The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Caffeine protects against oxidative stress and Alzheimer's disease-like pathology in rabbit hippocampus induced by cholesterol-enriched diet
Open accessAbstract
Cholesterol has been linked to the pathogenesis of sporadic Alzheimer’s disease (AD) as a risk factor increasing β-amyloid (Aβ) and oxidative stress levels. Caffeine has anti-oxidant properties and has been demonstrated to reduce Aβ levels in transgenic mouse models of familial AD. However, the effects of caffeine on cholesterol-induced sporadic AD pathology have not been determined. In the present study, we determined the effects of caffeine on Aβ levels, tau phosphorylation, oxidative stress generation, and caffeine-target receptors in rabbits fed a 2% cholesterol-enriched diet, a model system for sporadic AD. Our results showed that the cholesterol-enriched diet increased levels of Aβ, tau phosphorylation as well as oxidative stress measured as increased levels of reactive oxygen species, isoprostanes, glutathione depletion, and increased levels of endoplasmic reticulum (ER) stress marker proteins. Additionally, the cholesterol-enriched diet reduced levels of adenosine A1 (A1R) but not ryanodine (RyR) or adenosine A2A (A2AR) receptors. Caffeine, administered at 0.5 mg and 30 mg/day in the drinking water, reduced cholesterol-induced increase in Aβ, phosphorylated tau and oxidative stress levels, and reversed cholesterol-induced decrease in A1R levels. Our results suggest that even very low doses of caffeine might protect against sporadic AD-like pathology.
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Cites
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Caffeine as an Antioxidant: Inhibition of Lipid Peroxidation Induced by Reactive Oxygen Species
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BackgroundCaffeine protects against MPTP‐induced blood‐brain barrier dysfunction in mouse striatum
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Self-citation
Cited by
Caffeine: Cognitive and Physical Performance Enhancer or Psychoactive Drug?
Cappelletti, S., Daria, P., Sani, G., & Aromatario, M. (2015) · Current Neuropharmacology · doi:10.2174/1570159x13666141210215655 · Cited by 631
Antioxidant Property of Coffee Components: Assessment of Methods that Define Mechanisms of Action
Liang, N., & Kitts, D. (2014) · Molecules · doi:10.3390/molecules191119180 · Cited by 558
Manoharan, S., Guillemin, G. J., Abiramasundari, R. S., Essa, M. M., Akbar, M., & Akbar, M. D. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/8590578 · Cited by 523
Antioxidant Therapies for Alzheimer's Disease
Feng, Y., & Wang, X. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/472932 · Cited by 379
Pharmacological effects and mechanisms of tannic acid
Jing, W., Xiaolan, C., Yu, C., Feng, Q., & Haifeng, Y. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113561 · Cited by 299
Metadata
- Authors
- Prasanthi, J. R. P., Dasari, B., Marwarha, G., Larson, T., Chen, X., Geiger, J. D., & Ghribi, O.
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 49
- Issue
- 7
- Pages
- 1212-1220
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W2112288676
- Cited by
- 158
- References
- 10
- FWCI
- 4.76
- Type
- journal article
- Language
- en
- Open access
- green
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- Prasanthi, J. R. P., Dasari, B., Marwarha, G., Larson, T., Chen, X., Geiger, J. D., & Ghribi, O. (2010). Caffeine protects against oxidative stress and Alzheimer's disease-like pathology in rabbit hippocampus induced by cholesterol-enriched diet. Free Radical Biology and Medicine. https://doi.org/10.1016/j.freeradbiomed.2010.07.007
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