I., Maeda, S., Chang, L., Hirata, H., & Karin, M. (2005) · Cell · doi:10.1016/j.cell.2004.12.041 · Cited by 1,792 · see citing works
Role of oxidative stress in female reproduction
Agarwal, A., Gupta, S., & Sharma, R. K. (2005) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-3-28 · Cited by 1,729 · see citing works
Murri, M., Luque‐Ramírez, M., Insenser, M. R., Ojeda, M. O., & Escobar-Morreale, H. F. (2013) · Human Reproduction Update · doi:10.1093/humupd/dms059 · Cited by 657 · see citing works
Low grade chronic inflammation in women with polycystic ovarian syndrome
Kelly, C. C. J., Lyall, H., Petrie, J. R., Gould, G. W., Connell, J. M. C., & Sattar, N. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.6.7580 · Cited by 640 · see citing works
Treatment options for polycystic ovary syndrome
Badawy, A., & Elnashar (2011) · International Journal of Women s Health · doi:10.2147/ijwh.s11304 · Cited by 613 · see citing works
Circulating inflammatory markers in polycystic ovary syndrome: a systematic review and metaanalysis
Escobar-Morreale, H. F., Luque‐Ramírez, M., & González, F. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.11.036 · Cited by 522 · see citing works
González, F. (2012) · Steroids · doi:10.1016/j.steroids.2011.12.003 · Cited by 515 · see citing works
A novel and compact review on the role of oxidative stress in female reproduction
Lu, J., Wang, Z., Cao, J., Chen, Y., & Dong, Y. (2018) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-018-0391-5 · Cited by 482 · see citing works
The Role of Cyclooxygenase-2 in Cell Proliferation and Cell Death in Human Malignancies
Sobolewski, C., Cerella, C., Dicato, M. A., Ghibelli, L., & Diederich, M. F. (2010) · International Journal of Cell Biology · doi:10.1155/2010/215158 · Cited by 477 · see citing works
The Design of a Quantitative Western Blot Experiment
Taylor, S. C., & Posch, A. (2014) · BioMed Research International · doi:10.1155/2014/361590 · Cited by 412 · see citing works
A Defined Methodology for Reliable Quantification of Western Blot Data
Taylor, S. C., Berkelman, T., Yadav, G., & Hammond, M. (2013) · Molecular Biotechnology · doi:10.1007/s12033-013-9672-6 · Cited by 400 · see citing works
Keane, K. N., Cruzat, V. F., Carlessi, R., de Bittencourt, P. I. H., & Newsholme, P. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/181643 · Cited by 392 · see citing works
Proposed mechanisms for the induction of insulin resistance by oxidative stress
Bloch-Damti, A., & Bashan, N. (2005) · Antioxidants & Redox Signaling · doi:10.1089/ars.2005.7.1553 · Cited by 388 · see citing works
Boulman, N., Levy, Y., Leiba, R., Shachar, S. S., Linn, R., Zinder, O., & Blumenfeld, Z. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031096 · Cited by 332 · see citing works
Is PCOS an inflammatory process?
Duleba, A. J., & Dokras, A. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.11.023 · Cited by 327 · see citing works
Roles of oxidative stress in polycystic ovary syndrome and cancers
Zuo, T., Zhu, M., & Xu, W. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/8589318 · Cited by 319 · see citing works
The role of low-grade inflammation in the polycystic ovary syndrome
Repaci, A., Gambineri, A., & Pasquali, R. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.08.002 · Cited by 300 · see citing works
Peroxisome Proliferators Enhance Cyclooxygenase-2 Expression in Epithelial Cells
Meade, E. A., McIntyre, T. M., Zimmerman, G. A., & Prescott, S. M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.12.8328 · Cited by 293 · see citing works
Joham, A. E., Teede, H. J., Ranasinha, S., Zoungas, S., & Boyle, J. A. (2015) · Journal of Women s Health · doi:10.1089/jwh.2014.5000 · Cited by 262 · see citing works
The role of GSK3 in glucose homeostasis and the development of insulin resistance
Lee, J., & Kim, M. (2007) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2007.01.033 · Cited by 245 · see citing works
Sheep models of polycystic ovary syndrome phenotype
Padmanabhan, V., & Veiga‐Lopez, A. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.10.005 · Cited by 222 · see citing works
Wolf, C. J. (2002) · Toxicological Sciences · doi:10.1093/toxsci/65.1.71 · Cited by 216 · see citing works
Zhao, Y., Zhang, C., Huang, Y., Yu, Y., Li, R., Li, M., Liu, N., Liu, P., & Qiao, J. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-2419 · Cited by 154 · see citing works
Ovulation induction: a mini review
Messinis, I. E. (2005) · Human Reproduction · doi:10.1093/humrep/dei128 · Cited by 140 · see citing works
Dyslipidemia and Oxidative Stress in PCOS
Μacut, D., Bjekić-Macut, J., & Savic-Radojevic, A. R. (2012) · Frontiers of hormone research · doi:10.1159/000341683 · Cited by 139 · see citing works
Yilmaz, M., Bukan, N., Ayvaz, G., Karakoç, A., Törüner, F., Çakir, N., & Arslan, M. (2005) · Human Reproduction · doi:10.1093/humrep/dei258 · Cited by 138 · see citing works
Evidence of proatherogenic inflammation in polycystic ovary syndrome
González, F., Rote, N. S., Minium, J., & Kirwan, J. P. (2009) · Metabolism · doi:10.1016/j.metabol.2009.02.022 · Cited by 135 · see citing works
Insulin resistance and oxidative marker in women with PCOS
Bannigida, D., Nayak, B. S., & Vijayaraghavan, R. (2018) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2018.1499120 · Cited by 122 · see citing works
van Houten, E. L. A. F., & Visser, J. A. (2013) · Reproductive Biology · doi:10.1016/j.repbio.2013.09.007 · Cited by 103 · see citing works
Elia, E. M. (2006) · Molecular Human Reproduction · doi:10.1093/molehr/gal057 · Cited by 103 · see citing works
The pleiotropic function of PPARγ in the placenta
Schaiff, W. T., Barak, Y., & Sadovsky, Y. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.02.009 · Cited by 99 · see citing works
González, F., Minium, J., Rote, N. S., & Kirwan, J. P. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0694 · Cited by 97 · see citing works
̇ncer, Y. D., Akçay, T., Yesim, T. E., Saygılı, E. İ., & Gündoğdu, S. (2005) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365510500375263 · Cited by 95 · see citing works
Metformin Ameliorates Uterine Defects in a Rat Model of Polycystic Ovary Syndrome
Zhang, Y., Hu, M., Meng, F., Sun, X., Xu, H., Zhang, J., Cui, P., Morina, N., Li, X., Li, W., et al. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.03.023 · Cited by 90 · see citing works
Palomba, S., Falbo, A. I., Chiossi, G., Orio, F., Tolino, A., Colao, A., Sala, G. B. L., & Zullo, F. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1214 · Cited by 83 · see citing works
Abbott, D. H., Zhou, R., Bird, I. M., Dumesic, D. A., & Conley, A. J. (2008) · KARGER eBooks · doi:10.1159/000134831 · Cited by 81 · see citing works
Sasaki, H., Tanahashi, M., Yukiue, H., Moiriyama, S., Kobayashi, Y., Nakashima, Y., Kaji, M., Kiriyama, M., Fukai, I., Yamakawa, Y., et al. (2002) · Lung Cancer · doi:10.1016/s0169-5002(01)00449-4 · Cited by 69 · see citing works
Is interleukin-18 associated with polycystic ovary syndrome?
Yan, Y., Qiao, J., Li, R., & Li, M. (2011) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-9-7 · Cited by 66 · see citing works
Konstantinopoulos, P. A., Vandoros, G. P., Sotiropoulou‐Bonikou, G., Kominea, A., & Papavassiliou, A. G. (2006) · International Journal of Colorectal Disease · doi:10.1007/s00384-006-0112-y · Cited by 63 · see citing works
Badawi, A. F., & Badr, M. Z. (2002) · International Journal of Cancer · doi:10.1002/ijc.10770 · Cited by 60 · see citing works
Dehydroepiandrosterone to induce murine models for the study of polycystic ovary syndrome
Motta, A. B. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2010.02.015 · Cited by 60 · see citing works
Peroxisome Proliferator Activator Receptor Gamma (PPARG) Regulates Conceptus Elongation in Sheep1
Brooks, K. E., Burns, G. W., & Spencer, T. E. (2014) · Biology of Reproduction · doi:10.1095/biolreprod.114.123877 · Cited by 59 · see citing works
Gustafsson, A., Hansson, E., Kressner, U., Nordgren, S., Andersson, M., Wang, W., Lönnroth, C., & Lundholm, K. (2007) · International Journal of Cancer · doi:10.1002/ijc.22582 · Cited by 59 · see citing works
Amalfi, S., Vélez, L. M., Heber, M. F., Vighi, S., Ferreira, S. R., Orozco, A. S. V., Pignataro, O. P., & Motta, A. B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037658 · Cited by 58 · see citing works
COX-1 and COX-2 in health and disease
Adelizzi, R. A. (1999) · The Journal of the American Osteopathic Association · doi:10.7556/jaoa.1999.99.11.s7 · Cited by 57 · see citing works
Papaioannou, S., & Tzafettas, J. M. (2009) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2008.11.010 · Cited by 52 · see citing works
Nickkho‐Amiry, M., McVey, R. J., & Holland, C. M. (2011) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-11-0233 · Cited by 50 · see citing works
Endometrium in women with polycystic ovary syndrome during the window of implantation
Lopes, I. M. R. S., Baracat, M. C. P., JesusSimões, M., Simões, R. S., Baracat, E. C., & Soares, J. M. (2011) · Revista da Associação Médica Brasileira (English Edition) · doi:10.1016/s2255-4823(11)70138-2 · Cited by 49 · see citing works
Prenatal hyperandrogenism induces alterations that affect liver lipid metabolism
Abruzzese, G. A., Heber, M. F., Ferreira, S. R., Vélez, L. M., Reynoso, R., Pignataro, O. P., & Motta, A. B. (2016) · Journal of Endocrinology · doi:10.1530/joe-15-0471 · Cited by 48 · see citing works
Endométrio na janela de implantação em mulheres com síndrome dos ovários policísticos
Lopes, J. M., Baracat, M. C. P., Simões, M. D. J., Simões, R. S., Baracat, E. C., & Soares, J. M. (2011) · Revista da Associação Médica Brasileira · doi:10.1590/s0104-42302011000600020 · Cited by 42 · see citing works
Sheldrick, E. L., Derecka, K., Marshall, E., Chin-Smith, E. C., Hodges, L., Wathes, D. C., Abayasekara, D. R. E., & Flint, A. P. F. (2007) · Biochemical Journal · doi:10.1042/bj20070089 · Cited by 41 · see citing works
Minge, C. E., Ryan, N. K., der Hoek, K. H. V., Robker, R. L., & Norman, R. J. (2005) · Biology of Reproduction · doi:10.1095/biolreprod.105.043729 · Cited by 40 · see citing works
Karim, B. O., Landolfi, J. A., Christian, A., Arbona, R. J. R., Qiu, W., McAlonis‐Downes, M., Eyabi, P. O., Khan, K. A., Dicello, J. F., Mann, J. F., et al. (2003) · PubMed · Cited by 39 · see citing works
Regulation of lipid peroxidation by nitric oxide and PGF2α during luteal regression in rats
Motta, A., Estevez, A., Franchi, A. M., Pérez‐Martínez, S., Farina, M., Ribeiro, M., Lasserre, A., & Gimeno, M. (2001) · Reproduction · doi:10.1530/rep.0.1210631 · Cited by 38 · see citing works
Amjadi, F., Mehdizadeh, M., Ashrafi, M., Nasrabadi, D., Taleahmad, S., Mirzaei, M., Gupta, V., Salekdeh, G. H., & Aflatoonian, R. (2018) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2018.04.043 · Cited by 35 · see citing works
Li, J., Wu, Q., Wu, X.-K., Zhou, Z.-M., Fu, P., Chen, X.-H., Yan, Y., Wang, X., Yang, Z.-W., Li, W.-L., et al. (2018) · Human Reproduction · doi:10.1093/humrep/dey027 · Cited by 28 · see citing works
The use of Cox-2 and PPARγ signaling in anti-cancer therapies
Knopfová, L., & Šmarda, J. (2010) · Experimental and Therapeutic Medicine · doi:10.3892/etm_00000040 · Cited by 26 · see citing works
Polycystic Ovary Syndrome and Chronic Inflammation: Pharmacotherapeutic Implications
Sirmans, S. M., Weidman-Evans, E., Everton, V., & Thompson, D. (2012) · Annals of Pharmacotherapy · doi:10.1345/aph.1q514 · Cited by 24 · see citing works
The Possible Practical Implication of High CRP Levels in PCOS
Blumenfeld, Z. (2019) · Clinical Medicine Insights Reproductive Health · doi:10.1177/1179558119861936 · Cited by 23 · see citing works
Altered Peroxisome-Proliferator Activated Receptors Expression in Human Endometrial Cancer
Knapp, P., Chabowski, A., Błachnio-Zabielska, A. U., Jarząbek, K., & Wołczyński, S. (2012) · PPAR Research · doi:10.1155/2012/471524 · Cited by 21 · see citing works
Metformin improves ovarian insulin signaling alterations caused by fetal programming
Heber, M. F., Ferreira, S. R., Abruzzese, G. A., Raices, T., Pignataro, O. P., Vega, M., & Motta, A. B. (2019) · Journal of Endocrinology · doi:10.1530/joe-18-0520 · Cited by 20 · see citing works
Zare, M., Shahnazi, V., Fayezi, S., Darabi, M., Sadaghiani, M. M., Darabi, M., Khani, S., & Nouri, M. (2015) · PubMed Central · doi:10.22074/ijfs.2015.4240 · Cited by 19 · see citing works
Animal Models and Fetal Programming of the Polycystic Ovary Syndrome
Abbott, D. H., Dumesic, D. A., Levine, J. E., Dunaif, A. E., & Padmanabhan, V. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-179-6_23 · Cited by 14 · see citing works
Fetal programming by androgen excess in rats affects ovarian fuel sensors and steroidogenesis
Abruzzese, G. A., Heber, M. F., Arboccó, F. C. V., Ferreira, S. R., & Motta, A. B. (2019) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174419000126 · Cited by 14 · see citing works
Prenatally androgenized female rats develop uterine hyperplasia when adult
Ferreira, S. R., Goyeneche, A. A., Heber, M. F., Abruzzese, G. A., Telleria, C. M., & Motta, A. B. (2019) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2019.110610 · Cited by 13 · see citing works
The role of metformin in ovulation induction: Current status
Elnashar, A. M. (2011) · Middle East Fertility Society Journal · doi:10.1016/j.mefs.2010.10.003 · Cited by 12 · see citing works
Clinical outcome of various metformin treatments for women with polycystic ovary syndrome
Matsuzaki, T., Tungalagsuvd, A., Iwasa, T., Munkhzaya, M., Yano, K., Mayila, Y., Tokui, T., Yanagihara, R., Matsui, S., Kato, T., et al. (2017) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12026 · Cited by 10 · see citing works
Prenatal androgen excess alters the uterine peroxisome proliferator-activated receptor (PPAR) system
Ferreira, S. R., Vélez, L. M., Heber, M. F., Abruzzese, G. A., & Motta, A. B. (2019) · Reproduction Fertility and Development · doi:10.1071/rd18432 · Cited by 4 · see citing works
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- Authors
- Ferreira, S. R., Goyeneche, A. A., Heber, M. F., Abruzzese, G. A., Ferrer, M. J., Telleria, C. M., & Motta, A. B.
- Affiliations
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- McGill University (CA)
- Corresponding author
- Ferreira, Silvana Rocío
- ORCID
- Venue
- Molecular and Cellular Endocrinology
- Publisher
- Elsevier BV
- Published
- 2021-01
- Volume
- 519
- Pages
- 111045
- ISSN
- 0303-7207 (ISSN-L)
- OpenAlex
- W3094103827
- Cited by
- 8
- References
- 71
- Citations by year
- 2023: 5 · 2022: 2 · 2021: 1
- FWCI
- 1.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular and Cellular Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Agencia Nacional de Promoción Científica y Tecnológica
- Canada Foundation for Innovation
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Keywords
- testosterone, insulin resistance, hyperinsulinemia, hyperglycemia, metritis, PPARγ, endometrium, cyclooxygenase-2, lipid peroxidation, NF-κB, C-reactive protein, polycystic ovary syndrome, fetal programming, metabolic reprogramming
- MeSH terms
- Glycogen Synthase Kinase 3 beta, Androgens, Animals, Antioxidants, Female, Inflammation, Insulin Resistance, Organ Size, Oxidation-Reduction, Phosphorylation, Pregnancy, Prenatal Exposure Delayed Effects, Testosterone, Uterus, Biomarkers, Rats, Sprague-Dawley, Oxidative Stress, PPAR gamma, Rats, Cyclooxygenase 2
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