Age-associated analysis of oxidative stress parameters in human plasma and erythrocytes
Abstract
Oxidative damage accumulation in macromolecules has been considered as a cause of cellular damage and pathology. Rarely, the oxidative stress parameters in healthy humans related to the individual age have been reported. The purpose of this study was to examine the redox status in plasma and erythrocytes of healthy individuals and determine correlations between these parameters and the aging process. The following parameters were used: malondialdehyde (MDA), protein carbonyls (PCO), 4-hydroxy-2,3-trans-nonenal (HNE), reduced glutathione (GSH), glutathione disulfide (GSSG) and uric acid (UA) in blood and plasma samples of 194 healthy women and men of ages ranging from 18 to 84 years. The results indicate that the balance of oxidant and antioxidant systems in plasma shifts in favor of accelerated oxidation during ageing. That is demonstrated by increases of MDA, HNE, GSSG and by the slight decrease of erythrocytic GSH with age. As the content of UA is more determined by metabolic and nutritional influences than by the balance between prooxidants and antioxidants there was no significant age-related change observed. For plasma concentrations of HNE the first time age-dependent reference values for healthy humans are presented.
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Studies reveal an age-related increase in the level of oxidatively modified proteins.
“Studies reveal an age-related increase in the level of oxidatively modified proteins [10,11]”
From Protein oxidation - Formation mechanisms, detection and relevance as biomarkers in human diseases (2021) · cites this paper as [10]
Protein carbonyls have been found to be elevated in Alzheimer's diseases, diabetes, renal diseases, and other disorders.
“Protein carbonyls have been found to be elevated in Alzheimer’s diseases, diabetes, renal diseases, and other disorders (Gil et al. 2006).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Gil et al. 2006
Cites
Free Radicals in the Physiological Control of Cell Function
Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855 · see citing works
Aging: a theory based on free radical and radiation chemistry
Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567 · see citing works
Improved method for the determination of blood glutathione.
Beutler, E., Duron, O., & KELLY, B. M. (1963) · PubMed · Cited by 6,932 · see citing works
Schafer, F. Q., & Buettner, G. R. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00480-4 · Cited by 4,587 · see citing works
A fluorometric method for determination of oxidized and reduced glutathione in tissues
Hissin, P. J., & Hilf, R. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90326-2 · Cited by 4,116 · see citing works
The Free Radical Theory of Aging Matures
BECKMAN, K. B., & AMES, B. N. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.2.547 · Cited by 3,879 · see citing works
Biochemistry and pathology of radical-mediated protein oxidation
Dean, R. T., Fu, S., Stocker, R., & Davies, M. J. (1997) · Biochemical Journal · doi:10.1042/bj3240001 · Cited by 1,678 · see citing works
Wong, S. H., Knight, J. A., Hopfer, S. M., Zaharia, O., Leach, C. N., & Sunderman, F. W. (1987) · Clinical Chemistry · doi:10.1093/clinchem/33.2.214 · Cited by 814 · see citing works
Sohal, R. S., Ku, H.-H., Agarwal, S., Forster, M. J., & Lal, H. (1994) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(94)90104-x · Cited by 788 · see citing works
Protein Carbonyl Measurement by a Sensitive ELISA Method
Buss, H., Chan, T., Sluis, K. B., Domigan, N. M., & Winterbourn, C. C. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(97)00104-4 · Cited by 687 · see citing works
Protein Oxidation in Aging and Age‐Related Diseases
Stadtman, E. R. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb05632.x · Cited by 660 · see citing works
Grune, T., Jung, T., Merker, K., & Davies, K. J. A. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.04.020 · Cited by 653 · see citing works
Self-citationEsterbauer, H., Cheeseman, K. H., Mu, D., Poli, G., & Slater, T. F. (1982) · Biochemical Journal · doi:10.1042/bj2080129 · Cited by 618 · see citing works
Lenaz, G. (2001) · IUBMB Life · doi:10.1080/15216540152845957 · Cited by 585 · see citing works
Aging and acute exercise enhance free radical generation in rat skeletal muscle
Bejma, J., & Ji, L. L. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.87.1.465 · Cited by 445 · see citing works
Oxidative Stress and Antioxidants in Exercise
Leeuwenburgh, C., & Heinecke, J. W. (2001) · Current Medicinal Chemistry · doi:10.2174/0929867013372896 · Cited by 430 · see citing works
Handbook of the Biology of Aging
(2005) · Elsevier eBooks · doi:10.1016/b978-0-12-088387-5.x5000-6 · Cited by 426 · see citing works
Troen, B. R. (2003) · PubMed · Cited by 403 · see citing works
Jones, D. P., Mody, V. C., Carlson, J. L., Lynn, M. J., & Sternberg, P. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01040-7 · Cited by 392 · see citing works
Antioxidant enzyme activities and malondialdehyde levels related to aging
İnal, M., Kanbak, G., & Sunal, E. (2001) · Clinica Chimica Acta · doi:10.1016/s0009-8981(00)00422-8 · Cited by 383 · see citing works
Role of Oxidant Species in Aging
Stadtman, E. R. (2004) · Current Medicinal Chemistry · doi:10.2174/0929867043365341 · Cited by 368 · see citing works
Junqueira, V. B. C., Barros, S. B. D. M., Chan, S. S., Rodrigues, L., Giavarotti, L., Abud, R. L., & Deucher, G. P. (2004) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2004.02.003 · Cited by 329 · see citing works
Judge, S., Jang, Y. M., SMITH, A. R. W., Hagen, T. M., & Leeuwenburgh, C. (2005) · The FASEB Journal · doi:10.1096/fj.04-2622fje · Cited by 328 · see citing works
EVOLUTIONARY AND MECHANISTIC THEORIES OF AGING
Hughes, K. A., & Reynolds, R. M. (2004) · Annual Review of Entomology · doi:10.1146/annurev.ento.50.071803.130409 · Cited by 328 · see citing works
Viña, J., Borrás, C., Gambini, J., Sastre, J., & Pallardó, F. V. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.03.090 · Cited by 271 · see citing works
Griffiths, H. R. (2002) · Molecular Aspects of Medicine · doi:10.1016/s0098-2997(02)00017-1 · Cited by 263 · see citing works
Borrás, C., Gambini, J., Gómez-Cabrera, M. C., Sastre, J., Pallardó, F., Mann, G., & Viña, J. (2005) · Aging Cell · doi:10.1111/j.1474-9726.2005.00151.x · Cited by 257 · see citing works
Ageing, oxidative stress, and mitochondrial uncoupling
Harper, M., Bevilacqua, L., Hagopian, K., Weindruch, R. H., & Ramsey, J. J. (2004) · Acta Physiologica Scandinavica · doi:10.1111/j.1365-201x.2004.01370.x · Cited by 252 · see citing works
The Mitochondrial Production of Reactive Oxygen Species in Relation to Aging and Pathology
Genova, M. L., Pich, M. M., Bernacchia, A., Bianchi, C., Biondi, A., Bovina, C., Falasca, A. I., Formiggini, G., Castelli, G. P., & Lenaz, G. (2004) · Springer eBooks · doi:10.1007/978-3-662-41088-2_10 · Cited by 233 · see citing works
Rate of generation of oxidative stress-related damage and animal longevity
Barja, G. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00910-3 · Cited by 232 · see citing works
Oxidative stress and mitochondrial function with aging – the effects of calorie restriction
Merry, B. J. (2003) · Aging Cell · doi:10.1046/j.1474-9728.2003.00074.x · Cited by 207 · see citing works
Age‐related changes in the glutathione redox system
Erden‐İnal, M., Sunal, E., & Kanbak, G. (2001) · Cell Biochemistry and Function · doi:10.1002/cbf.937 · Cited by 201 · see citing works
The Mitochondrial Production of Reactive Oxygen Species in Relation to Aging and Pathology
Genova, M. L., Pich, M. M., Bernacchia, A., BIANCHI, C., Biondi, A., Bovina, C., Falasca, A. I., Formiggini, G., Castelli, G. P., & Lenaz, G. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1293.010 · Cited by 198 · see citing works
Age-Related Changes in Protein Oxidation and Proteolysis in Mammalian Cells
Grune, T., Shringarpure, R., Sitte, N., & Davies, K. J. A. (2001) · The Journals of Gerontology Series A · doi:10.1093/gerona/56.11.b459 · Cited by 193 · see citing works
Self-citationProteasome‐dependent degradation of oxidized proteins in MRC‐5 fibroblasts
Sitte, N., Merker, K., & Grune, T. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01495-1 · Cited by 171 · see citing works
Self-citationSolberg, H. E. (1983) · PubMed · Cited by 167 · see citing works
Stadtman, E. R. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00904-8 · Cited by 133 · see citing works
Biological ageing: A fundamental, biological link between socio-economic status and health?
Adams, J. M. (2004) · European Journal of Public Health · doi:10.1093/eurpub/14.3.331 · Cited by 126 · see citing works
A unifying view of ageing and disease: the double-agent theory
Lane, N. J. (2003) · Journal of Theoretical Biology · doi:10.1016/s0022-5193(03)00304-7 · Cited by 122 · see citing works
Camougrand, N. M., & Rigoulet, M. (2001) · Respiration Physiology · doi:10.1016/s0034-5687(01)00314-0 · Cited by 110 · see citing works
Animal models of oxidative stress, aging, and therapeutic antioxidant interventions
Melov, S. (2002) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(02)00086-9 · Cited by 106 · see citing works
Improved antioxidative protection in winter swimmers
Siems, W. G. (1999) · QJM · doi:10.1093/qjmed/92.4.193 · Cited by 95 · see citing works
Self-citationGrune, T., Wg, S., Zöllner, H., & Esterbauer, H. (1994) · PubMed · Cited by 92 · see citing works
Self-citationFeillet‐Coudray, C., Tourtauchaux, R., Niculescu, M., Rock, E., Tauveron, I., Alexandre-Gouabau, M. C., Rayssiguier, Y., Jalenques, I., & Mazur, A. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00096-9 · Cited by 89 · see citing works
Yang, C., Chou, S., Liu, L., Tsai, P.-J., & Kuo, J. (1995) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/0378-4347(95)00287-8 · Cited by 89 · see citing works
Özbay, B., & Dülger, H. (2002) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.197.119 · Cited by 80 · see citing works
Age-Related Changes in the Peroxyl Radical Scavenging Capacity of Human Plasma
Aejmelaeus, R., Holm, P., Kaukinen, U., Metsä‐Ketelä, T., Laippala, P. J., Hervonen, A., & Alho, H. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00591-6 · Cited by 70 · see citing works
Oxidative stress in chronic lymphoedema
Siems, W. G. (2002) · QJM · doi:10.1093/qjmed/95.12.803 · Cited by 57 · see citing works
Self-citationIncreased oxidative stress in younger as well as in older humans
Phillips, M., Cataneo, R. N., Greenberg, J. H., Gunawardena, R., & Rahbari-Oskoui, F. (2003) · Clinica Chimica Acta · doi:10.1016/s0009-8981(02)00380-7 · Cited by 55 · see citing works
Oxidative stress and aging – the use of superoxide dismutase/catalase mimetics to extend lifespan
Sampayo, J. N., Gill, M. S., & Lithgow, G. J. (2003) · Biochemical Society Transactions · doi:10.1042/bst0311305 · Cited by 53 · see citing works
Micronutrients and ageing: intakes and requirements
Richard, M., & Roussel, A. (1999) · Proceedings of The Nutrition Society · doi:10.1017/s0029665199000750 · Cited by 43 · see citing works
The mitochondrial theory of aging: Involvement of mitochondrial DNA damage and repair
de Souza-Pinto, N. C., & Bohr, V. A. (2002) · International review of neurobiology · doi:10.1016/s0074-7742(02)53018-x · Cited by 41 · see citing works
Sommerburg, O., Grune, T., Klee, S., Ungemach, F. R., & Siems, W. G. (1993) · Mediators of Inflammation · doi:10.1155/s0962935193000031 · Cited by 36 · see citing works
Self-citationDíaz, J., Serrano, E., Acosta, F., & Carbonell, L. F. (1998) · Clinical Chemistry · doi:10.1093/clinchem/44.10.2215 · Cited by 34 · see citing works
[Aging and oxidative stress. Which potential markers?].
Bonnefont‐Rousselot, D., Thérond, P., Beaudeux, J., Peynet, J., Legrand, A., & Delattre, J. (2001) · PubMed · Cited by 18 · see citing works
Esterbauer, H., & Cheeseman, K. H. (1987) · Chemistry and Physics of Lipids · doi:10.1016/0009-3084(87)90061-2 · Cited by 18 · see citing works
Poubelle, P. E., Chaintreuil, J., Bensadoun, J., Blotman, F., Simon, L., & de Paulet, A. C. (1982) · PubMed · Cited by 15 · see citing works
Healthy aging for functional longevity : molecular and cellular interactions in senescence
Park, S. C. (2001) · Cited by 7 · see citing works
Analysis of Redox Status in Serum during Aging
Kim, J., No, J. K., Yu, B., & Chung, H. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb05670.x · Cited by 4 · see citing works
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Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638 · see citing works
Clinical Relevance of Biomarkers of Oxidative Stress
Frijhoff, J., Winyard, P. G., Žarković, N., Davies, S. S., Stocker, R., Cheng, D., Knight, A. R., Taylor, E., Oettrich, J., Ruskovska, T., et al. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6317 · Cited by 918 · see citing works
Self-citationMeasurement and Clinical Significance of Biomarkers of Oxidative Stress in Humans
Marrocco, I., Fabio Altieri, F., & Peluso, I. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/6501046 · Cited by 874 · see citing works
Safety assessment of probiotics for human use
Sanders, M. E., Akkermans, L. M. A., Haller, D., Hammerman, C., Heimbach, J. T., Hörmannsperger, G., & Huys, G. (2010) · Gut Microbes · doi:10.4161/gmic.1.3.12127 · Cited by 816 · see citing works
Pathological aspects of lipid peroxidation
Nègre‐Salvayre, A., Augè, N., Ayala, V., Başağa, H., Boada, J., Brenke, R., Chapple, S. J., Cohen, G., Fehér, J., Grune, T., et al. (2010) · Free Radical Research · doi:10.3109/10715762.2010.498478 · Cited by 451 · see citing works
Self-citationMarkers of Oxidative Stress in Erythrocytes and Plasma During Aging in Humans
Pandey, K. B., & Rizvi, S. I. (2009) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.3.1.10476 · Cited by 444 · see citing works
Oxidative stress and human diseases: Origin, link, measurement, mechanisms, and biomarkers
Giustarini, D., Dalle‐Donne, I., Tsikas, D., & Rossi, R. (2009) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408360903142326 · Cited by 443 · see citing works
4‐Hydroxynonenal: A membrane lipid oxidation product of medicinal interest
Poli, G., Schaur, R. J., Siems, W. G., & Leonarduzzi, G. (2007) · Medicinal Research Reviews · doi:10.1002/med.20117 · Cited by 434 · see citing works
Self-citationThe ozone paradox: Ozone is a strong oxidant as well as a medical drug
Bocci, V. A., Borrelli, E., Travagli, V., & Zanardi, I. (2009) · Medicinal Research Reviews · doi:10.1002/med.20150 · Cited by 422 · see citing works
Höhn, A., Weber, D., Jung, T., Ott, C., Hugo, M., Kochlik, B., Kehm, R., König, J., Grune, T., & Castro, J. P. (2016) · Redox Biology · doi:10.1016/j.redox.2016.12.001 · Cited by 368 · see citing works
Self-citationRedox Signaling by Reactive Electrophiles and Oxidants
Parvez, S., Long, M. J. C., Poganik, J. R., & Aye, Y. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00698 · Cited by 357 · see citing works
Protein oxidation - Formation mechanisms, detection and relevance as biomarkers in human diseases
Kehm, R., Baldensperger, T., Raupbach, J., & Höhn, A. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101901 · Cited by 348 · see citing works
Barrera, G., Pizzimenti, S., Daga, M., Dianzani, C., Arcaro, A., Cetrangolo, G. P., Giordano, G., Cucci, M. A., Graf, M. E., & Gentile, F. (2018) · Antioxidants · doi:10.3390/antiox7080102 · Cited by 338 · see citing works
Health Effects with Consumption of the Flax Lignan Secoisolariciresinol Diglucoside
Adolphe, J. L., Whiting, S. J., Juurlink, B. H. J., Thorpe, L. U., & Alcorn, J. (2010) · British Journal of Nutrition · doi:10.1017/s0007114509992753 · Cited by 314 · see citing works
FECUNDITY AND SURVIVAL IN RELATION TO RESISTANCE TO OXIDATIVE STRESS IN A FREE‐LIVING BIRD
Bize, P., Devevey, G., Monaghan, P., Doligez, B., & Christe, P. (2008) · Ecology · doi:10.1890/07-1135.1 · Cited by 240 · see citing works
4-Hydroxy-nonenal—A Bioactive Lipid Peroxidation Product
Schaur, R. J., Siems, W., Bresgen, N., & Eckl, P. (2015) · Biomolecules · doi:10.3390/biom5042247 · Cited by 231 · see citing works
Self-citationMarkers of oxidant stress that are clinically relevant in aging and age-related disease
Jacob, K. D., Hooten, N. N., Trzeciak, A. R., & Evans, M. K. (2013) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2013.02.008 · Cited by 233 · see citing works
Bürkle, A., Moreno‐Villanueva, M., Bernhard, J., Blasco, M. A., Zondag, G. C. M., Hoeijmakers, J. H. J., Toussaint, O., Grubeck‐Loebenstein, B., Mocchegiani, E., Collino, S., et al. (2015) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2015.03.006 · Cited by 228 · see citing works
Self-citationAn experimental demonstration that early-life competitive disadvantage accelerates telomere loss
Nettle, D., Monaghan, P., Gillespie, R., Brilot, B., Bedford, T., & Melissa Bateson, B. (2014) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2014.1610 · Cited by 202 · see citing works
Antioxidants and HNE in redox homeostasis
Łuczaj, W., Gęgotek, A., & Skrzydlewska, E. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.11.033 · Cited by 197 · see citing works
Chapple, S., Cheng, X.-H., & Mann, G. (2013) · Redox Biology · doi:10.1016/j.redox.2013.04.001 · Cited by 183 · see citing works
Regulation of proteasome-mediated protein degradation during oxidative stress and aging
Breusing, N., & Grune, T. (2008) · Biological Chemistry · doi:10.1515/bc.2008.029 · Cited by 187 · see citing works
Self-citationAir pollution and circulating biomarkers of oxidative stress
Delfino, R. J., Staimer, N., & Vaziri, N. D. (2011) · Air Quality, Atmosphere & Health · doi:10.1007/s11869-010-0095-2 · Cited by 181 · see citing works
Modulation of oxidative stress and mitochondrial function by the ketogenic diet
Milder, J. B., & Patel, M. (2011) · Epilepsy Research · doi:10.1016/j.eplepsyres.2011.09.021 · Cited by 181 · see citing works
Inborn defects in the antioxidant systems of human red blood cells
van Zwieten, R., Verhoeven, A. J., & Roos, D. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.11.022 · Cited by 179 · see citing works
Markers of Oxidative Stress in Erythrocytes during Aging in Humans
Rizvi, S. I., & Maurya, P. K. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1395.041 · Cited by 179 · see citing works
Chemistry and analysis of HNE and other prominent carbonyl-containing lipid oxidation compounds
Sousa, B. C., Pitt, A. R., & Spickett, C. M. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.02.003 · Cited by 172 · see citing works
Hsu, C. G., Chávez, C. L., Zhang, C., Sowden, M. P., Chen, Y., & Berk, B. C. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-00966-5 · Cited by 173 · see citing works
Oxidative and reductive metabolism of lipid-peroxidation derived carbonyls
Singh, M., Kapoor, A., & Bhatnagar, A. (2015) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2014.12.028 · Cited by 165 · see citing works
Morris, G., Berk, M., Carvalho, A. F., Maes, M. H. J., Walker, A. J., & Puri, B. K. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.12.036 · Cited by 154 · see citing works
Potential biomarkers of ageing
Simm, A., Naß, N., Bartling, B., Hofmann, B., Silber, R., & Santos, A. N. (2008) · Biological Chemistry · doi:10.1515/bc.2008.034 · Cited by 146 · see citing works
The Role of Oxidative Stress in Amyotrophic Lateral Sclerosis and Parkinson’s Disease
Baillet, A. C., Chanteperdrix, V., Trocmé, C., Casez, P., Garrel, C., & Besson, G. (2010) · Neurochemical Research · doi:10.1007/s11064-010-0212-5 · Cited by 143 · see citing works
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Clinical oxidation parameters of aging
Voß, P., & Siems, W. (2006) · Free Radical Research · doi:10.1080/10715760600953859 · Cited by 134 · see citing works
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The antioxidative effects of probiotic Lactobacillus casei Zhang on the hyperlipidemic rats
Zhang, Y., Du, R., Wang, L., & Zhang, H. (2010) · European Food Research and Technology · doi:10.1007/s00217-010-1255-1 · Cited by 129 · see citing works
Weber, D., Milković, L., Bennett, S. J., Griffiths, H. R., Žarković, N., & Grune, T. (2013) · Redox Biology · doi:10.1016/j.redox.2013.01.012 · Cited by 121 · see citing works
Self-citationWang, Y., Li, Y., Xie, J., Zhang, Y., Wang, J., Sun, X., & Zhang, H. (2012) · International Immunopharmacology · doi:10.1016/j.intimp.2012.10.026 · Cited by 116 · see citing works
4-hydroxynonenal-mediated signaling and aging
Zhang, H., & Forman, H. J. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.11.032 · Cited by 114 · see citing works
Cysteinylation and homocysteinylation of plasma protein thiols during ageing of healthy human beings
Rossi, R., Giustarini, D., Milzani, A., & Dalle‐Donne, I. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00417.x · Cited by 112 · see citing works
Alterations in Antioxidant Enzymes During Aging in Humans
Rizvi, S. I., & Maurya, P. K. (2007) · Molecular Biotechnology · doi:10.1007/s12033-007-0048-7 · Cited by 111 · see citing works
Embryonal erythropoiesis and aging exploit ferroptosis
Zheng, H., Jiang, L., Tsuduki, T., Conrad, M., & Toyokuni, S. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102175 · Cited by 107 · see citing works
Michalska, P., & Leon, R. M. (2020) · Antioxidants · doi:10.3390/antiox9080740 · Cited by 112 · see citing works
Redox-related biomarkers in human cardiovascular disease - classical footprints and beyond
Daiber, A., Hahad, O., Andreadou, I., Steven, S., Daub, S., & Münzel, T. F. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101875 · Cited by 107 · see citing works
Protective role of tea catechins on erythrocytes subjected to oxidative stress during human aging
Maurya, P. K., & Rizvi, S. I. (2008) · Natural Product Research · doi:10.1080/14786410802267643 · Cited by 106 · see citing works
Markers of oxidative stress in ICU clinical settings: present and future
Grune, T., & Berger, M. M. (2007) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e3282f0c97c · Cited by 96 · see citing works
Self-citationAlonso‐Álvarez, C., Pérez‐Rodríguez, L., García, J. T., Viñuela, J., & Mateo, R. (2009) · Physiological and Biochemical Zoology · doi:10.1086/605395 · Cited by 94 · see citing works
Liu, H., Zhang, W., Dong, S., Song, L., Zhao, S., Wu, C., Wang, X., Liu, F., Xie, J., Wang, J., et al. (2015) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2015.10.029 · Cited by 93 · see citing works
Stier, A., Reichert, S., Criscuolo, F., & Bize, P. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.09.001 · Cited by 87 · see citing works
Go, Y., Halvey, P. J., Hansen, J. M., Reed, M., Pohl, J., & Jones, D. P. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.070218 · Cited by 89 · see citing works
Zhang, Y., Wang, L., Zhang, J., Li, Y., He, Q., Li, H., Guo, X., Guo, J., & Zhang, H. (2013) · European Journal of Nutrition · doi:10.1007/s00394-013-0519-5 · Cited by 88 · see citing works
Malondialdehyde (MDA) – product of lipid peroxidation as marker of homeostasis disorders and aging
Całyniuk, B., Grochowska‐Niedworok, E., Walkiewicz, K. W., Kawecka, S., Popiołek, E., & Fatyga, E. (2016) · Annales Academiae Medicae Silesiensis · doi:10.18794/aams/65697 · Cited by 88 · see citing works
Jahangir, A., Sagar, S., & Terzic, A. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00647.2007 · Cited by 88 · see citing works
Inflammatory and redox status of ponies with a history of pasture-associated laminitis
Treiber, K. H., Carter, R., Gay, L., Williams, C. A., & Geor, R. J. (2008) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2008.11.004 · Cited by 88 · see citing works
Donor‐variation effect on red blood cell storage lesion: A close relationship emerges
Tzounakas, V. L., Kriebardis, A. G., Papassideri, I. S., & Antonelou, M. H. (2016) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201500128 · Cited by 87 · see citing works
Kędziora–Kornatowska, K., Szewczyk‐Golec, K., Kozakiewicz, M., Pawluk, H., Czuczejko, J., Kornatowski, T., Bartosz, G., & Kędziora, J. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2009.00666.x · Cited by 87 · see citing works
Oxidative stress in aging: Theoretical outcomes and clinical evidences in humans
del Valle, L. G. (2011) · Biomedicine & Aging Pathology · doi:10.1016/j.biomag.2011.03.001 · Cited by 85 · see citing works
Oxidative stress and exceptional human longevity: Systematic review
Belenguer‐Varea, Á., Tarazona‐Santabalbina, F. J., Avellana-Zaragoza, J. A., Martínez-Reig, M., Mas‐Bargues, C., & Inglés, M. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.09.019 · Cited by 83 · see citing works
Pandey, K. B., & Rizvi, S. I. (2009) · Phytotherapy Research · doi:10.1002/ptr.2853 · Cited by 82 · see citing works
4-Hydroxynonenal metabolites and adducts in pre-carcinogenic conditions and cancer.
Guéraud, F. (2017) · Free Radical Biology & Medicine · doi:10.1016/j.freeradbiomed.2016.12.025 · Cited by 71 · see citing works
Plasma Protein Oxidation and Its Correlation with Antioxidant Potential During Human Aging
Pandey, K. B., Mehdi, M. M., Maurya, P. K., & Rizvi, S. I. (2010) · Disease Markers · doi:10.1155/2010/964630 · Cited by 77 · see citing works
Glutathione-Related Antioxidant Defense System in Elderly Patients Treated for Hypertension
Rybka, J., Kupczyk, D., Kędziora–Kornatowska, K., Motyl, J., Czuczejko, J., Szewczyk‐Golec, K., Kozakiewicz, M., Pawluk, H., de Carvalho, L. A., & Kȩdziora, J. (2010) · Cardiovascular Toxicology · doi:10.1007/s12012-010-9096-5 · Cited by 76 · see citing works
The Role of Antioxidants Supplementation in Clinical Practice: Focus on Cardiovascular Risk Factors
Cammisotto, V., Nocella, C., Bartimoccia, S., Sanguigni, V., Francomano, D., Sciarretta, S., Pastori, D., Peruzzi, M., Cavarretta, E., D’Amico, A., et al. (2021) · Antioxidants · doi:10.3390/antiox10020146 · Cited by 76 · see citing works
Biochemical Markers of Aging for Longitudinal Studies in Humans
Engelfriet, P. M., Jansen, E. H. J. M., Picavet, H. S. J., & Dollé, M. E. T. (2013) · Epidemiologic Reviews · doi:10.1093/epirev/mxs011 · Cited by 74 · see citing works
A Review of Oxidative Stress Products and Related Genes in Early Alzheimer’s Disease
Cioffi, F., Adam, R. H. I., Bansal, R., & Broersen, K. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210497 · Cited by 73 · see citing works
Role of the membrane in the formation of heme degradation products in red blood cells
Nagababu, E., Mohanty, J. G., Bhamidipaty‐Pelosi, S., Ostera, G. R., & Rifkind, J. M. (2009) · Life Sciences · doi:10.1016/j.lfs.2009.11.015 · Cited by 71 · see citing works
Evans, M., Wilson, D., & Guthrie, N. (2014) · Journal of Functional Foods · doi:10.1016/j.jff.2013.12.017 · Cited by 70 · see citing works
Krishnan, S., & Rani, P. U. (2014) · Biological Trace Element Research · doi:10.1007/s12011-014-9930-x · Cited by 70 · see citing works
Oxidative Modification of Proteins: From Damage to Catalysis, Signaling, and Beyond
Demasi, M., Augusto, O., Bechara, E. J. H., Bicev, R. N., Cerqueira, F. M., da Cunha, F. M., Denicola, A., Gomes, F., Miyamoto, S., Netto, L. E. S., et al. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8176 · Cited by 68 · see citing works
Wilms, E., An, R., Smolinska, A., Stevens, Y., Weseler, A. R., Elizalde, M., Drittij-Reijnders, M.-J., Ioannou, A., van Schooten, F., Smidt, H., et al. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2020.12.034 · Cited by 65 · see citing works
Takahashi, M., Miyashita, M., Suzuki, K., Bae, S.-R., Kim, H., Wakisaka, T., Matsui, Y., Takeshita, M., & Yasunaga, K. (2014) · British Journal Of Nutrition · doi:10.1017/s0007114514002530 · Cited by 63 · see citing works
Hormetic and regulatory effects of lipid peroxidation mediators in pancreatic beta cells
Maulucci, G., Daniel, B., Cohen, O., Avrahami, Y., & Sasson, S. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.03.001 · Cited by 63 · see citing works
Age-Related Changes in Hepatic Activity and Expression of Detoxification Enzymes in Male Rats
Vyskočilová, E., Szotáková, B., Skálová, L., Bártíková, H., Hlaváčová, J., & Boušová, I. (2013) · BioMed Research International · doi:10.1155/2013/408573 · Cited by 62 · see citing works
Rodriguez, K. A., Wywiał, E., Pérez, V., Lambert, A. J., Edrey, Y. H., Lewis, K. N., Grimes, K. M., Lindsey, M. L., Brand, M. D., & Buffenstein, R. (2011) · Current Pharmaceutical Design · doi:10.2174/138161211797052457 · Cited by 57 · see citing works
Not All Stressors Are Equal: Mechanism of Stressors on RPE Cell Degeneration
Tong, Y., & Wang, S. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.591067 · Cited by 54 · see citing works
Pandey, K. B., Mishra, N., & Rizvi, S. I. (2009) · Natural Product Communications · doi:10.1177/1934578x0900400211 · Cited by 57 · see citing works
Role of oxidative stress on platelet hyperreactivity during aging
Eduardo Fuentes, Q., & Palomo, I. F. (2016) · Life Sciences · doi:10.1016/j.lfs.2016.02.026 · Cited by 55 · see citing works
Lara‐Villoslada, F., Sierra, S., Martı́n, R., Delgado, S., Rodríguez, J. M., Olivares, M. M., & Xaus, J. (2006) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2006.03225.x · Cited by 54 · see citing works
Dietary Polyphenols and Their Effects on Cell Biochemistry and Pathophysiology 2013
Maraldi, T., Vauzour, D., & Angeloni, C. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/576363 · Cited by 53 · see citing works
Inverse correlation of protein oxidation and proteasome activity in liver and lung
Breusing, N., Arndt, J., Voß, P., Bresgen, N., Wiswedel, I., Gardemann, A., Siems, W., & Grune, T. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.09.004 · Cited by 52 · see citing works
Self-citationPhysiological Antioxidative Network of the Bilirubin System in Aging and Age-Related Diseases
Kim, S. Y., & Park, S. C. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00045 · Cited by 53 · see citing works
Redox Parameters as Markers of the Rate of Aging and Predictors of Life Span
de Toda, I. M., Vida, C., Garrido, A., & la Fuente, M. D. (2019) · The Journals of Gerontology Series A · doi:10.1093/gerona/glz033 · Cited by 50 · see citing works
Cheng, Q., Jiang, S., Huang, L., Ge, J., Wang, Y., & Yang, W. (2019) · Journal of Animal Science · doi:10.1093/jas/skz051 · Cited by 48 · see citing works
Biomarkers of protein oxidation from a chemical, biological and medical point of view
Breusing, N., & Grune, T. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.04.004 · Cited by 47 · see citing works
Self-citationKumar, P., & Maurya, P. K. (2013) · Rejuvenation Research · doi:10.1089/rej.2012.1394 · Cited by 47 · see citing works
Elmes, M. J., Szyszka, A., Pauliat, C., Clifford, B. L., Daniel, Z. C. T. R., Cheng, Z., Wathes, C., & McMullen, S. (2015) · Physiological Reports · doi:10.14814/phy2.12305 · Cited by 47 · see citing works
Effect of melatonin on the oxidative stress in erythrocytes of healthy young and elderly subjects*
Kędziora–Kornatowska, K., Szewczyk‐Golec, K., Czuczejko, J., de Lumen, K. V. M., Pawluk, H., Motyl, J., Karasek, M., & Kędziora, J. (2006) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2006.00394.x · Cited by 46 · see citing works
Implication of oxidative stress as a cause of autoimmune hemolytic anemia in NZB mice
Iuchi, Y., Kibe, N., Tsunoda, S., Suzuki, S., Mikami, T., Okada, F., Uchida, K., & Fujii, J. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.01.012 · Cited by 46 · see citing works
Weber, D., Stuetz, W., Toussaint, O., Debacq-Chainiaux, F., Dollé, M. E. T., Jansen, E., Gonos, E. S., Franceschi, C., Sikora, E., Hervonen, A., et al. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/1401452 · Cited by 46 · see citing works
Self-citationIuchi, Y., Okada, F., Takamiya, R., Kibe, N., Tsunoda, S., Nakajima, O., Toyoda, K., Nagae, R., Suematsu, M., Soga, T., et al. (2009) · Biochemical Journal · doi:10.1042/bj20090176 · Cited by 45 · see citing works
Age-dependent alteration of antioxidant defense system in hypertensive and type-2 diabetes patients
Okoduwa, S. I. R., Umar, I. A., Ibrahim, S., Bello, F., & Habila, N. (2015) · Journal of Diabetes & Metabolic Disorders · doi:10.1186/s40200-015-0164-z · Cited by 45 · see citing works
Winklhofer‐Roob, B. M., Faustmann, G., & Roob, J. M. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.04.345 · Cited by 44 · see citing works
Quantification of reduced glutathione by HPLC‐UV in erythrocytes of hemodialysis patients
García, S. C., Schott, K. L., Charão, M. F., Moro, A. M., Bulcão, R., Grotto, D., Valentini, J., Bohrer, D., Cardoso, S. G., & Pomblum, V. J. (2008) · Biomedical Chromatography · doi:10.1002/bmc.954 · Cited by 44 · see citing works
Liu, C., Chang, J., Zhang, L., Zhang, J., & Li, S. (2012) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2012.03.006 · Cited by 44 · see citing works
Fujii, J. (2015) · World Journal of Nephrology · doi:10.5527/wjn.v4.i2.213 · Cited by 43 · see citing works
RETRACTED: Proteomic studies on lactic acid bacteria: A review
Vinusha, K. S., Deepika, K., Johnson, T. S., Agrawal, G. K., & Rakwal, R. (2018) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2018.04.009 · Cited by 43 · see citing works
RetractedSafety Assessment of the Human Milk-Isolated Probiotic Lactobacillus salivarius CECT5713
Lara‐Villoslada, F., Sierra, S., Díaz-Ropero, M. P., Olivares, M. M., & Xaus, J. (2007) · Journal of Dairy Science · doi:10.3168/jds.2006-685 · Cited by 42 · see citing works
Racine, M. L., & Dinenno, F. A. (2019) · The Journal of Physiology · doi:10.1113/jp278338 · Cited by 40 · see citing works
Optimization of selenizing conditions for Seleno-Lentinan and its characteristics
Ren, G., Li, K., Hu, Y., Yu, M., Qu, J., & Xu, X. (2015) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2015.08.012 · Cited by 39 · see citing works
Safety Assessment ofLactobacillus fermentumCECT5716, a probiotic strain isolated from human milk
Lara‐Villoslada, F., Sierra, S., Díaz-Ropero, M. P., Rodríguez, J. M., Xaus, J., & Olivares, M. M. (2009) · Journal of Dairy Research · doi:10.1017/s0022029909004014 · Cited by 39 · see citing works
- Authors
- Gil, L., Siems, W., Mazurek, B., Gross, J., Schroeder, P., Voss, P., & Grune, T.
- Affiliations
- Instituto de Medicina Tropical “Pedro Kourí” (CU)
- Humboldt-Universität zu Berlin (DE)
- Heinrich Heine University Düsseldorf (DE)
- Corresponding author
- Voss, Peter
- Venue
- Free Radical Research
- Publisher
- Informa UK Limited
- Published
- 2006-01
- Volume
- 40
- Issue
- 5
- Pages
- 495-505
- ISSN
- 1029-2470 (ISSN-L)
- 1071-5762
- OpenAlex
- W2061523541
- Cited by
- 242
- References
- 59
- Citations by year
- 2026: 2 · 2025: 11 · 2024: 7 · 2023: 5 · 2022: 9 · 2021: 10 · 2020: 7 · 2019: 8 · 2018: 11 · 2017: 11 · 2016: 14 · 2015: 18 · 2014: 17 · 2013: 15 · 2012: 13
- FWCI
- 11.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Free Radical Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Alexander von Humboldt-Stiftung
- Deutsche Forschungsgemeinschaft
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- oxidative stress, aging, erythrocytes, plasma, malondialdehyde, protein carbonyls, reduced glutathione, glutathione disulfide, uric acid, age-related reference values, prooxidant-antioxidant balance, healthy adults
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Aging, Aldehydes, Erythrocytes, Female, Glutathione, Humans, Male, Malondialdehyde, Middle Aged, Oxidation-Reduction, Plasma, Sex Factors, Uric Acid, Biomarkers, Oxidative Stress, Glutathione Disulfide, Protein Carbonylation
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