Arginase 2 and nitric oxide synthase: Pathways associated with the pathogenesis of thyroid tumors
Open accessAbstract
We have previously shown that ARG2 expression was increased in most malignant thyroid tumors, but absent in benign lesions and normal tissues. Small interfering RNA knockdown was used to investigate the role of ARG2 in a thyroid carcinoma cell line. ARG2 knockdown decreased eNOS expression as well as the expression of eNOS-related genes (p21, Akt1, HIF-1, VEGF, and CAV1). ARG2 silencing changed tumor properties of thyroid cancer cells promoting apoptosis and reduced expression of cell proliferation markers. These results, coupled with enhanced nitric oxide production and elevated reactive oxygen species (ROS) levels, account for the altered intracellular redox environment. Genes related to either production (DUOX1 and NOX4) or catabolism (SODs) of ROS and reactive nitrogen species were negatively modulated by ARG2 knockdown. Additionally, a positive correlation of ARG2 with eNOS and related genes was investigated in thyroid tumors, further substantiating our in vitro findings. Our results suggest that ARG2 and eNOS may work in a coordinated manner and the underlying mechanism might be of major significance for thyroid tumorigenesis and/or tumor progression pathways. Fine modulation of ARG2, eNOS, and related genes may represent a potential source for targeted therapy of several cancer types.
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Adam17 and Arg2 proteins affect Hif-1α stability and activity by regulating production of tumor necrosis factor α (TNF-α) and nitric oxide, respectively, whereas Mmp3 has key roles in numerous physiological processes.
“The Adam17 and Arg2 proteins affect Hif-1α stability and activity by regulating production of tumor necrosis factor α (TNF-α) 31,32 and nitric oxide, respectively 33,34 , whereas Mmp3 has key roles in numerous physiological processes 35 .”
From The yak genome and adaptation to life at high altitude (2012) · cites this paper as [34]
The Discussion and Fig. 3 (page unavailable) report that ARG2 knockdown reduced HIF-1 expression in thyroid carcinoma cells; the Discussion also links ARG2 inhibition to increased nitric oxide production. The paper does not establish that nitric oxide mediates an effect on HIF-1α protein stability or activity. The Adam17 and Mmp3 clauses are assigned to other citations, not this source. (LLM, conf=0.88)
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- Authors
- Sousa, M. S. A., Latini, F. R. M., Monteiro, H. P., & Cerutti, J. M.
- Affiliations
- Universidade Federal de São Paulo (BR)
- Corresponding author
- Cerutti, Janete M.
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2010-09
- Volume
- 49
- Issue
- 6
- Pages
- 997-1007
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W2063520873
- Cited by
- 39
- References
- 42
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 8 · 2022: 3 · 2021: 2 · 2019: 2 · 2018: 1 · 2017: 2 · 2015: 3 · 2014: 2 · 2013: 2 · 2012: 7
- FWCI
- 2.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- UNIFESP Institutional Repository (Universidade Federal de São Paulo) (submittedVersion)
- Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo (05/60330-8, 09/11257-7)
- Universidade de São Paulo
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Keywords
- arginase II, endothelial nitric oxide synthase, nitric oxide synthase, thyroid cancer, thyroid tumorigenesis, reactive oxygen species, redox conditions, apoptosis, cell proliferation, p21, AKT1, HIF-1, vascular endothelial growth factor, caveolin-1, DUOX1, NOX4, superoxide dismutase, reactive nitrogen species, siRNA knockdown, targeted cancer therapy
- MeSH terms
- Arginase, Carcinoma, Cell Transformation, Neoplastic, Humans, Thyroid Neoplasms, Biomarkers, Tumor, Signal Transduction, Gene Expression Regulation, Neoplastic, Apoptosis, Oxidative Stress, Disease Progression, Nitric Oxide Synthase, RNA, Small Interfering, Cell Line, Tumor, Cell Proliferation, Cyclin-Dependent Kinase Inhibitor p21
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Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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