The DOI matches its Crossref record; 136 of the 140 references it cites were found in a registry or an index.
Biological and pharmacological aspects of tannins and potential biotechnological applications
Open accessAbstract
Secondary metabolites are divided into three classes: phenolic, terpenoid, and nitrogenous compounds. Phenolic compounds are also known as polyphenols and include tannins, classified as hydrolysable or condensed. Herein, we explored tannins for their ROS reduction characteristics and role in homeostasis. These activities are associated with the numbers and degree of polymerisation of reactive hydroxyl groups present in the phenolic rings of tannins. These characteristics are associated with anti-inflammatory, anti-aging, and anti-proliferative health benefits. Tannins can reduce the risk of cancer and neurodegenerative diseases, such as cardiovascular diseases and Alzheimer's, respectively. These biomolecules may be used as nutraceuticals to maintain good gut microbiota. Industrial applications include providing durability to leather, anti-corrosive properties to metals, and substrates for 3D printing and in bio-based foam manufacture. This review updates regarding tannin-based research and highlights its biological and pharmacological relevance and potential applications.
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“Tannic acid (TA), a natural polyphenolic compound, has attracted significant attention in the biomedical field due to its potent antioxidant and anti-inflammatory properties24,25, indicating its potential for application in the treatment of osteoporotic fractures.”
From Intelligence-responsive wettability switch coating on magnesium implants for treating osteoporotic fracture (2026) · cites this paper as [25]
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Cites
2 retracted
Ikram, M., Saeed, K., Khan, A., Muhammad, T., Khan, M., Jo, M., Rehman, S., & Kim, M. (2019) · Nutrients · doi:10.3390/nu11051082 · Cited by 97
RetractedKang, J. H., Boumenna, T., Stein, J. D., Khawaja, A. P., ROSNER, B. A., Wiggs, J. L., & Pasquale, L. R. (2020) · JAMA Ophthalmology · doi:10.1001/jamaophthalmol.2020.0027 · Cited by 3
RetractedCryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286
The Human Intestinal Microbiome in Health and Disease
Lynch, S. V., & Pedersen, O. (2016) · New England Journal of Medicine · doi:10.1056/nejmra1600266 · Cited by 3,637
Gut microbiota functions: metabolism of nutrients and other food components
Rowland, I., Gibson, G., Heinken, A., Scott, K., Swann, J., Thiele, I., & Tuohy, K. (2018) · European Journal of Nutrition · doi:10.1007/s00394-017-1445-8 · Cited by 2,878
The role of short chain fatty acids in health and disease
Tan, J., McKenzie, C., Potamitis, M., Thorburn, A. N., Mackay, C. R., & Macia, L. (2014) · Advances in immunology · doi:10.1016/b978-0-12-800100-4.00003-9 · Cited by 2,425
Tannins and Human Health: A Review
Chung, K.-T., Wong, T. Y., Wei, C.-I., Huang, Y.-W., & Lin, Y. (1998) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408699891274273 · Cited by 1,996
Dysbiosis and the immune system
Levy, M., Kolodziejczyk, A. A., Thaiss, C. A., & Elinav, E. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.7 · Cited by 1,769
Stress and defense responses in plant secondary metabolites production
Isah, T. (2019) · Biological Research · doi:10.1186/s40659-019-0246-3 · Cited by 1,492
Erb, M., & Kliebenstein, D. J. (2020) · Plant Physiology · doi:10.1104/pp.20.00433 · Cited by 1,333
Research works printed but not linked: 1
- Caballero, B., Finglas, P. M., & Toldrá, F. (Eds.). (2016). Encyclopedia of food and health. Academic Press is an imprint of Elsevier. (pp. 44-4011).
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Duret, E. (2023) · theses.fr (ABES) · doi:10.70675/eb7f2d02z59c3z4bf1z89caz57f7ae8400f9
Ferreira, I. J., Duarte, A. R. C., Diniz, M., & Salgado, R. M. N. (2026) · Lecture notes on multidisciplinary industrial engineering · doi:10.1007/978-3-032-19652-1_17
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Ismail, U., Ladio, H., & Saje, M. (2026) · Modern Chemistry · doi:10.11648/j.mc.20261403.11
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Metadata
- Authors
- Melo, L. F. M. D., Aquino-Martins, V. G. D. Q., Silva, A. P. D., Oliveira Rocha, H. A., & Scortecci, K. C.
- Affiliations
- Universidade Federal do Rio Grande do Norte (BR)
- Venue
- Food Chemistry
- Publisher
- Elsevier BV
- Published
- 2023-07
- Volume
- 414
- Pages
- 135645
- ISSN
- 0308-8146 (ISSN-L)
- OpenAlex
- W4319320211
- Semantic Scholar
- b37f05ad7ca85ab9bf6d1e0ebc562fb201cca365
- Cited by
- 137
- References
- 140
- Citations by year
- 2026: 34 · 2025: 45 · 2024: 43 · 2023: 15
- FWCI
- 2.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 235 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Food Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Tannin, Tannase and Anticancer Activities
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Physical Sciences › Chemical Engineering › Process Chemistry and Technology › Lignin and Wood Chemistry
- Keywords
- tannins, hydrolysable tannins, proanthocyanidins, polyphenols, reactive oxygen species scavenging, antioxidant activity, anti-inflammatory activity, anti-aging, antiproliferative activity, cancer prevention, neurodegenerative diseases, cardiovascular disease, nutraceuticals, gut microbiota, leather tanning, corrosion protection, 3D printing, bio-based foams
- MeSH terms
- Phenols, Plant Extracts, Tannins, Dietary Supplements, Polyphenols
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