FT-IR and FT-Raman Fingerprints of Flavonoids—A Review
Open accessAbstract
Flavonoids are secondary metabolites commonly found in plants. They are known for their antioxidant properties, are part of the defense mechanisms of plants and are responsible for the pigmentation of fruit and flowers petals. Consumption foods rich in flavonoids in the daily diet brings a number of pro-health benefits - for example blood pressure regulation, delaying the aging process or anti-cancer effect. These compounds in synthetic or natural form are also used in pharmacy. The profile of flavonoid compounds can be quickly, accurately and easy determine in the test sample by using the infrared and Raman spectroscopy. Those methods are successfully used in the food and pharmaceutical industries. Spectroscopy methods allow us to determine the chemical structure of these compounds. This review describes and compares differences between the spectroscopic spectra of individual compounds with the chemical structure for the flavonoids subgroups: flavones, isoflavones, flavanones, flavonols and anthocyanins.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A broad IR band at 3338 cm−1 extending from 3042 to 3600 cm−1 is indicative of O-H stretching vibrations associated with hydroxyl groups in phenolic compounds, flavonoids, and other hydroxylated molecules.
“Furthermore, a broad band at 3338 cm−1, extending from 3042 to 3600 cm−1, is indicative of O-H stretching vibrations, commonly associated with hydroxyl groups in phenolic compounds, flavonoids, and other hydroxylated molecules.”
From Comparative Analysis of Infusions and Ethanolic Extracts of Annona muricata Leaves from Colima, Mexico: Phytochemical Profile and Antioxidant Activity (2024) · cites this paper as [38]
The broadness of the O-H band suggests strong hydrogen bonding interactions characteristic of phenolic compounds.
“The broadness of this band suggests strong hydrogen bonding interactions, which are characteristic of phenolic compounds [37,38].”
From Comparative Analysis of Infusions and Ethanolic Extracts of Annona muricata Leaves from Colima, Mexico: Phytochemical Profile and Antioxidant Activity (2024) · cites this paper as [38]
Cites
Panche, A. N., Diwan, A. D., & Chandra, S. (2016) · Journal of Nutritional Science · doi:10.1017/jns.2016.41 · Cited by 5,644 · see citing works
Khoo, H. E., Azlan, A., Tang, S. T., & Lim, S. M. (2017) · Food & Nutrition Research · doi:10.1080/16546628.2017.1361779 · Cited by 2,988 · see citing works
Near‐Infrared Spectroscopy in Food Analysis
Osborne, B. G. (2000) · Wiley eBooks · doi:10.1002/9780470027318.a1018 · Cited by 986 · see citing works
Tannins in plant–herbivore interactions
Barbehenn, R. V., & Constabel, C. P. (2011) · Phytochemistry · doi:10.1016/j.phytochem.2011.01.040 · Cited by 978 · see citing works
Identification and quantification of valuable plant substances by IR and Raman spectroscopy
Schulz, H., & Barańśka, M. (2006) · Vibrational Spectroscopy · doi:10.1016/j.vibspec.2006.06.001 · Cited by 977 · see citing works
BROWN, E. J., Khodr, H., HIDER, C. R., & Rice-Evans, C. A. (1998) · Biochemical Journal · doi:10.1042/bj3301173 · Cited by 813 · see citing works
Křížová, L., Dadáková, K., Kašparovská, J., & Kašparovský, T. (2019) · Molecules · doi:10.3390/molecules24061076 · Cited by 714 · see citing works
Flavanols and Anthocyanins in Cardiovascular Health: A Review of Current Evidence
de Pascual‐Teresa, S., Moreno, D. A., & García‐Viguera, C. (2010) · International Journal of Molecular Sciences · doi:10.3390/ijms11041679 · Cited by 560 · see citing works
FT-IR imaging of native and tissue-engineered bone and cartilage
Boskey, A. L., & Pleshko, N. L. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.11.043 · Cited by 533 · see citing works
Zaheer, K., & Akhtar, M. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2014.989958 · Cited by 414 · see citing works
Drug Interactions with Grapefruit Juice
Ameer, B., & Weintraub, R. A. (1997) · Clinical Pharmacokinetics · doi:10.2165/00003088-199733020-00003 · Cited by 351 · see citing works
The chemical composition of exhausted coffee waste
Pujol, D., Liu, C., Gominho, J., Olivella, M. À., Fiol, N., Villaescusa, I., & Pereira, H. (2013) · Industrial Crops and Products · doi:10.1016/j.indcrop.2013.07.056 · Cited by 342 · see citing works
Flavonoids--food sources and health benefits.
Kozłowska, A., & Szostak-Węgierek, D. E. (2014) · PubMed · Cited by 294 · see citing works
Tahir, H. E., Xiaobo, Z., Li, Z., et al. (2017) · Food Chemistry · doi:10.1016/j.foodchem.2017.01.024 · Cited by 218 · see citing works
Švehlı́ková, V., Bennett, R. N., Mellon, F. A., et al. (2004) · Phytochemistry · doi:10.1016/j.phytochem.2004.07.011 · Cited by 197 · see citing works
Silva‐Navas, J., Moreno-Risueno, M. Á., Manzano, C., Téllez‐Robledo, B., Navarro‐Neila, S., Carrasco, V., Pollmann, S., Gallego, F. J., & del Pozo, J. C. (2015) · The Plant Cell · doi:10.1105/tpc.15.00857 · Cited by 178 · see citing works
Biosynthesis and biotechnological production of flavanones: current state and perspectives
Fowler, Z. L., & Koffas, M. A. G. (2009) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-009-2039-z · Cited by 169 · see citing works
Gniadecka, M., Wulf, H. C., Nielsen, O. F., et al. (1997) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1997.tb03167.x · Cited by 167 · see citing works
Chang, H., Kao, M., Chen, T.-L., et al. (2013) · International Journal of Photoenergy · doi:10.1155/2013/159502 · Cited by 164 · see citing works
Naringin and naringenin determination and control in grapefruit juice by a validated HPLC method
Ribeiro, I., & Ribeiro, M. H. L. (2007) · Food Control · doi:10.1016/j.foodcont.2007.05.007 · Cited by 152 · see citing works
Plant Flavonoids as Potential Source of Future Antimalarial leads
Rudrapal, M., & Chetia, D. (2016) · Systematic Reviews in Pharmacy · doi:10.5530/srp.2017.1.4 · Cited by 105 · see citing works
Raman and surface-enhanced Raman spectra of chrysin, apigenin and luteolin
Corredor, C., Teslova, T., Cañamares, M. V., Chen, Z., Zhang, J., Lombardi, J. R., & Leona, M. (2008) · Vibrational Spectroscopy · doi:10.1016/j.vibspec.2008.07.012 · Cited by 103 · see citing works
ANALYSIS OF GREEN TEA CONSTITUENTS BY HPLC-FTIR
Robb, C. S., Geldart, S. E., Seelenbinder, J. A., & Brown, P. R. (2002) · Journal of Liquid Chromatography & Related Technologies · doi:10.1081/jlc-120003036 · Cited by 96 · see citing works
Ünsalan, O., Erdoğdu, Y., & Gulluoglu, M. T. (2008) · Journal of Raman Spectroscopy · doi:10.1002/jrs.2166 · Cited by 86 · see citing works
Liu, H., Chen, Y., Shi, C., et al. (2019) · LWT · doi:10.1016/j.lwt.2019.108906 · Cited by 83 · see citing works
Geraldes, C. F. G. C. (2020) · Molecules · doi:10.3390/molecules25235547 · Cited by 82 · see citing works
Surface-enhanced Raman scattering (SERS) study of anthocyanidins
Zaffino, C., Russo, B., & Bruni, S. (2015) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2015.04.039 · Cited by 77 · see citing works
Pompeu, D. R., Larondelle, Y., Rogez, H., et al. (2017) · BASE · doi:10.25518/1780-4507.16270 · Cited by 73 · see citing works
Xia, J., Wang, D., Liang, P., De, Z., Du, X., Ni, D., & Yu, Z. G. (2019) · Biophysical Chemistry · doi:10.1016/j.bpc.2019.106282 · Cited by 61 · see citing works
In vitro and in vivo effects of naringin on cytochrome P450-dependent monooxygenase in mouse liver
Ueng, Y., Chang, Y., Oda, Y., Park, S. S., Liao, J., Lin, M.-F., & Chen, C. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00528-7 · Cited by 59 · see citing works
Systematic investigations of anthocyanin–metal interactions by Raman spectroscopy
Buchweitz, M., Gudi, G., Carle, R., et al. (2012) · Journal of Raman Spectroscopy · doi:10.1002/jrs.4123 · Cited by 55 · see citing works
Krekora, M., Szymańska‐Chargot, M., Niewiadomski, Z., et al. (2020) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2020.105935 · Cited by 54 · see citing works
Self-citationFlavonols in the Prevention of Diabetes-induced Vascular Dysfunction
Leo, C., & Woodman, O. L. (2014) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000180 · Cited by 48 · see citing works
Paczkowska‐Walendowska, M., Lewandowska, K., Bednarski, W., et al. (2014) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2014.12.050 · Cited by 47 · see citing works
Liang, J., Cao, L., Zhang, L., et al. (2014) · Food Science and Biotechnology · doi:10.1007/s10068-014-0078-4 · Cited by 47 · see citing works
Singh, H., Singh, S., Srivastava, A., et al. (2013) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2013.10.045 · Cited by 46 · see citing works
Anti-androgenic effects of flavonols in prostate cancer
Boam, T. (2015) · ecancermedicalscience · doi:10.3332/ecancer.2015.585 · Cited by 45 · see citing works
Synthesis and physicochemical properties of the Al(III), Ga(III) and In(III) complexes with chrysin
Pusz, J., Nitka, B., Zielińska, A., et al. (2000) · Microchemical Journal · doi:10.1016/s0026-265x(00)00121-1 · Cited by 41 · see citing works
Różyło, R., Szymańska‐Chargot, M., Gawlik‐Dziki, U., & Dziki, D. (2020) · Food Chemistry · doi:10.1016/j.foodchem.2020.128889 · Cited by 39 · see citing works
Self-citationMahesar, S. A., Lucarini, M., Durazzo, A., Santini, A., Lampe, A. I., & Kiefer, J. (2019) · Journal of Spectroscopy · doi:10.1155/2019/5319024 · Cited by 37 · see citing works
Molecular structure and vibrational spectra of quercetin and quercetin-5’-sulfonic acid
Hanuza, J., Godlewska, P., Kucharska, E., Ptak, M., Kopacz, M., Mączka, M., Hermanowicz, K., & Macalik, L. (2016) · Vibrational Spectroscopy · doi:10.1016/j.vibspec.2016.11.007 · Cited by 36 · see citing works
Wang, D., Kim, D., Shin, C.-H., et al. (2019) · Environmental Earth Sciences · doi:10.1007/s12665-019-8127-1 · Cited by 35 · see citing works
Apigenin-7-O-β-d-glycoside isolation from the highly copper-tolerant plant Elsholtzia splendens
Peng, H., Zhang, X., & Xu, J. (2016) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b1500242 · Cited by 32 · see citing works
Geng, S., Shan, S., Ma, H., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0150412 · Cited by 28 · see citing works
Raman, infrared and computational analysis of genistein and its methoxy derivatives
Sekine, R., Robertson, E. G., & McNaughton, D. (2011) · Vibrational Spectroscopy · doi:10.1016/j.vibspec.2011.09.005 · Cited by 26 · see citing works
Condurso, C., Cincotta, F., Tripodi, G., et al. (2018) · European Food Research and Technology · doi:10.1007/s00217-017-3025-9 · Cited by 23 · see citing works
Govindammal, M., Prasath, M., Kamaraj, S., et al. (2019) · Biocatalysis and Agricultural Biotechnology · doi:10.1016/j.bcab.2019.101086 · Cited by 20 · see citing works
Antibacterial lead compounds and their targets for drug development
Gupta, A., & Pandey, A. K. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-817890-4.00018-4 · Cited by 18 · see citing works
Miramont, C., Jourdes, M., & Teissèdre, P. (2020) · OENO One · doi:10.20870/oeno-one.2020.54.4.3731 · Cited by 18 · see citing works
Application of FT-Raman spectroscopy to the study of selected organometallic complexes and proteins
Barnett, S. M., Dicaire, F., & Ismail, A. A. (1990) · Canadian Journal of Chemistry · doi:10.1139/v90-185 · Cited by 8 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Hernandez-Fuentes, G. A., Delgado-Enciso, O. G., Larios-Cedeño, E. G., Sánchez-Galindo, J. M., Ceballos-Magaña, S. G., Pineda-Urbina, K., Alcalá-Pérez, M. A., Magaña-Vergara, N. E., Delgado-Enciso, J., Díaz-Llerenas, U., et al. (2024) · Life · doi:10.3390/life14121702 · Cited by 15 · see citing works
Hernández-Rangel, A. E., Cabrera-Licona, A., Hernandez-Fuentes, G. A., Beas-Guzmán, O. F., Martínez-Martínez, F. J., Alcalá-Pérez, M. A., Montes-Galindo, D. A., Rodriguez-Sanchez, I. P., Martinez-Fierro, M. L., Casarez-Price, J. C., et al. (2024) · Biomedicines · doi:10.3390/biomedicines12081804 · Cited by 7 · see citing works
- Authors
- Krysa, M., Szymańska-Chargot, M., & Zdunek, A.
- Affiliations
- Institute of Agrophysics, Polish Academy of Sciences (PL)
- Venue
- Food Chemistry
- Publisher
- Elsevier BV
- Published
- 2022-11
- Volume
- 393
- Pages
- 133430
- ISSN
- 0308-8146 (ISSN-L)
- OpenAlex
- W4281606116
- Cited by
- 305
- References
- 50
- Citations by year
- 2026: 100 · 2025: 112 · 2024: 61 · 2023: 26 · 2022: 6
- FWCI
- 7.89
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Food Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Narodowe Centrum Nauki (UMO-2018/29/B/NZ9/00141)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Spectroscopy Techniques in Biomedical and Chemical Research
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Physical Sciences › Chemistry › Analytical Chemistry › Spectroscopy and Chemometric Analyses
- Keywords
- flavonoids, FTIR spectroscopy, FT-Raman spectroscopy, vibrational spectra, flavones, isoflavones, flavanones, flavonols, anthocyanins, food analysis, pharmaceutical analysis, plant secondary metabolites
- MeSH terms
- Anthocyanins, Antioxidants, Flavonoids, Spectrum Analysis, Raman, Spectroscopy, Fourier Transform Infrared
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
