Red raspberry (Rubus idaeus L.) intake decreases oxidative stress in obese diabetic (db/db) mice
Abstract
Red raspberry fruit intake was investigated on obese diabetic (db/db) mice for 8weeks. Animals fed isocaloric diets (5.3% freeze-dried raspberry, or control) were assessed for obesity-diabetes-disease risk biomarkers. Results showed that raspberry intake improved antioxidant status and lessened plasma interleukin (IL)-6 (0.3-fold of control, p<0.1); most likely through enhancing glutathione peroxidase (GPx) activity in liver (4.3-fold of control), and in blood (2.1-fold of control). Other disease-risk biomarkers were similar between groups (p>0.05). Plasma levels of total cholesterol (T-CHL), low density lipoprotein-cholesterol (LDL-CHL), and resistin were higher in the raspberry group. Overall, the enhanced detoxifying cell defenses exerted by raspberry intake might be due to its polyphenolics and fibre. This study demonstrates in vivo that raspberry intake, at a dose that can be achieved by human consumption, might protect against diabetes-induced oxidative stress.
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Consumption of Rubus idaeus fruit in diabetic (db/db) mice reduced proinflammatory plasma interleukin 6 and may protect against diabetes-induced oxidative stress.
“Consumption of Rubus idaeus fruit in diabetic (db/db) mice reduced proinflammatory plasma interleukin 6 and may protect against diabetes-induced oxidative stress [37].”
From Evaluating Traditional Chinese Medicine and Herbal Products for the Treatment of Gestational Diabetes Mellitus (2019) · cites this paper as [37]
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- Authors
- Noratto, G. D., Chew, B. P., & Atienza, L. M.
- Affiliations
- Washington State University (US)
- Texas A&M University (US)
- University of the Philippines Los Baños (PH)
- Corresponding author
- Noratto, Giuliana D.
- Venue
- Food Chemistry
- Publisher
- Elsevier BV
- Published
- 2017-07
- Volume
- 227
- Pages
- 305-314
- ISSN
- 0308-8146 (ISSN-L)
- OpenAlex
- W2572190564
- Cited by
- 104
- References
- 41
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 16 · 2023: 10 · 2022: 7 · 2021: 10 · 2020: 18 · 2019: 16 · 2018: 10 · 2017: 2
- FWCI
- 7.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Raspberry Council
- Topics
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Nursing › Nutrition and Dietetics › Pomegranate: compositions and health benefits
- Keywords
- red raspberry, raspberry, oxidative stress, obesity, type 2 diabetes, db/db mice, antioxidant status, glutathione peroxidase, interleukin-6, polyphenols, dietary fiber, resistin, cholesterol, liver detoxification
- MeSH terms
- Animals, Antioxidants, Cholesterol, Diabetes Mellitus, Humans, Cholesterol, LDL, Liver, Male, Mice, Obese, Obesity, Plant Extracts, Interleukin-6, Oxidative Stress, Mice, Rubus
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