Cytochrome P4502E1, oxidative stress, JNK, and autophagy in acute alcohol-induced fatty liver

Signal transduction by the JNK group of MAP kinases

Davis, R. J. (2000) · Cell · doi:10.1016/s0092-8674(00)00116-1 · Cited by 4,237 · see citing works

Autophagy as a regulated pathway of cellular degradation.

Klionsky, D., & Emr, S. (2000) · Science · doi:10.1126/science.290.5497.1717 · Cited by 3,794 · see citing works

mTOR regulation of autophagy

Jung, C. H., Ro, S.-H., Cao, J., Otto, N. M., & Kim, D.-H. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.01.017 · Cited by 2,090 · see citing works

mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway

Peterson, T. R., Sengupta, S., Harris, T. E., Carmack, A. E., Kang, S. A. W., Balderas, E., Guertin, D. A., Madden, K. L., Carpenter, A. E., Finck, B. N., et al. (2011) · Cell · doi:10.1016/j.cell.2011.06.034 · Cited by 1,233 · see citing works

Ethanol Induces Fatty Acid Synthesis Pathways by Activation of Sterol Regulatory Element-binding Protein (SREBP)

You, M., Fischer, M., Deeg, M. A., & Crabb, D. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202411200 · Cited by 543 · see citing works

Regulation of macroautophagy by mTOR and Beclin 1 complexes

Pattingre, S., Espert, L., Biard‐Piechaczyk, M., & Codogno, P. (2007) · Biochimie · doi:10.1016/j.biochi.2007.08.014 · Cited by 521 · see citing works

Autophagy Reduces Acute Ethanol-Induced Hepatotoxicity and Steatosis in Mice

Ding, W., Li, M., Chen, X., Ni, H., Lin, C., Gao, W., Lu, B., Stolz, D. B., Clemens, D. L., & Yin, X. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.07.041 · Cited by 515 · see citing works

C-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity

Gunawan, B. K., Liu, Z., Han, D., Hanawa, N., Gaarde, W. A., & Kaplowitz, N. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.03.045 · Cited by 471 · see citing works

Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Transcriptional and post-transcriptional regulation of the rat enzyme.

Song, B., Gelboin, H. V., Park, S. S., Yang, C. S., & Gonzalez, F. J. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)66620-7 · Cited by 405 · see citing works

JNK1 but not JNK2 promotes the development of steatohepatitis in mice

Schattenberg, J. M., Singh, R., Wang, Y., Lefkowitch, J. H., Rigoli, R. M., Scherer, P. E., & Czaja, M. J. (2006) · Hepatology · doi:10.1002/hep.20999 · Cited by 384 · see citing works

Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide

Kaneto, H., Nakatani, Y., Miyatsuka, T., Kawamori, D., Matsuoka, T., Matsuhisa, M., Kajimoto, Y., Ichijo, H., Yamasaki, Y., & Hori, M. (2004) · Nature Medicine · doi:10.1038/nm1111 · Cited by 337 · see citing works

Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice

Lu, Y., Zhuge, J., Wang, X., Bai, J., & Cederbaum, A. I. (2008) · Hepatology · doi:10.1002/hep.22222 · Cited by 310 · see citing works

c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity

Saito, C., Lemasters, J. J., & Jaeschke, H. (2010) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2010.04.015 · Cited by 269 · see citing works

Autophagy in the liver

Yin, X., Ding, W., & Gao, W. (2008) · Hepatology · doi:10.1002/hep.22146 · Cited by 254 · see citing works

Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance†

Singh, R., Wang, Y., Xiang, Y., Tanaka, K. E., Gaarde, W. A., & Czaja, M. J. (2008) · Hepatology · doi:10.1002/hep.22578 · Cited by 224 · see citing works

Autophagy in nonalcoholic steatohepatitis

Amir, M., & Czaja, M. J. (2011) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/egh.11.4 · Cited by 216 · see citing works

Tumor Necrosis Factor-induced Toxic Liver Injury Results from JNK2-dependent Activation of Caspase-8 and the Mitochondrial Death Pathway

Wang, Y., Singh, R., Lefkowitch, J. H., Rigoli, R. M., & Czaja, M. J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512953200 · Cited by 206 · see citing works

MAP kinase signaling in diverse effects of ethanol

Aroor, A. R., & Shukla, S. D. (2004) · Life Sciences · doi:10.1016/j.lfs.2003.11.001 · Cited by 204 · see citing works

c-Jun N-Terminal Protein Kinase 1 (JNK1), but Not JNK2, Is Essential for Tumor Necrosis Factor Alpha-Induced c-Jun Kinase Activation and Apoptosis

Liu, J., Minemoto, Y., & Lin, A. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.24.10844-10856.2004 · Cited by 201 · see citing works

c-Jun N-terminal Kinase-1 From Hematopoietic Cells Mediates Progression From Hepatic Steatosis to Steatohepatitis and Fibrosis in Mice

Kodama, Y., Kisseleva, T., Iwaisako, K., Miura, K., Taura, K., Minicis, S. D., Österreicher, C. H., Schnabl, B., Seki, E., & Brenner, D. A. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.06.045 · Cited by 195 · see citing works

Chronic alcohol-induced liver injury and oxidant stress are decreased in cytochrome P4502E1 knockout mice and restored in humanized cytochrome P4502E1 knock-in mice

Lu, Y., Wu, D., Wang, X., Ward, S. C., & Cederbaum, A. I. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.07.026 · Cited by 193 · see citing works

Hepatic steatosis in response to acute alcohol exposure in zebrafish requires sterol regulatory element binding protein activation #

Passeri, M. J., Cinaroglu, A., Gao, C., & Sadler, K. C. (2008) · Hepatology · doi:10.1002/hep.22667 · Cited by 190 · see citing works

Prevention of Steatosis by Hepatic JNK1

Sabio, G., Cavanagh, J., Ko, H. J., Jung, D. Y., Gray, S., Jun, J. Y., Barrett, T., Mora, A., Kim, J. K., & Davis, R. J. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.09.007 · Cited by 148 · see citing works

MOLECULAR ASPECTS OF ALCOHOL METABOLISM: Transcription Factors Involved in Early Ethanol-Induced Liver Injury

Nagy, L. E. (2004) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.24.012003.132258 · Cited by 145 · see citing works

Autophagy in health and disease. 2. Regulation of lipid metabolism and storage by autophagy: pathophysiological implications

Czaja, M. J. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00527.2009 · Cited by 138 · see citing works

Role of CYP2E1 in Ethanol-Induced Oxidant Stress, Fatty Liver and Hepatotoxicity

Cederbaum, A. I. (2010) · Digestive Diseases · doi:10.1159/000324289 · Cited by 131 · see citing works

JNK regulation of hepatic manifestations of the metabolic syndrome

Czaja, M. J. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.08.010 · Cited by 124 · see citing works

Free fatty acids stimulate autophagy in pancreatic β-cells via JNK pathway

Komiya, K., Uchida, T., Ueno, T., Koike, M., Abe, H., Hirose, T., Kawamori, R., Uchiyama, Y., Kominami, E., Fujitani, Y., et al. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.09.101 · Cited by 115 · see citing works

Selective Inactivation of c-Jun NH2-Terminal Kinase in Adipose Tissue Protects Against Diet-Induced Obesity and Improves Insulin Sensitivity in Both Liver and Skeletal Muscle in Mice

Zhang, X., Xu, A., Chung, S. K., Cresser, J., Sweeney, G., Wong, R. L. C., Lin, A., & Lam, K. S. L. (2011) · Diabetes · doi:10.2337/db10-0650 · Cited by 115 · see citing works

Autophagy and ethanol-induced liver injury

Donohue, T. M. (2009) · World Journal of Gastroenterology · doi:10.3748/wjg.15.1178 · Cited by 107 · see citing works

JNK2 Translocates to the Mitochondria and Mediates Cytochrome c Release in PC12 Cells in Response to 6-Hydroxydopamine

Eminel, S., Klettner, A., Roemer, L., Herdegen, T., & Waetzig, V. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405858200 · Cited by 103 · see citing works

Alcohol steatosis and cytotoxicity: The role of cytochrome P4502E1 and autophagy

Wu, D., Wang, X., Zhou, R., Yang, L., & Cederbaum, A. I. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.07.005 · Cited by 93 · see citing works

Different fatty acids inhibit apoB100 secretion by different pathways: unique roles for ER stress, ceramide, and autophagy

Caviglia, J. M., Gayet, C., Ota, T., Hernández‐Ono, A., Conlon, D., Jiang, H., Fisher, E. A. A., & Ginsberg, H. N. (2011) · Journal of Lipid Research · doi:10.1194/jlr.m016931 · Cited by 87 · see citing works

Rapid changes in cytochrome P4502E1 (CYP2E1) activity and other P450 isozymes following ethanol withdrawal in rats

Roberts, B. J., Shoaf, S. E., & Song, B. J. (1995) · Biochemical Pharmacology · doi:10.1016/0006-2952(95)00098-k · Cited by 82 · see citing works

Ischemic preconditioning induces autophagy and limits necrosis in human recipients of fatty liver grafts, decreasing the incidence of rejection episodes

Esposti, D. D., Sebagh, M., Pham, P., Reffas, M., Poüs, C., Brenner, C., Azoulay, D., & Lemoine, A. (2011) · Cell Death and Disease · doi:10.1038/cddis.2010.89 · Cited by 77 · see citing works

CYP2E1 enhances ethanol-induced lipid accumulation but impairs autophaghy in HepG2 E47 cells

Wu, D., Wang, X., Zhou, R., & Cederbaum, A. I. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.09.127 · Cited by 77 · see citing works

Ethanol rapidly causes activation of JNK associated with ER stress under inhibition of ADH

Nishitani, Y., & Matsumoto, H. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.11.030 · Cited by 58 · see citing works

Restoration of autophagy by puerarin in ethanol-treated hepatocytes via the activation of AMP-activated protein kinase

Noh, B.-K., Lee, J. K., Jun, H., Lee, J. H., Jia, Y., Hoang, M.-H., Kim, J. W., Park, K. H., & Lee, S. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.09.077 · Cited by 57 · see citing works

Differential Changes in MAP Kinases, Histone Modifications, and Liver Injury in Rats Acutely Treated With Ethanol

Aroor, A. R., James, T. T., Jackson, D. E., & Shukla, S. D. (2010) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01239.x · Cited by 54 · see citing works

Involvement of autophagy in alcoholic liver injury and hepatitis C pathogenesis

Osna, N. A. (2011) · World Journal of Gastroenterology · doi:10.3748/wjg.v17.i20.2507 · Cited by 37 · see citing works

Estrés oxidativo hepatocitario y hepatopatía alcohólica

de la Rosa, L. C., Moshage, H. J., & Nieto, N. (2008) · Revista Española de Enfermedades Digestivas · doi:10.4321/s1130-01082008000300006 · Cited by 36 · see citing works

Ethanol Enhances Susceptibility to Apoptotic Cell Death via Down-Regulation of Autophagy-Related Proteins

von Haefen, C., Sifringer, M., Menk, M., & Spies, C. (2011) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2011.01473.x · Cited by 34 · see citing works

Hepatitis C virus protein and iron overload induce hepatic steatosis through the unfolded protein response in mice

Nishina, S., Korenaga, M., Hidaka, I., Shinozaki, A., Sakai, A., Gondo, T., Tabuchi, M., Kishi, F., & Hino, K. (2010) · Liver International · doi:10.1111/j.1478-3231.2010.02210.x · Cited by 33 · see citing works

MnSOD Overexpression Prevents Liver Mitochondrial DNA Depletion after an Alcohol Binge but Worsens This Effect after Prolonged Alcohol Consumption in Mice

Mansouri, A., Tarhuni, A., Larosche, I., Reyl-Desmars, F., Demeilliers, C., Degoul, F., Nahon, P., Sutton, A., Moreau, R., Fromenty, B., et al. (2010) · Digestive Diseases · doi:10.1159/000324284 · Cited by 24 · see citing works

Hepatotoxicity mediated by pyrazole (cytochrome P450 2E1) plus tumor necrosis factor alpha treatment occurs in c-Jun N-terminal kinase 2-/- but not in c-Jun N-terminal kinase 1−/− mice

Wang, X., Wu, D., Yang, L., & Cederbaum, A. I. (2011) · Hepatology · doi:10.1002/hep.24540 · Cited by 19 · see citing works

Chronic ethanol feeding potentiates Fas Jo2-induced hepatotoxicity: Role of CYP2E1 and TNF-α and activation of JNK and P38 MAP kinase

Wang, X., Lu, Y., Xie, B., & Cederbaum, A. I. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.05.021 · Cited by 18 · see citing works

Ethanol induced induction of cytochrome P450 2E1 and activation of mitogen activated protein kinases in peripheral blood lymphocytes

Sharma, A., Saurabh, K., Yadav, S., Jain, S. K., & Parmar, D. (2011) · Xenobiotica · doi:10.3109/00498254.2011.624648 · Cited by 17 · see citing works

Effects of chronic ethanol treatment on the angiotensin II–mediated p42/p44 mitogen-activated protein kinase and phosphorylase a activation in rat hepatocytes

Weng, Y.-I., & Shukla, S. D. (2003) · Alcohol · doi:10.1016/s0741-8329(02)00325-7 · Cited by 9 · see citing works

Detection of a Fatty Liver After Binge Drinking

Korkusuz, H., Keese, D., Raschidi, B. A., Hübner, F., Namgaladze, D., Hintereder, G., Hammerstingl, R., Korkusuz, Y., Mönch, C., & Vogl, T. J. (2011) · Academic Radiology · doi:10.1016/j.acra.2011.07.009 · Cited by 9 · see citing works

Pathogenesis of alcoholic liver disease: Role of oxidative metabolism

Ceni, E., Mello, T., & Galli, A. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i47.17756 · Cited by 521 · see citing works

Absence of receptor interacting protein kinase 3 prevents ethanol-induced liver injury

Roychowdhury, S., McMullen, M. R., Pisano, S. G., Liu, X., & Nagy, L. E. (2013) · Hepatology · doi:10.1002/hep.26200 · Cited by 304 · see citing works

Alcoholic Liver Disease: Alcohol Metabolism, Cascade of Molecular Mechanisms, Cellular Targets, and Clinical Aspects

Teschke, R. (2018) · Biomedicines · doi:10.3390/biomedicines6040106 · Cited by 244 · see citing works

CYP2E1 potentiates binge alcohol-induced gut leakiness, steatohepatitis, and apoptosis

Abdelmegeed, M. A., Banerjee, A., Jang, S., Yoo, S.-H., Yun, J.-W., Gonzalez, F. J., Keshavarzian, A., & Song, B.-J. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.09.009 · Cited by 191 · see citing works

Liver autophagy: much more than just taking out the trash

Schneider, J. L., & Cuervo, A. M. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.211 · Cited by 189 · see citing works

Kupffer Cells

Slevin, E., Baiocchi, L., Wu, N., Ekser, B., Sato, K., Lin, E. P.-Y., Ceci, L., Chen, L., Ramos‐Lorenzo, S., Xu, W., et al. (2020) · American Journal Of Pathology · doi:10.1016/j.ajpath.2020.08.014 · Cited by 164 · see citing works

Cannabidiol protects liver from binge alcohol-induced steatosis by mechanisms including inhibition of oxidative stress and increase in autophagy

Yang, L., Rozenfeld, R., Wu, D., Devi, L. A., Zhang, Z., & Cederbaum, A. I. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.12.026 · Cited by 137 · see citing works

Cardiovascular risk, lipidemic phenotype and steatosis. A comparative analysis of cirrhotic and non-cirrhotic liver disease due to varying etiology

Loria, P., Marchesini, G., Nascimbeni, F., Ballestri, S., Maurantonio, M., Carubbi, F., Ratziu, V., & Lonardo, A. (2013) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.10.030 · Cited by 135 · see citing works

Critical Roles of Kupffer Cells in the Pathogenesis of Alcoholic Liver Disease: From Basic Science to Clinical Trials

Zeng, T., Zhang, C., Xiao, M., Yang, R., & Xie, K. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00538 · Cited by 130 · see citing works

Mitochondrial dysfunction and tissue injury by alcohol, high fat, nonalcoholic substances and pathological conditions through post-translational protein modifications

Song, B.-J., Akbar, M., Abdelmegeed, M. A., Byun, K., Lee, B., Yoon, S. K., & Hardwick, J. P. (2014) · Redox Biology · doi:10.1016/j.redox.2014.10.004 · Cited by 123 · see citing works

Cytochrome P450S and Alcoholic Liver Disease

Lu, Y., & Cederbaum, A. I. (2018) · Current Pharmaceutical Design · doi:10.2174/1381612824666180410091511 · Cited by 116 · see citing works

Impairment of Akt activity by CYP2E1 mediated oxidative stress is involved in chronic ethanol-induced fatty liver

Zeng, T., Zhang, C., Zhao, N., Guan, M.-J., Xiao, M., Yang, R., Zhao, X., Yu, L.-H., Zhu, Z., & Xie, K. (2017) · Redox Biology · doi:10.1016/j.redox.2017.09.018 · Cited by 113 · see citing works

Hydrogen sulfide exposure induces jejunum injury via CYP450s/ROS pathway in broilers

Zheng, S., Jin, X., Chen, M., Shi, Q., Zhang, H., & Xu, S. (2018) · Chemosphere · doi:10.1016/j.chemosphere.2018.09.002 · Cited by 110 · see citing works

Role of CYP2E1 in Mitochondrial Dysfunction and Hepatic Injury by Alcohol and Non-Alcoholic Substances

Abdelmegeed, M. A., Ha, S.-K., Choi, Y., Akbar, M. D., & Song, B. (2017) · Current Molecular Pharmacology · doi:10.2174/1874467208666150817111114 · Cited by 102 · see citing works

New advances in molecular mechanisms and emerging therapeutic targets in alcoholic liver diseases

Williams, J., Manley, S., & Ding, W. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i36.12908 · Cited by 102 · see citing works

Regulation of the effects of CYP2E1-induced oxidative stress by JNK signaling

Schattenberg, J. M., & Czaja, M. J. (2014) · Redox Biology · doi:10.1016/j.redox.2014.09.004 · Cited by 98 · see citing works

Nrf2 Knockdown Disrupts the Protective Effect of Curcumin on Alcohol-Induced Hepatocyte Necroptosis

Lu, C., Xu, W., Zhang, F., Shao, J., & Zheng, S. (2016) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.6b00562 · Cited by 97 · see citing works

Environmental Influences in the Etiology of Colorectal Cancer: the Premise of Metabolomics

Rattray, N. J. W., Charkoftaki, G., Rattray, Z., Hansen, J. E., Vasiliou, V., & Johnson, C. H. (2017) · Current Pharmacology Reports · doi:10.1007/s40495-017-0088-z · Cited by 88 · see citing works

Activation of autophagy by globular adiponectin attenuates ethanol-induced apoptosis in HepG2 cells: Involvement of AMPK/FoxO3A axis

Nepal, S., & Park, P. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.05.013 · Cited by 84 · see citing works

Inhibition of autophagy promotes CYP2E1-dependent toxicity in HepG2 cells via elevated oxidative stress, mitochondria dysfunction and activation of p38 and JNK MAPK

Wu, D., & Cederbaum, A. I. (2013) · Redox Biology · doi:10.1016/j.redox.2013.10.008 · Cited by 84 · see citing works

Role for intestinal CYP2E1 in alcohol-induced circadian gene-mediated intestinal hyperpermeability

Forsyth, C. B., Voigt, R. M., Shaikh, M. W., Tang, Y., Cederbaum, A. I., Turek, F. W., & Keshavarzian, A. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00354.2012 · Cited by 79 · see citing works

Pomegranate prevents binge alcohol-induced gut leakiness and hepatic inflammation by suppressing oxidative and nitrative stress

Cho, Y.-E., & Song, B.-J. (2018) · Redox Biology · doi:10.1016/j.redox.2018.07.012 · Cited by 78 · see citing works

Role of Zinc in the Regulation of Autophagy During Ethanol Exposure in Human Hepatoma Cells

Liuzzi, J. P., & Yoo, C. (2013) · Biological Trace Element Research · doi:10.1007/s12011-013-9816-3 · Cited by 78 · see citing works

Nutritional Support for Alcoholic Liver Disease

Tadokoro, T., Morishita, A., Himoto, T., & Masaki, T. (2023) · Nutrients · doi:10.3390/nu15061360 · Cited by 66 · see citing works

Autophagy, Oxidative Stress, and Alcoholic Liver Disease: A Systematic Review and Potential Clinical Applications

Salete-Granado, D., Carbonell, C., Puertas-Miranda, D., Vega-Rodríguez, V.-J., Macia, M. G., Herrero, A. B., & Marcos, M. (2023) · Antioxidants · doi:10.3390/antiox12071425 · Cited by 65 · see citing works

Autophagy Protects against CYP2E1/Chronic Ethanol-Induced Hepatotoxicity

Lu, Y., & Cederbaum, A. I. (2015) · Biomolecules · doi:10.3390/biom5042659 · Cited by 60 · see citing works

Lipophagy and Alcohol-Induced Fatty Liver

Li, Y., Yang, C., Thomes, P. G., Kharbanda, K. K., Casey, C. A., McNiven, M. A., & Donohue, T. M. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00495 · Cited by 60 · see citing works

Translational Implications of the Alcohol-Metabolizing Enzymes, Including Cytochrome P450-2E1, in Alcoholic and Nonalcoholic Liver Disease

Song, B., Akbar, M. D., Jo, I., Hardwick, J. P., & Abdelmegeed, M. A. (2015) · Advances in pharmacology · doi:10.1016/bs.apha.2015.04.002 · Cited by 49 · see citing works

Corosolic acid protects hepatocytes against ethanol-induced damage by modulating mitogen-activated protein kinases and activating autophagy

Guo, X., Cui, R., Zhao, J., Mo, R., Peng, L., & Yan, M. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.09.031 · Cited by 47 · see citing works

Oral or Intraperitoneal Binge Drinking and Oxidative Balance in Adolescent Rats

Nogales, F., Rua, R. M., Ojeda, M. L., Murillo, M. L. O., & Carreras, O. (2014) · Chemical Research in Toxicology · doi:10.1021/tx5002628 · Cited by 43 · see citing works

Chemical composition, antioxidant properties and hepatoprotective effects of chamomile (Matricaria recutita L.) decoction extract against alcohol-induced oxidative stress in rat

Sebaï, H., Jabri, M., Souli, A., Hosni, K., Rtibi, K., Tebourbi, O., Benna, J. E., & Sakly, M. (2015) · General Physiology and Biophysics · doi:10.4149/gpb_2014039 · Cited by 40 · see citing works

Endogenously elevated n‐3 polyunsaturated fatty acids alleviate acute ethanol‐induced liver steatosis

Huang, W. Y., Wang, B., Li, X., & Kang, J. X. (2015) · BioFactors · doi:10.1002/biof.1246 · Cited by 39 · see citing works

ATF3 mediates inhibitory effects of ethanol on hepatic gluconeogenesis

Tsai, W., Matsumura, S., Liu, W., Phillips, N., Sonntag, T., Hao, E., Lee, S., Hai, T., & Montminy, M. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1424641112 · Cited by 38 · see citing works

Ethanol Induces Platelet Apoptosis

Liu, L., Chen, M., Zhao, L., Zhao, Q., Hu, R., Zhu, J., Yan, R., & Dai, K. (2017) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13295 · Cited by 38 · see citing works

Molecular Effectors of Photodynamic Therapy-Mediated Resistance to Cancer Cells

Aniogo, E. C., George, B. P. A., & Abrahamse, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413182 · Cited by 38 · see citing works

Identification of cytochrome CYP2E1 as critical mediator of synergistic effects of alcohol and cellular lipid accumulation in hepatocytes in vitro

Mahli, A., Thasler, W. E., Patsenker, E., Müller, S., Stickel, F., Müller, M., Seitz, H. K., Cederbaum, A. I., & Hellerbrand, C. (2015) · Oncotarget · doi:10.18632/oncotarget.6203 · Cited by 30 · see citing works

Effects of Different Green Tea Extracts on Chronic Alcohol Induced‐Fatty Liver Disease by Ameliorating Oxidative Stress and Inflammation in Mice

Li, B., Li, H., Zhou, D.-D., Huang, S., Luo, M., Gan, R., Mao, Q., Saimaiti, A., Shang, A., & Li, H. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/5188205 · Cited by 29 · see citing works

Synergistic Toxic Interactions Between CYP2E1, LPS/TNFα, and JNK/p38 MAP Kinase and Their Implications in Alcohol-Induced Liver Injury

Cederbaum, A. I., Lu, Y., Wang, X., & Wu, D. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-09614-8_9 · Cited by 29 · see citing works

Nerve Growth Factor Protects Against Alcohol-Induced Neurotoxicity in PC12 Cells via PI3K/Akt/mTOR Pathway

Liu, L., Sun, T., Xin, F., Cui, W., Guo, J., & Hu, J. (2016) · Alcohol and Alcoholism · doi:10.1093/alcalc/agw077 · Cited by 28 · see citing works

Cilostazol protects hepatocytes against alcohol-induced apoptosis via activation of AMPK pathway

Lee, Y. J., Shu, M.-S., Kim, J., Kim, Y.-H., Sim, K. H., Sung, W. J., & Eun, J. R. (2019) · PLoS ONE · doi:10.1371/journal.pone.0211415 · Cited by 27 · see citing works

Root bark of Ulmus davidiana var. japonica restrains acute alcohol-induced hepatic steatosis onset in mice by inhibiting ROS accumulation

Pan, J. H., Lim, Y., Kim, J. H., Heo, W., Lee, K. Y., Shin, H. J., Kim, J. K., Lee, J. H., & Kim, Y. J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0188381 · Cited by 26 · see citing works

Combining Photodynamic Therapy and Targeted Drug Delivery Systems: Enhancing Mitochondrial Toxicity for Improved Cancer Outcomes

Merlin, J. P. J., Crous, A., & Abrahamse, H. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251910796 · Cited by 25 · see citing works

Network Pharmacology-Based Antioxidant Effect Study of Zhi-Zi-Da-Huang Decoction for Alcoholic Liver Disease

Li, A., & Fěng, F. (2015) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2015/492470 · Cited by 25 · see citing works

Autophagy and microRNA dysregulation in liver diseases

Kim, K. M., & Kim, S. G. (2014) · Archives of Pharmacal Research · doi:10.1007/s12272-014-0439-9 · Cited by 22 · see citing works

Babao Dan attenuates acute ethanol-induced liver injury via Nrf2 activation and autophagy

Yu, Y., Tian, Z., Liang, L., Yang, X. F., Sheng, D., Zeng, J., Li, X., Shi, R., Han, Z., & Wei, L.-X. (2019) · Cell & Bioscience · doi:10.1186/s13578-019-0343-6 · Cited by 22 · see citing works

Identification of serum insulin-like growth factor binding protein 1 as diagnostic biomarker for early-stage alcohol-induced liver disease

Li, H.-H., Doiron, K., Patterson, A. D., Gonzalez, F. J., & Fornace, A. J. (2013) · Journal of Translational Medicine · doi:10.1186/1479-5876-11-266 · Cited by 21 · see citing works

Synthesis, characterization and hepatoprotective effect of silymarin phytosome nanoparticles on ethanol-induced hepatotoxicity in rats

Mahmoudabad, A. G., Gheybi, F., Mehrabi, M., Masoudi, A., Mobasher, Z., Vahedi, H., Gharravi, A. M., Bitaraf, F. S., & Rezayat, S. M. (2023) · Bioimpacts · doi:10.34172/bi.2023.24128 · Cited by 21 · see citing works

Modulation of Atg5 expression by globular adiponectin contributes to autophagy flux and suppression of ethanol-induced cell death in liver cells

Nepal, S., Kim, M. J., Lee, E.-S., Kim, J., Choi, D., Sohn, D., Lee, S., Song, K., Kim, S., Jeong, G., et al. (2014) · Food and Chemical Toxicology · doi:10.1016/j.fct.2014.02.027 · Cited by 21 · see citing works

Nrf2 signalling pathway and autophagy impact on the preventive effect of green tea extract against alcohol-induced liver injury

Zhang, Y., Yang, X., Yu, D., Xiao, H., & Du, J. (2021) · Journal of Pharmacy and Pharmacology · doi:10.1093/jpp/rgab027 · Cited by 18 · see citing works

Perspective on alcohol-induced organ damage via autophagy-dependent cellular changes

Bakheet, A., Anbazhagan, M., Barve, S. S., Dasarathy, S., Dickinson, J. J., Ding, W., Donohue, T. M., Gopal, T., Gukovskaya, A. S., Kharbanda, K. K., et al. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103879 · Cited by 16 · see citing works

Advancing Photodynamic Therapy with Nano-Conjugated Hypocrellin: Mechanisms and Clinical Applications

Rajan, S. S., Chandran, R., & Abrahamse, H. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s486014 · Cited by 16 · see citing works

Detailed review on phytosomal formulation attenuating new pharmacological therapies

Dwivedi, J., Sachan, P., Wal, P., Dwivedi, S., Sharma, M. C., & Rao, S. P. (2023) · Oriental Pharmacy and Experimental Medicine · doi:10.1007/s13596-023-00712-3 · Cited by 15 · see citing works

Narrative Review: Glucocorticoids in Alcoholic Hepatitis—Benefits, Side Effects, and Mechanisms

Lü, H. (2022) · Journal of Xenobiotics · doi:10.3390/jox12040019 · Cited by 13 · see citing works

Chronic intake of high-dose of blueberry leaf extract does not augment the harmful effects of ethanol in rats

Yamasaki, K., Sugamoto, K., Arakawa, T., Nishiyama, K., & Yamasaki, M. (2019) · PeerJ · doi:10.7717/peerj.6989 · Cited by 12 · see citing works

Causal roles of stress kinase JNK2 in DNA methylation and binge alcohol withdrawal-evoked behavioral deficits

Yang, M., Barrios, J., Yan, J., Zhao, W., Yuan, S., Dong, E., & Ai, X. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105375 · Cited by 11 · see citing works

Periplaneta americana extract alleviates steatohepatitis in a mouse model by modulating HMGB1-mediated inflammatory response

Xiao, Y., Gao, C., Wu, J., Li, J., Wang, L., You, Y., Peng, T., Zhang, K., Cao, M., & Hong, J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.995523 · Cited by 10 · see citing works

The Chemical Chaperone 4‐Phenylbutyric Acid Prevents Alcohol‐Induced Liver Injury in Obese KK‐Ay Mice

Suzuki, M., Kon, K., Ikejima, K., Arai, K., Uchiyama, A., Aoyama, T., Yamashina, S., Ueno, T., & Watanabe, S. (2019) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13982 · Cited by 10 · see citing works

Fabrication of molecularly imprinted polymer‐based interdigital sensor for L‐ascorbic acid

Akbar, M., Sadiq, N., Shakoor, M., Shafique, M., Tahir, A., Zahid, M., & Mustafa, G. (2023) · Surface and Interface Analysis · doi:10.1002/sia.7266 · Cited by 9 · see citing works

Protective Effects of Curcumin against Alcoholic Fatty Liver

Khoshakhlagh, M., Butler, A. E., Jamialahmadi, T., & Sahebkar, A. (2023) · Current Medicinal Chemistry · doi:10.2174/0929867331666230815113921 · Cited by 9 · see citing works

CYP2E1, oxidative stress and MAPK signaling pathways in alcohol-induced hepatotoxicity

Yang, L., Wu, D., & Cederbaum, A. I. (2014) · Cited by 8 · see citing works

Anti-inflammatory Effects of Alcohol Are Associated with JNK-STAT3 Downregulation in an In Vitro Inflammation Model in HepG2 Cells

Mörs, K., Sturm, R., Hörauf, J.-A., Kany, S., Cavalli, P., Omari, J., Powerski, M. J., Surov, A., Marzi, İ., Nowak, A. J., et al. (2021) · Disease Markers · doi:10.1155/2021/6622701 · Cited by 8 · see citing works

Inhibition of Abelson Tyrosine-Protein Kinase 2 Suppresses the Development of Alcohol-Associated Liver Disease by Decreasing PPARgamma Expression

Malnassy, G., Keating, C. R., Gad, S. A., Bridgeman, B. B., Perera, A., Hou, W., Cotler, S. J., Ding, X., Choudhry, M. A., Sun, Z., et al. (2023) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2023.07.006 · Cited by 8 · see citing works

Food plants as adjuvant medicines: a review of protective effects and clinical potential in alcoholic liver disease

Li, C., Zhang, Q., Chen, Z., Hu, W., & Liu, F. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1586238 · Cited by 7 · see citing works

Autophagy in ethanol-exposed liver disease

Wang, L., Zhu, G., Shi, K., Braddock, M., & Zheng, M. (2015) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2015.1052065 · Cited by 7 · see citing works

The Role of Oxidative Stress in Chronic Liver Diseases

Ezhilarasan, D., Rajeshkumar, S., & Thangavelu, L. P. (2020) · Springer eBooks · doi:10.1007/978-981-15-1568-2_2 · Cited by 7 · see citing works

Stress-driven cardiac calcium mishandling via a kinase-to-kinase crosstalk

McKee, C., Bare, D. J., & Ai, X. (2021) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-021-02533-2 · Cited by 7 · see citing works

Hydrogen gas alleviates acute alcohol‑induced liver injury by inhibiting JNK activation

Zhang, Y., Bi, M., Chen, Z., Dai, M., Zhou, G., Hu, Y., Yang, H., & Guan, W. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.9884 · Cited by 7 · see citing works

Myeloid Mixed Lineage Kinase 3 Contributes to Chronic Ethanol-Induced Inflammation and Hepatocyte Injury in Mice

McCullough, R. L., Saikia, P., Pollard, K. A., McMullen, M. R., Nagy, L. E., & Roychowdhury, S. (2016) · Gene Expression · doi:10.3727/105221616x691730 · Cited by 6 · see citing works

Long-Term Alcohol-Activated c-Jun N-terminal Kinase Isoform 2 Preserves Cardiac Function but Drives Ca2+-Triggered Arrhythmias

Ricchiuti, N., Chenoweth, K. P., Gao, X., Bare, D. J., Yan, J., & Ai, X. (2023) · Cells · doi:10.3390/cells12182233 · Cited by 5 · see citing works

Hepatocyte-specific mitogen-activated protein kinase phosphatase 1 in sexual dimorphism and susceptibility to alcohol induced liver injury

Walter, M. N., Montoya-Durango, D. E., Rodriguez, W. E., Wang, Y., Zhang, J., Chariker, J. H., Rouchka, E. C., Maldonado, C. J., Bennett, A. M., McClain, C. J., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1316228 · Cited by 5 · see citing works

The JNK signaling pathway as a potential new target for depression

Zhang, J., & Lin, W. (2018) · Chinese Science Bulletin (Chinese Version) · doi:10.1360/n972018-00157 · Cited by 5 · see citing works

Lactobacillus rhamnosus GG Combined with Metformin Alleviates Alcohol-Induced Liver Inflammation in Mice by Maintaining the Intestinal Barrier and Regulating Treg/Th1 Cells

Zhu, Y., Pan, Y., Wang, X., Wei, L., Zhu, L., Yu, G., Jin, H., Gu, Y., Wang, Y., Chen, Y., et al. (2025) · Journal of Medicinal Food · doi:10.1089/jmf.2024.k.0184 · Cited by 3 · see citing works

Deficiency of NLR family member NLRC5 alleviates alcohol induced hepatic injury and steatosis by enhancing autophagy of hepatocytes

Wu, Y., Huang, C., Shi, T., & Li, J. (2023) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2023.116406 · Cited by 3 · see citing works

Ammonia exposure-triggered redox imbalance with the occurrence of inflammatory response, cell apoptosis, and the circadian clock disturbance leads to lung injury in growing pigs

Tang, S., Liu, Z., Deng, F., Xu, Y., Zhong, R., Chen, L., & Zhang, H. (2024) · Air Quality Atmosphere & Health · doi:10.1007/s11869-024-01607-1 · Cited by 3 · see citing works

Cytochrome P4502E1, Oxidative Stress, JNK, and Autophagy in Acute Alcohol-Induced Fatty Liver

Cederbaum, A. I. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-405877-4.00024-x · Cited by 3 · see citing works

Cell-Specific Effects of Ethanol on Nitric Oxide Synthase Induced by Inflammatory Mediators

Obih, P., & Potter, B. J. (2014) · Pharmacology &amp Pharmacy · doi:10.4236/pp.2014.513132 · Cited by 1 · see citing works

The effect of ethanol on the mechanisms of liver antioxidant defence – a review of rodent model studies

Kołota, A. (2020) · Alcoholism and Drug Addiction · doi:10.5114/ain.2020.95981 · Cited by 1 · see citing works

Host homeostatic responses to alcohol-induced cellular stress in animal models of alcoholic liver disease

Wang, H. J., Murray, G. J., & Jung, M. K. (2015) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2015.1069705

Oxidative stress and endoplasmic reticulum stress induced hepatic steatosis

Liu, D., & Han, C. (2014)

Liver Cirrhosis with Steatohepatitis: Nonalcoholic Steatohepatitis and Alcoholic Steatohepatitis

Miyake, T., & Hiasa, Y. (2019) · Springer eBooks · doi:10.1007/978-981-13-7979-6_1

Peer Review #1 of "Chronic intake of high-dose of blueberry leaf extract does not augment the harmful effects of ethanol in rats (v0.1)"

(2019) · PeerJ · doi:10.7287/peerj.6989v0.1/reviews/1

Peer Review #1 of "Chronic intake of high-dose of blueberry leaf extract does not augment the harmful effects of ethanol in rats (v0.2)"

(2019) · PeerJ · doi:10.7287/peerj.6989v0.2/reviews/1

Peer Review #2 of "Chronic intake of high-dose of blueberry leaf extract does not augment the harmful effects of ethanol in rats (v0.1)"

(2019) · PeerJ · doi:10.7287/peerj.6989v0.1/reviews/2

Flos Puerariae-Semen Hoveniae herb pair ameliorates acute alcohol-induced liver injury by dual-modulating IL-11-driven inflammation and restoring lipid homeostasis via the PI3K/AKT/mTO pathway

Li, S., Wang, P., Xu, Y., Shang, Y., Zhao, S., Yu, C., Yu, J. H., Chi, M., & Han, F. (2026) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2026.122174

CYP2E1, oxidative stress and MAPK signaling pathways in alcohol-induced hepatotoxicity

Yang, L., Wu, D., & Cederbaum, A. I. (2014) · Cited by 8 · see citing works

Regulation of the effects of CYP2E1-induced oxidative stress by JNK signaling

Schattenberg, J. M., & Czaja, M. J. (2014) · Redox Biology · doi:10.1016/j.redox.2014.09.004 · Cited by 98 · see citing works

Alcohol steatosis and cytotoxicity: The role of cytochrome P4502E1 and autophagy

Wu, D., Wang, X., Zhou, R., Yang, L., & Cederbaum, A. I. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.07.005 · Cited by 93 · see citing works

Identification of cytochrome CYP2E1 as critical mediator of synergistic effects of alcohol and cellular lipid accumulation in hepatocytes in vitro

Mahli, A., Thasler, W., Patsenker, E., Müller, S., Stickel, F., Müller, M., Seitz, H., Cederbaum, A. I., & Hellerbrand, C. (2015) · Zeitschrift für Gastroenterologie · doi:10.1055/s-0035-1568037 · Cited by 2 · see citing works

Synergistic Toxic Interactions Between CYP2E1, LPS/TNFα, and JNK/p38 MAP Kinase and Their Implications in Alcohol-Induced Liver Injury

Cederbaum, A. I., Lu, Y., Wang, X., & Wu, D. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-09614-8_9 · Cited by 29 · see citing works