Role of nuclear progesterone receptor isoforms in uterine pathophysiology

The Steroid and Thyroid Hormone Receptor Superfamily

Evans, R. M. (1988) · Science · doi:10.1126/science.3283939 · Cited by 7,442 · see citing works

The nuclear receptor superfamily: the second decade

Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90199-x · Cited by 6,964 · see citing works

American Journal of Pathology

(2015) · American Journal Of Pathology · doi:10.2353/ajpath · Cited by 4,961 · see citing works

Cancer statistics, 2011

Siegel, R. L., Ward, E., Brawley, O. W., & Jemal, A. (2011) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.20121 · Cited by 4,075 · see citing works

Papillomaviruses and cancer: from basic studies to clinical application

Hausen, H. Z. (2002) · Nature reviews. Cancer · doi:10.1038/nrc798 · Cited by 4,031 · see citing works

Bulletin of the World Health Organization

C., N. H. (1955) · British Journal of Sociology · doi:10.2307/587237 · Cited by 3,658 · see citing works

Endometriosis

Giudice, L. C., & Kao, L. C. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17403-5 · Cited by 3,166 · see citing works

THE JOURNAL OF REPRODUCTIVE MEDICINE

Reddy, D. M., & Wasserman, S. A. (1999) · AJN American Journal of Nursing · doi:10.1097/00000446-199901000-00024 · Cited by 2,483 · see citing works

International Journal of Oncology

(2026) · International Journal of Oncology · doi:10.3892/ijo · Cited by 2,332 · see citing works

Consensus on women’s health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group

Fauser, B. C. J. M., Tarlatzis, B. C., Rebar, R. W., Legro, R. S., Balen, A. H., Lobo, R., Carmina, E., Chang, J., Yildiz, B. O., Laven, J. S. E., et al. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.09.024 · Cited by 1,976 · see citing works

Endometriosis

Giudice, L. C. (2010) · New England Journal of Medicine · doi:10.1056/nejmcp1000274 · Cited by 1,924 · see citing works

Nuclear Receptor Coregulators: Cellular and Molecular Biology

McKenna, N. J., Lanz, R. B., & O’Malley, B. W. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.3.0366 · Cited by 1,905 · see citing works

Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities.Preprint

Lydon, J. P., DeMayo, F. J., Funk, C. R., Mani, S. K., Hughes, A. R., Montgomery, C. A., Shyamala, G., Conneely, O. M., & O’Malley, B. W. (1995) · Genes & Development · doi:10.1101/gad.9.18.2266 · Cited by 1,862 · see citing works

EPIDEMIOLOGY OF ENDOMETRIOSIS

Eskenazi, B., & Warner, M. L. (1997) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/s0889-8545(05)70302-8 · Cited by 1,617 · see citing works

Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B

Kastner, P., Krust, A., Turcotte, B., Stropp, U., Tora, L., Gronemeyer, H., & Chambon, P. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb08280.x · Cited by 1,534 · see citing works

Nuclear Receptor Coactivator ACTR Is a Novel Histone Acetyltransferase and Forms a Multimeric Activation Complex with P/CAF and CBP/p300

Chen, H., Lin, R. J., Schiltz, R. L., Chakravarti, D., Nash, A., Nagy, L., Privalsky, M. L., Nakatani, Y., & Evans, R. M. (1997) · Cell · doi:10.1016/s0092-8674(00)80516-4 · Cited by 1,465 · see citing works

Knobil and Neill's Physiology of Reproduction

(2015) · Elsevier eBooks · doi:10.1016/c2011-1-07288-0 · Cited by 1,276 · see citing works

Implantation and the Survival of Early Pregnancy

Norwitz, E. R., Schust, D. J., & Fisher, S. J. (2001) · New England Journal of Medicine · doi:10.1056/nejmra000763 · Cited by 1,267 · see citing works

Metastatic or Embolic Endometriosis, due to the Menstrual Dissemination of Endometrial Tissue into the Venous Circulation.

(1927) · PubMed Central · Cited by 1,008 · see citing works

Ovarian cancer and hormone replacement therapy in the Million Women Study

Beral, V. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60534-0 · Cited by 937 · see citing works

Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes

Zhu, Y., Rice, C. D., Pang, Y., Pace, M. C., & Thomas, P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0336132100 · Cited by 798 · see citing works

Nuclear Receptor Coregulators: Cellular and Molecular Biology

McKenna, N. J. (1999) · Endocrine Reviews · doi:10.1210/er.20.3.321 · Cited by 782 · see citing works

Progesterone favors the development of human T helper cells producing Th2-type cytokines and promotes both IL-4 production and membrane CD30 expression in established Th1 cell clones

Piccinni, M., Giudizi, M. G., Biagiotti, R., Beloni, L., Giannarini, L., Sampognaro, S., Parronchi, P., Manetti, R., Annunziato, F., & Livi, C. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.1.128 · Cited by 743 · see citing works

Gene Expression Analysis of Endometrium Reveals Progesterone Resistance and Candidate Susceptibility Genes in Women with Endometriosis

Burney, R. O., Talbi, S., Hamilton, A. E., Vo, K. C., Nyegaard, M., Nezhat, C. R., Lessey, B. A., & Giudice, L. C. (2007) · Endocrinology · doi:10.1210/en.2006-1692 · Cited by 735 · see citing works

Etiology, symptomatology, and diagnosis of uterine myomas

Parker, W. H. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.01.093 · Cited by 718 · see citing works

Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor

Zhu, Y., Bond, J. E., & Thomas, P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0436133100 · Cited by 710 · see citing works

Subgroup of reproductive functions of progesterone mediated by progesterone receptor-B isoform

Mulac-Jericevic, B., Mullinax, R. A., DeMayo, F. J., Lydon, J. P., & Conneely, O. M. (2000) · Science · doi:10.1126/science.289.5485.1751 · Cited by 704 · see citing works

Expression Profiling of Endometrium from Women with Endometriosis Reveals Candidate Genes for Disease-Based Implantation Failure and Infertility

Kao, L. C., Germeyer, A., Tulac, S., Lobo, S., Yang, J. P., Taylor, R. N., Osteen, K., Lessey, B. A., & Giudice, L. C. (2003) · Endocrinology · doi:10.1210/en.2003-0043 · Cited by 696 · see citing works

Effect of oral contraceptives on risk of cervical cancer in women with human papillomavirus infection: the IARC multicentric case-control study

Moreno, V. R., Bosch, F. X., Muñóz, N., Meijer, C. J. L. M., Shah, K. V., Walboomers, J. M. M., Herrero, R., & Franceschi, S. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08150-3 · Cited by 687 · see citing works

Ulipristal Acetate versus Placebo for Fibroid Treatment before Surgery

Donnez, J., Татарчук, Т. Ф., Bouchard, P., Pușcașiu, L., Zakharenko, N. F., Ivanova, T. V., Ugocsai, G., Mára, M., Jilla, M. P., Bestel, E., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1103182 · Cited by 679 · see citing works

Immunohistochemical Analysis of Human Uterine Estrogen and Progesterone Receptors Throughout the Menstrual Cycle*

Lessey, B. A., Killam, A. P., METZGER, D. A., Haney, A. F., Greene, G. L., & McCarty, K. S. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-67-2-334 · Cited by 647 · see citing works

Endometrial cancer and hormone-replacement therapy in the Million Women Study

Beral, V., Bull, D., & REEVES, G. K. (2005) · The Lancet · doi:10.1016/s0140-6736(05)66455-0 · Cited by 613 · see citing works

Ulipristal Acetate versus Leuprolide Acetate for Uterine Fibroids

Donnez, J., Tomaszewski, J., Vázquez, F., Bouchard, P., Lemieszczuk, B., Baró, F., Nouri, K., Selvaggi, L. E., Sodowski, K., Bestel, E., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1103180 · Cited by 604 · see citing works

Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis

Barry, J. A., Azizia, M., & Hardiman, P. J. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmu012 · Cited by 603 · see citing works

Progesterone Receptor Contains a Proline-Rich Motif that Directly Interacts with SH3 Domains and Activates c-Src Family Tyrosine Kinases

Boonyaratanakornkit, V., Scott, M. P., Ribon, V., Sherman, L., Anderson, S. M., Maller, J. L., Miller, W. T., & Edwards, D. P. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00304-5 · Cited by 590 · see citing works

Endocrine regulation of menstruation

Jabbour, H. N., Kelly, R. W., Fraser, H. M., & Critchley, H. O. D. (2006) · Endocrine Reviews · doi:10.1210/er.2004-0021 · Cited by 588 · see citing works

Differential Gene Regulation by the Two Progesterone Receptor Isoforms in Human Breast Cancer Cells

Richer, J. K., Jacobsen, B. M., Manning, N. G., Abel, M. G., Horwitz, K. B., & Wolf, D. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110090200 · Cited by 570 · see citing works

Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoform

Mulac‐Jeričević, B., Lydon, J. P., DeMayo, F. J., & Conneely, O. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1732707100 · Cited by 542 · see citing works

Interim Guidelines for Management of Abnormal Cervical Cytology

Kurman, R. J. (1994) · JAMA · doi:10.1001/jama.1994.03510470070037 · Cited by 539 · see citing works

Leukocytes infiltrate the myometrium during human parturition: further evidence that labour is an inflammatory process

Thomson, A. J., Telfer, J. F., Young, A., Campbell, S., Stewart, C., Cameron, I. T., Greer, I. A., & Norman, J. E. (1999) · Human Reproduction · doi:10.1093/humrep/14.1.229 · Cited by 530 · see citing works

Progesterone action in endometrial cancer, endometriosis, uterine fibroids, and breast cancer

Kim, J. J., Kurita, T., & Bulun, S. E. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1043 · Cited by 520 · see citing works

Review of the in Vivo Functions of the p160 Steroid Receptor Coactivator Family

Xu, J., & Li, Q. (2003) · Molecular Endocrinology · doi:10.1210/me.2003-0116 · Cited by 493 · see citing works

Progesterone Receptor Isoform A But Not B Is Expressed in Endometriosis

Attia, G. R. (2000) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.8.2897 · Cited by 488 · see citing works

Oral Medroxyprogesterone Acetate in the Treatment of Advanced or Recurrent Endometrial Carcinoma: A Dose-Response Study by the Gynecologic Oncology Group

Thigpen, J. T., Brady, M. F., Alvarez, R. D., ADELSON, M. D., Homesley, H. D., Manetta, A., Soper, J. T., & Given, F. T. (1999) · Journal of Clinical Oncology · doi:10.1200/jco.1999.17.6.1736 · Cited by 483 · see citing works

Phosphorylation of human progesterone receptors at serine-294 by mitogen-activated protein kinase signals their degradation by the 26S proteasome

Lange, C. A., Shen, T., & Horwitz, K. B. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.3.1032 · Cited by 451 · see citing works

Cyclic AMP and progesterone receptor cross-talk in human endometrium: a decidualizing affair

Gellersen, B., & Brosens, J. J. (2003) · Journal of Endocrinology · doi:10.1677/joe.0.1780357 · Cited by 435 · see citing works

Progesterone Withdrawal and Estrogen Activation in Human Parturition Are Coordinated by Progesterone Receptor A Expression in the Myometrium

Mesiano, S. A., Chan, E., Fitter, J. T., Kwek, K. Y. C., Yeo, G. S., & Smith, R. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.6.8609 · Cited by 427 · see citing works

The dynamics of rapid sperm transport through the female genital tract, evidence from vaginal sonography of uterine peristalsis and hysterosalpingoscintigraphy

Kunz, G., Beil, D., Deininger, H., Wildt, L., & Leyendecker, G. (1996) · Human Reproduction · doi:10.1093/humrep/11.3.627 · Cited by 408 · see citing works

Progesterone resistance in endometriosis: link to failure to metabolize estradiol.

Bulun, S. E., Cheng, Y.-H., Yin, P., Imir, G., Utsunomiya, H., Attar, E., Innes, J., & Julie Kim, J. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2005.11.041 · Cited by 397 · see citing works

The Opposing Transcriptional Activities of the Two Isoforms of the Human Progesterone Receptor Are Due to Differential Cofactor Binding

Giangrande, P. H., Kimbrel, E. A., Edwards, D. P., & McDonnell, D. P. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.9.3102-3115.2000 · Cited by 377 · see citing works

Progesterone and Placental Hormone Actions on the Uterus: Insights from Domestic Animals1

Spencer, T. E., Johnson, G. A., Burghardt, R. C., et al. (2004) · Biology of Reproduction · doi:10.1095/biolreprod.103.024133 · Cited by 375 · see citing works

The A and B Isoforms of the Human Progesterone Receptor Operate through Distinct Signaling Pathways within Target Cells

Wen, D. X., Xu, Y., Mais, D. E., Goldman, M. E., & McDonnell, D. P. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.12.8356 · Cited by 355 · see citing works

Interim guidelines for management of abnormal cervical cytology. The 1992 National Cancer Institute Workshop

Kurman, R. J. (1994) · JAMA · doi:10.1001/jama.271.23.1866 · Cited by 354 · see citing works

Negative Interaction between the RelA(p65) Subunit of NF-κB and the Progesterone Receptor

Kalkhoven, E., Wissink, S., van der Saag, P. T., & van der Burg, B. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.11.6217 · Cited by 350 · see citing works

A third transactivation function (AF3) of human progesterone receptors located in the unique N-terminal segment of the B-isoform

Sartorius, C. A., Melville, M. Y., Hovland, A. R., Tung, L. W., Takimoto, G. S., & Horwitz, K. B. (1994) · Molecular Endocrinology · doi:10.1210/mend.8.10.7854352 · Cited by 342 · see citing works

Long-term treatment of uterine fibroids with ulipristal acetate☆

Donnez, J., Vázquez, F., Tomaszewski, J., Nouri, K., Bouchard, P., Fauser, B. C. J. M., Barlow, D. H., Palacios, S., Donnez, O., Bestel, E., et al. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.02.008 · Cited by 331 · see citing works

Antagonist-occupied human progesterone B-receptors activate transcription without binding to progesterone response elements and are dominantly inhibited by A-receptors.

Tung, L. W., Mohamed, M. K., Hoeffler, J. P., Takimoto, G. S., & Horwitz, K. B. (1993) · Molecular Endocrinology · doi:10.1210/mend.7.10.8123133 · Cited by 324 · see citing works

Promoter Hypermethylation of Progesterone Receptor Isoform B (PR-B) in Endometriosis

Wu, Y., Strawn, E., Basir, Z., Halverson, G., & Guo, S. (2006) · Epigenetics · doi:10.4161/epi.1.2.2766 · Cited by 323 · see citing works

Selective progesterone receptor modulators and progesterone antagonists: mechanisms of action and clinical applications

Chabbert-Buffet, N., Meduri, G., Bouchard, P., & Spitz, I. M. (2005) · Human Reproduction Update · doi:10.1093/humupd/dmi002 · Cited by 310 · see citing works

Proliferation kinetics of human endometrium during the normal menstrual cycle

Ferenczy, A. S., Bertrand, G., & Gelfand, M. M. (1979) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(79)90302-8 · Cited by 291 · see citing works

Progesterone Receptor Plays a Major Antiinflammatory Role in Human Myometrial Cells by Antagonism of Nuclear Factor-κB Activation of Cyclooxygenase 2 Expression

Hardy, D. B., Janowski, B. A., Corey, D. R., & Mendelson, C. R. (2006) · Molecular Endocrinology · doi:10.1210/me.2006-0112 · Cited by 289 · see citing works

Up-Regulation of the Progesterone Receptor (PR)-C Isoform in Laboring Myometrium by Activation of Nuclear Factor-κB May Contribute to the Onset of Labor through Inhibition of PR Function

Condon, J. C., Hardy, D. B., Kovaric, K., & Mendelson, C. R. (2005) · Molecular Endocrinology · doi:10.1210/me.2005-0242 · Cited by 288 · see citing works

Differential Uterine Expression of Estrogen and Progesterone Receptors Correlates with Uterine Preparation for Implantation and Decidualization in the Mouse1

Tan, J., Paria, B. C., Dey, S. K., & Das, S. K. (1999) · Endocrinology · doi:10.1210/endo.140.11.7148 · Cited by 278 · see citing works

A decline in the levels of progesterone receptor coactivators in the pregnant uterus at term may antagonize progesterone receptor function and contribute to the initiation of parturition

Condon, J. C., Jeyasuria, P., Faust, J. M., Wilson, J. W., & Mendelson, C. R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1633616100 · Cited by 270 · see citing works

Colocalization of Progesterone Receptors A and B by Dual Immunofluorescent Histochemistry in Human Endometrium during the Menstrual Cycle1

Mote, P. A., Balleine, R. L., McGowan, E. M., & Clarke, C. L. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.8.5928 · Cited by 270 · see citing works

Nuclear Progesterone Receptors in the Human Pregnancy Myometrium: Evidence that Parturition Involves Functional Progesterone Withdrawal Mediated by Increased Expression of Progesterone Receptor-A

Merlino, A. A., Welsh, T. N., Tan, H., Yi, L. J., Cannon, V., Mercer, B. M., & Mesiano, S. A. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0077 · Cited by 263 · see citing works

Phase II trial of alternating courses of megestrol acetate and tamoxifen in advanced endometrial carcinoma: a Gynecologic Oncology Group study

Fiorica, J. V. (2004) · Gynecologic Oncology · doi:10.1016/j.ygyno.2003.11.008 · Cited by 250 · see citing works

Regression of uterine leiomyomata in response to the antiprogesterone RU 486.

Murphy, A. A., Kettel, L. M., Morales, A. J., Roberts, V. J., & YEN, S. S. C. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.76.2.8432797 · Cited by 247 · see citing works

Mitotic activity in uterine leiomyomas during the menstrual cycle

Kawaguchi, K., Fujii, S., Konishi, I., Nanbu, Y., Nonogaki, H., & Mori, T. (1989) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(89)80046-8 · Cited by 239 · see citing works

The spectrum of endometrial pathology induced by progesterone receptor modulators

Mutter, G. L., Bergeron, C., Deligdisch, L., Ferenczy, A. S., Glant, M., Merino, M. J., Williams, A. R. W., & Blithe, D. (2008) · Modern Pathology · doi:10.1038/modpathol.2008.19 · Cited by 235 · see citing works

Progestogen for preventing miscarriage

Oates-Whitehead, R., Haas, D. M., & Carrier, J. (2003) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003511 · Cited by 223 · see citing works

Transforming growth factor-β3 is expressed at high levels in leiomyoma where it stimulates fibronectin expression and cell proliferation

Arici, A. M., & Sozen, I. (2000) · Fertility and Sterility · doi:10.1016/s0015-0282(00)00418-0 · Cited by 222 · see citing works

Progesterone receptor transcription and non-transcription signaling mechanisms

Leonhardt, S. A., Boonyaratanakornkit, V., & Edwards, D. P. (2003) · Steroids · doi:10.1016/s0039-128x(03)00129-6 · Cited by 217 · see citing works

The evolution of the nuclear receptor superfamily

Escrivá, H., Bertrand, S., & Laudet, V. (2004) · Essays in Biochemistry · doi:10.1042/bse0400011 · Cited by 214 · see citing works

Histologic Alterations in Endometrial Hyperplasia and Well-differentiated Carcinoma Treated With Progestins

Wheeler, D. T., Bristow, R. E., & Kurman, R. J. (2007) · The American Journal of Surgical Pathology · doi:10.1097/pas.0b013e31802d68ce · Cited by 212 · see citing works

Interactions between progesterone receptor isoforms in myometrial cells in human labour

Pieber, D. (2001) · Molecular Human Reproduction · doi:10.1093/molehr/7.9.875 · Cited by 212 · see citing works

Progesterone as an immunomodulatory molecule

Szekeres‐Barthó, J., Barakonyi, A., Pár, G., Polgár, B., Palkovics, T., & Szereday, L. (2001) · International Immunopharmacology · doi:10.1016/s1567-5769(01)00035-2 · Cited by 211 · see citing works

Progesterone Receptor-A and -B Have Opposite Effects on Proinflammatory Gene Expression in Human Myometrial Cells: Implications for Progesterone Actions in Human Pregnancy and Parturition

Tan, H., Yi, L., Rote, N. S., Hurd, W. W., & Mesiano, S. A. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-3251 · Cited by 210 · see citing works

Neurosteroid regulation of central nervous system development

Mellon, S. H. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.04.011 · Cited by 209 · see citing works

Progesterone receptor messenger ribonucleic acid and protein are overexpressed in human uterine leiomyomas

Brandon, D. D., Bethea, C. L., Strawn, E. Y., Novy, M. J., Burry, K. A., Harrington, M. S., Erickson, T. E., Warner, C., Keenan, E. J., & Clinton, G. M. (1993) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(93)90135-6 · Cited by 206 · see citing works

Transcriptional Hyperactivity of Human Progesterone Receptors Is Coupled to Their Ligand-Dependent Down-Regulation by Mitogen-Activated Protein Kinase-Dependent Phosphorylation of Serine 294

Shen, T., Horwitz, K. B., & Lange, C. A. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.18.6122-6131.2001 · Cited by 204 · see citing works

The Parturition Defect in Steroid 5α-Reductase Type 1 Knockout Mice Is Due to Impaired Cervical Ripening

Mahendroo, M., Porter, A., Russell, D. W., & Word, R. A. (1999) · Molecular Endocrinology · doi:10.1210/mend.13.6.0307 · Cited by 202 · see citing works

Phase II study of medroxyprogesterone acetate plus tamoxifen in advanced endometrial carcinoma: a Gynecologic Oncology Group study

Whitney, C. (2003) · Gynecologic Oncology · doi:10.1016/j.ygyno.2003.09.018 · Cited by 193 · see citing works

Effect of Mifepristone for Symptomatic Leiomyomata on Quality of Life and Uterine Size

Fiscella, K. A., Eisinger, S. H., Meldrum, S. C., et al. (2006) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000243776.23391.7b · Cited by 193 · see citing works

Progesterone Receptor Isoform A But Not B Is Expressed in Endometriosis1

Attia, G. R., Zeitoun, K., Edwards, D., Johns, A., Carr, B. R., & Bulun, S. E. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.8.6739 · Cited by 193 · see citing works

Mapping and Characterization of the Functional Domains Responsible for the Differential Activity of the A and B Isoforms of the Human Progesterone Receptor

Giangrande, P. H., Pollio, G., & McDonnell, D. P. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.52.32889 · Cited by 186 · see citing works

High-dose megestrol acetate in advanced or recurrent endometrial carcinoma: a Gynecologic Oncology Group Study.

Lentz, S. S., Brady, M. F., Major, F. J., Reid, G. C., & Soper, J. T. (1996) · Journal of Clinical Oncology · doi:10.1200/jco.1996.14.2.357 · Cited by 186 · see citing works

Short Communication

Gerdes, D., Wehling, M., Leube, B., & Falkenstein, E. (1998) · Biological Chemistry · doi:10.1515/bchm.1998.379.7.907 · Cited by 186 · see citing works

Health care resource use for uterine fibroid tumors in the United States

Flynn, M., Jamison, M. G., Datta, S., & Myers, E. R. (2006) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2006.02.020 · Cited by 184 · see citing works

Receptor Mechanisms Mediating Non-Genomic Actions of Sex Steroids

Boonyaratanakornkit, V., & Edwards, D. (2007) · Seminars in Reproductive Medicine · doi:10.1055/s-2007-973427 · Cited by 178 · see citing works

Recurrent pregnancy loss: the key potential mechanisms

Baek, K., Lee, E.-J., & Kim, Y. (2007) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2007.05.005 · Cited by 175 · see citing works

Increased Activation of the PI3K/AKT Pathway Compromises Decidualization of Stromal Cells from Endometriosis

Yin, X., Pavone, M. E., Lu, Z., Wei, J., & Kim, J. J. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1527 · Cited by 171 · see citing works

Systematic Review of Mifepristone for the Treatment of Uterine Leiomyomata

Steinauer, J. E., Pritts, E. A., Jackson, R., & Jacoby, A. F. (2004) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000127622.63269.8b · Cited by 166 · see citing works

Relationship of estrogen and progesterone receptors to clinical outcome in metastatic endometrial carcinoma: A Gynecologic Oncology Group Study

Singh, M., Zaino, R. J., Filiaci, V. L., et al. (2007) · Gynecologic Oncology · doi:10.1016/j.ygyno.2007.03.042 · Cited by 165 · see citing works

Hormone therapy in advanced and recurrent endometrial cancer: a systematic review

Decruze, S. B., & Green, J. A. (2007) · International Journal of Gynecological Cancer · doi:10.1111/j.1525-1438.2007.00897.x · Cited by 164 · see citing works

Low-dose mifepristone for uterine leiomyomata

Eisinger, S. H. (2003) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(02)02511-5 · Cited by 164 · see citing works

Reduced expression of progesterone receptor-B in the endometrium of women with endometriosis and in cocultures of endometrial cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin

Igarashi, T. M., Bruner-Tran, K. L., Yeaman, G. R., Lessey, B. A., Edwards, D. P., Eisenberg, E., & Osteen, K. G. (2005) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.01.113 · Cited by 163 · see citing works

Regression of uterine leiomyomata to the antiprogesterone RU486: dose-response effect

Murphy, A. A., Morales, A. J., Kettel, L. M., & Yen, S. S. C. (1995) · Fertility and Sterility · doi:10.1016/s0015-0282(16)57678-x · Cited by 162 · see citing works

Progesterone Receptors in the Human Pregnancy Uterus: Do they Hold the Key to Birth Timing?

Mesiano, S. A., Wang, Y., & Norwitz, E. R. (2010) · Reproductive Sciences · doi:10.1177/1933719110382922 · Cited by 161 · see citing works

Immunohistochemical study of the proliferation index, oestrogen receptors and progesterone receptors A and B in leiomyomata and normal myometrium during the menstrual cycle and under gonadotrophin-releasing hormone agonist therapy

Nisolle, M., Gillerot, S., Casanas‐Roux, F., Squifflet, J. P., Berlière, M., & Donnez, J. (1999) · Human Reproduction · doi:10.1093/humrep/14.11.2844 · Cited by 159 · see citing works

Progesterone Receptor Rapid Signaling Mediates Serine 345 Phosphorylation and Tethering to Specificity Protein 1 Transcription Factors

Faivre, E. J., Daniel, A. R., Hillard, C. J., & Lange, C. A. (2008) · Molecular Endocrinology · doi:10.1210/me.2007-0437 · Cited by 156 · see citing works

CDB-2914 for Uterine Leiomyomata Treatment

Levens, E. D., Potlog‐Nahari, C., Armstrong, A. Y., WESLEY, R. A., Premkumar, A., Blithe, D., Blocker, W., & Nieman, L. K. (2008) · Obstetrics and Gynecology · doi:10.1097/aog.0b013e3181705d0e · Cited by 156 · see citing works

In Situ Estrogen Synthesized by Aromatase P450 in Uterine Leiomyoma Cells Promotes Cell Growth Probably Via an Autocrine/Intracrine Mechanism

Sumitani, H., Shozu, M., Segawa, T., Murakami, K., Yang, H.-J., Shimada, K., & Inoue, M. (2000) · Endocrinology · doi:10.1210/endo.141.10.7719 · Cited by 155 · see citing works

Hormone receptor loss in endometrial carcinoma curettage predicts lymph node metastasis and poor outcome in prospective multicentre trial

Trovik, J., Wik, E., Werner, H. M. J., Krakstad, C., Helland, H., Vandenput, I., Njølstad, T. S., Stefansson, I. M., Marcickiewicz, J., Tingulstad, S., et al. (2013) · European Journal of Cancer · doi:10.1016/j.ejca.2013.06.016 · Cited by 154 · see citing works

Regression of uterine leiomyomata in response to the antiprogesterone RU 486

Murphy, A. A. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.76.2.513 · Cited by 154 · see citing works

Early luteal phase treatment with mifepristone (RU 486) for fertility regulation

Gemzell‐Danielsson, K., Swahn, M. L., Svalander, P. C., et al. (1993) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a138157 · Cited by 147 · see citing works

Relative overexpression of collagen type I and collagen type III messenger ribonucleic acids by uterine leiomyomas during the proliferative phase of the menstrual cycle.

Stewart, E. A., Friedman, A. J., Peck, K., et al. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.3.8077380 · Cited by 147 · see citing works

Progesterone-Independent Effects of Human Progesterone Receptors (PRs) in Estrogen Receptor-Positive Breast Cancer: PR Isoform-Specific Gene Regulation and Tumor Biology

Jacobsen, B. M., Schittone, S. A., Richer, J. K., & Horwitz, K. B. (2004) · Molecular Endocrinology · doi:10.1210/me.2004-0287 · Cited by 146 · see citing works

Effects of progesterone on uterine leiomyoma growth and apoptosis

Maruo, T. (2000) · Steroids · doi:10.1016/s0039-128x(00)00171-9 · Cited by 145 · see citing works

Up-Regulation by Progesterone of Proliferating Cell Nuclear Antigen and Epidermal Growth Factor Expression in Human Uterine Leiomyoma1

Shimomura, Y., Matsuo, H., Samoto, T., et al. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.6.4879 · Cited by 145 · see citing works

Nuclear Receptors: One Big Family

McEwan, I. J. (2009) · Methods in molecular biology · doi:10.1007/978-1-60327-575-0_1 · Cited by 144 · see citing works

Progesterone receptor distribution in the human endometrium. Analysis using monoclonal antibodies to the human progesterone receptor.

Press, M. F., Udove, J. A., & Greene, G. L. (1988) · PubMed Central · Cited by 142 · see citing works

Twelve-month safety and efficacy of low-dose mifepristone for uterine myomas

Eisinger, S. H., Bonfiglio, T. A., Fiscella, K. A., et al. (2005) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2005.01.022 · Cited by 139 · see citing works

The use of progesterone antagonists for cervical ripening and as an adjunct to labour and delivery

Chwalisż, K. (1994) · Human Reproduction · doi:10.1093/humrep/9.suppl_1.131 · Cited by 138 · see citing works

Myometrial Progesterone Responsiveness

Mesiano, S. A. (2007) · Seminars in Reproductive Medicine · doi:10.1055/s-2006-956771 · Cited by 138 · see citing works

A randomized, controlled trial of asoprisnil, a novel selective progesterone receptor modulator, in women with uterine leiomyomata

Chwalisż, K., Larsen, L. M., Mattia‐Goldberg, C., Edmonds, A., Elger, W. A. G., & Winkel, C. A. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.11.094 · Cited by 138 · see citing works

Isoform/variant mRNAs for sex steroid hormone receptors in humans

Hirata, S., Shoda, T., Kato, J., & Hoshi, K. (2003) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(03)00028-6 · Cited by 136 · see citing works

The Effect of Progestins on the Mitotic Activity of Uterine Fibromyomas

Tiltman, A. J. (1985) · International Journal of Gynecological Pathology · doi:10.1097/00004347-198506000-00001 · Cited by 136 · see citing works

Immortalization of Human Uterine Leiomyoma and Myometrial Cell Lines After Induction of Telomerase Activity: Molecular and Phenotypic Characteristics

Carney, S. A., Tahara, H., Swartz, C. D., Risinger, J. I., He, H., Moore, A. B., Haseman, J. K., Barrett, J. C., & Dixon, D. (2002) · Laboratory Investigation · doi:10.1097/01.lab.0000017499.51216.3e · Cited by 136 · see citing works

Reactivity of lymphocytes to a progesterone receptor-specific monoclonal antibody

Szekeres‐Barthó, J., Szekeres, G., Debré, P., Autran, B., & Chaouat, G. (1990) · Cellular Immunology · doi:10.1016/0008-8749(90)90083-4 · Cited by 134 · see citing works

De novo synthesis of estrogen in pregnant uterus is critical for stromal decidualization and angiogenesis

Das, A., Mantena, S. R., Kannan, A., Evans, D. B., Bagchi, M. K., & Bagchi, I. C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901647106 · Cited by 131 · see citing works

Medical methods for mid-trimester termination of pregnancy

Wildschut, H. I. J., Bouwland-Both, M. I., Medema, S., Thomee, E., Wildhagen, M. F., & Kapp, N. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005216.pub2 · Cited by 129 · see citing works

Mechanisms of action of mifepristone and levonorgestrel when used for emergency contraception

Gemzell‐Danielsson, K. (2004) · Human Reproduction Update · doi:10.1093/humupd/dmh027 · Cited by 128 · see citing works

Progestogen for preventing miscarriage

Haas, D. M., & Ramsey, P. S. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003511.pub3 · Cited by 126 · see citing works

Heterogeneity of progesterone receptors A and B expression in human endometrial glands and stroma

Mote, P. A., Balleine, R. L., McGowan, E. M., et al. (2000) · Human Reproduction · doi:10.1093/humrep/15.suppl_3.48 · Cited by 125 · see citing works

A prospective, randomized trial of gonadotropin-releasing hormone agonist plus estrogen-progestin or progestin "add-back" regimens for women with leiomyomata uteri.

Friedman, A. J., Daly, M., Juneau-Norcross, M., Rein, M. S., Fine, C., Gleason, R. E., & LeBoff, M. S. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.76.6.8501148 · Cited by 124 · see citing works

Clinical utility of progesterone receptor modulators and their effect on the endometrium

Spitz, I. M. (2009) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0b013e32832e07e8 · Cited by 124 · see citing works

Efficacy and tolerability of CDB-2914 treatment for symptomatic uterine fibroids: a randomized, double-blind, placebo-controlled, phase IIb study

Nieman, L. K., Blocker, W., Nansel, T. R., Mahoney, S. F., Reynolds, J. C., Blithe, D., WESLEY, R. A., & Armstrong, A. Y. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.09.059 · Cited by 123 · see citing works

Reduced progesterone action during endometrial maturation: A potential risk factor for the development of endometriosis

Osteen, K. G., Bruner-Tran, K. L., & Eisenberg, E. (2005) · Fertility and Sterility · doi:10.1016/j.fertnstert.2004.11.026 · Cited by 122 · see citing works

The effects of the selective progesterone receptor modulator asoprisnil on the morphology of uterine tissues after 3 months treatment in patients with symptomatic uterine leiomyomata

Williams, A. R. W., Critchley, H., Osei, J., Ingamells, S., Cameron, I. T., Han, C., & Chwalisż, K. (2007) · Human Reproduction · doi:10.1093/humrep/dem026 · Cited by 122 · see citing works

Antagonist-occupied human progesterone B-receptors activate transcription without binding to progesterone response elements and are dominantly inhibited by A-receptors [published erratum appears in Mol Endocrinol 1993 Nov;7(11):1378]

Tung, L. W. (1993) · Molecular Endocrinology · doi:10.1210/me.7.10.1256 · Cited by 118 · see citing works

Altered Progesterone Receptor Isoform Expression Remodels Progestin Responsiveness of Breast Cancer Cells

Graham, J. D., Yager, M. L., Hill, H. D., Byth, K., O’Neill, G. M., & Clarke, C. L. (2005) · Molecular Endocrinology · doi:10.1210/me.2005-0126 · Cited by 118 · see citing works

Progesterone inhibits in-vitro embryotoxic Th1 cytokine production to trophoblast in women with recurrent pregnancy loss

Choi, B. C., Polgár, K., Xiao, L., & Hill, J. A. (2000) · Human Reproduction · doi:10.1093/humrep/15.suppl_1.46 · Cited by 114 · see citing works

Immunohistochemical analysis of oestrogen receptors, progesterone receptors and Ki-67 in leiomyoma and myometrium during the menstrual cycle and pregnancy

Kawaguchi, K., Fujii, S., Konishi, I., Iwai, T., Nanbu, Y., Nonogaki, H., Ishikawa, Y., & Mori, T. (1991) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf01606522 · Cited by 112 · see citing works

Antiproliferative effects of progesterone antagonists and progesterone receptor modulators on the endometrium

Chwalisż, K. (2000) · Steroids · doi:10.1016/s0039-128x(00)00190-2 · Cited by 112 · see citing works

Human Homologs of the Putative G Protein-Coupled Membrane Progestin Receptors (mPRα, β, and γ) Localize to the Endoplasmic Reticulum and Are Not Activated by Progesterone

Krietsch, T., Fernandes, M. S., Kero, J. T., Lösel, R., Heyens, M., Lam, E. W. ‐., Huhtaniemi, I. T., Brosens, J. J., & Gellersen, B. (2006) · Molecular Endocrinology · doi:10.1210/me.2006-0129 · Cited by 111 · see citing works

Asoprisnil (J867): a selective progesterone receptor modulator for gynecological therapy

DeManno, D. A., Elger, W. A. G., Garg, R. C., Lee, R., Schneider, B., Hess‐Stumpp, H., Schubert, G., & Chwalisż, K. (2003) · Steroids · doi:10.1016/j.steroids.2003.09.008 · Cited by 111 · see citing works

CYP19 (aromatase cytochrome P450) gene expression in human malignant endometrial tumors

Bulun, S. E., Economos, K., Miller, D. S., & Simpson, E. R. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.6.7989490 · Cited by 108 · see citing works

Mechanism and functional consequences of loss of FOXO1 expression in endometrioid endometrial cancer cells

Goto, T., Takano, M., Albergaria, A., Briese, J., Pomeranz, K. M., Cloke, B., Fusi, L., Feroze-Zaidi, F., Maywald, N., Sajin, M., et al. (2007) · Oncogene · doi:10.1038/sj.onc.1210626 · Cited by 106 · see citing works

Effects of the Selective Progesterone Receptor Modulator Asoprisnil on Uterine Artery Blood Flow, Ovarian Activity, and Clinical Symptoms in Patients with Uterine Leiomyomata Scheduled for Hysterectomy

Wilkens, J., Chwalisż, K., Han, C., Walker, J., Cameron, I. T., Ingamells, S., Lawrence, A. C., Lumsden, M. A., Hapangama, D. K., Williams, A. R. W., et al. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1104 · Cited by 101 · see citing works

Progesterone regulates HLA-G gene expression through a novel progesterone response element

Yie, S.-M., Xiao, R., & Librach, C. L. (2006) · Human Reproduction · doi:10.1093/humrep/del126 · Cited by 101 · see citing works

HMGI(Y) expression in human uterine leiomyomata. Involvement of another high-mobility group architectural factor in a benign neoplasm.

Williams, A. J., Powell, W. L., Collins, T., & Morton, C. C. (1997) · Europe PMC (PubMed Central) · Cited by 99 · see citing works

Phosphorylated and sumoylation-deficient progesterone receptors drive proliferative gene signatures during breast cancer progression

Knutson, T. P., Daniel, A. R., Fan, D., Silverstein, K. A. T., Covington, K. R., Fuqua, S. A. W., & Lange, C. A. (2012) · Breast Cancer Research · doi:10.1186/bcr3211 · Cited by 99 · see citing works

The effect of lifestyle factors on gynaecological cancer

Rieck, G. C., & Fiander, A. (2006) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2005.10.010 · Cited by 99 · see citing works

Progesterone enhances HLA-G gene expression in JEG-3 choriocarcinoma cells and human cytotrophoblasts in vitro

Yie, S.-M., Li, L.-H., Li, G., et al. (2005) · Human Reproduction · doi:10.1093/humrep/dei305 · Cited by 99 · see citing works

Clinical Pharmacokinetics of Mifepristone

Heikinheimo, O. (1997) · Clinical Pharmacokinetics · doi:10.2165/00003088-199733010-00002 · Cited by 99 · see citing works

Endometrial Intraepithelial Neoplasia

Owings, R. A., & Quick, C. M. (2014) · Archives of Pathology & Laboratory Medicine · doi:10.5858/arpa.2012-0709-ra · Cited by 98 · see citing works

Modulation of AP-1 activity by the human progesterone receptor in endometrial adenocarcinoma cells.

Bamberger, A., Bamberger, C. M., Gellersen, B., & Schulte, H. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.12.6169 · Cited by 97 · see citing works

Myometrial cells undergo fibrotic transformation under the influence of transforming growth factor β-3

Joseph, D., Malik, M., Nurudeen, S. K., et al. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.01.081 · Cited by 96 · see citing works

Oncogenic transformation by human papillomavirus type 16 deoxyribonucleic acid in the presence of progesterone or progestins from oral contraceptives

Pater, A., Bayatpour, M., & Pater, M. M. (1990) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(90)91323-5 · Cited by 96 · see citing works

Distribution of the A and B forms of the progesterone receptor messenger ribonucleic acid and protein in uterine leiomyomata and adjacent myometrium

Viville, B., Jones, D. S., Sharkey, A., Wetzka, B., & Smith, S. K. (1997) · Human Reproduction · doi:10.1093/humrep/12.4.815 · Cited by 96 · see citing works

Progesterone Receptor Regulates Bcl-2 Gene Expression through Direct Binding to Its Promoter Region in Uterine Leiomyoma Cells

Yin, P., Lin, Z., Cheng, Y.-H., Marsh, E. E., Utsunomiya, H., Ishikawa, H., Xue, Q., Reierstad, S., Innes, J. E., Thung, S., et al. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0725 · Cited by 96 · see citing works

Mifepristone (RU486) alone or in combination with a prostaglandin analogue for termination of early pregnancy: a review

Avrech, O. M., Golan, A., Weinraub, Z., et al. (1991) · Fertility and Sterility · doi:10.1016/s0015-0282(16)54527-0 · Cited by 96 · see citing works

Immunohistochemical analysis of estrogen and progesterone receptors in endometrium and peritoneal endometriosis: a new quantitative method

Nisolle, M., Casanas‐Roux, F., Wyns, C., de MENTEN, Y., Mathieu, P.-E., & Donnez, J. (1994) · Fertility and Sterility · doi:10.1016/s0015-0282(16)57000-9 · Cited by 95 · see citing works

Oestrogen-induced progesterone receptor in human uterus

Jänne, O. A., KONTULA, K. K., Luukkainen, T., et al. (1975) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(75)90179-x · Cited by 95 · see citing works

Progestins Activate the AKT Pathway in Leiomyoma Cells and Promote Survival

Hoekstra, A. V., Sefton, E. C., Berry, E., Lu, Z., Hardt, J. L., Marsh, E. E., Yin, P., Clardy, J., Chakravarti, D., Bulun, S. E., et al. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2093 · Cited by 93 · see citing works

Progesterone receptor modulator CDB-2914 down-regulates vascular endothelial growth factor, adrenomedullin and their receptors and modulates progesterone receptor content in cultured human uterine leiomyoma cells

Xu, Q. (2006) · Human Reproduction · doi:10.1093/humrep/del159 · Cited by 93 · see citing works

A Novel Selective Progesterone Receptor Modulator Asoprisnil (J867) Inhibits Proliferation and Induces Apoptosis in Cultured Human Uterine Leiomyoma Cells in the Absence of Comparable Effects on Myometrial Cells

Chen, W., Ohara, N., Wang, J., Xu, Q., Liu, J., Morikawa, A., Sasaki, H., Yoshida, S., DeManno, D. A., Chwalisż, K., et al. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2379 · Cited by 92 · see citing works

Ovarian steroid receptor expression in endometriosis and in two potential parent epithelia: endometrium and peritoneal mesothelium

Prentice, A., Randall, B., Weddell, A., McGill, A. C., Henry, L., Horne, C. H. W., & Thomas, E. J. (1992) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a137848 · Cited by 91 · see citing works

Colocalization of Progesterone Receptors A and B by Dual Immunofluorescent Histochemistry in Human Endometrium during the Menstrual Cycle

Mote, P. A. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.8.2963 · Cited by 89 · see citing works

Effects of GnRH analogues, `add-back' steroid therapy, antiestrogen and antiprogestins on leiomyoma and myometrial smooth muscle cell growth and transforming growth factor-beta expression

Chegini, N. (2002) · Molecular Human Reproduction · doi:10.1093/molehr/8.12.1071 · Cited by 88 · see citing works

New medical treatments for endometriosis

Olive, D. L., Lindheim, S. R., & Pritts, E. A. (2004) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2004.03.005 · Cited by 86 · see citing works

Endometriosis: Oestrogen and progesterone receptors in endometriotic tissue and endometrium: comparison of different cycle phases and ages*

Bergqvist, A., & Fernö, M. (1993) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a138005 · Cited by 86 · see citing works

The A and B Isoforms of the Human Progesterone Receptor Operate through Distinct Signaling Pathways within Target Cells

Wen, D. X., Xu, Y., Mais, D. E., et al. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.12.8356-8364.1994 · Cited by 86 · see citing works

Estrogen and progesterone receptors in cervical human papillomavirus related lesions

Monsonégo, J., Magdelénat, H., Catalan, F., et al. (1991) · International Journal of Cancer · doi:10.1002/ijc.2910480410 · Cited by 85 · see citing works

Post-translational modifications of the progesterone receptors

Abdel-Hafiz, H. A., & Horwitz, K. B. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.12.008 · Cited by 84 · see citing works

Past, present, and future of hormonal therapy in recurrent endometrial cancer

Leslie, K. K., Thiel, K. W., & Carlson, M. J. (2014) · International Journal of Women s Health · doi:10.2147/ijwh.s40942 · Cited by 84 · see citing works

Progesterone-induced immunosuppression is not mediated through the progesterone receptor

Schust, D. J., Anderson, D. J., & Hill, J. A. (1996) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a019335 · Cited by 84 · see citing works

Histone Deacetylase Inhibitors Induce Differentiation of Human Endometrial Adenocarcinoma Cells through Up-Regulation of Glycodelin

Uchida, H., Maruyama, T., Nagashima, T., Asada, H., & Yoshimura, Y. (2005) · Endocrinology · doi:10.1210/en.2005-0359 · Cited by 83 · see citing works

Endometriosis: Immunohistochemical analysis of oestrogen and progesterone receptors in endometriotic tissue and endometrium

Bergqvist, A., Ljungberg, O., & Skoog, L. K. (1993) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a137960 · Cited by 82 · see citing works

Molecular Bases for the Actions of Ovarian Sex Steroids in the Regulation of Proliferation and Apoptosis of Human Uterine Leiomyoma

Matsuo, H., Kurachi, O., Shimomura, Y., Samoto, T., & Maruo, T. (1999) · Oncology · doi:10.1159/000055275 · Cited by 82 · see citing works

Cell-Type Specific Actions of Progesterone Receptor Modulators in the Regulation of Uterine Leiomyoma Growth

Yoshida, S., Ohara, N., Xu, Q., Chen, W., Wang, J., Nakabayashi, K., Sasaki, H., Morikawa, A., & Maruo, T. (2010) · Seminars in Reproductive Medicine · doi:10.1055/s-0030-1251483 · Cited by 82 · see citing works

The Endocrine Effects of Long-Term Treatment with Mifepristone (RU 486)

Lamberts, S. W. J., Koper, J. W., & de Jong, F. H. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-1-187 · Cited by 82 · see citing works

The Regulation and Function of the Forkhead Transcription Factor, Forkhead Box O1, Is Dependent on the Progesterone Receptor in Endometrial Carcinoma

Ward, E. C., Hoekstra, A. V., Blok, L. J., et al. (2007) · Endocrinology · doi:10.1210/en.2007-0756 · Cited by 82 · see citing works

The Progesterone Receptor Coactivator Hic-5 Is Involved in the Pathophysiology of Endometriosis

Aghajanova, L., Velarde, M. C., & Giudice, L. C. (2009) · Endocrinology · doi:10.1210/en.2009-0008 · Cited by 82 · see citing works

Quantification of messenger ribonucleic acid for epidermal growth factor in human myometrium and leiomyomata using reverse transcriptase polymerase chain reaction.

Harrison‐Woolrych, M., Jones, D. S., & Smith, S. K. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.78.5.8175976 · Cited by 79 · see citing works

Estrogen and Progestin Regulation of the Progesterone Receptor Concentration in Human Endometrium*

Kreitmann, B., Bugat, R., & Bayard, F. (1979) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-49-6-926 · Cited by 77 · see citing works

The effects of hormone replacement therapy on uterine fibroids in postmenopausal women

Şener, A. B., Seçkin, N. C., Özmen, Ş., et al. (1996) · Fertility and Sterility · doi:10.1016/s0015-0282(16)58098-4 · Cited by 77 · see citing works

Injectable depot medroxyprogesterone acetate contraception: an update for U.S. clinicians.

Kaunitz, A. M. (1998) · PubMed · Cited by 74 · see citing works

The suppressive effect of progesterone on lymphocyte cytotoxicity: unique progesterone sensitivity of pregnancy lymphocytes

Szekeres‐Barthó, J., Hadnagy, J., & Pacsa, A. S. (1985) · Journal of Reproductive Immunology · doi:10.1016/0165-0378(85)90066-x · Cited by 72 · see citing works

The IARC Commitment to Cancer Prevention: The Example of Papillomavirus and Cervical Cancer

Franceschi, S. (2005) · Recent results in cancer research/Recent Results in Cancer Research · doi:10.1007/3-540-26980-0_18 · Cited by 71 · see citing works

Progesterone receptor modulator CDB-2914 induces extracellular matrix metalloproteinase inducer in cultured human uterine leiomyoma cells

Xu, Q., Ohara, N., Liu, J., Amano, M., Sitruk-Ware, R. L., Yoshida, S., & Maruo, T. (2008) · Molecular Human Reproduction · doi:10.1093/molehr/gan004 · Cited by 70 · see citing works

Differential Uterine Expression of Estrogen and Progesterone Receptors Correlates with Uterine Preparation for Implantation and Decidualization in the Mouse

Tan, J. (1999) · Endocrinology · doi:10.1210/en.140.11.5310 · Cited by 70 · see citing works

Endometrial changes from short-term therapy with CDB-4124, a selective progesterone receptor modulator

Ioffe, O. B., Zaino, R. J., & Mutter, G. L. (2009) · Modern Pathology · doi:10.1038/modpathol.2008.204 · Cited by 69 · see citing works

ck2-Dependent Phosphorylation of Progesterone Receptors (PR) on Ser81 Regulates PR-B Isoform-Specific Target Gene Expression in Breast Cancer Cells

Hagan, C. R., Regan, T. M., Dressing, G. E., & Lange, C. A. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.01246-10 · Cited by 69 · see citing works

Uterine Estrogen Receptors Are Increased by RU486 in Late Pregnant Rhesus Macaques but not after Spontaneous Labor*

Haluska, G. J., West, N. B., Novy, M. J., & Brenner, R. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-70-1-181 · Cited by 68 · see citing works

Systematic expression analysis and antibody screening do not support the existence of naturally occurring progesterone receptor (PR)-C, PR-M, or other truncated PR isoforms.

Samalecos, A., & Gellersen, B. (2008) · Endocrinology · doi:10.1210/en.2008-0602 · Cited by 68 · see citing works

The role of gamma/delta T-cell receptor-positive cells in pregnancy: part II.

Barakonyi, A., Polgár, B., & Szekeres‐Barthó, J. (1999) · PubMed · Cited by 67 · see citing works

Vaginosonography for recording of cycle-related myometrial contractions

Chalubinski, K., Deutinger, J., & Bernaschek, G. (1993) · Fertility and Sterility · doi:10.1016/s0015-0282(16)55644-1 · Cited by 67 · see citing works

A mouse model to dissect progesterone signaling in the female reproductive tract and mammary gland

Fernandez‐Valdivia, R., Jeong, J., Mukherjee, A., et al. (2009) · genesis · doi:10.1002/dvg.20586 · Cited by 66 · see citing works

Immunocytochemical study of progesterone receptors in the human endometrium during the menstrual cycle.

Bergeron, C., Ferenczy, A. S., Do, T., et al. (1988) · PubMed · Cited by 65 · see citing works

Cloning and expression of a novel, truncated, progesterone receptor

Saner, K. J., Welter, B. H., Zhang, F., Hansen, E., Dupont, B., Wei, Y., & Price, T. M. (2003) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(02)00380-5 · Cited by 64 · see citing works

A Prospective Randomized Study Comparing Endocrinological and Clinical Effects of Two Types of GnRH Agonists in Cases of Uterine Leiomyomas or Endometriosis

Takeuchi, H., 小堀, 宏., Kikuchi, I., et al. (2000) · Journal of obstetrics and gynaecology research · doi:10.1111/j.1447-0756.2000.tb01334.x · Cited by 63 · see citing works

Progesterone receptor modulators and progesterone antagonists in women's health

Spitz, I. M. (2000) · Steroids · doi:10.1016/s0039-128x(00)00194-x · Cited by 62 · see citing works

A novel selective progesterone receptor modulator asoprisnil (J867) down-regulates the expression of EGF, IGF-I, TGFβ3 and their receptors in cultured uterine leiomyoma cells

Wang, J., Ohara, N., Wang, Z., Chen, W., Morikawa, A., Sasaki, H., DeManno, D. A., Chwalisż, K., & Maruo, T. (2006) · Human Reproduction · doi:10.1093/humrep/del035 · Cited by 62 · see citing works

Distinct functional differences of human progesterone receptors A and B on gene expression and growth regulation in two endometrial carcinoma cell lines

Smid-Koopman, E. (2003) · Journal of the Society for Gynecologic Investigation · doi:10.1016/s1071-5576(02)00217-4 · Cited by 61 · see citing works

A novel estrogen-free oral contraceptive pill for women: multicentre, double-blind, randomized controlled trial of mifepristone and progestogen-only pill (levonorgestrel)

Lakha, F., Ho, P. C., van der Spuy, Z. M., et al. (2007) · Human Reproduction · doi:10.1093/humrep/dem177 · Cited by 61 · see citing works

Alternative splicing and the progesterone receptor in breast cancer

Cork, D. M. W., Lennard, T. W. J., & Tyson-Capper, A. J. (2008) · Breast Cancer Research · doi:10.1186/bcr2097 · Cited by 60 · see citing works

Identification of Progesterone Receptor in Human Subcutaneous Adipose Tissue

O’Brien, S. N., Welter, B. H., Mantzke, K. A., & Price, T. M. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.2.4561 · Cited by 60 · see citing works

Selective progesterone receptor modulator asoprisnil down-regulates collagen synthesis in cultured human uterine leiomyoma cells through up-regulating extracellular matrix metalloproteinase inducer

Morikawa, A., Ohara, N., Xu, Q., Nakabayashi, K., DeManno, D. A., Chwalisż, K., Yoshida, S., & Maruo, T. (2008) · Human Reproduction · doi:10.1093/humrep/den025 · Cited by 60 · see citing works

Endometriosis

Zondervan, K. T., Becker, C. M., Koga, K., Missmer, S. A., Taylor, R. N., & Viganò, P. (2018) · Nature Reviews Disease Primers · doi:10.1038/s41572-018-0008-5 · Cited by 1,257 · see citing works

Hormonal treatments for endometriosis: The endocrine background

Vannuccini, S., Clemenza, S., Rossi, M., & Petraglia, F. (2022) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-021-09666-w · Cited by 336 · see citing works

Progesterone resistance in endometriosis: origins, consequences and interventions

Patel, B. G., Rudnicki, M., Yu, J., Shu, Y., & Taylor, R. N. (2017) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1111/aogs.13156 · Cited by 336 · see citing works

Endometrial receptivity in the eutopic endometrium of women with endometriosis: it is affected, and let me show you why

Lessey, B. A., & Kim, J. J. (2017) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.05.031 · Cited by 286 · see citing works

Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review

Donnez, J., & Dolmans, M.-M. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10051085 · Cited by 182 · see citing works

Progesterone receptor ligands for the treatment of endometriosis: the mechanisms behind therapeutic success and failure

Reis, F. M., Coutinho, L. M., Vannuccini, S., Batteux, F., Chapron, C., & Petraglia, F. (2020) · Human Reproduction Update · doi:10.1093/humupd/dmaa009 · Cited by 166 · see citing works

miR-196a overexpression activates the MEK/ERK signal and represses the progesterone receptor and decidualization in eutopic endometrium from women with endometriosis

Zhou, M., Fu, J., Xiao, L., Yang, S., Song, Y., Zhang, X., Feng, X., Sun, H., Xu, W., & Huang, W. (2016) · Human Reproduction · doi:10.1093/humrep/dew223 · Cited by 91 · see citing works

miR-194-3p represses the progesterone receptor and decidualization in eutopic endometrium from women with endometriosis

Pei, T., Liu, C., Liu, T., Xiao, L., Luo, B., Tan, J., Li, X., Zhou, G., Duan, C., & Huang, W. (2018) · Endocrinology · doi:10.1210/en.2018-00374 · Cited by 73 · see citing works

Early-life factors, in-utero exposures and endometriosis risk: a meta-analysis

Ottolina, J., Schimberni, M., Makieva, S., Bartiromo, L., Fazia, T., Bernardinelli, L., Viganò, P., Candiani, M., & Gentilini, D. (2020) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2020.04.005 · Cited by 42 · see citing works

Risk of major adverse cardiovascular and cerebrovascular events in Taiwanese women with endometriosis

Chiang, H.-J., Lan, K.-C., Yang, Y.-H., Chiang, J. Y., Kung, F.-T., Huang, F.-J., Lin, Y.-J., Su, Y.-T., & Sung, P.-H. (2021) · Journal of the Formosan Medical Association · doi:10.1016/j.jfma.2020.10.005 · Cited by 42 · see citing works

Expression of oxytocin receptor in human pregnant myometrium

Kimura, T., Takemura, M., Nomura, S., Nobunaga, T., Kubota, Y., Inoue, T., Hashimoto, K., KUMAZAWA, I., Ito, Y., Ohashi, K., et al. (1996) · Endocrinology · doi:10.1210/endo.137.2.8593830 · Cited by 222 · see citing works

Primary Culture of Cells Derived from Human Myometrium: Both Myometrium and Cultured Cells Stained with Desmin by the Enzyme‐Labeled Antibody Method

Otsuka, H., Yoshida, K., Kusano, S., et al. (1987) · Asia-Oceania Journal of Obstetrics and Gynaecology · doi:10.1111/j.1447-0756.1987.tb00019.x

Expression of Glucocorticoid Receptor in Human Myometrium during Pregnancy and Labour

Sethna, F., Tyson-Capper, A. J., Shiells, E. A., et al. (2008) · Reproductive Sciences

Electrical coupling in rat myometrium during pregnancy

Zelcer, E., & Daniel, E. E. (1979) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y79-074 · Cited by 6 · see citing works

C-fos and c-jun expression in human endometrium and myometrium

Salmi, A., & Rutanen, F.-M. (1996) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(95)03759-4 · Cited by 27 · see citing works