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Hypolipemic and hypoglycaemic activity of bergamot polyphenols: From animal models to human studies
Abstract
Bergamot juice produces hypolipemic activity in rats though the mechanism remains unclear. Here we investigated on the effect of bergamot extract (BPF) in diet-induced hyperlipemia in Wistar rats and in 237 patients suffering from hyperlipemia either associated or not with hyperglycaemia. BPF, given orally for 30 days to both rats and patients, reduces total and LDL cholesterol levels (an effect accompanied by elevation of cHDL), triglyceride levels and by a significant decrease in blood glucose. Moreover, BPF inhibited HMG-CoA reductase activity and enhanced reactive vasodilation thus representing an efficient phytotherapeutic approach in combating hyperlipemic and hyperglycaemic disorders.
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“The results showed dose-dependent lipid-lowering action of bergamot (groups A and B LDL-C: À24.1% and À30.6%, TG: À28.2% and À37.9%, and HDL-C: þ22.3% and þ40.1%, respectively; p < 0.001 for all) compared with baseline.”
From The Role of Nutraceuticals in Statin Intolerant Patients (2018) · cites this paper as [135]
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“Group C (placebo) did not show significant reductions in serum cholesterol”
From The Role of Nutraceuticals in Statin Intolerant Patients (2018) · cites this paper as [135]
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“some nutraceuticals are then able to enhance (126,127,135-137,145-147) or potentially replace the action of statins (63-66,50-52,58,168,169).”
From The Role of Nutraceuticals in Statin Intolerant Patients (2018) · cites this paper as [135]
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Pathophysiological Basis for Nutraceutical Supplementation in Heart Failure: A Comprehensive Review
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Gualtieri, P., Marchetti, M., Frank, G., Smeriglio, A., Trombetta, D., Colica, C., Cianci, R., LORENZO, A. D., & Renzo, L. D. (2023) · Genes · doi:10.3390/genes14010206 · Cited by 40
Recent Pharmacological Options in Type 2 Diabetes and Synergic Mechanism in Cardiovascular Disease
Andreadi, A., Muscoli, S., Tajmir, R., Meloni, M., Muscoli, C., Ilari, S., Mollace, V., Della‐Morte, D., Bellia, A., Daniele, N. D., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021646 · Cited by 36
Gidaro, M. C., Alcaro, F. D., Carradori, S., Costa, G., Vullo, D., Supuran, C. T., & Alcaro, S. (2015) · Planta Medica · doi:10.1055/s-0034-1396139 · Cited by 33
Cai, Y., Xing, G., Tian, S., Zhang, S., Rao, J., & Shi, R. (2017) · Lipids in Health and Disease · doi:10.1186/s12944-017-0640-1 · Cited by 33
Loizzo, M. R., Sicari, V., Tundis, R., Leporini, M., Falco, T., & Calabrò, V. (2019) · Antioxidants · doi:10.3390/antiox8010023 · Cited by 33
Loizzo, M. R., Leporini, M., Sicari, V., Falco, T., Pellicanò, T. M., & Tundis, R. (2017) · European Food Research and Technology · doi:10.1007/s00217-017-2978-z · Cited by 31
Fernandes, A. C. F., Santana, Á. L., Martins, I. M., Moreira, D. K. T., Macedo, J. A., & Macêdo, G. A. (2020) · Preparative Biochemistry & Biotechnology · doi:10.1080/10826068.2020.1737941 · Cited by 31
Chu, J., Li, S., Yin, Z., Ye, W., & Zhang, Q. (2012) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2012.03.041 · Cited by 32
Kuchta, A., Konopacka, A., Waleron, K., Viapiana, A., Wesołowski, M., Dąbkowski, K., Ćwiklińska, A., Mickiewicz, A., Śledzińska, A., Wieczorek, E., et al. (2019) · Cardiology Journal · doi:10.5603/cj.a2019.0028 · Cited by 30
Carresi, C., Scicchitano, M., Scarano, F., Macrì, R., Bosco, F., Nucera, S., Ruga, S., Zito, M. C., Mollace, R., Guarnieri, L., et al. (2021) · Nutrients · doi:10.3390/nu13010275 · Cited by 33
Bergamot Polyphenol Extract Reduces Hepatocyte Neutral Fat by Increasing Beta-Oxidation
Mirarchi, A., Mare, R., Musolino, V., Nucera, S., Mollace, V., Pujia, A., Montalcini, T., Romeo, S., & Maurotti, S. (2022) · Nutrients · doi:10.3390/nu14163434 · Cited by 30
Role of Nutraceuticals in Hypolipidemic Therapy
Barbagallo, C. M., Cefalu, A. B., Noto, D., & Averna, M. R. (2015) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2015.00022 · Cited by 29
Evaluation of lipid and cholesterol-lowering effect of bioflavonoids from bergamot extract
Ballistreri, G., Amenta, M., Fabroni, S., Consoli, V., Grosso, S., Vanella, L., Sorrenti, V., & Rapisarda, P. (2020) · Natural Product Research · doi:10.1080/14786419.2020.1768085 · Cited by 29
Riva, A., Petrangolini, G., Allegrini, P., Perna, S., Giacosa, A., Peroni, G., Faliva, M. A., Naso, M., & Rondanelli, M. (2021) · Nutrients · doi:10.3390/nu14010108 · Cited by 29
Rondanelli, M., Peroni, G., Riva, A., Petrangolini, G., Allegrini, P., Fazia, T., Bernardinelli, L., Naso, M., Faliva, M. A., Tartara, A., et al. (2020) · Phytotherapy Research · doi:10.1002/ptr.6950 · Cited by 28
Huang, Y., Tocmo, R., Nauman, M. C., Haughan, M. A., & Johnson, J. J. (2021) · Nutrients · doi:10.3390/nu13093156 · Cited by 31
Re-assessing the mechanism of action of n−3 PUFAs
Mollace, V., Gliozzi, M., Carresi, C., Musolino, V., & Oppedisano, F. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.06.038 · Cited by 27
Guarnieri, L., Bosco, F., Leo, A., Citraro, R., Palma, E., Sarro, G. D., & Mollace, V. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102210 · Cited by 28
Mollace, R., Macrì, R., Tavernese, A., Gliozzi, M., Musolino, V., Carresi, C., Maiuolo, J., Fini, M., Volterrani, M., & Mollace, V. (2022) · Nutrients · doi:10.3390/nu14030477 · Cited by 26
Metadata
- Authors
- Mollace, V., Sacco, I., Janda, E., Malara, C., Ventrice, D., Colica, C., Visalli, V., Muscoli, S., Ragusa, S., Muscoli, C., Rotiroti, D., & Romeo, F.
- Affiliations
- Magna Graecia University (IT)
- Agenzia Regionale per la Protezione dell'Ambiente della Calabria (IT)
- University of Rome Tor Vergata (IT)
- Corresponding author
- Mollace, Vincenzo
- Venue
- Fitoterapia
- Publisher
- Elsevier BV
- Published
- 2011-04
- Volume
- 82
- Issue
- 3
- Pages
- 309-316
- ISSN
- 0367-326X (ISSN-L)
- OpenAlex
- W2073068954
- Cited by
- 246
- References
- 29
- Citations by year
- 2026: 16 · 2025: 9 · 2024: 23 · 2023: 25 · 2022: 19 · 2021: 15 · 2020: 18 · 2019: 18 · 2018: 18 · 2017: 17 · 2016: 20 · 2015: 19 · 2014: 12 · 2013: 8 · 2012: 6
- FWCI
- 5.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Fitoterapia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Natural Products and Biological Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Keywords
- Citrus aurantium, hypolipidemic activity, hypoglycemic activity, hyperlipidemia, hyperglycemia, LDL cholesterol, HDL cholesterol, triglycerides, HMG-CoA reductase inhibition, herbal medicine, diet-induced hyperlipidemia
- MeSH terms
- Adult, Aged, Animals, Hypolipidemic Agents, Blood Glucose, Citrus, Double-Blind Method, Female, Humans, Hydroxymethylglutaryl CoA Reductases, Hyperglycemia, Hyperlipidemias, Hypoglycemic Agents, Lipids, Male, Phytotherapy, Middle Aged, Plant Extracts, Vasodilation, Rats, Wistar, Rats
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