Cited by 104Phytochemicals and Antioxidant ActivitiesNatural Antidiabetic Agents StudiesPomegranate: compositions and health benefits

Red raspberry (Rubus idaeus L.) intake decreases oxidative stress in obese diabetic (db/db) mice

Noratto, Giuliana D., Chew, Boon P., Atienza, Liezl M.·2017·Food Chemistry

Abstract

Red raspberry fruit intake was investigated on obese diabetic (db/db) mice for 8weeks. Animals fed isocaloric diets (5.3% freeze-dried raspberry, or control) were assessed for obesity-diabetes-disease risk biomarkers. Results showed that raspberry intake improved antioxidant status and lessened plasma interleukin (IL)-6 (0.3-fold of control, p<0.1); most likely through enhancing glutathione peroxidase (GPx) activity in liver (4.3-fold of control), and in blood (2.1-fold of control). Other disease-risk biomarkers were similar between groups (p>0.05). Plasma levels of total cholesterol (T-CHL), low density lipoprotein-cholesterol (LDL-CHL), and resistin were higher in the raspberry group. Overall, the enhanced detoxifying cell defenses exerted by raspberry intake might be due to its polyphenolics and fibre. This study demonstrates in vivo that raspberry intake, at a dose that can be achieved by human consumption, might protect against diabetes-induced oxidative stress.

Integrity signals

Registry

Crossref · 10.1016/j.foodchem.2017.01.097

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Noratto, G. D., Chew, B. P., & Atienza, L. M.
Affiliations
  • Washington State University (US)
  • Texas A&M University (US)
  • University of the Philippines Los Baños (PH)
Corresponding author
Noratto, Giuliana D.
Venue
Food Chemistry
Publisher
Elsevier BV
Published
2017-07
Volume
227
Pages
305-314
ISSN
0308-8146 (ISSN-L)
OpenAlex
W2572190564
Cited by
104
References
41
Citations by year
2026: 4 · 2025: 11 · 2024: 16 · 2023: 10 · 2022: 7 · 2021: 10 · 2020: 18 · 2019: 16 · 2018: 10 · 2017: 2
FWCI
7.86
Type
journal article
Language
en
Open access
closed
Locations
  • Food Chemistry (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Raspberry Council
Topics
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
  • Health Sciences › Nursing › Nutrition and Dietetics › Pomegranate: compositions and health benefits
Keywords
red raspberry, raspberry, oxidative stress, obesity, type 2 diabetes, db/db mice, antioxidant status, glutathione peroxidase, interleukin-6, polyphenols, dietary fiber, resistin, cholesterol, liver detoxification
MeSH terms
Animals, Antioxidants, Cholesterol, Diabetes Mellitus, Humans, Cholesterol, LDL, Liver, Male, Mice, Obese, Obesity, Plant Extracts, Interleukin-6, Oxidative Stress, Mice, Rubus

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review