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Cited by 523Alzheimer's disease research and treatmentsParkinson's Disease Mechanisms and TreatmentsAntioxidant Activity and Oxidative Stress

The Role of Reactive Oxygen Species in the Pathogenesis of Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease: A Mini Review

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Manoharan, Shanmugam, Guillemin, Gilles J., Abiramasundari, Rajagopal Selladurai, Essa, Musthafa Mohamed, Akbar, Mohammed, Akbar, Mohammed D.·2016·Oxidative Medicine and Cellular Longevity
DOI 10.1155/2016/8590578PMC PMC5223034
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Abstract

Neurodegenerative diseases affect not only the life quality of aging populations, but also their life spans. All forms of neurodegenerative diseases have a massive impact on the elderly. The major threat of these brain diseases includes progressive loss of memory, Alzheimer’s disease (AD), impairments in the movement, Parkinson’s disease (PD), and the inability to walk, talk, and think, Huntington’s disease (HD). Oxidative stress and mitochondrial dysfunction are highlighted as a central feature of brain degenerative diseases. Oxidative stress, a condition that occurs due to imbalance in oxidant and antioxidant status, has been known to play a vital role in the pathophysiology of neurodegenerative diseases including AD, PD, and HD. A large number of studies have utilized oxidative stress biomarkers to investigate the severity of these neurodegenerative diseases and medications are available, but these only treat the symptoms. In traditional medicine, a large number of medicinal plants have been used to treat the symptoms of these neurodegenerative diseases. Extensive studies scientifically validated the beneficial effect of natural products against neurodegenerative diseases using suitable animal models. This short review focuses the role of oxidative stress in the pathogenesis of AD, PD, and HD and the protective efficacy of natural products against these diseases.

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  • For males, no significant GO terms were identified at 25% FDR; the strongest enrichment with nominal P<0.001 involved immune responses to accumulation of amyloid-β in the brain, such as regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell, and other biological processes recently implicated in AD such as response to angiotensin [

    “For males, we did not identify any significant GO terms at 25% FDR; the strongest enrichment with nominal P-value less than 0.001 involved immune responses to the accumulation of amyloid-β (Aβ) in the brain, such as regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell, and other biological processes recently implicated in AD such”

    From Sex-specific DNA methylation differences in Alzheimer’s disease pathology (2021) · cites this paper as [59]

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Cited by

Sorted by citations

Authors
Manoharan, S., Guillemin, G. J., Abiramasundari, R. S., Essa, M. M., Akbar, M., & Akbar, M. D.
Affiliations
  • Annamalai University (IN)
  • Macquarie University (AU)
  • Sultan Qaboos University (OM)
Corresponding author
Guillemin, Gilles J.
ORCID
Venue
Oxidative Medicine and Cellular Longevity
Publisher
Wiley
Published
2016-01
Volume
2016
Issue
1
Pages
8590578-8590578
ISSN
  • 1942-0994 (ISSN-L)
  • 1942-0900
DOI
10.1155/2016/8590578
PMC
PMC5223034
OpenAlex
W2564095879
Cited by
523
References
14
Citations by year
2026: 31 · 2025: 53 · 2024: 55 · 2023: 50 · 2022: 67 · 2021: 72 · 2020: 61 · 2019: 55 · 2018: 46 · 2017: 33
FWCI
5.24
Type
journal article
Language
en
Open access
Licence
Locations
  • Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords
reactive oxygen species, oxidative stress, neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, Huntington's disease, mitochondrial dysfunction, oxidative stress biomarkers, natural products, medicinal plants, neuroprotection
MeSH terms
Alzheimer Disease, Biological Products, Humans, Huntington Disease, Parkinson Disease, Reactive Oxygen Species, Oxidative Stress

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