Endometriosis: the elusive gray area between evidence-based and evidence-biased medicine
Open accessAbstract
Primary (randomized controlled trials) and secondary (systematic reviews and meta-analyses) research guides clinical practice and patients' decisions. However, general and gynecologic medical journals warn that not all that glitters is gold, bringing into the spotlight the perils that may be hidden in the folds of apparently elegant methodology (1).
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New options that act on specific pathogenetic mechanisms are not expected to overcome the need for long-term use.
“In fact, new options that are foreseen for the management of endometriosis act on specific pathogenetic mechanisms and are thus not expected to overcome the need for long-term use that is the most important drawback of progestins [105].”
From Oral and depot progestin therapy for endometriosis: towards a personalized medicine (2017) · cites this paper as [105]
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Cites
Wager, E., Williams, P., & on behalf of the OPEN Project (Overcome failure to Publish nEgative fiNdings) Consortium (2013) · BMJ · doi:10.1136/bmj.f5248 · Cited by 139 · see citing works
An overview of the current status of clinical trials on endometriosis: issues and concerns
Guo, S. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.08.050 · Cited by 54 · see citing works
Lack of Transparency of Clinical Trials on Endometriosis
Guo, S., & Evers, J. L. H. (2013) · Obstetrics and Gynecology · doi:10.1097/aog.0b013e318291f299 · Cited by 40 · see citing works
A failed attempt at collaboration
Garattini, S. K., Bertelè, V., & Bertolini, G. (2013) · BMJ · doi:10.1136/bmj.f5354 · Cited by 10 · see citing works
Conflicts of Interest and Medical Publishing
Hurd, W. W. (2013) · Obstetrics and Gynecology · doi:10.1097/aog.0b013e31829f5d64 · Cited by 3 · see citing works
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Estrogen-progestins and progestins for the management of endometriosis
Vercellini, P., Buggio, L., Berlanda, N., Barbara, G., Somigliana, E., & Bosari, S. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2016.10.022 · Cited by 243 · see citing works
Self-citationVercellini, P., Bracco, B., Mosconi, P., Roberto, A., Alberico, D., Dhouha, D., & Somigliana, E. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.11.016 · Cited by 127 · see citing works
Self-citationRole of medical therapy in the management of deep rectovaginal endometriosis
Vercellini, P., Buggio, L., & Somigliana, E. (2017) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.08.038 · Cited by 62 · see citing works
Self-citationOral and depot progestin therapy for endometriosis: towards a personalized medicine
Buggio, L., Somigliana, E., Barbara, G., Frattaruolo, M. P., & Vercellini, P. (2017) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2017.1381086 · Cited by 58 · see citing works
Self-citationVercellini, P., Somigliana, E., Cortinovis, I., Bracco, B., de Braud, L., Dridi, D., & Milani, S. (2015) · BMC Women's Health · doi:10.1186/s12905-015-0248-4 · Cited by 22 · see citing works
Self-citationReconsidering evidence-based management of endometriosis
Koninckx, P. R., Ussia, A., Al-Suwaidi, S., Amro, B., Keckstein, J., Adamyan, L. V., Donnez, J., Dan, M. C., & Wattiez, A. (2022) · Facts Views and Vision in ObGyn · doi:10.52054/fvvo.14.3.033 · Cited by 16 · see citing works
The 10 “Cardinal Sins” in the Clinical Diagnosis and Treatment of Endometriosis: A Bayesian Approach
Koninckx, P. R., Ussia, A., Gordts, S., Keckstein, J., Sarıdoğan, E., Malzoni, M., Stepanian, A. A., Setúbal, A., Adamyan, L. V., & Wattiez, A. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12134547 · Cited by 9 · see citing works
- Authors
- Vercellini, P.
- Affiliations
- University of Milan (IT)
- Corresponding author
- Vercellini, Paolo
- ORCID
- Vercellini, Paolo
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 101
- Issue
- 1
- Pages
- 45-46
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2115737175
- Cited by
- 7
- References
- 5
- Citations by year
- 2023: 1 · 2022: 1 · 2017: 2 · 2016: 1 · 2015: 2
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion, public-domain)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Meta-analysis and systematic reviews
- Health Sciences › Health Professions › General Health Professions › Health Sciences Research and Education
- Keywords
- endometriosis, evidence-based medicine, research quality, randomized controlled trials, systematic reviews, meta-analysis, methodological errors, clinical practice
- MeSH terms
- Clinical Trials as Topic, Endometriosis, Female, Humans
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