Cited by 42Probiotics and Fermented FoodsGut microbiota and healthTryptophan and brain disorders

The DOI matches its Crossref record; 218 of the 219 references it cites were found in a registry or an index.

Intermingling of gut microbiota with brain: Exploring the role of probiotics in battle against depressive disorders

Tyagi, Priya, Tasleem, Mohd, Prakash, Shweta, Chouhan, Garima·2020·Food Research International

DOI 10.1016/j.foodres.2020.109489

Open this paper in CoChat — free account

Abstract

Depression is a debilitating psychiatric ailment which exerts disastrous effects on one's mental and physical health. Depression is accountable for augmentation of various life-threatening maladies such as neurodegenerative anomalies, cardiovascular diseases and diabetes. Depressive episodes are recurrent, pose a negative impact on life quality, decline life expectancy and enhance suicidal tendencies. Anti-depression chemotherapy displays marked adverse effects and frequent relapses. Thus, newer therapeutic interventions to prevent or combat depression are desperately required. Discovery of gut microbes as our mutualistic partner was made a long time ago and it is surprising that their functions still continue to expand and as of yet many are still to be uncovered. Experimental studies have revealed astonishing role of gut commensals in gut-brain signaling, immune homeostasis and hormonal regulation. Now, it is a well-established fact that gut microbes can alleviate stress or depression associated symptoms by modulating brain functions. Here in, we provide an overview of physiological alleyways involved in cross-talk between gut and brain, part played by probiotics in regulation of these pathways and use of probiotic bacteria as psychobiotics in various mental or depressive disorders.

Integrity signals

Registry

Crossref · 10.1016/j.foodres.2020.109489

Cites

218 of 218 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1 retracted

RETRACTED ARTICLE: The effects of probiotics on mental health and hypothalamic–pituitary–adrenal axis: A randomized, double-blind, placebo-controlled trial in petrochemical workers
Mohammadi, A. A., Jazayeri, S., Khosravi‐Darani, K., Solati, Z., Mohammadpour, N., Asemi, Z., Adab, Z., Djalali, M., Tehrani‐Doost, M., Hosseini, M., et al. (2015) · Nutritional Neuroscience · doi:10.1179/1476830515y.0000000023 · Cited by 241
Retracted
Untitled work
Hill (2014) · doi:10.1038/nrgastro.2014.66 · Cited by 9,592
From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites
Koh, A., De Vadder, F., Kovatcheva-Datchary, P., & Bäckhed, F. (2016) · Cell · doi:10.1016/j.cell.2016.05.041 · Cited by 7,070
Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal
Ayala, A., Muñoz, M., & Argüelles, S. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/360438 · Cited by 6,837
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve
Bravo, J. A., Forsythe, P., Chew, M. V., Escaravage, E., Savignac, H. M., Dinan, T. G., Bienenstock, J., & Cryan, J. F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102999108 · Cited by 3,888
Introduction to the human gut microbiota
Thursby, E., & Juge, N. (2017) · Biochemical Journal · doi:10.1042/bcj20160510 · Cited by 3,600
Host microbiota constantly control maturation and function of microglia in the CNS
Erny, D., Hrabě de Angelis, A. L., Jaitin, D., Wieghofer, P., Staszewski, O., David, E., Keren-Shaul, H., Mahlakoiv, T., Jakobshagen, K., Buch, T., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4030 · Cited by 3,569
Bipolar Disorder
Yatham, L. N., & Malhi, G. S. (2011) · Oxford University Press eBooks · doi:10.1093/med/9780199562305.001.0001 · Cited by 3,515
Inflammasomes: mechanism of action, role in disease, and therapeutics
Guo, H., Callaway, J. B., & Ting, J. P.-Y. (2015) · Nature Medicine · doi:10.1038/nm.3893 · Cited by 3,340
Pathways towards and Away from Alzheimer’s Disease
Mattson, M. P. (2004) · Nature · doi:10.1038/nature02621 · Cited by 3,052

Show all 219 references

Sorted by citations

Lactic Acid Bacteria in Raw-Milk Cheeses: From Starter Cultures to Probiotic Functions
Coelho, M. C., Malcata, F. X., & Silva, C. C. G. (2022) · Foods · doi:10.3390/foods11152276 · Cited by 276
“These act through the brain-gut axis, and exert antidepressant effects by altering emotional, cognitive, and neuronal indices [236,239].”
Bifidobacteria with indole-3-lactic acid-producing capacity exhibit psychobiotic potential via reducing neuroinflammation
Qian, X., Li, Q., Zhu, H., Chen, Y., Lin, G., Zhang, H., Chen, W., Wang, G., & Tian, P. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101798 · Cited by 135
Cardiovascular disease and depression: a narrative review
Li, X., Zhou, J., Wang, M., Yang, C., & Sun, G. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1274595 · Cited by 115
Neuroinflammation, Microbiota-Gut-Brain Axis, and Depression: The Vicious Circle
Reyes-Martínez, S., Segura-Real, L., Gómez-García, A. P., Tesoro-Cruz, E., Constantino-Jonapa, L. A., Amedei, A., & Aguirre‐García, M. M. (2023) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2203065 · Cited by 78
Integrated multi-omics analysis reveals gut microbiota dysbiosis and systemic disturbance in major depressive disorder
Xie, Z., Huang, J., Sun, G., He, S., Luo, Z., Zhang, L., Li, L., Yao, M., Du, C., Yu, W., et al. (2024) · Psychiatry Research · doi:10.1016/j.psychres.2024.115804 · Cited by 68
Interactions Between Antidepressants and Intestinal Microbiota
Xu, F., Xie, Q., Kuang, W., & Dong, Z. (2023) · Neurotherapeutics · doi:10.1007/s13311-023-01362-8 · Cited by 59
Weissella paramesenteroides WpK4 plays an immunobiotic role in gut-brain axis, reducing gut permeability, anxiety-like and depressive-like behaviors in murine models of colitis and chronic stress
Sandes, S. H. C., Figueiredo, N. C., Pedroso, S. H. S. P., de Sant’Anna, F. M., Acúrcio, L. B., Abatemarco, M., Barros, P., Oliveira, F. M. S., Cardoso, V. N., Generoso, S. D. V., et al. (2020) · Food Research International · doi:10.1016/j.foodres.2020.109741 · Cited by 52
Modulation of the Gut Microbiota and Glycometabolism by a Probiotic to Alleviate Amyloid Accumulation and Cognitive Impairments in AD Rats
Wang, Y., Wang, D., Lv, H., Dong, Q., Li, J., Geng, W., Wang, J., Liu, F., Jia, L., & Wang, Y. (2022) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202200265 · Cited by 48
Polygonum sibiricum polysaccharides exert the antidepressant‐like effects in chronic unpredictable mild stress‐induced depressive mice by modulating microbiota‐gut‐brain axis
Zhang, Y., Sun, Y., Liu, Y., Liu, J., Sun, J., Liu, X., Fan, B., Lü, C., & Wang, F. (2023) · Phytotherapy Research · doi:10.1002/ptr.7813 · Cited by 45
Exploring the gut-brain Axis: Potential therapeutic impact of Psychobiotics on mental health
Cocean, A.-M., & Vodnar, D. C. (2024) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2024.111073 · Cited by 52
Insights on the Critical Parameters Affecting the Probiotic Viability During Stabilization Process and Formulation Development
Gurram, S., Jha, D. K., Shah, D. S., Kshirsagar, M. M., & Amin, P. D. (2021) · AAPS PharmSciTech · doi:10.1208/s12249-021-02024-8 · Cited by 41
Probiotics and the microbiota-gut-brain axis in neurodegeneration: Beneficial effects and mechanistic insights
Ghassab, F. T., Mahmoudi, F. S., Tinjani, R. T., Meibodi, A. E., Zali, M. R., & Yadegar, A. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122748 · Cited by 40
Lactobacillus rhamnosus zz-1 exerts preventive effects on chronic unpredictable mild stress-induced depression in mice via regulating the intestinal microenvironment
Xu, J., Tang, M., Wu, X., Kong, X., Liu, Y., & Xu, X. (2022) · Food & Function · doi:10.1039/d1fo03804d · Cited by 41
Saccharina japonica Ethanol Extract Ameliorates Depression/Anxiety-Like Behavior by Inhibiting Inflammation, Oxidative Stress, and Apoptosis in Dextran Sodium Sulfate Induced Ulcerative Colitis Mice
Dong, X., Lu, K., Lin, P., Che, H., Li, H., Song, L., Yang, X., & Xie, W. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.784532 · Cited by 27
Dietary Polyphenols as Prospective Natural-Compound Depression Treatment from the Perspective of Intestinal Microbiota Regulation
Wang, X., Yu, J., & Zhang, X. (2022) · Molecules · doi:10.3390/molecules27217637 · Cited by 22
Unveiling the Therapeutic Potential of Modern Probiotics in Addressing Neurodegenerative Disorders: A Comprehensive Exploration, Review and Future Perspectives on Intervention Strategies
Sharma, H., Pathak, R., & Biswas, D. (2024) · Current Psychiatry Research and Reviews · doi:10.2174/0126660822304321240520075036 · Cited by 24
Consumption of fermented dairy products is associated with lower anxiety levels in Azorean university students
Sousa, R. J. M., Baptista, J., & Silva, C. C. G. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.930949 · Cited by 21
Fermented Wheat Germ Alleviates Depression-like Behavior in Rats with Chronic and Unpredictable Mild Stress
Hu, Z., Zhao, P., Liao, A., Pan, L., Zhang, J., Dong, Y.-Q., Huang, J., He, W., & Ou, X. (2023) · Foods · doi:10.3390/foods12050920 · Cited by 20
Integrated physiological, intestinal microbiota, and metabolomic responses of adult zebrafish (Danio rerio) to subacute exposure to antimony at environmentally relevant concentrations
Liu, C., Huang, D., Sheng, X., Zhu, J., Dong, S., Chen, S., Wang, Y., Tang, A., Duan, R., Yang, Z., et al. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.116326 · Cited by 20
Unlocking the potential of low FODMAPs sourdough technology for management of irritable bowel syndrome
Arora, R., & Chandel, A. K. (2023) · Food Research International · doi:10.1016/j.foodres.2023.113425 · Cited by 18
An insight into the health beneficial of probiotics dairy products: a critical review
He, J., Li, W., Deng, J., Lin, Q., Bai, J., Zhang, L., & Fang, Y. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2090493 · Cited by 20
Potential role of gut microbiota in major depressive disorder: A review
Khaledi, M., Sameni, F., Gholipour, A., Shahrjerdi, S., Golmohammadi, R., Ghaleh, H. E. G., Poureslamfar, B., Hemmati, J., Mobarezpour, N., Milasi, Y. E., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e33157 · Cited by 18
Ketogenic Diet and Gut Microbiota: Exploring New Perspectives on Cognition and Mood
Jiang, Y., Chen, Y., Chen, Y., Gong, X., Chen, Z., & Zhang, X. (2025) · Foods · doi:10.3390/foods14071215 · Cited by 15
Role of Bifidobacterium spp. intake in improving depressive mood and well-being and its link to kynurenine blood level: an interventional study
Kazem, Y. I., Mahmoud, M. H., Essa, H. A., Azmy, O. M., Kandeel, W. A., Al‐Moghazy, M., El-Attar, I., Hashish, A. F., & Mehanna, N. S. (2021) · Journal of Complementary and Integrative Medicine · doi:10.1515/jcim-2021-0351 · Cited by 15
Appraising the role of biotics and fermented foods in gut microbiota modulation and sleep regulation
Singh, A., & Negi, P. S. (2025) · Journal of Food Science · doi:10.1111/1750-3841.17634 · Cited by 16
The Human Superorganism: Using Microbes for Freedom vs. Fear
Dietert, R. R., & Dietert, J. M. (2023) · Applied Microbiology · doi:10.3390/applmicrobiol3030061 · Cited by 12
The role of probiotics in nutritional health: probiotics as nutribiotics
Chávarri, M., Diez-Gutiérrez, L., Marañón, I., Villarán, M. C., & Barrón, L. J. R. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823733-5.00018-0 · Cited by 11
Probiotic Bactolac alleviates depression-like behaviors by modulating BDNF, NLRP3 and MC4R levels, reducing neuroinflammation and promoting neural repair in rat model
Işık, M., Köse, F., Budak, Ö., Özbayer, C., KELEŞ, R., Aydın, S., Küçük, A. C., Demirci, M. A., Doğanay, S., & Bağcı, C. (2025) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-025-03084-6 · Cited by 12
Lactiplantibacillus plantarum WH021 Alleviates Lipopolysaccharide-Induced Neuroinflammation via Regulating the Intestinal Microenvironment and Protecting the Barrier Integrity
He, B., Cui, R., Hu, T., & Wu, H. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c00825 · Cited by 9
Antidepressant‐Like Effect of Saffron ( Crocus sativus L.) in Mice Exposed to Chronic Unpredictable Mild Stress via Attenuating Neuroinflammation and Recovering Neuroplasticity
Zhou, J., Hu, Y., & Jing, P. (2025) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.70201 · Cited by 8
A PRISMA Systematic Review of Sexual Dysfunction and Probiotics with Pathophysiological Mechanisms
Yang, S.-J., Nguyen, T. T. M., Jin, X., Zheng, Q., Park, S.-J., Yi, G.-S., & Yi, T. (2025) · Biology · doi:10.3390/biology14030286 · Cited by 6
The Impact of Microbiota on Neurological Disorders: Mechanisms and Therapeutic Implications
Merra, G., Placa, G. L., Covino, M., Candelli, M., Gasbarrini, A., & Franceschi, F. (2025) · OBM Neurobiology · doi:10.21926/obm.neurobiol.2501273 · Cited by 6
Association between Dairy Consumption and Psychological Symptoms: Evidence from a Cross-Sectional Study of College Students in the Yangtze River Delta Region of China
Zhao, Z., Cai, R., Zhao, Y., Hu, Y., Liu, J., & Wu, M. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20043261 · Cited by 5
The Maneuver of Psychobiotics in the Medical Aid of Clinical Depression
Balaprabha, G. R., Neerajakshi, P., Kaur, P., Kumar, G. N., & Ramarao, T. (2024) · International Journal Of Pharmaceutical Research And Allied Sciences · doi:10.51847/xbbvwpttng · Cited by 2
The Intestinal Neuro-immune Axis
Ibrahim, I., Krishnan, S. S., & Ayariga, J. A. (2024) · Springer eBooks · doi:10.1007/978-3-031-24297-7_28-1 · Cited by 1
Causality Between Irritable Bowel Syndrome and Suicide Attempt: A Mendelian Randomization Study
Deng, Z., Wang, K., & Hou, T. (2025) · Brain and Behavior · doi:10.1002/brb3.70513 · Cited by 2
Probiotics in pregnancy and lactation
Treven, P., Majhenič, A. Č., Paveljšek, D., & Matijašić, B. B. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-89908-6.00012-1 · Cited by 1
Nutrition and Mental Health
Deif, R., & LAWLOR, B. A. (2022) · Nutritional neurosciences · doi:10.1007/978-981-16-9205-5_5 · Cited by 2
Bakterie Modyfikowane Genetycznie – Perspektywy Zastosowania w Profilaktyce, Diagnostyce I Terapii
Macura, B., Kiecka, A., & Szczepanik, M. (2022) · Postępy Mikrobiologii - Advancements of Microbiology · doi:10.2478/am-2022.0003
Probiotic Bactolac Provides Antidepressant Effect by Increasing BDNF level and Reducing NLRP3 and MC4R Expression Levels, Neuron Damage, Glial Activity and Depression-Like Behaviors in RatsPreprint
Işık, M., Köse, F., Budak, Ö., Özbayer, C., KELEŞ, R., Aydın, S., Küçük, A. C., Demirci, M. A., Doğanay, S., & Bağcı, C. (2024) · Research Square · doi:10.21203/rs.3.rs-4014136/v1
The Intestinal Neuro-immune Axis
Ibrahim, I., Krishnan, S. S., & Ayariga, J. A. (2024) · Springer eBooks · doi:10.1007/978-3-031-60006-7_28
AI-Driven Delivery of Psychobiotics: Enhancing Targeted Treatments of the Gut-Brain Axis and Prospects for Personalized Applications
Huang, D., Gao, Y., Hao, K., Hu, C., Zhang, S., Gong, W., Qin, X., Du, G., Li, H., & Zhou, Y. (2026) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2026.101674

Authors: Tyagi, P., Tasleem, M., Prakash, S., & Chouhan, G.
Affiliations: Sharda University (IN)
Corresponding author: Chouhan, Garima
ORCID: Tyagi, Priya
Tasleem, Mohd
Chouhan, Garima
Venue: Food Research International
Publisher: Elsevier BV
Published: 2020-11
Volume: 137
Pages: 109489
ISSN: 0963-9969 (ISSN-L)
DOI: 10.1016/j.foodres.2020.109489
OpenAlex: W3038366553
Cited by: 42
References: 219
Citations by year: 2026: 1 · 2025: 8 · 2024: 11 · 2023: 8 · 2022: 9 · 2021: 4 · 2020: 1
FWCI: 3.57
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Food Research International (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: gut microbiota, depression, probiotics, psychobiotics, gut-brain axis, depressive disorders, stress, immune homeostasis, hormonal regulation, antidepressant side effects, neurodegenerative diseases
MeSH terms: Gastrointestinal Microbiome, Bacteria, Brain, Depressive Disorder, Humans, Probiotics

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Intermingling of gut microbiota with brain: Exploring the role of probiotics in battle against depressive disorders

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks