The DOI matches its Crossref record; 218 of the 219 references it cites were found in a registry or an index.
Intermingling of gut microbiota with brain: Exploring the role of probiotics in battle against depressive disorders
Abstract
Depression is a debilitating psychiatric ailment which exerts disastrous effects on one's mental and physical health. Depression is accountable for augmentation of various life-threatening maladies such as neurodegenerative anomalies, cardiovascular diseases and diabetes. Depressive episodes are recurrent, pose a negative impact on life quality, decline life expectancy and enhance suicidal tendencies. Anti-depression chemotherapy displays marked adverse effects and frequent relapses. Thus, newer therapeutic interventions to prevent or combat depression are desperately required. Discovery of gut microbes as our mutualistic partner was made a long time ago and it is surprising that their functions still continue to expand and as of yet many are still to be uncovered. Experimental studies have revealed astonishing role of gut commensals in gut-brain signaling, immune homeostasis and hormonal regulation. Now, it is a well-established fact that gut microbes can alleviate stress or depression associated symptoms by modulating brain functions. Here in, we provide an overview of physiological alleyways involved in cross-talk between gut and brain, part played by probiotics in regulation of these pathways and use of probiotic bacteria as psychobiotics in various mental or depressive disorders.
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“These act through the brain-gut axis, and exert antidepressant effects by altering emotional, cognitive, and neuronal indices [236,239].”
From Lactic Acid Bacteria in Raw-Milk Cheeses: From Starter Cultures to Probiotic Functions (2022) · cites this paper as [239]
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Lactic Acid Bacteria in Raw-Milk Cheeses: From Starter Cultures to Probiotic Functions
Coelho, M. C., Malcata, F. X., & Silva, C. C. G. (2022) · Foods · doi:10.3390/foods11152276 · Cited by 276
“These act through the brain-gut axis, and exert antidepressant effects by altering emotional, cognitive, and neuronal indices [236,239].”
Qian, X., Li, Q., Zhu, H., Chen, Y., Lin, G., Zhang, H., Chen, W., Wang, G., & Tian, P. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101798 · Cited by 135
Cardiovascular disease and depression: a narrative review
Li, X., Zhou, J., Wang, M., Yang, C., & Sun, G. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1274595 · Cited by 115
Neuroinflammation, Microbiota-Gut-Brain Axis, and Depression: The Vicious Circle
Reyes-Martínez, S., Segura-Real, L., Gómez-García, A. P., Tesoro-Cruz, E., Constantino-Jonapa, L. A., Amedei, A., & Aguirre‐García, M. M. (2023) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2203065 · Cited by 78
Xie, Z., Huang, J., Sun, G., He, S., Luo, Z., Zhang, L., Li, L., Yao, M., Du, C., Yu, W., et al. (2024) · Psychiatry Research · doi:10.1016/j.psychres.2024.115804 · Cited by 68
Metadata
- Authors
- Tyagi, P., Tasleem, M., Prakash, S., & Chouhan, G.
- Affiliations
- Sharda University (IN)
- Corresponding author
- Chouhan, Garima
- Venue
- Food Research International
- Publisher
- Elsevier BV
- Published
- 2020-11
- Volume
- 137
- Pages
- 109489
- ISSN
- 0963-9969 (ISSN-L)
- OpenAlex
- W3038366553
- Cited by
- 42
- References
- 219
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 11 · 2023: 8 · 2022: 9 · 2021: 4 · 2020: 1
- FWCI
- 3.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food Research International (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- gut microbiota, depression, probiotics, psychobiotics, gut-brain axis, depressive disorders, stress, immune homeostasis, hormonal regulation, antidepressant side effects, neurodegenerative diseases
- MeSH terms
- Gastrointestinal Microbiome, Bacteria, Brain, Depressive Disorder, Humans, Probiotics
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