The DOI matches its Crossref record; 28 of the 29 references it cites were found in a registry or an index.
Hypolipemic and hypoglycaemic activity of bergamot polyphenols: From animal models to human studies
Abstract
Bergamot juice produces hypolipemic activity in rats though the mechanism remains unclear. Here we investigated on the effect of bergamot extract (BPF) in diet-induced hyperlipemia in Wistar rats and in 237 patients suffering from hyperlipemia either associated or not with hyperglycaemia. BPF, given orally for 30 days to both rats and patients, reduces total and LDL cholesterol levels (an effect accompanied by elevation of cHDL), triglyceride levels and by a significant decrease in blood glucose. Moreover, BPF inhibited HMG-CoA reductase activity and enhanced reactive vasodilation thus representing an efficient phytotherapeutic approach in combating hyperlipemic and hyperglycaemic disorders.
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“The results showed dose-dependent lipid-lowering action of bergamot (groups A and B LDL-C: À24.1% and À30.6%, TG: À28.2% and À37.9%, and HDL-C: þ22.3% and þ40.1%, respectively; p < 0.001 for all) compared with baseline.”
From The Role of Nutraceuticals in Statin Intolerant Patients (2018) · cites this paper as [135]
In the citing paper
“Group C (placebo) did not show significant reductions in serum cholesterol”
From The Role of Nutraceuticals in Statin Intolerant Patients (2018) · cites this paper as [135]
In the citing paper
“some nutraceuticals are then able to enhance (126,127,135-137,145-147) or potentially replace the action of statins (63-66,50-52,58,168,169).”
From The Role of Nutraceuticals in Statin Intolerant Patients (2018) · cites this paper as [135]
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Cites
Flavonoid Composition of Fruit Tissues of Citrus Species
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Antioxidant Activity of Citrus Limonoids, Flavonoids, and Coumarins
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Narrative review: statin-related myopathy
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Antioxidative activity of naringin and lovastatin in high cholesterol-fed rabbits
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Grapes and Cardiovascular Disease
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Alam, M. A., Subhan, N., Rahman, M., Uddin, S. J., Reza, H. M., & Sarker, S. D. (2014) · Advances in Nutrition · doi:10.3945/an.113.005603 · Cited by 818
Flavanones: Citrus phytochemical with health‐promoting properties
Barreca, D., Gattuso, G., Bellocco, E., Calderaro, A., Trombetta, D., Smeriglio, A., Laganà, G., Daglia, M., Meneghini, S., & Nabavi, S. M. (2017) · BioFactors · doi:10.1002/biof.1363 · Cited by 401
Cicero, A. F. G., Colletti, A., Bajraktari, G., Descamps, O. S., Djuric, D. M., Владиславович, Е. М., Fras, Z., Katsiki, N., Langlois, M. R., Latkovskis, G., et al. (2017) · Nutrition Reviews · doi:10.1093/nutrit/nux047 · Cited by 303
Cicero, A. F. G., Colletti, A., Bajraktari, G., Descamps, O., Djuric, D. M., Ezhov, M., Fras, Z., Katsiki, N., Langlois, M., Latkovskis, G., et al. (2017) · Archives of Medical Science · doi:10.5114/aoms.2017.69326 · Cited by 281
Metadata
- Authors
- Mollace, V., Sacco, I., Janda, E., Malara, C., Ventrice, D., Colica, C., Visalli, V., Muscoli, S., Ragusa, S., Muscoli, C., Rotiroti, D., & Romeo, F.
- Affiliations
- Magna Graecia University (IT)
- Agenzia Regionale per la Protezione dell'Ambiente della Calabria (IT)
- University of Rome Tor Vergata (IT)
- Corresponding author
- Mollace, Vincenzo
- Venue
- Fitoterapia
- Publisher
- Elsevier BV
- Published
- 2011-04
- Volume
- 82
- Issue
- 3
- Pages
- 309-316
- ISSN
- 0367-326X (ISSN-L)
- OpenAlex
- W2073068954
- Cited by
- 246
- References
- 29
- Citations by year
- 2026: 16 · 2025: 9 · 2024: 23 · 2023: 25 · 2022: 19 · 2021: 15 · 2020: 18 · 2019: 18 · 2018: 18 · 2017: 17 · 2016: 20 · 2015: 19 · 2014: 12 · 2013: 8 · 2012: 6
- FWCI
- 5.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Fitoterapia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Natural Products and Biological Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Keywords
- Citrus aurantium, hypolipidemic activity, hypoglycemic activity, hyperlipidemia, hyperglycemia, LDL cholesterol, HDL cholesterol, triglycerides, HMG-CoA reductase inhibition, herbal medicine, diet-induced hyperlipidemia
- MeSH terms
- Adult, Aged, Animals, Hypolipidemic Agents, Blood Glucose, Citrus, Double-Blind Method, Female, Humans, Hydroxymethylglutaryl CoA Reductases, Hyperglycemia, Hyperlipidemias, Hypoglycemic Agents, Lipids, Male, Phytotherapy, Middle Aged, Plant Extracts, Vasodilation, Rats, Wistar, Rats
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