Age-related loss of stress-induced nuclear proteasome activation is due to low PARP-1 activity
Open accessAbstract
Changes in protein turnover are among the dominant metabolic changes during aging. Of special importance is the maintenance of nuclear protein homeostasis to ensure a coordinated cellular metabolism. Therefore, in the nucleus a special PARP-1-mediated mechanism of proteasomal activation exists to ensure a rapid degradation of oxidized nuclear proteins. It was already demonstrated earlier that the cytosolic proteasomal system declines dramatically with aging, whereas the nuclear proteasome remains less affected. We demonstrate here that the stress-mediated proteasomal activation in the nucleus declines during replicative senescence of human fibroblasts. Furthermore, we clearly show that this decline in the PARP-1-mediated proteasomal activation is due to a decline in the expression and activity of PARP-1 in senescent fibroblasts. In a final study we show that this process also happens in vivo, because the protein expression level of PARP-1 is significantly lower in the skin of aged donors compared to that of young ones. Therefore, we conclude that the rate-limiting factor in poly(ADP-ribose)-mediated proteasomal activation in oxidative stress is PARP-1 and not the nuclear proteasome itself.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
PARP1 activity positively correlates with longevity across species.
“It has been observed that PARP1 activity positively correlates with longevity in different species (Bakondi et al., 2011; Beneke et al., 2010; Noren-Hooten et al., 2012)”
From A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline (2018) · cites this paper as Bakondi et al., 2011
Cites
Endoplasmic Reticulum Stress and Oxidative Stress: A Vicious Cycle or a Double-Edged Sword?
Malhotra, J., & Kaufman, R. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1782 · Cited by 1,507 · see citing works
Age-related changes in oxidized proteins.
Oliver, C. N., Ahn, B. W., Moerman, E. J., Goldstein, S., & Stadtman, E. R. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45598-6 · Cited by 1,306 · see citing works
Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease.
Smith, C. D., Carney, J. M., Starke-Reed, P. E., Oliver, C. N., Stadtman, E. R., Floyd, R. A., & Markesbery, W. R. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10540 · Cited by 1,296 · see citing works
Carney, J. M., Starke-Reed, P. E., Oliver, C., Landum, R. W., Cheng, M. S., Wu, J., & Floyd, R. A. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.9.3633 · Cited by 724 · see citing works
Base excision repair of oxidative DNA damage and association with cancer and aging
Maynard, S., Schurman, S. H., Harboe, C., de Souza-Pinto, N. C., & Bohr, V. A. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn250 · Cited by 685 · see citing works
Heinecke, J. W., Li, W., Daehnke, H. L., & Goldstein, J. A. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53581-x · Cited by 485 · see citing works
Comparative resistance of the 20S and 26S proteasome to oxidative stress
REINHECKEL, T., SITTE, N., ULLRICH, O., KUCKELKORN, U., DAVIES, K. J. A., & GRUNE, T. (1998) · Biochemical Journal · doi:10.1042/bj3350637 · Cited by 447 · see citing works
Self-citationProteolysis in Cultured Liver Epithelial Cells during Oxidative Stress
Grune, T., Reinheckel, T., Joshi, M., & Davies, K. J. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.5.2344 · Cited by 407 · see citing works
Self-citationPARP-1, a determinant of cell survival in response to DNA damage
Bouchard, V. J., Rouleau, M., & Poirier, G. G. (2003) · Experimental Hematology · doi:10.1016/s0301-472x(03)00083-3 · Cited by 390 · see citing works
Jung, T., Catalgol, B., & Grune, T. (2009) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2009.04.001 · Cited by 389 · see citing works
Self-citationBiochemical basis of lipofuscin, ceroid, and age pigment-like fluorophores
Yin, D. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(96)00175-x · Cited by 379 · see citing works
Degradation of Oxidized Proteins in K562 Human Hematopoietic Cells by Proteasome
Grune, T., Reinheckel, T., & Davies, K. J. A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.26.15504 · Cited by 328 · see citing works
Self-citationProteasome inhibition by lipofuscin/ceroid during postmitotic aging of fibroblasts
Sitte, N., Huber, M., Grune, T., Ladhoff, A., Doecke, W., Zglinicki, T. V., & Davies, K. J. A. (2000) · The FASEB Journal · doi:10.1096/fj.14.11.1490 · Cited by 318 · see citing works
Self-citationFriguet, B., Stadtman, E. R., & Szweda, L. I. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31853-7 · Cited by 311 · see citing works
Grube, K., & Bürkle, A. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.24.11759 · Cited by 301 · see citing works
Decreased levels of proteasome activity and proteasome expression in aging spinal cord
Keller, J. N., Huang, F. F., & Markesbery, W. R. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00067-1 · Cited by 297 · see citing works
Rivett, A. J. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)89731-9 · Cited by 279 · see citing works
Peroxynitrite Increases the Degradation of Aconitase and Other Cellular Proteins by Proteasome
Grune, T., Blasig, I. E., Sitte, N., Roloff, B., Haseloff, R., & Davies, K. J. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.18.10857 · Cited by 250 · see citing works
Self-citationDisulfide Formation in the ER and Mitochondria: Two Solutions to a Common Process
Riemer, J., Bulleid, N. J., & Herrmann, J. M. (2009) · Science · doi:10.1126/science.1170653 · Cited by 250 · see citing works
Age-associated analysis of oxidative stress parameters in human plasma and erythrocytes
Gil, L., Siems, W., Mazurek, B., Gross, J., Schroeder, P., Voss, P., & Grune, T. (2006) · Free Radical Research · doi:10.1080/10715760600592962 · Cited by 242 · see citing works
Self-citationPoly-ADP ribose polymerase activates nuclear proteasome to degrade oxidatively damaged histones
Ullrich, O., Reinheckel, T., Sitte, N., Hass, R., Grune, T., & Davies, K. J. A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.11.6223 · Cited by 229 · see citing works
Self-citationChondrogianni, N., Tzavelas, C., Pemberton, A. J., Nezis, I. P., Rivett, A. J., & Gonos, E. S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413007200 · Cited by 224 · see citing works
Sitte, N., Merker, K., von Zglinicki, T., Grune, T., & Davies, K. J. A. (2000) · The FASEB Journal · doi:10.1096/fj.00-0209com · Cited by 213 · see citing works
Self-citationPARP inhibitors: New partners in the therapy of cancer and inflammatory diseases
Peralta-Leal, A., Rodríguez-Vargas, J. M., Aguilar‐Quesada, R., Rodríguez, M. I., Linares, J. L., de Almodóvar, M. R., & Oliver, F. J. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.04.008 · Cited by 181 · see citing works
Medicherla, B., & Goldberg, A. L. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200803022 · Cited by 175 · see citing works
Proteasome‐dependent degradation of oxidized proteins in MRC‐5 fibroblasts
Sitte, N., Merker, K., & Grune, T. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01495-1 · Cited by 171 · see citing works
Self-citationFriguet, B., Szweda, L. I., & Stadtman, E. R. (1994) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1994.1222 · Cited by 171 · see citing works
The proteasome and its role in the degradation of oxidized proteins
Jung, T., & Grune, T. (2008) · IUBMB Life · doi:10.1002/iub.114 · Cited by 162 · see citing works
Self-citationSitte, N., Merker, K., von Zglinicki, T., Davies, K. J. A., & Grune, T. (2000) · The FASEB Journal · doi:10.1096/fj.00-0210com · Cited by 157 · see citing works
Self-citationGiulivi, C., Pacifici, R. E., & Davies, K. J. A. (1994) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1994.1245 · Cited by 155 · see citing works
Protein oxidation and degradation during proliferative senescence of human MRC-5 fibroblasts
Sitte, N., Merker, K., von Zglinicki, T., & Grune, T. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00279-8 · Cited by 153 · see citing works
Self-citationOxidized Mitochondrial Protein Degradation and Repair in Aging and Oxidative Stress
Ugarte, N., Petropoulos, I., & Friguet, B. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2998 · Cited by 136 · see citing works
Protein oxidation and degradation during postmitotic senescence
Grune, T., Merker, K., Jung, T., Sitte, N., & Davies, K. J. A. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.06.009 · Cited by 117 · see citing works
Self-citationStadtman, E. R., Starke-Reed, P. E., Oliver, C., Carney, J. M., & Floyd, R. A. (1992) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-7460-1_7 · Cited by 117 · see citing works
Aging and protein oxidative damage
Agarwal, S., & Sohal, R. S. (1994) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(94)90024-8 · Cited by 116 · see citing works
Rukhsana Sultana, A., & Butterfield, D. A. (2009) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-009-9241-7 · Cited by 108 · see citing works
Poly(ADP-ribosyl)ation in mammalian ageing
Beneke, S., & Bürkle, A. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm735 · Cited by 106 · see citing works
Yarian, C. S., Toroser, D., & Sohal, R. S. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.09.028 · Cited by 106 · see citing works
Age-related increases of 8-hydroxy-2′-deoxyguanosine and DNA–protein crosslinks in mouse organs
Izzotti, A., Cartiglia, C., Taningher, M., Flora, S. D., & Balansky, R. M. (1999) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/s1383-5718(99)00189-8 · Cited by 105 · see citing works
Hydrogen Peroxide-induced Structural Alterations of RNase A
Lasch, P., Petras, T., Ullrich, O., Backmann, J., Naumann, D., & Grune, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008528200 · Cited by 99 · see citing works
Self-citationCantoni, O., Cattabeni, F., Stocchi, V., Meyn, R. E., Cerutti, P., & Murray, D. L. (1989) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(89)90234-6 · Cited by 97 · see citing works
DNA Repair in Premature Aging Disorders and Neurodegeneration
Coppedè, F., & Migliore, L. (2010) · Current Aging Science · doi:10.2174/1874609811003010003 · Cited by 93 · see citing works
Bakondi, E., Bai, P., Szabó, É., Hunyadi, J., Gergely, P., Szabó, C., & Virág, L. (2002) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215540205000110 · Cited by 85 · see citing works
Self-citationOxidation-induced ferritin turnover in microglial cells: role of proteasome
Mehlhase, J., Sandig, G., Pantopoulos, K., & Grune, T. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.10.025 · Cited by 84 · see citing works
Self-citationAge-related differences in oxidative protein-damage in young and senescent fibroblasts
Jung, T., Höhn, A., Catalgol, B., & Grune, T. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.12.007 · Cited by 81 · see citing works
Self-citationIdentification of potential active-site residues in the human poly(ADP-ribose) polymerase.
Simonin, F., Poch, O., Delarue, M. H., & de MURCIA, G. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)52907-0 · Cited by 79 · see citing works
Intracellular distribution of oxidized proteins and proteasome in HT22 cells during oxidative stress
Jung, T., Engels, M., Kaiser, B., Poppek, D., & Grune, T. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.11.023 · Cited by 72 · see citing works
Self-citationHydrogen Peroxide-Mediated Protein Oxidation in Young and Old Human MRC-5 Fibroblasts
Merker, K., Sitte, N., & Grune, T. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1657 · Cited by 71 · see citing works
Self-citationAging and dietary restriction alter proteasome biogenesis and composition in the brain and liver
Dasuri, K., Zhang, L., Ebenezer, P. J., Liu, Y., Fernandez‐Kim, S. O., & Keller, J. N. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.10.003 · Cited by 69 · see citing works
Gilmer, L. K., Ansari, M. A., Roberts, K. N., & Scheff, S. W. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.12.011 · Cited by 68 · see citing works
The Proteasome Is an Integral Part of Solar Ultraviolet A Radiation-induced Gene Expression
Catalgol, B., Ziaja, I., Breusing, N., Jung, T., Höhn, A., Alpertunga, B., Schröeder, P., Chondrogianni, N., Gonos, E. S., Petropoulos, I., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.044503 · Cited by 66 · see citing works
Self-citationProteasomal degradation of oxidatively damaged endogenous histones in K562 human leukemic cells
Ullrich, O., & Grune, T. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00672-4 · Cited by 62 · see citing works
Self-citationProteasome activation as a novel antiaging strategy
Chondrogianni, N., & Gonos, E. S. (2008) · IUBMB Life · doi:10.1002/iub.99 · Cited by 62 · see citing works
Chromatin modifications: The driving force of senescence and aging?
DiMauro, T., & David, G. (2009) · Aging · doi:10.18632/aging.100023 · Cited by 56 · see citing works
Chromatin repair after oxidative stress: Role of PARP-mediated proteasome activation
Catalgol, B., Wendt, B., Grimm, S., Breusing, N., Özer, N. K., & Grune, T. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.12.010 · Cited by 56 · see citing works
Self-citationInverse correlation of protein oxidation and proteasome activity in liver and lung
Breusing, N., Arndt, J., Voß, P., Bresgen, N., Wiswedel, I., Gardemann, A., Siems, W., & Grune, T. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.09.004 · Cited by 52 · see citing works
Self-citationProteasome response to interferon‐γ is altered in senescent human fibroblasts
Stratford, F. L. L., Chondrogianni, N., Trougakos, I. P., Gonos, E. S., & Rivett, A. J. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.06.029 · Cited by 50 · see citing works
Ullrich, O., Diestel, A., Bechmann, I., Homberg, M., Grune, T., Hass, R., & Nitsch, R. (2001) · The FASEB Journal · doi:10.1096/fj.00-0540fje · Cited by 47 · see citing works
Self-citationNitrotyrosine and protein carbonyls are equally distributed in HT22 cells after nitrosative stress
Jung, T., Engels, M., Klotz, L., Kröncke, K., & Grune, T. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.11.029 · Cited by 43 · see citing works
Self-citationUllrich, O., Ciftci, Ö., & Hass, R. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00399-3 · Cited by 42 · see citing works
Ferritin oxidation and proteasomal degradation: Protection by antioxidants
Voß, P., Horáková, Ľ., Jakstadt, M., Kiekebusch, D., & Grune, T. (2006) · Free Radical Research · doi:10.1080/10715760500419357 · Cited by 41 · see citing works
Self-citationInfluence of DNA Binding on the Degradation of Oxidized Histones by the 20S Proteasome
Ullrich, O., Sitte, N., Sommerburg, O., Sandig, V., Davies, K. J. A., & Grune, T. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1998.1031 · Cited by 41 · see citing works
Self-citationWidmer, R., Kaiser, B., Engels, M., Jung, T., & Grune, T. (2007) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2007.03.027 · Cited by 41 · see citing works
Self-citationPARP‐mediated proteasome activation: A co‐ordination of DNA repair and protein degradation?
Arnold, J., & Grune, T. (2002) · BioEssays · doi:10.1002/bies.10179 · Cited by 38 · see citing works
Self-citationCiftci, Ö., Ullrich, O., Schmidt, C. A., Diestel, A., & Hass, R. (2001) · Blood · doi:10.1182/blood.v97.9.2830 · Cited by 37 · see citing works
Functional Interaction of Poly(ADP-ribose) with the 20S Proteasome in Vitro
Mayer‐Kuckuk, P., Ullrich, O., Ziegler, M., Grune, T., & Schweiger, M. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0824 · Cited by 36 · see citing works
Self-citationStability of the nuclear protein turnover during cellular senescence of human fibroblasts
Merker, K., Ullrich, O., Schmidt, H., Sitte, N., & Grune, T. (2003) · The FASEB Journal · doi:10.1096/fj.03-0177fje · Cited by 35 · see citing works
Self-citationProteomics Identification of Carbonylated and HNE-Bound Brain Proteins in Alzheimer’s Disease
Rukhsana Sultana, A., & Butterfield, D. A. (2009) · Methods in molecular biology · doi:10.1007/978-1-59745-562-6_9 · Cited by 31 · see citing works
Accumulation of oxidative damage during replicative aging of the yeast Saccharomyces cerevisiae
Grzelak, A., Macierzyńska, E., & Bartosz, G. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.06.049 · Cited by 24 · see citing works
Increased protein hydrophobicity in response to aging and Alzheimer disease
Dasuri, K., Ebenezer, P. J., Zhang, L., Fernandez‐Kim, S. O., Bruce‐Keller, A. J., Markesbery, W. R., & Keller, J. N. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.02.012 · Cited by 19 · see citing works
Poly(ADP-ribose) polymerase-1, DNA repair and mammalian longevity
Bürkle, A., Beneke, S., Brabeck, C., Leake, A., Meyer, R. G., Muiras, M.-L., & Pfeiffer, R. (2002) · Experimental Gerontology · doi:10.1016/s0531-5565(02)00144-4 · Cited by 18 · see citing works
Malapetsa, A., Noe, A., Poirier, G. G., Desnoyers, S., Berger, N. A., & Panasci, L. (1996) · Mutation Research/DNA Repair · doi:10.1016/0921-8777(95)00030-5 · Cited by 12 · see citing works
Malignant lymphoma arising in a large congenital neurofibroma of the head and neck.Report of a case
Radi, M. J., Foucar, E., Palmer, C. H., & Gooding, R. A. (1988) · Cancer · doi:10.1002/1097-0142(19880415)61:8 · Cited by 8 · see citing works
Flagged first, then by citations
1 of the 74 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Camacho-Pereira, J., Tarragó, M. G., Chini, C. C. S., Nin, V., Escande, C., Warner, G. M., Puranik, A. S., Schoon, R. A., Reid, J. M., Galina, A., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.006 · Cited by 901 · see citing works
On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1Preprint
Luo, X., & Kraus, W. L. (2012) · Genes & Development · doi:10.1101/gad.183509.111 · Cited by 725 · see citing works
Tarragó, M. G., Chini, C. C. S., Kanamori, K. S., Warner, G. M., Caride, A., de Oliveira, G. C., Rud, M., Samani, A., Hein, K. Z., Huang, R., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.03.016 · Cited by 384 · see citing works
Höhn, A., Weber, D., Jung, T., Ott, C., Hugo, M., Kochlik, B., Kehm, R., König, J., Grune, T., & Castro, J. P. (2016) · Redox Biology · doi:10.1016/j.redox.2016.12.001 · Cited by 368 · see citing works
Self-citationRegulating the 20S Proteasome Ubiquitin-Independent Degradation Pathway
Ben‐Nissan, G., & Sharon, M. (2014) · Biomolecules · doi:10.3390/biom4030862 · Cited by 333 · see citing works
Cellular stress response pathways and ageing: intricate molecular relationships
Kourtis, N., & Tavernarakis, N. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.162 · Cited by 305 · see citing works
Castro-Portuguez, R., & Sutphin, G. L. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.110841 · Cited by 282 · see citing works
Proteostasis, oxidative stress and aging
Korovila, I., Hugo, M., Castro, J. P., Weber, D., Höhn, A., Grune, T., & Jung, T. (2017) · Redox Biology · doi:10.1016/j.redox.2017.07.008 · Cited by 274 · see citing works
Self-citationProtein damage, repair and proteolysis
Chondrogianni, N., Petropoulos, I., Grimm, S., Georgila, K., Catalgol, B., Friguet, B., Grune, T., & Gonos, E. S. (2012) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.09.001 · Cited by 254 · see citing works
Self-citationNAD and the aging process: role in life, death and everything in between
Chini, C. C. S., Tarragó, M. G., & Chini, E. N. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.11.003 · Cited by 208 · see citing works
Jung, T., Höhn, A., & Grune, T. (2014) · Redox Biology · doi:10.1016/j.redox.2013.12.029 · Cited by 134 · see citing works
Self-citationThe ubiquitin proteasome system in neurodegenerative diseases: Culprit, accomplice or victim?
Dennissen, F. J. A., Kholod, N., & van Leeuwen, F. W. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.01.003 · Cited by 124 · see citing works
García‐Giménez, J. L., Marković, J., Dası́, F., Queval, G., Schnaubelt, D., Foyer, C. H., & Pallardó, F. V. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.10.005 · Cited by 120 · see citing works
Wang, Y., Yang, Q., Wang, H., Zhu, J., Cong, L., Li, H., & Sun, Y. (2021) · Biology of Reproduction · doi:10.1093/biolre/ioab078 · Cited by 78 · see citing works
The Amazing Ubiquitin-Proteasome System: Structural Components and Implication in Aging
Tsakiri, E. N., & Trougakos, I. P. (2014) · International review of cytology · doi:10.1016/bs.ircmb.2014.09.002 · Cited by 78 · see citing works
Fluorescence labeling of carbonylated lipids and proteins in cells using coumarin-hydrazide
Vemula, V., Ni, Z., & Fedorova, M. (2015) · Redox Biology · doi:10.1016/j.redox.2015.04.006 · Cited by 42 · see citing works
Pregnancy‐associated venous insufficiency course with placental and systemic oxidative stress
Ortega, M. A., Romero, B., Asúnsolo, Á., Martínez‐Vivero, C., Sáinz, F., Bravo, C., León‐Luis, J. D., Álvarez‐Mon, M., Buján, J., & García‐Honduvilla, N. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15077 · Cited by 34 · see citing works
Histone carbonylation occurs in proliferating cells
García‐Giménez, J. L., Velázquez-Ledesma, A. M., Esmorís, I., Mateo, C. R., Sanz, P., Viña, J., & Pallardó, F. V. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.01.022 · Cited by 33 · see citing works
Cheong, W.-C., Park, J.-H., Kang, H.-R., & Song, M. J. (2015) · Journal of Virology · doi:10.1128/jvi.00559-15 · Cited by 29 · see citing works
Bortezomib Amplifies Effect on Intracellular Proteasomes by Changing Proteasome Structure
Pitcher, D. S., de Mattos-Shipley, K. M. J., Tzortzis, K. N., Auner, H. W., Karadimitris, A., & Kleijnen, M. F. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.05.016 · Cited by 21 · see citing works
A promiscuous recognition mechanism between GPR17 and SDF-1: Molecular insights
Parravicini, C., Daniele, S., Palazzolo, L., Trincavelli, M. L., Martini, C., Zaratin, P., Primi, R., Coppolino, G., Gianazza, E., Abbracchio, M. P., et al. (2016) · Cellular Signalling · doi:10.1016/j.cellsig.2016.03.001 · Cited by 16 · see citing works
Guimera, A. M., Clark, P. A., Wordsworth, J., Anugula, S., Rasmussen, L. J., & Shanley, D. P. (2022) · Experimental Gerontology · doi:10.1016/j.exger.2022.111889 · Cited by 13 · see citing works
The PARP inhibitor olaparib promotes senescence in murine macrophages
Kieronska‐Rudek, A., Zuhra, K., Ascenção, K., Chłopicki, S., & Szabó, C. (2025) · GeroScience · doi:10.1007/s11357-025-01679-6 · Cited by 10 · see citing works
Pitcher, D. S., de Mattos-Shipley, K. M. J., Wang, Z., Tzortzis, K. N., Goudevenou, K., Flynn, H. R., Bohn, G., Rahemtulla, A., Roberts, I. A. G., Snijders, A. P., et al. (2014) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2014.08.013 · Cited by 7 · see citing works
Oxidative Stress and Protein Oxidation
Grune, T., Catalgol, B., & Jung, T. (2012) · Wiley eBooks · doi:10.1002/9781118493038.ch1 · Cited by 7 · see citing works
Proteasome Modulation: A Way to Delay Aging?
Chondrogianni, N., Vasilopoulou, M. Α., Καπετάνου, Μ., & Gonos, E. S. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.11461-8 · Cited by 4 · see citing works
Protein Oxidation and Aging: Different Model Systems and Affecting Factors
Grune, T., Karademir-Yilmaz, B., & Jung, T. (2012) · Wiley eBooks · doi:10.1002/9781118493038.ch3 · Cited by 4 · see citing works
Self-citationPeng, C. Y., Maiuri, T., & Truant, R. (2025) · Journal of Huntington s Disease · doi:10.1177/18796397251372667 · Cited by 2 · see citing works
Multitasking Roles for Poly(ADP-ribosyl)ation in Aging and Longevity
Mangerich, A., & Bürkle, A. (2015) · Cancer drug discovery and develogment/Cancer drug discovery and development · doi:10.1007/978-3-319-14151-0_6 · Cited by 2 · see citing works
Guimera, A. M., & Shanley, D. P. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/753566 · Cited by 1 · see citing works
- Authors
- Bakondi, E., Catalgol, B., Bak, I., Jung, T., Bozaykut, P., Bayramicli, M., Ozer, N. K., & Grune, T.
- Affiliations
- University of Hohenheim (DE)
- Marmara University (TR)
- Corresponding author
- Grune, Tilman
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 50
- Issue
- 1
- Pages
- 86-92
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W1979724580
- Cited by
- 30
- References
- 74
- Citations by year
- 2025: 2 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 4 · 2015: 4 · 2014: 4 · 2012: 7
- FWCI
- 1.04
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- University of Debrecen Electronic Archive (University of Debrecen) (submittedVersion, other-oa)
- Dspace Repository (Marmara Üniversitesi) (submittedVersion)
- Dspace Repository (Marmara Üniversitesi) (submittedVersion, other-oa)
- Funders
- Alexander von Humboldt-Stiftung
- Deutsche Forschungsgemeinschaft
- Magyar Tudományos Akadémia
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- PARP1, nuclear proteasome, proteasome activation, aging, replicative senescence, human fibroblasts, oxidative stress, poly(ADP-ribose), protein turnover, skin aging
- MeSH terms
- Poly(ADP-ribose) Polymerase Inhibitors, Poly (ADP-Ribose) Polymerase-1, Aging, Benzamides, Biopsy, Cell Nucleus, Cell Survival, Cells, Cultured, Enzyme Activation, Enzyme Inhibitors, Fibroblasts, Humans, Hydrogen Peroxide, Poly Adenosine Diphosphate Ribose, Poly(ADP-ribose) Polymerases, Down-Regulation, Cellular Senescence, Oxidative Stress, Proteasome Endopeptidase Complex, Cell Proliferation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
