Oxidative Stress and Endometriosis: A Systematic Review of the Literature
Open accessAbstract
Endometriosis is one of the most common gynaecologic diseases in women of reproductive age. It is characterized by the presence of endometrial tissue outside the uterine cavity. The women affected suffer from pelvic pain and infertility. The complex etiology is still unclear and it is based on three main theories: retrograde menstruation, coelomic metaplasia, and induction theory. Genetics and epigenetics also play a role in the development of endometriosis. Recent studies have put the attention on the role of oxidative stress, defined as an imbalance between reactive oxygen species (ROS) and antioxidants, which may be implicated in the pathophysiology of endometriosis causing a general inflammatory response in the peritoneal cavity. Reactive oxygen species are intermediaries produced by normal oxygen metabolism and are inflammatory mediators known to modulate cell proliferation and to have deleterious effects. A systematic review was performed in order to clarify the different roles of oxidative stress and its role in the development of endometriosis. Several issues have been investigated: iron metabolism, oxidative stress markers (in the serum, peritoneal fluid, follicular fluid, peritoneal environment, ovarian cortex, and eutopic and ectopic endometrial tissue), genes involved in oxidative stress, endometriosis‐associated infertility, and cancer development.
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The pathogenesis of malignant transformation of endometriosis remains unelucidated; however, certain studies implicate oxidative stress according to a two-step process in endometriotic carcinogenesis.
“The pathogenesis of malignant transformation of endometriosis remains unelucidated; however, certain studies implicate oxidative stress according to a two-step process in endometriotic carcinogenesis [13].”
From Clear cell carcinoma arising from abdominal wall endometriosis—A report on two cases and literature review (2022) · cites this paper as [13]
In the second step of endometriotic carcinogenesis, cancer progression occurs due to antioxidant production which prolongs the survival of affected cell populations, thus promoting carcinogenesis.
“In the second step, cancer progression occurs due to antioxidant production which prolongs the survival of affected cell populations, thus promoting carcinogenesis [13, 14].”
From Clear cell carcinoma arising from abdominal wall endometriosis—A report on two cases and literature review (2022) · cites this paper as [13]
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Targeting Oxidative Stress Involved in Endometriosis and Its Pain
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“The pathogenesis of malignant transformation of endometriosis remains unelucidated; however, certain studies implicate oxidative stress according to a two-step process in endometriotic carcinogenesis [13].”
BackgroundRole of Oxidative Stress and Antioxidant Therapies in Endometriosis
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“Accumulating evidence indicates that oxidative stress (OS) plays an important role in the etiology of EMS.[2,3] It is reported to play an active role in the initiation, maintenance, and progression of the disease.”
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The Impact of Laparoscopic Surgery on Fertility Outcomes in Patients with Minimal/Mild Endometriosis
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- Authors
- Scutiero, G., Iannone, P., Bernardi, G., Bonaccorsi, G., Spadaro, S., Volta, C. A., Greco, P., & Nappi, L.
- Affiliations
- University of Ferrara (IT)
- University of Foggia (IT)
- Corresponding author
- Iannone, Piergiorgio
- ORCID
- Venue
- Oxidative Medicine and Cellular Longevity
- Publisher
- Wiley
- Published
- 2017-01
- Volume
- 2017
- Issue
- 1
- Pages
- 7265238-7265238
- ISSN
- 1942-0994 (ISSN-L)
- 1942-0900
- PMC
- PMC5625949
- OpenAlex
- W2754055756
- Cited by
- 436
- References
- 62
- Citations by year
- 2026: 67 · 2025: 74 · 2024: 65 · 2023: 59 · 2022: 46 · 2021: 40 · 2020: 38 · 2019: 34 · 2018: 12 · 2015: 1
- FWCI
- 3.75
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion, cc-by)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
- Funders
- Università degli Studi di Ferrara
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- endometriosis, oxidative stress, reactive oxygen species, antioxidants, iron metabolism, oxidative stress biomarkers, endometriosis-associated infertility, endometriosis-associated cancer, endometriosis pathophysiology, peritonitis, endometriosis etiology
- MeSH terms
- Endometriosis, Female, Humans, Oxidative Stress
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