Cited by 242Antioxidant Activity and Oxidative StressRedox biology and oxidative stressExercise and Physiological Responses

Age-associated analysis of oxidative stress parameters in human plasma and erythrocytes

Gil, Lizette, Siems, Werner, Mazurek, Birgit, Gross, Johann, Schroeder, Peter, Voss, Peter, Grune, Tilman·2006·Free Radical Research

Abstract

Oxidative damage accumulation in macromolecules has been considered as a cause of cellular damage and pathology. Rarely, the oxidative stress parameters in healthy humans related to the individual age have been reported. The purpose of this study was to examine the redox status in plasma and erythrocytes of healthy individuals and determine correlations between these parameters and the aging process. The following parameters were used: malondialdehyde (MDA), protein carbonyls (PCO), 4-hydroxy-2,3-trans-nonenal (HNE), reduced glutathione (GSH), glutathione disulfide (GSSG) and uric acid (UA) in blood and plasma samples of 194 healthy women and men of ages ranging from 18 to 84 years. The results indicate that the balance of oxidant and antioxidant systems in plasma shifts in favor of accelerated oxidation during ageing. That is demonstrated by increases of MDA, HNE, GSSG and by the slight decrease of erythrocytic GSH with age. As the content of UA is more determined by metabolic and nutritional influences than by the balance between prooxidants and antioxidants there was no significant age-related change observed. For plasma concentrations of HNE the first time age-dependent reference values for healthy humans are presented.

Integrity signals

Registry

Crossref · 10.1080/10715760600592962

Cites

59 of 59 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Gil, L., Siems, W., Mazurek, B., Gross, J., Schroeder, P., Voss, P., & Grune, T.
Affiliations
  • Instituto de Medicina Tropical “Pedro Kourí” (CU)
  • Humboldt-Universität zu Berlin (DE)
  • Heinrich Heine University Düsseldorf (DE)
Corresponding author
Voss, Peter
Venue
Free Radical Research
Published
2006-01
Volume
40
Issue
5
Pages
495-505
ISSN
  • 1029-2470 (ISSN-L)
  • 1071-5762
OpenAlex
W2061523541
Cited by
242
References
59
Citations by year
2026: 2 · 2025: 11 · 2024: 7 · 2023: 5 · 2022: 9 · 2021: 10 · 2020: 7 · 2019: 8 · 2018: 11 · 2017: 11 · 2016: 14 · 2015: 18 · 2014: 17 · 2013: 15 · 2012: 13
FWCI
11.66
Type
journal article
Language
en
Open access
closed
Locations
  • Free Radical Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Alexander von Humboldt-Stiftung
  • Deutsche Forschungsgemeinschaft
Topics
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords
oxidative stress, aging, erythrocytes, plasma, malondialdehyde, protein carbonyls, reduced glutathione, glutathione disulfide, uric acid, age-related reference values, prooxidant-antioxidant balance, healthy adults
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Aging, Aldehydes, Erythrocytes, Female, Glutathione, Humans, Male, Malondialdehyde, Middle Aged, Oxidation-Reduction, Plasma, Sex Factors, Uric Acid, Biomarkers, Oxidative Stress, Glutathione Disulfide, Protein Carbonylation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review