Upregulation of uncoupling protein-3 in skeletal muscle during exercise: a potential antioxidant function

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 315,771 · see citing works

Hydroperoxide metabolism in mammalian organs.

Chance, B., Sies, H., & Boveris, A. (1979) · Physiological Reviews · doi:10.1152/physrev.1979.59.3.527 · Cited by 5,827 · see citing works

Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators

St-Pierre, J., Drori, S., Uldry, M., Silvaggi, J. M., Rhee, J., Jäger, S., Handschin, C., Zheng, K., Lin, J., Yang, W., et al. (2006) · Cell · doi:10.1016/j.cell.2006.09.024 · Cited by 2,233 · see citing works

[7] Mitochondrial respiratory control and the polarographic measurement of ADP : O ratios

Estabrook, R. W. (1967) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(67)10010-4 · Cited by 1,782 · see citing works

Free radicals and tissue damage produced by exercise

Davies, K. J. A., Quintanilha, A. T., Brooks, G. A., & Packer, L. (1982) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(82)80124-1 · Cited by 1,739 · see citing works

Superoxide activates mitochondrial uncoupling proteins

Echtay, K. S., Roussel, D., St-Pierre, J., Jekabsons, M. B., Cadenas, S., Stuart, J. A., Harper, J. A., Roebuck, S. J., Morrison, A., Pickering, S., et al. (2002) · Nature · doi:10.1038/415096a · Cited by 1,382 · see citing works

Uncoupling protein‐3: a new member of the mitochondrial carrier family with tissue‐specific expression

Boss, O., Samec, S., Paoloni‐Giacobino, A., Rossier, C., Dulloo, A. G., Seydoux, J., Muzzin, P., & Giacobino, J. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00384-0 · Cited by 1,041 · see citing works

Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1

Baar, K., Wende, A. R., Jones, T. E., Marison, M., Nolte, L. A., Chen, M., Kelly, D. P., & Holloszy, J. O. (2002) · The FASEB Journal · doi:10.1096/fj.02-0367com · Cited by 1,020 · see citing works

An improved spectrophotometric assay for superoxide dismutase based on epinephrine autoxidation

Sun, M., & Zigman, S. (1978) · Analytical Biochemistry · doi:10.1016/0003-2697(78)90010-6 · Cited by 782 · see citing works

Exercise Stimulates Pgc-1α Transcription in Skeletal Muscle through Activation of the p38 MAPK Pathway

Akimoto, T., Pohnert, S. C., Li, P., Zhang, M., Gumbs, C., Rosenberg, P. B., Williams, R. S., & Yan, Z. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m408862200 · Cited by 714 · see citing works

UCP3: An Uncoupling Protein Homologue Expressed Preferentially and Abundantly in Skeletal Muscle and Brown Adipose Tissue

Vidal‐Puig, A., Solanes, G., Grujić, D., Flier, J. S., & Lowell, B. B. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6740 · Cited by 711 · see citing works

Energy metabolism in uncoupling protein 3 gene knockout mice

Vidal-Puig, A. J., Grujic, D., Zhang, C.-Y., Hagen, T., Boss, O., Ido, Y., Szczepanik, A., Wade, J., Mootha, V., Cortright, R., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m910179199 · Cited by 677 · see citing works

The mitochondrial uncoupling-protein homologues

Krauss, S., Zhang, C., & Lowell, B. B. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1592 · Cited by 663 · see citing works

Thiobarbituric acid test for monitoring lipid oxidation in meat

Fernández‐López, J., Pérez‐Álvarez, J. Á., & Fernández-López, J. A. (1997) · Food Chemistry · doi:10.1016/s0308-8146(96)00114-8 · Cited by 657 · see citing works

Maximum oxygen consumption of rats and its changes with various experimental procedures

BEDFORD, T. G., Tipton, C. M., Wilson, N. C., Oppliger, R. A., & GISOLFI, C. V. (1979) · Journal of Applied Physiology · doi:10.1152/jappl.1979.47.6.1278 · Cited by 518 · see citing works

Intrinsic and extrinsic uncoupling of oxidative phosphorylation

Kadenbach, B. (2003) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(03)00027-6 · Cited by 486 · see citing works

Reactive oxygen species, mitochondria, apoptosis and aging

Papa, S., & Skulachev, V. P. (1997) · Springer eBooks · doi:10.1007/978-1-4615-6111-8_47 · Cited by 462 · see citing works

Aging and acute exercise enhance free radical generation in rat skeletal muscle

Bejma, J., & Ji, L. L. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.87.1.465 · Cited by 445 · see citing works

Reactive oxygen species, mitochondria, apoptosis and aging

Papa, S., & Скулачев, В. П. (1997) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006873518427 · Cited by 389 · see citing works

Structure and function of the uncoupling protein from brown adipose tissue

Klingenberg, M., & Huang, S. (1999) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(98)00232-6 · Cited by 359 · see citing works

HSP70 and other possible heat shock or oxidative stress proteins are induced in skeletal muscle, heart, and liver during exercise

Salo, D. C., Donovan, C. M., & Davies, K. J. A. (1991) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(91)90119-n · Cited by 357 · see citing works

PPARγ coactivator-1α expression during thyroid hormone- and contractile activity-induced mitochondrial adaptations

Irrcher, I., Adhihetty, P. J., Sheehan, T. E., Joseph, A.-M., & Hood, D. A. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00409.2002 · Cited by 315 · see citing works

Sensitive and rapid quantitation of oxygen reactive species formation in rat synaptosomes

LeBel, C. P., & Bondy, S. C. (1990) · Neurochemistry International · doi:10.1016/0197-0186(90)90025-o · Cited by 313 · see citing works

Role of nitric oxide in skeletal muscle: synthesis, distribution and functional importance

Reid, M. B. (1998) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.1998.0303f.x · Cited by 263 · see citing works

PGC-1α mRNA expression is influenced by metabolic perturbation in exercising human skeletal muscle

Norrbom, J., Sundberg, C. J., Rundqvist, H., Kraus, W. E., Jansson, E., & Gustafsson, T. P. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00765.2003 · Cited by 263 · see citing works

cDNA Cloning and mRNA Analysis of PGC-1 in Epitrochlearis Muscle in Swimming-Exercised Rats

Goto, M., Terada, S., Kato, M., Katoh, M., Yokozeki, T., Tabata, I., & Shimokawa, T. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3134 · Cited by 258 · see citing works

Superoxide dismutase gene expression is activated by a single bout of exercise in rat skeletal muscle

Hollander, J. M., Fiebig, R., Gore, M. T., Ookawara, T., Ohno, H., & Ji, L. (2001) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s004240100539 · Cited by 231 · see citing works

A function for novel uncoupling proteins: antioxidant defense of mitochondrial matrix by translocating fatty acid peroxides from the inner to the outer membrane leaflet

Goglia, F., & Skulachev, V. P. (2003) · The FASEB Journal · doi:10.1096/fj.03-0159hyp · Cited by 229 · see citing works

The ‘Novel’‘Uncoupling’ Proteins UCP2 and UCP3: What Do They Really do? Pros and Cons for Suggested Functions

Nedergaard, J., & Cannon, B. (2003) · Experimental Physiology · doi:10.1113/eph8802502 · Cited by 226 · see citing works

Generating, Partitioning, Targeting and Functioning of Superoxide in Mitochondria

Liu, S. (1997) · Bioscience Reports · doi:10.1023/a:1027328510931 · Cited by 217 · see citing works

Location and effects of long-term NaCl stress on superoxide dismutase and ascorbate peroxidase isoenzymes of pea (Pisum sativum cv. Puget) chloroplasts

Gomez, J. M. (2003) · Journal of Experimental Botany · doi:10.1093/jxb/erh013 · Cited by 191 · see citing works

Cytokines and oxidative signalling in skeletal muscle

Reid, M. B., & Li, Y. ‐. (2001) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2001.00824.x · Cited by 187 · see citing works

Oxidative damage and phospholipid fatty acyl composition in skeletal muscle mitochondria from mice underexpressing or overexpressing uncoupling protein 3

BRAND, M. D., PAMPLONA, R., PORTERO-OTÍN, M., REQUENA, J. R., ROEBUCK, S. J., BUCKINGHAM, J. A., CLAPHAM, J. C., & CADENAS, S. (2002) · Biochemical Journal · doi:10.1042/bj20021077 · Cited by 184 · see citing works

Effect of duration of exercise on excess postexercise O2 consumption

Bahr, R., Ingnes, I., VAAGE, O., Sejersted, O. M., & Newsholme, E. A. (1987) · Journal of Applied Physiology · doi:10.1152/jappl.1987.62.2.485 · Cited by 181 · see citing works

Control of mitochondrial membrane potential and ROS formation by reversible phosphorylation of cytochrome c oxidase

Lee, I., Bender, E., & Kadenbach, B. (2002) · Molecular and Cellular Biochemistry · doi:10.1023/a:1015921513720 · Cited by 173 · see citing works

UCP-3 expression in skeletal muscle: effects of exercise, hypoxia, and AMP-activated protein kinase

Zhou, M., Lin, B.-Z., Coughlin, S., Vallega, G., & Pilch, P. F. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.3.e622 · Cited by 166 · see citing works

Induction of Endogenous Uncoupling Protein 3 Suppresses Mitochondrial Oxidant Emission during Fatty Acid-supported Respiration

Anderson, E. J., Yamazaki, H., & Neufer, P. D. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706129200 · Cited by 151 · see citing works

Bezafibrate Reduces mRNA Levels of Adipocyte Markers and Increases Fatty Acid Oxidation in Primary Culture of Adipocytes

Cabrero, À., Alegret, M., Sánchez, R. M., Adzet, T., Laguna, J. C., & Vázquez‐Carrera, M. (2001) · Diabetes · doi:10.2337/diabetes.50.8.1883 · Cited by 124 · see citing works

Cooperation of a “Reactive Oxygen Cycle” with The Q Cycle and The Proton Cycle in the Respiratory Chain—Superoxide Generating and Cycling Mechanisms in Mitochondria

Liu, S. (1999) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1018650103259 · Cited by 119 · see citing works

Regulation of mitochondrial uncoupling respiration during exercise in rat heart: Role of reactive oxygen species (ROS) and uncoupling protein 2

Hai, B., Jiang, N., Ma, G., Qu, J., Zhang, G., Cao, D., Wen, L., Liu, S., Ji, L. L., & Zhang, Y. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.12.033 · Cited by 108 · see citing works

Aging skeletal muscle mitochondria in the rat: decreased uncoupling protein-3 content

Kerner, J., Turkaly, P. J., Minkler, P. E., & Hoppel, C. L. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.281.5.e1054 · Cited by 106 · see citing works

In the rat, tumor necrosis factor α administration results in an increase in both UCP2 and UCP3 mRNAs in skeletal muscle: a possible mechanism for cytokine‐induced thermogenesis?

Busquets, S., Sanchı́s, D., Alvarez, B., Ricquier, D., López-Soriano, F. J., & Argilés, J. M. A. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01485-9 · Cited by 101 · see citing works

Regulation of skeletal muscle UCP-2 and UCP-3 gene expression by exercise and denervation

Cortright, R. N., Zheng, D., Jones, J. P., Fluckey, J. D., DiCarlo, S. E., Grujić, D., Lowell, B. B., & Dohm, G. L. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.1.e217 · Cited by 88 · see citing works

Free radicals and exercise: An introduction

Packer, L., Cadenas, E., & Davies, K. J. A. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.05.031 · Cited by 86 · see citing works

Tumor necrosis factor-α regulates in vivo expression of the rat UCP family differentially

Masaki, T., Yoshimatsu, H., Chiba, S., Hidaka, S., Tajima, D., Kakuma, T., Kurokawa, M., & Sakata, T. (1999) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s0005-2760(98)00173-8 · Cited by 55 · see citing works

Role of UCP3 in state 4 respiration during contractile activity-induced mitochondrial biogenesis

Ljubicic, V., Adhihetty, P. J., & Hood, D. A. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00336.2004 · Cited by 45 · see citing works

Impaired Cardiac Mitochondrial Membrane Potential and Respiration in Copper-Deficient Rats

Chen, X., Jennings, D. B., & Medeiros, D. M. (2002) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1021258204921 · Cited by 31 · see citing works

Superoxide Dismutase Is Induced During Rat Pancreatic Acinar Cell Injury

Su, S.-B., Motoo, Y., Xie, M.-J., Mouri, H., Asayama, K., & Sawabu, N. (2002) · Pancreas · doi:10.1097/00006676-200203000-00005 · Cited by 20 · see citing works

Mitochondrial cytochrome c reacts with nitric oxide via S-nitrosation

Larson, S. K., Dwyer, D. S., Lo, H., & Ghafourifar, P. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.02.067 · Cited by 9 · see citing works

Uncoupling proteins and the control of mitochondrial reactive oxygen species production

Mailloux, R. J., & Harper, M. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.06.022 · Cited by 534 · see citing works

Exercise alters SIRT1, SIRT6, NAD and NAMPT levels in skeletal muscle of aged rats

Koltai, E., Szabo, Z., Atalay, M., Boldogh, I., Naito, H., Goto, S., Nyakas, C., & Radak, Z. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.11.002 · Cited by 283 · see citing works

Exercise Training Induces Mitochondrial Biogenesis and Glucose Uptake in Subcutaneous Adipose Tissue Through eNOS-Dependent Mechanisms

Trevellin, E., Scorzeto, M., Olivieri, M., Granzotto, M., Valerio, A., Tedesco, L., Fabris, R., Serra, R., Quarta, M., Reggiani, C., et al. (2014) · Diabetes · doi:10.2337/db13-1234 · Cited by 176 · see citing works

Exercise-induced hormesis and skeletal muscle health

Ji, L. L., Kang, C., & Zhang, Y. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.02.025 · Cited by 176 · see citing works

Redox biology of exercise: an integrative and comparative consideration of some overlooked issues

Nikolaidis, M. G., Kyparos, A., Spanou, C., Paschalis, V., Theodorou, A. A., & Vrabas, I. S. (2012) · Journal of Experimental Biology · doi:10.1242/jeb.067470 · Cited by 152 · see citing works

Response of mitochondrial fusion and fission protein gene expression to exercise in rat skeletal muscle

Ding, H., Jiang, N., Liu, H., Liu, X., Liu, D., Zhao, F., Wen, L., Liu, S., Ji, L. L., & Zhang, Y. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.08.007 · Cited by 149 · see citing works

The regulation and turnover of mitochondrial uncoupling proteins

Azzu, V., Jastroch, M., Divakaruni, A. S., & Brand, M. D. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.02.035 · Cited by 146 · see citing works

Total fluid intake and its determinants: cross-sectional surveys among adults in 13 countries worldwide

Ferreira‐Pêgo, C., Guelinckx, I., Moreno, L. A., Kavouras, S. A., Gandy, J., Martı́nez, H., Bardosono, S., Abdollahi, M., Nasseri, E., Jarosz, A., et al. (2015) · European Journal of Nutrition · doi:10.1007/s00394-015-0943-9 · Cited by 144 · see citing works

Proinflammatory NFkB signalling promotes mitochondrial dysfunction in skeletal muscle in response to cellular fuel overloading

Nisr, R. B., Shah, D. S., Ganley, I. G., & Hundal, H. S. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03148-8 · Cited by 142 · see citing works

Exercise with low glycogen increases PGC-1α gene expression in human skeletal muscle

Psilander, N., Frank, P., Flockhart, M., & Sahlin, K. (2013) · European Journal of Applied Physiology · doi:10.1007/s00421-012-2504-8 · Cited by 101 · see citing works

Cold tolerance of UCP1-ablated mice: A skeletal muscle mitochondria switch toward lipid oxidation with marked UCP3 up-regulation not associated with increased basal, fatty acid- or ROS-induced uncoupling or enhanced GDP effects

Shabalina, I. G., Joris Hoeks, J., Kramarova, T. V., Schrauwen, P., Cannon, B., & Nedergaard, J. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.02.033 · Cited by 101 · see citing works

Coenzyme Q10 Depletion in Medical and Neuropsychiatric Disorders: Potential Repercussions and Therapeutic Implications

Morris, G., Anderson, G., Berk, M., & Maes, M. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8477-8 · Cited by 96 · see citing works

Eccentric contraction induces inflammatory responses in rat skeletal muscle: role of tumor necrosis factor-alpha.

Liao, P., Zhou, J.-P., Ji, L. L., & Zhang, Y. (2010) · American Journal of Physiology. Regulatory Integrative and Comparative Physiology · doi:10.1152/ajpregu.00480.2009 · Cited by 103 · see citing works

The transcription factor Nrf2 promotes survival by enhancing the expression of uncoupling protein 3 under conditions of oxidative stress

Anedda, A., López-Bernardo, E., Acosta‐Iborra, B., Suleiman, M. S., Landázuri, M. O., & Cadenas, S. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.04.007 · Cited by 92 · see citing works

Mutation in dystrophin-encoding gene affects energy metabolism in mouse myoblasts

Onopiuk, M., Brutkowski, W., Wierzbicka, K., Wojciechowska, S., Szczepanowska, J., Fronk, J., Lochmüller, H., Górecki, D. C., & Zabłocki, K. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.06.053 · Cited by 85 · see citing works

Skeletal muscle ATP turnover by31P magnetic resonance spectroscopy during moderate and heavy bilateral knee extension

Cannon, D. T., Bimson, W. E., Hampson, S. A., Bowen, T. S., Murgatroyd, S. R., Marwood, S., Kemp, G. J., & Rossiter, H. B. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2014.279174 · Cited by 82 · see citing works

Oxidative Stress, Mitochondrial Function and Adaptation to Exercise: New Perspectives in Nutrition

Vargas-Mendoza, N., Ángeles-Valencia, M., Morales‐González, Á., Madrigal‐Santillán, E., Morales-Martínez, M., Madrigal‐Bujaidar, E., Álvarez‐González, I., Gutiérrez‐Salinas, J., Esquivel-Chirino, C., Chamorro, G., et al. (2021) · Life · doi:10.3390/life11111269 · Cited by 83 · see citing works

Hibernating squirrel muscle activates the endurance exercise pathway despite prolonged immobilization

Xu, R., Andrés‐Mateos, E., Mejı́as, R., MacDonald, E. M., Leinwand, L. A., Merriman, D. K., Fink, R., & Cohn, R. D. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.01.005 · Cited by 67 · see citing works

Nox4 mediates skeletal muscle metabolic responses to exercise

Specht, K. S., Kant, S., Addington, A. K., McMillan, R. P., Hulver, M. W., Learnard, H., Campbell, M., Donnelly, S. R., Caliz, A. D., Pei, Y., et al. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101160 · Cited by 64 · see citing works

4-Hydroxynonenal induces Nrf2-mediated UCP3 upregulation in mouse cardiomyocytes

López-Bernardo, E., Anedda, A., Sánchez-Pérez, P., Acosta‐Iborra, B., & Cadenas, S. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.03.032 · Cited by 57 · see citing works

Diet supplementation with DHA-enriched food in football players during training season enhances the mitochondrial antioxidant capabilities in blood mononuclear cells

Capó, X., Martorell, M., Sureda, A., Llompart, I., Tur, J. A., & Pons, A. (2014) · European Journal of Nutrition · doi:10.1007/s00394-014-0683-2 · Cited by 56 · see citing works

Changes in the power-duration relationship following prolonged exercise: estimation using conventional and all-out protocols and relationship with muscle glycogen

Clark, I. E., Vanhatalo, A., Thompson, C., Wylie, L. J., Bailey, S. J., Kirby, B. S., Wilkins, B. W., & JONES, A. M. (2019) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00031.2019 · Cited by 52 · see citing works

Endurance exercise-induced histone methylation modification involved in skeletal muscle fiber type transition and mitochondrial biogenesis

Li, J., Zhang, S., Li, C., Zhang, X., Shan, Y., Zhang, Z., Hai, B., & Zhang, Y. (2024) · Scientific Reports · doi:10.1038/s41598-024-72088-6 · Cited by 57 · see citing works

The role of mitochondria in redox signaling of muscle homeostasis

Ji, L. L., Yeo, D., Kang, C., & Zhang, T. (2020) · Journal of sport and health science/Journal of Sport and Health Science · doi:10.1016/j.jshs.2020.01.001 · Cited by 51 · see citing works

Mitochondrial Uncoupling Proteins (UCPs) as Key Modulators of ROS Homeostasis: A Crosstalk between Diabesity and Male Infertility?

Monteiro, B. S., Freire‐Brito, L., Carrageta, D. F., Oliveira, P. F., & Alves, M. G. (2021) · Antioxidants · doi:10.3390/antiox10111746 · Cited by 47 · see citing works

Training Enhances Immune Cells Mitochondrial Biosynthesis, Fission, Fusion, and Their Antioxidant Capabilities Synergistically with Dietary Docosahexaenoic Supplementation

Busquets-Cortés, C., Capó, X., Martorell, M., Tur, J. A., Sureda, A., & Pons, A. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/8950384 · Cited by 45 · see citing works

How the mitochondrion was shaped by radical differences in substrates

Speijer, D. (2014) · BioEssays · doi:10.1002/bies.201400033 · Cited by 44 · see citing works

Being right on Q: shaping eukaryotic evolution

Speijer, D. (2016) · Biochemical Journal · doi:10.1042/bcj20160647 · Cited by 41 · see citing works

Stanozolol treatment decreases the mitochondrial ROS generation and oxidative stress induced by acute exercise in rat skeletal muscle

Saborido, A., Naudí, A., Portero‐Otín, M., Pamplona, R., & Megı́as, A. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00790.2010 · Cited by 42 · see citing works

PGC‐1α encoded by the PPARGC1A gene regulates oxidative energy metabolism in equine skeletal muscle during exercise

Eivers, S. S., McGivney, B. A., Gu, J., MacHugh, D. E., Katz, L. M., & Hill, E. W. (2011) · Animal Genetics · doi:10.1111/j.1365-2052.2011.02238.x · Cited by 41 · see citing works

Dietary Supplementation with the MicroalgaGaldieria sulphuraria(Rhodophyta) Reduces Prolonged Exercise-Induced Oxidative Stress in Rat Tissues

Carfagna, S., Napolitano, G., Barone, D., Pinto, G., Pollio, A., & Venditti, P. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/732090 · Cited by 40 · see citing works

Uncoupling Proteins: Molecular, Functional, Regulatory, Physiological and Pathological Aspects

Sluse, F. E. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-2869-1_6 · Cited by 40 · see citing works

Antioxidant and anti-inflammatory effects of exercise: role of redox signaling

Ji, L. L., & Zhang, Y. (2013) · Free Radical Research · doi:10.3109/10715762.2013.844341 · Cited by 39 · see citing works

Uncoupled respiration, ROS production, acute lipotoxicity and oxidative damage in isolated skeletal muscle mitochondria from UCP3-ablated mice

Nabben, M., Shabalina, I. G., Moonen‐Kornips, E., van Beurden, D., Cannon, B., Schrauwen, P., Nedergaard, J., & Joris Hoeks, J. (2011) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2011.04.003 · Cited by 39 · see citing works

Hexokinase II acts through UCP3 to suppress mitochondrial reactive oxygen species production and maintain aerobic respiration

Mailloux, R. J., Dumouchel, T., Aguer, C., deKemp, R., Beanlands, R. S., & Harper, M. (2011) · Biochemical Journal · doi:10.1042/bj20110571 · Cited by 38 · see citing works

Training and acute exercise modulates mitochondrial dynamics in football players’ blood mononuclear cells

Busquets-Cortés, C., Capó, X., Martorell, M., Tur, J. A., Sureda, A., & Pons, A. (2017) · European Journal of Applied Physiology · doi:10.1007/s00421-017-3684-z · Cited by 37 · see citing works

Energy (and Reactive Oxygen Species Generation) Saving Distribution of Mitochondria for the Activation of ATP Production in Skeletal Muscle

Espinosa, A., Casas, M., & Jaimovich, E. (2023) · Antioxidants · doi:10.3390/antiox12081624 · Cited by 31 · see citing works

Gene expression survey of mitochondrial uncoupling proteins (UCP1/UCP3) in gilthead sea bream (Sparus aurata L.)

Bermejo-Nogales, A., Calduch-Giner, J. À., & Pérez‐Sánchez, J. (2010) · Journal of Comparative Physiology B · doi:10.1007/s00360-009-0441-6 · Cited by 31 · see citing works

β2-Adrenergic Signaling Modulates Mitochondrial Function and Morphology in Skeletal Muscle in Response to Aerobic Exercise

Voltarelli, V. A., Coronado, M. J., Fernandes, L. G., Campos, J. C., Jannig, P. R., Ferreira, J. C. B., Fajardo, G., Brum, P. C., & Bernstein, D. (2021) · Cells · doi:10.3390/cells10010146 · Cited by 31 · see citing works

Exercise influences circadian gene expression in equine skeletal muscle

Murphy, B. A., Wagner, A. L., McGlynn, O. F., Kharazyan, F., Browne, J. A., & Elliott, J. A. (2014) · The Veterinary Journal · doi:10.1016/j.tvjl.2014.03.028 · Cited by 30 · see citing works

Human Stanniocalcin-1 Suppresses Angiotensin II-Induced Superoxide Generation in Cardiomyocytes through UCP3-Mediated Anti-Oxidant Pathway

Liu, D., Huang, L., Wang, Y., Wang, W., Wehrens, X. H. T., Belousova, T., Abdelrahim, M., DiMattia, G. E., & Sheikh‐Hamad, D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036994 · Cited by 30 · see citing works

Mitochondrial redox metabolism in aging: Effect of exercise interventions

Hai, B., Jiang, N., Ji, L. L., & Zhang, Y. (2013) · Journal of sport and health science/Journal of Sport and Health Science · doi:10.1016/j.jshs.2013.03.006 · Cited by 28 · see citing works

Molecular Mechanisms of Diaphragm Myopathy in Humans With Severe Heart Failure

Mangner, N., Garbade, J., Heyne, E., van den Berg, M., Winzer, E. B., Hommel, J., Sandri, M., Jozwiak‐Nozdrzykowska, J., Meyer, A. L., Lehmann, S., et al. (2021) · Circulation Research · doi:10.1161/circresaha.120.318060 · Cited by 28 · see citing works

Downregulation of peroxisome proliferator-activated receptor α and its coactivators in liver and skeletal muscle mediates the metabolic adaptations during lactation in mice

Gutgesell, A., Ringseis, R., Schmidt, E., Brandsch, C., Stangl, G. I., & Eder, K. (2009) · Journal of Molecular Endocrinology · doi:10.1677/jme-09-0064 · Cited by 27 · see citing works

Low expression of thiosulfate sulfurtransferase (rhodanese) predicts mortality in hemodialysis patients

Krueger, K., Koch, K., Jühling, A., Tepel, M., & Scholze, A. (2009) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2009.08.005 · Cited by 27 · see citing works

UCP-3 uncoupling protein confers hypoxia resistance to renal epithelial cells and is upregulated in renal cell carcinoma

Braun, N., Klumpp, D., Hennenlotter, J., Bedke, J., Duranton, C., Bleif, M., & Huber, S. M. (2015) · Scientific Reports · doi:10.1038/srep13450 · Cited by 26 · see citing works

The balance of apoptosis and autophagy via regulation of the AMPK signal pathway in aging rat striatum during regular aerobic exercise

Liu, W., Wang, Z., Xia, Y., Kuang, H., Liu, S., Li, L., Tang, C., & Yin, D. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.110647 · Cited by 26 · see citing works

Impact of methylmercury exposure on mitochondrial energetics in AC16 and H9C2 cardiomyocytes

Truong, J., Mailloux, R. J., & Chan, H. M. (2015) · Toxicology in Vitro · doi:10.1016/j.tiv.2015.03.016 · Cited by 23 · see citing works

Feed restriction up-regulates uncoupling protein 3 (UCP3) gene expression in heart and red muscle tissues of gilthead sea bream (Sparus aurata L.)

Bermejo-Nogales, A., Benedito‐Palos, L., Calduch-Giner, J. À., & Pérez‐Sánchez, J. (2011) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2011.03.024 · Cited by 23 · see citing works

Promoting a pro-oxidant state in skeletal muscle: Potential dietary, environmental, and exercise interventions for enhancing endurance-training adaptations

Jordan, A., Perry, C. G. R., & Cheng, A. J. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.09.014 · Cited by 22 · see citing works

Impaired lymphocyte mitochondrial antioxidant defences in variegate porphyria are accompanied by more inducible reactive oxygen species production and DNA damage

Ferrer, M. D., Sureda, A., Tauler, P., Palacín, C., Tur, J. A., & Pons, A. (2010) · British Journal of Haematology · doi:10.1111/j.1365-2141.2010.08149.x · Cited by 20 · see citing works

UV-B exposure reduces locomotor performance by impairing muscle function but not mitochondrial ATP production

Kazerouni, E. G., Franklin, C. E., & Seebacher, F. (2015) · Journal of Experimental Biology · doi:10.1242/jeb.131615 · Cited by 20 · see citing works

An ursolic acid-enriched Cynomorium songarium extract attenuates high fat diet-induced obesity in mice possibly through mitochondrial uncoupling

Chen, J., Wong, H. S., Leung, H. Y., Leong, P. K., Chan, W. M., & Ko, K. M. (2014) · Journal of Functional Foods · doi:10.1016/j.jff.2014.04.021 · Cited by 19 · see citing works

Adenylate kinase derived ATP shapes respiration and calcium storage of isolated mitochondria

Deline, M. L., Grashei, M., van Heijster, F. H. A., Schilling, F., Straub, J., & Fromme, T. (2021) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2021.148409 · Cited by 17 · see citing works

Pre-endurance training prevents acute alcoholic liver injury in rats through the regulation of damaged mitochondria accumulation and mitophagy balance

Ma, G., Liu, Y., Zhang, Q., Zhang, B.-G., Zhao, N. O., Wang, Q.-L., & Wang, X. (2014) · Hepatology International · doi:10.1007/s12072-014-9529-5 · Cited by 15 · see citing works

Recombinant Adeno-associated Virus–Delivered Hypoxia-inducible Stanniocalcin-1 Expression Effectively Inhibits Hypoxia-induced Cell Apoptosis in Cardiomyocytes

Shi, X., Wang, J., & Qin, Y. (2014) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000146 · Cited by 15 · see citing works

Human mitochondrial uncoupling protein 3 functions as a metabolite transporter

Leonardis, F. D., Ahmed, A., Vozza, A., Capobianco, L., Riley, C. L., Barile, S. N., Molfetta, D. D., Tiziani, S., DiGiovanni, J., Palmieri, L., et al. (2023) · FEBS Letters · doi:10.1002/1873-3468.14784 · Cited by 14 · see citing works

Increased vulnerability with aging to MPTP: the mechanisms underlying mitochondrial dynamics

Jiang, N., Hai, B., Song, C., Guo, J., Zhao, F., Feng, H., Ding, H., Ji, L., & Zhang, Y. (2013) · Neurological Research · doi:10.1179/1743132813y.0000000296 · Cited by 14 · see citing works

Diaphragm muscle weakness and increased UCP-3 gene expression following acute hypoxic stress in the mouse

O’Leary, A. J., & O’Halloran, K. D. (2015) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2015.10.018 · Cited by 14 · see citing works

Rapid regulation of substrate use for oxidative phosphorylation during a single session of high intensity interval or aerobic exercises in different rat skeletal muscles

Martins, E. L., Ricardo, J. C., de‐Souza‐Ferreira, E., Camacho-Pereira, J., Filho, D. M. R., & Galina, A. (2017) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2017.11.013 · Cited by 13 · see citing works

Moderate‐Intensity Exercise Maintains Redox Homeostasis for Cardiovascular Health

Jiang, J., Ni, L., Zhang, X., Gokulnath, P., Vulugundam, G., Li, G., Wang, H., & Xiao, J. (2023) · Advanced Biology · doi:10.1002/adbi.202200204 · Cited by 13 · see citing works

Occlusal interference induces oxidative stress and increases the expression of UCP3 in the masseter muscle: A rat model

Wu, D., & Liu, J. (2019) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2019.04.022 · Cited by 12 · see citing works

Effect of 5-week moderate intensity endurance training on the oxidative stress, muscle specific uncoupling protein (UCP3) and superoxide dismutase (SOD2) contents in vastus lateralis of young, healthy men.

Majerczak, J., Rychlik, B., Grzelak, A., Grzmil, P., Karasiński, J., Pierzchalski, P., Pułaski, Ł., Bartosz, G., & Zoladz, J. A. (2010) · PubMed · Cited by 12 · see citing works

Hydroxy-octadecenoic acids instead of phorbol esters are responsible for the Jatropha curcas kernel cake’s toxicity

Wang, X., Liu, J., Chen, S., Yin, Y., Liu, Y., & Zhang, C. (2020) · Communications Biology · doi:10.1038/s42003-020-0919-z · Cited by 12 · see citing works

One Health: Circadian Medicine Benefits Both Non-human Animals and Humans Alike

Farag, H. I., Murphy, B. A., Templeman, J. R., Hanlon, C., Joshua, J., Koch, T. G., Niel, L., Shoveller, A. K. K., Bédécarrats, G. Y., Ellison, A., et al. (2024) · Journal of Biological Rhythms · doi:10.1177/07487304241228021 · Cited by 10 · see citing works

Alteration in cardiac uncoupling proteins and eNOS gene expression following high-intensity interval training in favor of increasing mechanical efficiency.

Fallahi, A. A., Shekarfroush, S., Rahimi, M., Jalali, A., & Khoshbaten, A. (2016) · PubMed Central · Cited by 11 · see citing works

A Cistanches Herba Fraction/β-Sitosterol Causes a Redox-Sensitive Induction of Mitochondrial Uncoupling and Activation of Adenosine Monophosphate-Dependent Protein Kinase/Peroxisome Proliferator-Activated ReceptorγCoactivator-1 in C2C12 Myotubes: A Possible Mechanism Underlying the Weight Reduction Effect

Wong, H. S., Chen, J., Leong, P. K., Leung, H. Y., Chan, W. M., & Ko, K. M. (2015) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2015/142059 · Cited by 11 · see citing works

Cistanches Herba reduces the weight gain in high fat diet-induced obese mice possibly through mitochondrial uncoupling

Wong, H. S., Chen, J., Leong, P. K., Leung, H. Y., Chan, W. M., & Ko, K. M. (2014) · Journal of Functional Foods · doi:10.1016/j.jff.2014.06.019 · Cited by 10 · see citing works

Unraveling the metabolic gene expression and energetic patterns of the seasonally acclimatized gilthead seabream

Makri, V., Giantsis, I. Α., Feidantsis, K. G., Georgoulis, I., Gougousi, A., & Michaelidis, B. (2025) · Fish Physiology and Biochemistry · doi:10.1007/s10695-025-01513-y · Cited by 8 · see citing works

Potentiation of Ecstasy-induced hyperthermia and FAT/CD36 expression in chronically exercised animals

Hrometz, S. L., Ebert, J. A., Grice, K. E., Nowinski, S. M., Mills, E., Myers, B. J., & Sprague, J. E. (2016) · Temperature · doi:10.1080/23328940.2016.1166310 · Cited by 6 · see citing works

An Energy-Saving Distribution of Mitochondria Activation of ATP Production in Skeletal Muscle. A Design That Minimizes Mitochondria Ros ProductionPreprint

Espinosa, A., Casas, M., & Jaimovich, E. (2023) · Preprints.org · doi:10.20944/preprints202305.2112.v1 · Cited by 6 · see citing works

Age-Dependent Skeletal Muscle Mitochondrial Response to Short-Term Increased Dietary Fructose

Gatto, C., Porzio, A. D., Crescenzo, R., Barrella, V., Iossa, S., & Mazzoli, A. (2023) · Antioxidants · doi:10.3390/antiox12020299 · Cited by 5 · see citing works

Long-Term Treatment with an Herbal Formula MCC Reduces the Weight Gain in High Fat Diet-Induced Obese Mice

Leong, P. K., Leung, H. Y., Wong, H. S., Chen, J., Ma, C. W., Yang, Y., & Ko, K. M. (2013) · Chinese Medicine · doi:10.4236/cm.2013.43010 · Cited by 4 · see citing works

Antioxidant effects of LEDT in dystrophic muscle cells: involvement of PGC-1α and UCP-3 pathways

da Rocha, G. L., Guimarães, D. S. P. S. F., da Cruz, M. V., Mizobuti, D. S., da Silva, H. N. M., Pereira, E. C. L., Silveira, L. R., & Minatel, E. (2023) · Photochemical & Photobiological Sciences · doi:10.1007/s43630-023-00506-1 · Cited by 4 · see citing works

THE FUNCTIONAL STATE OF THE RAT HEART DURING ISCHEMIA-REPERFUSION, THE SENSITIVITY OF CALCIUM-INDUCED MITOCHONDRIAL PERMEABILITY TRANSITION PORE OPENING AND THE UNCOUPLING PROTEIN 3 EXPRESSION FOLLOWING LONG EXERCISE TRAINING

Chorna, S. V., Talanov, S. O., Strutynska, N. A., Vavilova, G. L., Kotsuruba, A. V., Gaidai, N. M., & Sagach, V. F. (2010) · Fìzìologìčnij žurnal · doi:10.15407/fz56.01.013 · Cited by 4 · see citing works

Effect of different kinds of anoxia/reoxygenation on the mitochondrial function and the free radicals production of cultured primary equine skeletal myoblasts

Ceusters, J. D., Mouithys-Mickalad, A. A., Franck, T. J., Deby-Dupont, G. P., Derochette, S., & Serteyn, D. A. (2013) · Research in Veterinary Science · doi:10.1016/j.rvsc.2013.09.004 · Cited by 4 · see citing works

Mitochondrial uncoupling protein 2 (UCP2), but not UCP3, is sensitive to oxygen concentration in cellsPreprint

Hilse, K. E., Rupprecht, A., Ford, K., Andrukhova, O., Erben, R. G., & Pohl, E. E. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.01.181768 · Cited by 2 · see citing works

Correction: Human Stanniocalcin-1 Suppresses Angiotensin II-Induced Superoxide Generation in Cardiomyocytes through UCP3-Mediated Anti-Oxidant Pathway

Liu, D., Huang, L., Wang, Y., Wang, W., Wehrens, X. H. T., Belousova, T., Abdelrahim, M., DiMattia, G. E., & Sheikh‐Hamad, D. (2012) · PLoS ONE · doi:10.1371/annotation/52d155b7-66af-425f-9a6a-2d853d5fd95d · Cited by 1 · see citing works

Metabolic and Antioxidant Adaptation to Exercise: Role of Redox Signaling

Ji, L. L. (2015) · Healthy ageing and longevity · doi:10.1007/978-3-319-14830-4_6

MARCADORES MITOCONDRIALES DE ESTRÉS OXIDATIVO Y LIPOTOXICIDAD EN DORADA (Sparus aurata)

Bermejo-Nogales, A. (2012) · doi:10.4995/thesis/10251/15189

Genomics of the Circadian Clock

Murphy, B. A. (2013) · Wiley eBooks · doi:10.1002/9781118522158.ch18

Insulin Resistance and Progression of Heart Failure in the Older Adult

Sinha, S. S., & Shannon, R. P. (2011) · Aging Health · doi:10.2217/ahe.10.92

The influence of exercise on entrainment of skeletal muscle transcription in the horse

McGlynn, O. F., Browne, J. A., Blake, C., & Murphy, B. A. (2011) · Journal of Equine Veterinary Science · doi:10.1016/j.jevs.2011.03.047

The Metabolic Effects of Low Grade Inflammation on Postprandial Metabolism Following a High Fat Meal

Pittman, J. T. (2013) · VTechWorks (Virginia Tech)

Contribuição dos receptores \'beta\'2-adrenérgicos na função e dinâmica mitocondriais da musculatura esquelética em resposta ao exercício físico aeróbico

Voltarelli, V. A. (2017) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.39.2017.tde-12012017-104741

Acute hypoxia-induced diaphragm dysfunction is prevented by antioxidant pre-treatment

O’Leary, A. J. (2016) · Arrow@dit (Dublin Institute of Technology)

EFFECT OF CALCIUM LOAD ON HEART FUNCTION, MPTP OPENING IN SITU AND UCP2/3 MRNA EXPRESSION IN THE HEART OF TRAINED RATS

Goshovska, Y. V., Strutynska, N. A., & Sagach, V. F. (2020) · Fìzìologìčnij žurnal · doi:10.15407/fz66.06.003

Oxidative stress in athletes: From the scientific basis to practical aspects

Martinović, J., & Dopsaj, V. (2014) · FarFar (University of Belgrade, Faculty of Chemistry (Belgrade, Serbia))

Role of Antioxidant Signaling in Mitochondrial Adaptation to Muscle Contraction

Ji, L. L. (2014) · Springer eBooks · doi:10.1007/978-3-642-30018-9_195

Explore the role of irisin in mitohormesis by PGC-1α

HAIBO, X., Ahmad, A., Phuoc, J. C., & BAOGUI, W. (2022) · Gazzetta Medica Italiana Archivio per le Scienze Mediche · doi:10.23736/s0393-3660.22.04790-8

Effect of severe-heavy exercise transitions on measures of oxygen uptake and blood lactate accumulation in moderate-well trained males

Bartlett, M. F. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/gma3-kv20

Mechanistic interactions of diet, exercise, and pharmacotherapy in skeletal muscle metabolism: evidence and translational perspectives

Wang, Y., Qin, M., Liu, X., & Ma, J. (2026) · Frontiers in Physiology · doi:10.3389/fphys.2026.1957316

UCP3 Attenuates Mitochondrial H2O2 Production in Skeletal Muscle During Recovery from Exercise

Anderson, E. J., Akeda-Yamazaki, H., & Neufer, D. (2006) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-200611001-00053

A rapid up-regulation in UCP3 transcriptional activity in response to moderate intensity exercise in rat skeletal muscle.

Kusuhara, K., Tobe, T., Negoro, T., & Abe, T. (2005) · Europe PMC (PubMed Central) · Cited by 5 · see citing works

Acute Exercise Induced Uncoupling Protein 3 Fast Increase in Rat Skeletal Mitochondria——a Proof of UCP3 Protein Pool in Skeletal Muscular Cells

Ma, G. (2007) · Chengdu Tiyu Xueyuan xuebao

Investigations into the physiological expression of UCP1 and UCP3

Brennan, C. M. (2005) · Arrow@dit (Dublin Institute of Technology)

The Mechanism of Oxidative Stress in Muscle Mitochondria during the Acute Exercise

Zhang, Y. (2009) · Neimenggu Shi-da xuebao. Zhexue shehui kexue hanwen ban