Adenylate kinase derived ATP shapes respiration and calcium storage of isolated mitochondria
Open accessAbstract
The ratio of ADP and ATP is a natural indicator of cellular bioenergetic state and thus a prominent analyte in metabolism research. Beyond adenylate interconversion via oxidative phosphorylation and ATPase activities, ADP and ATP act as steric regulators of enzymes, e.g. cytochrome C oxidase, and are major factors in mitochondrial calcium storage potential. Consideration of all routes of adenylate conversion is critical to successfully predict their abundance in an experimental system and to correctly interpret many aspects of mitochondrial function. We showcase here how adenylate kinases elicit considerable impact on the outcome of a variety of mitochondrial assays through their drastic manipulation of the adenylate profile. Parameters affected include cytochrome c oxidase activity, P/O ratio, and mitochondrial calcium dynamics. Study of the latter revealed that the presence of ATP is required for mitochondrial calcium to be shaped into a particularly dense form of mitochondrial amorphous calcium phosphate.
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Experiments on Posner clusters have been conducted, but their coherence has not yet been studied experimentally.
“Furthermore, experiments on Posner clusters have been conducted to provide insights into their properties, but their coherence has not yet been studied experimentally [92,93,94,95,96].”
From Quantum Models of Consciousness from a Quantum Information Science Perspective (2025) · cites this paper as [96]
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- Authors
- Deline, M. L., Grashei, M., van Heijster, F. H. A., Schilling, F., Straub, J., & Fromme, T.
- Affiliations
- Else Kröner Fresenius Zentrum für Ernährungsmedizin (DE)
- Technical University of Munich (DE)
- University of California, Santa Barbara (US)
- Corresponding author
- Fromme, Tobias
- Venue
- Biochimica et Biophysica Acta (BBA) - Bioenergetics
- Publisher
- Elsevier BV
- Published
- 2021-07
- Volume
- 1862
- Issue
- 7
- Pages
- 148409
- ISSN
- 0005-2728 (ISSN-L)
- OpenAlex
- W3138149565
- Cited by
- 17
- References
- 80
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 4 · 2023: 3 · 2022: 3 · 2021: 1
- FWCI
- 0.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 365 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Biochimica et Biophysica Acta (BBA) - Bioenergetics (publishedVersion)
- PubMed (publishedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- Funders
- Heising-Simons Foundation (2017–0496)
- Deutsche Forschungsgemeinschaft (SFB 824)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- adenylate kinase, ATP, ADP, mitochondrial respiration, cytochrome c oxidase, P/O ratio, mitochondrial calcium dynamics, amorphous calcium phosphate, mitochondrial bioenergetics
- MeSH terms
- Adenosine Triphosphate, Adenylate Kinase, Animals, Calcium, Energy Metabolism, Mice, Inbred C57BL, Mitochondria, Liver, Oxidative Phosphorylation, Oxygen Consumption, Cell Respiration, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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