The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Identification of the key excreted molecule by Lactobacillus fermentum related to host iron absorption
Open accessAbstract
We have taken a vital step towards understanding why probiotic bacteria increase iron absorption in the gastrointestinal tract. We show here that Lactobacillus fermentum, one of the main probiotics of the microbiota, exhibits an extraordinary ferric-reducing activity. This activity is predominantly due to an excreted molecule: p-hydroxyphenyllactic acid (HPLA). Reduction of Fe(III) to Fe(II) is essential for iron absorption in the gastrointestinal tract. By reducing Fe(III), HPLA boosts Fe(II) absorption through the DMT1 channels of enterocytes. An in vitro experiment tested and confirmed this hypothesis. This discovery opens new avenues for the treatment of iron deficiency in humans, one of the most common and widespread nutritional disorders in the world.
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“Lactobacillus fermentum increases iron absorption at DMT-1 by converting Fe 3+ to Fe 2+ via its ferric reducing activity; therefore, it could help reduce the GI side effects of iron [50].”
From Oral Iron Supplementation—Gastrointestinal Side Effects and the Impact on the Gut Microbiota (2021) · cites this paper as [50]
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Cites
The gut microbiota--masters of host development and physiology
Sommer, F., & Bäckhed, F. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro2974 · Cited by 3,681
Identification of an Intestinal Heme Transporter
Shayeghi, M., Latunde-Dada, G. O., Oakhill, J. S., Laftah, A. H., Takeuchi, K., Halliday, N., Khan, Y., Warley, A., McCann, F. E., Hider, R. C., et al. (2005) · Cell · doi:10.1016/j.cell.2005.06.025 · Cited by 755
Lavermicocca, P., Valerio, F., Evidente, A., Lazzaroni, S., Corsetti, A., & Gobbetti, M. (2000) · Applied and Environmental Microbiology · doi:10.1128/aem.66.9.4084-4090.2000 · Cited by 654
Current perspectives on antifungal lactic acid bacteria as natural bio-preservatives
Crowley, S., Mahony, J., & van Sinderen, D. (2013) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2013.07.004 · Cited by 328
An overview of molecular basis of iron metabolism regulation and the associated pathologies
Silva, B., & Faustino, P. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.03.011 · Cited by 300
Valerio, F., Lavermicocca, P., Pascale, M., & Visconti, A. (2004) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2004.tb09494.x · Cited by 275
Scientific Opinion on Dietary Reference Values for vitamin A
EFSA Panel on Dietetic Products, N. (2015) · EFSA Journal · doi:10.2903/j.efsa.2015.4028 · Cited by 247
Inorganic Biochemistry of Iron Metabolism: From Molecular Mechanisms to Clinical Consequences
Crichton, R. R. (2001) · Cited by 244
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Duodenal Cytochrome b (DCYTB) in Iron Metabolism: An Update on Function and Regulation
Lane, D. J. R., Bae, D.-H., Merlot, A. M., Sahni, S., & Richardson, D. R. (2015) · Nutrients · doi:10.3390/nu7042274 · Cited by 164
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Ciont, C., Pop, R. M., Tăbăran, F., Pop, R., Simon, E., Barbu–Tudoran, L., Mesaroş, A., Suharoschi, R., Vodnar, D. C., & Pop, O. L. (2026) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2026.109010
Metadata
- Authors
- González, A., Gálvez, N., Martín, J., Reyes, F., Pérez-Victoria, I., & Dominguez-Vera, J. M.
- Affiliations
- Universidad de Granada (ES)
- Fundación Medina (ES)
- Corresponding author
- Dominguez-Vera, Jose M.
- Venue
- Food Chemistry
- Publisher
- Elsevier BV
- Published
- 2017-08
- Volume
- 228
- Pages
- 374-380
- ISSN
- 0308-8146 (ISSN-L)
- OpenAlex
- W2585727439
- Cited by
- 100
- References
- 23
- Citations by year
- 2026: 10 · 2025: 15 · 2024: 18 · 2023: 14 · 2022: 18 · 2021: 10 · 2020: 3 · 2019: 7 · 2018: 3 · 2017: 2
- FWCI
- 4.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Food Chemistry (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (acceptedVersion)
- Institutional Repository of the University of Granada (University of Granada) (submittedVersion, cc-by-nc-nd)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-nd)
- RISalud Institutional Health Repository of Andalucía (submittedVersion, cc-by-nc-nd)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, cc-by)
- Funders
- MINECO (PCT-010000-2010-4, INP-2011-0016-PCT-010000-ACT6)
- FEDER (CTQ2015-64538-R)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- Lactobacillus fermentum, probiotics, iron absorption, Fe(III) reduction, p-hydroxyphenyllactic acid, DMT1, enterocytes, iron deficiency, gut microbiota
- MeSH terms
- Fermentation, Humans, Iron, Probiotics, Limosilactobacillus fermentum
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