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Cited by 332

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Long-term treatment of uterine fibroids with ulipristal acetate☆

Open access
Donnez, Jacques, Vázquez, Francisco, Tomaszewski, Janusz, Nouri, Kazem, Bouchard, Philippe, Fauser, Bart C.J.M., Barlow, David H., Palacios, Santiago, Donnez, Olivier, Bestel, Elke, Osterloh, Ian, Loumaye, Ernest·2014·Fertility and Sterility
DOI 10.1016/j.fertnstert.2014.02.008
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Abstract

OBJECTIVE: To investigate the efficacy and safety of ulipristal acetate (UPA) for long-term treatment of symptomatic uterine fibroids. DESIGN: Repeated intermittent open-label UPA courses, each followed by randomized double-blind norethisterone acetate (NETA) or placebo. SETTING: European clinical gynecology centers. PATIENT(S): Two hundred and nine women with symptomatic fibroids including heavy menstrual bleeding. INTERVENTION(S): Patients received up to four 3-month courses of UPA 10 mg daily, immediately followed by 10-day double-blind treatment with NETA (10 mg daily) or placebo. MAIN OUTCOME MEASURE(S): Amenorrhea, fibroid volume, endometrial histology. RESULT(S): After the first UPA course, amenorrhea occurred in 79% of women, with median onset (from treatment start) of 4 days (interquartile range, 2-6 days). Median fibroid volume change was -45% (interquartile range, -66%; -25%). Amenorrhea rates were 89%, 88%, and 90% for the 131, 119, and 107 women who received treatment courses 2, 3, and 4, respectively. Median times to amenorrhea were 2, 3, and 3 days for treatment courses 2, 3, and 4, respectively. Median fibroid volume changes from baseline were -63%, -67%, and -72% after treatment courses 2, 3, and 4, respectively. All endometrial biopsies showed benign histology without hyperplasia; NETA did not affect fibroid volume or endometrial histology. CONCLUSION(S): Repeated 3-month UPA courses effectively control bleeding and shrink fibroids in patients with symptomatic fibroids. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov (www.clinicaltrials.gov) registration numbers NCT01156857 (PEARL III) and NCT01252069 (PEARL III extension).

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Metadata

Authors
Donnez, J., Vázquez, F., Tomaszewski, J., Nouri, K., Bouchard, P., Fauser, B. C. J. M., Barlow, D. H., Palacios, S., Donnez, O., Bestel, E., Osterloh, I., & Loumaye, E.
Venue
Fertility and Sterility
Publisher
Elsevier BV
Published
2014-06
Volume
101
Issue
6
Pages
1565-1573.e18
ISSN
0015-0282 (ISSN-L)
DOI
10.1016/j.fertnstert.2014.02.008
OpenAlex
W1996100965
Cited by
332
References
34
FWCI
49.24
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Long-term treatment of uterine fibroids with ulipristal acetate☆. https://app.cochat.ai/papers/10.1016/j.fertnstert.2014.02.008
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Donnez, J., Vázquez, F., Tomaszewski, J., Nouri, K., Bouchard, P., Fauser, B. C. J. M., Barlow, D. H., Palacios, S., Donnez, O., Bestel, E., Osterloh, I., & Loumaye, E. (2014). Long-term treatment of uterine fibroids with ulipristal acetate☆. Fertility and Sterility. https://doi.org/10.1016/j.fertnstert.2014.02.008

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.