Oxidative stress increases expression and activity of BACE in NT2 neurons

Tamagno, Elena; Bardini, Paola; Obbili, Alessandra; Vitali, Antonella; Borghi, Roberta; Zaccheo, Damiano; Pronzato, Maria A.; Danni, Oliviero; Smith, Mark A.; Perry, George; Tabaton, Massimo

doi:10.1006/nbdi.2002.0515

Cited by 385Alzheimer's disease research and treatmentsAntioxidant Activity and Oxidative StressRedox biology and oxidative stress

Oxidative stress increases expression and activity of BACE in NT2 neurons

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Tamagno, Elena, Bardini, Paola, Obbili, Alessandra, Vitali, Antonella, Borghi, Roberta, Zaccheo, Damiano, Pronzato, Maria A., Danni, Oliviero +3 more·2002·Neurobiology of Disease

DOI 10.1006/nbdi.2002.0515

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Abstract

Recently an aspartyl protease with beta-secretase activity called BACE was identified. In the present paper we showed that BACE is modulated by the oxidative stress product 4-hydroxynonenal (HNE). Exposure of NT(2) neurons to the two classical pro-oxidant stimuli ascorbate/FeSO(4) and H(2)O(2)/FeSO(4) resulted in a significant generation of HNE, which is temporally followed by an increased production of BACE protein levels. HNE mediated BACE induction is accompanied by a proportional elevation of carboxy-terminal fragments of amyloid precursor protein. Moreover, the direct relationship between BACE induction and lipid peroxidation products was strongly confirmed by the protection exerted by a short pretreatment with alpha-tocopherol, the most important antioxidant known to prevent the formation of aldehydic end-products of lipid peroxidation, including HNE. Our results support the hypothesis that oxidative stress and A beta production are strictly interrelated events and suggest that inhibition of BACE may have a therapeutic effect synergic with antioxidant compounds.

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Oxidative stress induces β-secretase upregulation.
“Oxidative stress also induces β-secretase upregulation”
From The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer’s disease (2011) · cites this paper as Tamagno et al., 2002
Oxidative stress increases Aβ generation.
“consequently, increased Aβ generation”
From The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer’s disease (2011) · cites this paper as Tamagno et al., 2002
Oxidative stress-induced β-secretase upregulation and increased Aβ generation are preventable by antioxidant treatment in vitro.
“both of which are preventable by antioxidant treatment in vitro”
From The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer’s disease (2011) · cites this paper as Tamagno et al., 2002
Free radicals, a byproduct of ETC electron transfer, activate BACE.
“Free radicals, a byproduct of ETC electron transfer, further appear to activate BACE [135].”
From Brain aging, Alzheimer's disease, and mitochondria (2011) · cites this paper as [135]

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Authors: Tamagno, E., Bardini, P., Obbili, A., Vitali, A., Borghi, R., Zaccheo, D., Pronzato, M. A., Danni, O., Smith, M. A., Perry, G., & Tabaton, M.
Affiliations: University of Turin (IT)
University of Genoa (IT)
Case Western Reserve University (US)
ORCID: Tamagno, Elena
Pronzato, Maria A.
Smith, Mark A.
Perry, George
Venue: Neurobiology of Disease
Publisher: Elsevier BV
Published: 2002-08
Volume: 10
Issue: 3
Pages: 279-288
ISSN: 0969-9961 (ISSN-L)
DOI: 10.1006/nbdi.2002.0515
OpenAlex: W2144539581
Cited by: 385
References: 37
Citations by year: 2026: 8 · 2025: 15 · 2024: 10 · 2023: 10 · 2022: 14 · 2021: 11 · 2020: 13 · 2019: 19 · 2018: 17 · 2017: 13 · 2016: 17 · 2015: 20 · 2014: 11 · 2013: 18 · 2012: 29
FWCI: 6.39
Type: journal article
Language: en
Open access: green
doaj.org
Licence: cc-by-sa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurobiology of Disease (publishedVersion)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
Funders: Amgen
Ministero dell'Università e della Ricerca
Topics: Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: beta-secretase, BACE, oxidative stress, 4-hydroxynonenal, amyloid precursor protein, C-terminal fragment, lipid peroxidation, alpha-tocopherol, amyloid-beta production, antioxidants
MeSH terms: Aldehydes, Enzyme Activation, Humans, Neurons, Endopeptidases, Tumor Cells, Cultured, Aspartic Acid Endopeptidases, Oxidative Stress, Amyloid Precursor Protein Secretases

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Oxidative stress increases expression and activity of BACE in NT2 neurons

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