The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.
Oxidative stress in the pelvic cavity and its role in the pathogenesis of endometriosis
Open accessAbstract
Endometriosis is a disorder associated with a general inflammatory response in the peritoneal cavity. Oxidative stress is a potential factor involved in the pathophysiology of this disease, and reactive oxygen species (ROS) are implicated in this process. Indeed, in healthy individuals, ROS and antioxidants are in balance, but when balance is tipped toward an overabundance of ROS, oxidative stress occurs and can impact the entire reproductive lifespan of a woman. Reactive oxygen species are intermediaries produced by normal oxygen metabolism but are known to have deleterious effects. Excessive release of ROS induces cellular damage and alters cellular function by regulating protein activity and gene expression, leading to harmful effects. To protect themselves, cells have developed antioxidant systems to limit production of ROS, inactivate them, and repair cell damage. Understanding of the control of hemoglobin, heme, and iron-induced redox balance in endometriosis led us to propose a number of hypotheses to explain why oxidative stress is induced in case of pelvic endometriosis. Erythrocytes, apoptotic endometrial tissue, and cell debris transplanted into the peritoneal cavity by menstrual reflux and macrophages have all been cited as potential inducers of oxidative stress. Erythrocytes are likely to release pro-oxidant and proinflammatory factors, such as hemoglobin and its highly toxic by-products heme and iron, into the peritoneal environment. Iron and heme are essential to living cells, but unless appropriately chelated, free iron, and to a lesser extent heme, play a key role in the formation of deleterious ROS.
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In the citing paper
“First, the oxidative stress in the uterus during menstruation and in the peritoneal cavity following retrograde menstruation (248) are recognized as potential causative factors to induce genetic or epigenetic changes.”
From Pathogenesis of endometriosis: The genetic/epigenetic theory (2019) · cites this paper as [248]
In the citing paper
“Retrograde menstruation and bleeding of endometriotic lesions are responsible for the presence of erythrocytes in the pelvic cavity, which are likely to release pro-oxidant and proinflammatory factors like hemoglobin and its highly toxic byproducts heme and iron [27,28,29,30].”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [30]
In the citing paper
“Of course, suppressing ovulation and reducing the amount of menstrual bleeding greatly reduces the number of erythrocytes regurgitated into the pelvis, resulting in a decrease in oxidative stress and the inflammatory environment [30].”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [30]
In the citing paper
“By inducing amenorrhea and halting menstrual bleeding and reflux, or even simply lessening its severity, pelvic oxidative stress, the main source of inflammation, can be significantly reduced [30].”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [30]
In the citing paper
“Retrograde menstruation and bleeding in endometriosis lesions generate an iron overload and oxidative stress in the peritoneal cavity (109) and/or in the endometriosis tissue (110).”
From Pathogenesis of deep endometriosis (2017) · cites this paper as [109]
Citations
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Cited by
Sorted by citations
Oxidative Stress and Endometriosis: A Systematic Review of the Literature
Scutiero, G., Iannone, P., Bernardi, G., Bonaccorsi, G., Spadaro, S., Volta, C. A., Greco, P., & Nappi, L. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/7265238 · Cited by 436
Pathogenesis of endometriosis: The genetic/epigenetic theory
Koninckx, P. R., Ussia, A., Adamyan, L., Wattiez, A., Gomel, V., & Martin, D. C. (2019) · Fertility and Sterility · doi:10.1016/j.fertnstert.2018.10.013 · Cited by 427
Influence of follicular fluid and cumulus cells on oocyte quality: clinical implications
Broi, M. G. D., Giorgi, V. S. I., Wang, F., Keefe, D. L., Albertini, D. F., & Navarro, P. A. (2018) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-018-1143-3 · Cited by 314
Estrogen-progestins and progestins for the management of endometriosis
Vercellini, P., Buggio, L., Berlanda, N., Barbara, G., Somigliana, E., & Bosari, S. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2016.10.022 · Cited by 243
Pathogenesis of deep endometriosis
Gordts, S., Koninckx, P., & Brosens, I. (2017) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.08.036 · Cited by 241
Metadata
- Authors
- Donnez, J., Binda, M. M., Donnez, O., & Dolmans, M.-M.
- Affiliations
- UCLouvain (BE)
- Cliniques Universitaires Saint-Luc (BE)
- Corresponding author
- Dolmans, Marie-Madeleine
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2016-10
- Volume
- 106
- Issue
- 5
- Pages
- 1011-1017
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2515189190
- Semantic Scholar
- 167a6e84e12265cafa8a82a56c2deaae1e4d2fc9
- Cited by
- 251
- References
- 71
- Citations by year
- 2026: 14 · 2025: 36 · 2024: 32 · 2023: 28 · 2022: 30 · 2021: 26 · 2020: 23 · 2019: 17 · 2018: 22 · 2017: 20 · 2016: 3
- FWCI
- 2.92
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Libraries (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Keywords
- endometriosis, oxidative stress, reactive oxygen species, antioxidants, heme, iron, hemoglobin, erythrocytes, macrophages, peritonitis, redox homeostasis, pathogenesis
- MeSH terms
- Animals, Antioxidants, Endometriosis, Erythrocytes, Female, Hemoglobins, Humans, Iron, Macrophages, Peritoneal Cavity, Risk Factors, Biomarkers, Reactive Oxygen Species, Oxidative Stress, Inflammation Mediators
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