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Reactive oxygen species in cardiovascular disease
Open accessAbstract
Based on the "free radical theory" of disease, researchers have been trying to elucidate the role of oxidative stress from free radicals in cardiovascular disease. Considerable data indicate that reactive oxygen species and oxidative stress are important features of cardiovascular diseases including atherosclerosis, hypertension, and congestive heart failure. However, blanket strategies with antioxidants to ameliorate cardiovascular disease have not generally yielded favorable results. However, our understanding of reactive oxygen species has evolved to the point at which we now realize these species have important roles in physiology as well as pathophysiology. Thus, it is overly simplistic to assume a general antioxidant strategy will yield specific effects on cardiovascular disease. Indeed, there are several sources of reactive oxygen species that are known to be active in the cardiovascular system. This review addresses our understanding of reactive oxygen species sources in cardiovascular disease and both animal and human data defining how reactive oxygen species contribute to physiology and pathology.
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“The expression of NOX4 is upregulated by TGF-β (201, 906).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [906]
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1 retracted
Uncoupling of Endothelial Nitric Oxidase Synthase by Hypochlorous Acid
Xu, J., Xie, Z., Reece, R., Pimental, D. R., & Zou, M. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000249394.94588.82 · Cited by 146
RetractedOxidants, oxidative stress and the biology of ageing
Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413
Aging: a theory based on free radical and radiation chemistry
Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567
Inflammation and Atherosclerosis
Libby, P., Ridker, P. M., & Maseri, A. (2002) · Circulation · doi:10.1161/hc0902.104353 · Cited by 7,724
The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
Bedard, K., & Krause, K.-H. (2007) · Physiological Reviews · doi:10.1152/physrev.00044.2005 · Cited by 6,989
Hydroperoxide metabolism in mammalian organs.
Chance, B., Sies, H., & Boveris, A. (1979) · Physiological Reviews · doi:10.1152/physrev.1979.59.3.527 · Cited by 5,827
Oxygen-Derived Free Radicals in Postischemic Tissue Injury
Epstein, F. H., & McCord, J. M. (1985) · New England Journal of Medicine · doi:10.1056/nejm198501173120305 · Cited by 5,399
Cillà, S. D., Farruggio, S., Vujosevic, S., Raina, G., Filippini, D. A., Gatti, V., Clemente, N., Mary, D., Vezzola, D., Casini, G., et al. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479441 · Cited by 5,154
Nitric oxide synthases: structure, function and inhibition
ALDERTON, W. K., COOPER, C. E., & KNOWLES, R. G. (2001) · Biochemical Journal · doi:10.1042/bj3570593 · Cited by 4,110
Cited by
Sorted by citations
Kamaly, N., Yameen, B., Wu, J., & Farokhzad, O. C. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00346 · Cited by 3,070
Cardiac Energy Metabolism in Heart Failure
Lopaschuk, G. D., Karwi, Q. G., Tian, R., Wende, A. R., & Abel, E. D. (2021) · Circulation Research · doi:10.1161/circresaha.121.318241 · Cited by 1,458
Vatansever, F., Melo, W., Avci, P., Vecchio, D., Sadasivam, M., Gupta, A., Chandran, R., Karimi, M., Parizotto, N. A., Yin, R., et al. (2013) · FEMS Microbiology Reviews · doi:10.1111/1574-6976.12026 · Cited by 1,157
Long-Lived Emissive Probes for Time-Resolved Photoluminescence Bioimaging and Biosensing
Zhang, K. Y., Yu, Q., Wei, H., Liu, S., Zhao, Q., & Huang, W. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00425 · Cited by 933
ROS and redox signaling in myocardial ischemia-reperfusion injury and cardioprotection
Cadenas, S. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.01.024 · Cited by 832
Sedger, L. M., & McDermott, M. (2014) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2014.07.016 · Cited by 814
Reviews on Mechanisms of In Vitro Antioxidant Activity of Polysaccharides
Wang, J., Hu, S., Nie, S., Yu, Q., & Xie, M. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/5692852 · Cited by 727
Vascular oxidative stress, nitric oxide and atherosclerosis
Li, H., Horke, S., & Förstermann, U. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.09.001 · Cited by 678
Liu, L., MacKenzie, K. R., Putluri, N., Maletić-Savatić, M., & Bellen, H. J. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.08.024 · Cited by 556
Huynh, K., Bernardo, B. C., McMullen, J. R., & Ritchie, R. H. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.01.003 · Cited by 556
Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation
Tejero, J., Shiva, S., & Gladwin, M. T. (2019) · Physiological Reviews · doi:10.1152/physrev.00036.2017 · Cited by 541
Antioxidants and human diseases
Rajendran, P., Nandakumar, N., Rengarajan, T., Palaniswami, R., Edwinoliver, N. G., Uppalapati, L., Gopas, J., & Nishigaki, I. (2014) · Clinica Chimica Acta · doi:10.1016/j.cca.2014.06.004 · Cited by 553
Regulation of Signal Transduction by Reactive Oxygen Species in the Cardiovascular System
Brown, D., & Griendling, K. K. (2015) · Circulation Research · doi:10.1161/circresaha.116.303584 · Cited by 498
Recent Advances and Uses of Grape Flavonoids as Nutraceuticals
Georgiev, V., Ananga, A., & Tsolova, V. M. (2014) · Nutrients · doi:10.3390/nu6010391 · Cited by 493
Role of pyroptosis in cardiovascular disease
Zeng, Z., Li, G., Wu, S., & Zuo, W. (2018) · Cell Proliferation · doi:10.1111/cpr.12563 · Cited by 500
Polyphenols and their benefits: A review
Rasouli, H., Farzaei, M. H., & Khodarahmi, R. (2017) · International Journal of Food Properties · doi:10.1080/10942912.2017.1354017 · Cited by 490
Polyphenols: Benefits to the Cardiovascular System in Health and in Aging
Khurana, S., Venkataraman, K., Hollingsworth, A., Piché, M., & Tai, T. C. (2013) · Nutrients · doi:10.3390/nu5103779 · Cited by 447
The effects of hypertension on the cerebral circulation
Pires, P. W., Dams, C. M., Matin, N., & Dorrance, A. M. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00490.2012 · Cited by 417
Deshmukh, P. H., Unni, S., Krishnappa, G., & Padmanabhan, B. (2016) · Biophysical Reviews · doi:10.1007/s12551-016-0244-4 · Cited by 405
Wang, Y., Li, L., Zhao, W., Dou, Y., An, H., Tao, H., Xu, X., Jia, Y., Lu, S., Zhang, J., et al. (2018) · ACS Nano · doi:10.1021/acsnano.8b02037 · Cited by 364
Current Progress in Reactive Oxygen Species (ROS)‐Responsive Materials for Biomedical Applications
Lee, S. H., Gupta, M. K., Bang, J. B., Bae, H., & Sung, H. (2013) · Advanced Healthcare Materials · doi:10.1002/adhm.201200423 · Cited by 352
Khan, J., Deb, P. K., Priya, S., Damian-Medina, K., Devi, R., Walode, S. G., & Rudrapal, M. (2021) · Molecules · doi:10.3390/molecules26134021 · Cited by 350
Ebselen, a promising antioxidant drug: mechanisms of action and targets of biological pathways
Azad, G. K., & Tomar, R. S. (2014) · Molecular Biology Reports · doi:10.1007/s11033-014-3417-x · Cited by 346
Hemostasis, endothelial stress, inflammation, and the metabolic syndrome
Grandl, G., & Wolfrum, C. (2017) · Seminars in Immunopathology · doi:10.1007/s00281-017-0666-5 · Cited by 358
Kehrer, J. P., & Klotz, L. (2015) · Critical Reviews in Toxicology · doi:10.3109/10408444.2015.1074159 · Cited by 359
Yao, Y., Zhang, H., Wang, Z., Ding, J., Wang, S., Huang, B., Ke, S., & Gao, C. (2019) · Journal of Materials Chemistry B · doi:10.1039/c9tb00847k · Cited by 324
Muthusamy, V. R., Kannan, S., Sadhaasivam, K., Gounder, S. S., Davidson, C. J., Boeheme, C., Hoidal, J. R., Wang, L., & Rajasekaran, N. S. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.10.440 · Cited by 317
Boron Chemicals in Diagnosis and Therapeutics
Das, B. C., Thapa, P., Karki, R., Schinke, C., Das, S., Kambhampati, S., Banerjee, S. K., Veldhuizen, P. J. V., Verma, A. K., Weiss, L. M., et al. (2013) · Future Medicinal Chemistry · doi:10.4155/fmc.13.38 · Cited by 280
Radiation-induced heart disease: a review of classification, mechanism and prevention
Wang, H., Wei, J., Zheng, Q., Meng, L., Xin, Y., Yin, X., & Jiang, X. M. (2019) · International Journal of Biological Sciences · doi:10.7150/ijbs.35460 · Cited by 284
Panchal, S. K., Poudyal, H., & Brown, L. (2012) · Journal of Nutrition · doi:10.3945/jn.111.157263 · Cited by 275
Current evidence on the effect of dietary polyphenols intake on chronic diseases
Costa, C., Tsatsakis, A. M., Mamoulakis, C., Teodoro, M., Briguglio, G., Caruso, E., Tsoukalas, D., Margina, D. M., Dardiotis, E., Kouretas, D., et al. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.10.023 · Cited by 262
Microvesicles: ROS scavengers and ROS producers
Bodega, G., Alique, M., Puebla, L., Carracedo, J., & Ramı́rez, R. (2019) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2019.1626654 · Cited by 263
Plant Polyphenols and Their Potential Benefits on Cardiovascular Health: A Review
Iqbal, I., Wilairatana, P., Saqib, F., Nasir, B., Wahid, M., Latif, M. F., Iqbal, A., Naz, R., & Mubarak, M. S. (2023) · Molecules · doi:10.3390/molecules28176403 · Cited by 271
Kapil, V., Khambata, R. S., Jones, D. A., Rathod, K., Primus, C., Massimo, G., Fukuto, J. M., & Ahluwalia, A. (2020) · Pharmacological Reviews · doi:10.1124/pr.120.019240 · Cited by 248
Redox Roles of Reactive Oxygen Species in Cardiovascular Diseases
He, F. J., & Zuo, L. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161126059 · Cited by 240
Montezano, A. C. I., & Touyz, R. M. (2012) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2012.01.017 · Cited by 237
Antioxidant properties of diverse cereal grains: A review on in vitro and in vivo studies.
Masisi, K., Beta, T., & Moghadasian, M. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2015.09.021 · Cited by 210
Protein Posttranslational Modifications: Roles in Aging and Age‐Related Disease
Santos, A. L., & Lindner, A. B. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/5716409 · Cited by 239
The role of declining adaptive homeostasis in ageing
Pomatto, L. C. D., & Davies, K. J. A. (2017) · The Journal of Physiology · doi:10.1113/jp275072 · Cited by 231
Links Between Ectopic Fat and Vascular Disease in Humans
Lim, S. K., & Meigs, J. B. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.303035 · Cited by 224
Antioxidant effects and mechanism of silymarin in oxidative stress induced cardiovascular diseases
Taleb, A., Ahmad, K. A., Ihsan, A. U., Qu, J., Lin, N., Hezam, K., Koju, N., Hui, L., & Qi-long, D. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.03.140 · Cited by 222
Mitochondrial Reactive Oxygen Species at the Heart of the Matter
Kornfeld, O. S., Hwang, S., Disatnik, M., Chen, C., Qvit, N., & Mochly‐Rosen, D. (2015) · Circulation Research · doi:10.1161/circresaha.116.305432 · Cited by 215
In Vitro/In Vivo Toxicity Evaluation and Quantification of Iron Oxide Nanoparticles
Patil, U., Adireddy, S., Jaiswal, A. R., Mandava, S. H., Lee, B. G., & Chrisey, D. B. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161024417 · Cited by 209
The Role of Nrf2-Mediated Pathway in Cardiac Remodeling and Heart Failure
Zhou, S., Sun, W., Zhang, Z., & Zheng, Y. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/260429 · Cited by 205
Molecular Characterization of Reactive Oxygen Species in Myocardial Ischemia-Reperfusion Injury
Zhou, T., Chuang, C., & Zuo, L. (2015) · BioMed Research International · doi:10.1155/2015/864946 · Cited by 200
I Diretriz sobre o consumo de Gorduras e Saúde Cardiovascular
Santos, R., Gagliardi, A., Xavier, H. T., Magnoni, C., Cassani, R., Lottenberg, A., Filho, A. C., Araújo, D., Cesena, F., Alves, R., et al. (2013) · Arquivos Brasileiros de Cardiologia · doi:10.5935/abc.2013s003 · Cited by 211
Antioxidant Therapeutic Strategies for Cardiovascular Conditions Associated with Oxidative Stress
Farías, J. G., Molina, V. M., Carrasco, R. A., Zepeda, A. B., Figueroa, E., Letelier, P. J., & Castillo, R. L. (2017) · Nutrients · doi:10.3390/nu9090966 · Cited by 195
Oxidative Stress in Radiation-Induced Cardiotoxicity
Ping, Z., Yang, P., Hong, L., Xinyong, C., Zhiyi, Z., Xiao-Cheng, W., Zeng, H., & Shao, L. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/3579143 · Cited by 194
Oxidative stress in patients with cardiovascular disease and chronic renal failure
Popolo, A., Autore, G., Pinto, A., & Marzocco, S. (2013) · Free Radical Research · doi:10.3109/10715762.2013.779373 · Cited by 185
Invited review: Whey proteins as antioxidants and promoters of cellular antioxidant pathways
Corrochano, A. R., Buckin, V. A., Kelly, P. M., & Giblin, L. M. (2018) · Journal of Dairy Science · doi:10.3168/jds.2017-13618 · Cited by 182
Oxidative Stress-Responsive MicroRNAs in Heart Injury
Kura, B., Bačová, B. S., Kaločayová, B., Sýkora, M., & Slezák, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21010358 · Cited by 184
Sun, Y., & Davis, E. W. (2021) · Nanomaterials · doi:10.3390/nano11030746 · Cited by 183
Neutrophil counts and cardiovascular disease
Luo, J. M., Thomassen, J. Q., Nordestgaard, B. G., Tybjærg‐Hansen, A., & Frikke‐Schmidt, R. (2023) · European Heart Journal · doi:10.1093/eurheartj/ehad649 · Cited by 183
Atherosclerotic cardiovascular disease: a review of initiators and protective factors
Ellulu, M. S., Patimah, I., Khaza’ai, H., Rahmat, A. B., Abed, Y. A., & Ali, F. (2016) · Inflammopharmacology · doi:10.1007/s10787-015-0255-y · Cited by 173
Reactive Oxygen Species Scavenging Nanomedicine for the Treatment of Ischemic Heart Disease
Zhang, Z., Dalan, R., Hu, Z., Wang, J., Chew, N., Poh, K. K., Tan, R., Soong, T. W., Dai, Y., Ye, L., et al. (2022) · Advanced Materials · doi:10.1002/adma.202202169 · Cited by 174
Gounder, S. S., Kannan, S., Devadoss, D., Miller, C. J., Whitehead, K. S., Odelberg, S. J., Firpo, M. A., Paine, R., Hoidal, J. R., Abel, E. D., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045697 · Cited by 173
Conner, T. S., Brookie, K. L., Richardson, A. C., & Polak, M. (2014) · British Journal of Health Psychology · doi:10.1111/bjhp.12113 · Cited by 183
MicroRNA-210 Controls Mitochondrial Metabolism and Protects Heart Function in Myocardial Infarction
Song, R., Dasgupta, C., Mulder, C., & Zhang, L. (2022) · Circulation · doi:10.1161/circulationaha.121.056929 · Cited by 171
Daiber, A., & Münzel, T. F. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6376 · Cited by 173
Authors' Perspective: What is the Optimum Intake of Vitamin C in Humans?
Frei, B. B., Birlouez‐Aragon, I., & Lykkesfeldt, J. (2012) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2011.649149 · Cited by 173
Nitric oxide synthase uncoupling: A therapeutic target in cardiovascular diseases
Roe, N. D., & Ren, J. T. (2012) · Vascular Pharmacology · doi:10.1016/j.vph.2012.02.004 · Cited by 161
Impact of Volatile Anesthetics on Oxidative Stress and Inflammation
Lee, Y.-M., Song, B. C., & Yeum, K. (2015) · BioMed Research International · doi:10.1155/2015/242709 · Cited by 154
Ullah, R., Khan, M., Shah, S. A., Saeed, K. M., & Kim, M. O. (2019) · Nutrients · doi:10.3390/nu11061195 · Cited by 158
Corin protects H2O2-induced apoptosis through PI3K/AKT and NF-κB pathway in cardiomyocytes
Li, Y., Xia, J., Jiang, N., Xian, Y.-Q., Ju, H.-N., Wei, Y., & Zhang, X. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.10.090 · Cited by 152
Li, L., Guo, J., Wang, Y., Xiong, X., Tao, H., Li, J., Jia, Y., Hu, H., & Zhang, J. (2018) · Advanced Science · doi:10.1002/advs.201800781 · Cited by 150
Tocopherols in the Prevention and Treatment of Atherosclerosis and Related Cardiovascular Disease
Mathur, P., Ding, Z., Saldeen, T. G. P., & Mehta, J. L. (2015) · Clinical Cardiology · doi:10.1002/clc.22422 · Cited by 155
Jong, K. A. D., & Lopaschuk, G. D. (2017) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2017.03.009 · Cited by 153
Mitochondria as a source and target of lipid peroxidation products in healthy and diseased heart
Anderson, E. J., Katunga, L. A., & Willis, M. S. (2011) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2011.05641.x · Cited by 146
Organic Peroxides in Aerosol: Key Reactive Intermediates for Multiphase Processes in the Atmosphere
Wang, S., Zhao, Y., Chan, A. W. H., Yao, M., Chen, Z., & Abbatt, J. P. D. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.2c00430 · Cited by 141
Assies, J., Mocking, R. J. T., Lok, A., Ruhé, H. G., Pouwer, F., & Schene, A. H. (2014) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12265 · Cited by 134
Nwanya, A. C., Ndipingwi, M. M., Ikpo, C. O., Obodo, R. M., Nwanya, S. C., Botha, S. S., Ezema, F. I., Iwuoha, E. I., & Mâaza, M. (2019) · Journal of Alloys and Compounds · doi:10.1016/j.jallcom.2019.153581 · Cited by 133
Reactive Oxygen Species: Physiological Roles in the Regulation of Vascular Cells
Vara, D. S., & Pula, G. (2014) · Current Molecular Medicine · doi:10.2174/1566524014666140603114010 · Cited by 135
Redox regulation of the actin cytoskeleton and its role in the vascular system
Xu, Q., Huff, L. P., Fujii, M., & Griendling, K. K. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.03.004 · Cited by 132
Cardioprotective Effect of Resveratrol in a Postinfarction Heart Failure Model
Riba, Á., Deres, L., Sümegi, B., Tóth, K., Szabados, E., & Halmosi, R. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/6819281 · Cited by 129
Mitjavila, M. T., & Moreno, J. J. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.07.017 · Cited by 126
Ezz, H. S. A., Khadrawy, Y. A., & Mourad, I. M. (2013) · Cytotechnology · doi:10.1007/s10616-013-9672-1 · Cited by 129
Diet-Derived Circulating Antioxidants and Risk of Coronary Heart Disease
Luo, J. M., le Cessie, S., van Heemst, D., & Noordam, R. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.10.048 · Cited by 128
Role of flavonoids in thrombotic, cardiovascular, and inflammatory diseases
Vazhappilly, C. G., Ansari, S. A., Al-Jaleeli, R., Al-Azawi, A. M., Ramadan, W. S. H., Menon, V., Hodeify, R. F., Siddiqui, S. S., Merheb, M. M., Matar, R., et al. (2019) · Inflammopharmacology · doi:10.1007/s10787-019-00612-6 · Cited by 127
Kalinowska, M., Gołębiewska, E., Świderski, G., Męczyńska‐Wielgosz, S., Lewandowska, H., Pietryczuk, A., Cudowski, A., Astel, A. M., Świsłocka, R., Samsonowicz, M., et al. (2021) · Nutrients · doi:10.3390/nu13093107 · Cited by 122
Mitochondrial calcium and reactive oxygen species in cardiovascular disease
Murphy, E., & Liu, J. C. (2022) · Cardiovascular Research · doi:10.1093/cvr/cvac134 · Cited by 123
Regulation of NAD(P)H oxidases by AMPK in cardiovascular systems
Song, P., & Zou, M. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.01.025 · Cited by 122
Kim, M., Sahu, A., Hwang, Y.-M., Kim, G. B., Nam, G., Kim, I., Kwon, I. C., & Tae, G. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119550 · Cited by 120
Biomarkers of Oxidative Stress Tethered to Cardiovascular Diseases
Panda, P., Verma, H. K., Lakkakula, S., Merchant, N., Kadir, F. B. M., Rahman, S., Jeffree, M. S., Bhaskar, L. V., & Pasupuleti, V. R. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/9154295 · Cited by 126
Zhang, Q., Zhang, F., Chen, Y., Dou, Y., Tao, H., Zhang, D., Wang, R., Li, X., & Zhang, J. (2017) · Chemistry of Materials · doi:10.1021/acs.chemmater.7b02412 · Cited by 118
The antioxidant activity of some curcuminoids and chalcones
Sökmen, M., & Khan, M. A. (2016) · Inflammopharmacology · doi:10.1007/s10787-016-0264-5 · Cited by 117
Volmert, B. D., Kiselev, A. M., Juhong, A., Wang, F., Riggs, A., Kostina, A. S., O’Hern, C., Muniyandi, P., Wasserman, A. H., Huang, A., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-43999-1 · Cited by 117
The renin–angiotensin system and its involvement in vascular disease
van Thiel, B. S., van der Pluijm, I., Riet, L. T., Essers, J., & Danser, A. H. J. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.03.090 · Cited by 120
Riaz, T., Iqbal, M. W., Mahmood, S., Yasmin, I., Leghari, A. A., Rehman, A., Mushtaq, A., Ali, K., Azam, M., & Bilal, M. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1963206 · Cited by 114
Guo, S., Yao, Q., Ke, Z., Chen, H., Wu, J., & Liu, C. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.05.034 · Cited by 114
Bulut, O., Akın, D., Sönmez, Ç., Öktem, A., Yücel, M., & Öktem, H. A. (2019) · Journal of Applied Phycology · doi:10.1007/s10811-018-1726-5 · Cited by 112
Turdi, S., Han, X., Huff, A. F., Roe, N. D., Hu, N., Gao, F., & Ren, J. T. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.07.084 · Cited by 113
RetractedReversibility of endothelial dysfunction in diabetes: role of polyphenols
Suganya, N., Bhakkiyalakshmi, E., Sarada, D. V. L., & Ramkumar, K. M. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114516001884 · Cited by 116
Protective Mechanisms of Quercetin Against Myocardial Ischemia Reperfusion Injury
Zhang, Y., Zhang, Z., & Wang, R. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00956 · Cited by 111
Kundur, A., Singh, I., & Bulmer, A. C. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.12.042 · Cited by 110
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Metadata
- Authors
- Sugamura, K., & Keaney
- Affiliations
- University of Massachusetts Chan Medical School (US)
- Corresponding author
- Keaney,, John F.
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2011-09
- Volume
- 51
- Issue
- 5
- Pages
- 978-992
- ISSN
- 0891-5849 (ISSN-L)
- PMC
- PMC3156326
- OpenAlex
- W2037586146
- Cited by
- 769
- References
- 304
- Citations by year
- 2026: 12 · 2025: 31 · 2024: 40 · 2023: 48 · 2022: 56 · 2021: 48 · 2020: 51 · 2019: 56 · 2018: 58 · 2017: 67 · 2016: 45 · 2015: 69 · 2014: 72 · 2013: 49 · 2012: 58
- FWCI
- 6.50
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Uehara Memorial Foundation
- Japan Heart Foundation
- National Institutes of Health
- Bayer Yakuhin
- National Heart, Lung, and Blood Institute (HL081587, R01HL098407, P01HL081587, HL098407, HL092122, R01HL092122)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 32520, P30DK032520)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- reactive oxygen species, oxidative stress, free radicals, cardiovascular disease, atherosclerosis, hypertension, congestive heart failure, antioxidants, antioxidant therapy, redox signaling
- MeSH terms
- Animals, Antioxidants, Cardiovascular Diseases, Clinical Trials as Topic, Heart, Humans, Biomarkers, Reactive Oxygen Species, Oxidative Stress, Molecular Targeted Therapy
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