Pathogenesis of alcoholic liver disease: Role of oxidative metabolism
Open accessAbstract
Alcohol consumption is a predominant etiological factor in the pathogenesis of chronic liver diseases, resulting in fatty liver, alcoholic hepatitis, fibrosis/cirrhosis, and hepatocellular carcinoma (HCC). Although the pathogenesis of alcoholic liver disease (ALD) involves complex and still unclear biological processes, the oxidative metabolites of ethanol such as acetaldehyde and reactive oxygen species (ROS) play a preeminent role in the clinical and pathological spectrum of ALD. Ethanol oxidative metabolism influences intracellular signaling pathways and deranges the transcriptional control of several genes, leading to fat accumulation, fibrogenesis and activation of innate and adaptive immunity. Acetaldehyde is known to be toxic to the liver and alters lipid homeostasis, decreasing peroxisome proliferator-activated receptors and increasing sterol regulatory element binding protein activity via an AMP-activated protein kinase (AMPK)-dependent mechanism. AMPK activation by ROS modulates autophagy, which has an important role in removing lipid droplets. Acetaldehyde and aldehydes generated from lipid peroxidation induce collagen synthesis by their ability to form protein adducts that activate transforming-growth-factor-β-dependent and independent profibrogenic pathways in activated hepatic stellate cells (HSCs). Furthermore, activation of innate and adaptive immunity in response to ethanol metabolism plays a key role in the development and progression of ALD. Acetaldehyde alters the intestinal barrier and promote lipopolysaccharide (LPS) translocation by disrupting tight and adherent junctions in human colonic mucosa. Acetaldehyde and LPS induce Kupffer cells to release ROS and proinflammatory cytokines and chemokines that contribute to neutrophils infiltration. In addition, alcohol consumption inhibits natural killer cells that are cytotoxic to HSCs and thus have an important antifibrotic function in the liver. Ethanol metabolism may also interfere with cell-mediated adaptive immunity by impairing proteasome function in macrophages and dendritic cells, and consequently alters allogenic antigen presentation. Finally, acetaldehyde and ROS have a role in alcohol-related carcinogenesis because they can form DNA adducts that are prone to mutagenesis, and they interfere with methylation, synthesis and repair of DNA, thereby increasing HCC susceptibility.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Acetaldehyde activates HSCs in ALD by inducing oxidative stress.
“An accumulating body of evidence indicates that acetaldehyde activates HSCs in ALD by inducing oxidative stress [60].”
From Pathophysiological Aspects of Alcohol Metabolism in the Liver (2021) · cites this paper as [60]
MAA adducts are found in HSCs, liver sinusoidal endothelial cells, and Kupffer cells in ALD models; they stimulate transformation of HSCs into activated myofibroblasts, resulting in elevated production of profibrotic factors such as PDGF, and can induce proinflammatory cytokines such as TNF-α, IL-12, IL-18, and MIF.
“In addition to individual AA and MDA adducts, MAA adducts (AA-MDA-protein hybrid adducts) are found in HSCs, liver sinusoidal endothelial cells, and Kupffer cells in ALD models.”
From Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury (2021) · cites this paper as [222]
Cites
3 retracted
S-adenosyl-L-methionine for alcoholic liver diseases
Rambaldi, A., & Gluud, C. N. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002235.pub2 · Cited by 124 · see citing works
RetractedI148M PNPLA3 variant and progressive liver disease: A new paradigm in hepatology
Valenti, L. V. C., Alisi, A., & Nobili, V. (2012) · Hepatology · doi:10.1002/hep.25634 · Cited by 33 · see citing works
RetractedI148M PNPLA3 Variant and Progressive Liver Disease: A New Paradigm in Hepatology
Valenti, L. V. C., Alisi, A., & Nobili, V. (2011) · Hepatology · doi:10.1002/hep.25506 · Cited by 4 · see citing works
RetractedHydroperoxide metabolism in mammalian organs.
Chance, B., Sies, H., & Boveris, A. (1979) · Physiological Reviews · doi:10.1152/physrev.1979.59.3.527 · Cited by 5,827 · see citing works
Hepatocellular Carcinoma: Epidemiology and Molecular Carcinogenesis
El‐Serag, H. B., & Rudolph, K. L. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.04.061 · Cited by 5,401 · see citing works
Hypoxia-inducible factors in physiology and medicine
Semenza, G. L. (2012) · Cell · doi:10.1016/j.cell.2012.01.021 · Cited by 3,645 · see citing works
Yang, Y., Li, S., Yang, Q., Shi, Y., Zheng, M., Liu, Y., Chen, F., Song, G., Xu, H., Wan, T., et al. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000358696 · Cited by 3,262 · see citing works
Mechanisms of Hepatic Fibrogenesis
Friedman, S. L. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.03.003 · Cited by 2,640 · see citing works
Eaten alive: a history of macroautophagy
Yang, Z., & Klionsky, D. J. (2010) · Nature Cell Biology · doi:10.1038/ncb0910-814 · Cited by 2,096 · see citing works
TLR4 enhances TGF-β signaling and hepatic fibrosis
Seki, E., De Minicis, S., Österreicher, C. H., Kluwe, J., Osawa, Y., Brenner, D. A., & Schwabe, R. F. (2007) · Nature Medicine · doi:10.1038/nm1663 · Cited by 1,942 · see citing works
Regulation of Mammalian O <sub>2</sub> Homeostasis by Hypoxia-Inducible Factor 1
Semenza, G. L. (1999) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.15.1.551 · Cited by 1,914 · see citing works
Rifaximin Treatment in Hepatic Encephalopathy
Bass, N. M., Mullen, K. D., Sanyal, A., Poordad, F., Neff, G., Leevy, C. B., Sigal, S., Sheikh, M. Y., Beavers, K., Frederick, T., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0907893 · Cited by 1,300 · see citing works
mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway
Peterson, T. R., Sengupta, S., Harris, T. E., Carmack, A. E., Kang, S. A. W., Balderas, E., Guertin, D. A., Madden, K. L., Carpenter, A. E., Finck, B. N., et al. (2011) · Cell · doi:10.1016/j.cell.2011.06.034 · Cited by 1,233 · see citing works
Reactions of oxyl radicals with DNA
Breen, A. P., & Murphy, J. A. (1995) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)00209-3 · Cited by 1,038 · see citing works
Corticosteroid therapy of alcoholic hepatitis
Maddrey, W. C., Boitnott, J. K., Bedine, M. S., Weber, F. L., Mezey, E., & White, R. I. (1978) · Gastroenterology · doi:10.1016/0016-5085(78)90401-8 · Cited by 922 · see citing works
Cytochrome P-4502E1: its physiological and pathological role
Lieber, C. S. (1997) · Physiological Reviews · doi:10.1152/physrev.1997.77.2.517 · Cited by 889 · see citing works
CYP2E1 and oxidative liver injury by alcohol
Lu, Y., & Cederbaum, A. I. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.11.004 · Cited by 805 · see citing works
Enteric dysbiosis associated with a mouse model of alcoholic liver disease
Yan, A. W., Fouts, D. E., Brandl, J., Stärkel, P., Torralba, M., Schott, E., Tsukamoto, H., Nelson, K. E., Brenner, D. A., & Schnabl, B. (2011) · Hepatology · doi:10.1002/hep.24018 · Cited by 791 · see citing works
IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice
Petrasek, J., Bala, S., Csak, T., Lippai, D., Kodys, K., Menashy, V., Barrieau, M., Min, S.-Y., Kurt-Jones, E. A., & Szabo, G. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60777 · Cited by 735 · see citing works
Meng, F., Wang, K., Aoyama, T., Grivennikov, S. I., Paik, Y., Scholten, D., Cong, M., Iwaisako, K., Liu, X., Zhang, M., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.05.049 · Cited by 711 · see citing works
Essential role of tumor necrosis factor α in alcohol-induced liver injury in mice
Yin, M., Wheeler, M. D., Kono, H., Bradford, B. U., Gallucci, R. M., Luster, M. I., & Thurman, R. G. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70354-9 · Cited by 699 · see citing works
Radaeva, S., Sun, R., Pan, H., Hong, F., & Gao, B. (2004) · Hepatology · doi:10.1002/hep.20184 · Cited by 638 · see citing works
Alcohol and hepatocellular carcinoma
Morgan, T. R. M., Mandayam, S., & Jamal, M. M. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.09.020 · Cited by 631 · see citing works
Zenewicz, L. A., Yancopoulos, G. D., Valenzuela, D. M., Murphy, A. J., Karow, M. L., & Flavell, R. A. (2007) · Immunity · doi:10.1016/j.immuni.2007.07.023 · Cited by 628 · see citing works
Reactive oxygen species‐induced molecular damage and its application in pathology
Toyokuni, S. (1999) · Pathology International · doi:10.1046/j.1440-1827.1999.00829.x · Cited by 547 · see citing works
You, M., Fischer, M., Deeg, M. A., & Crabb, D. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202411200 · Cited by 543 · see citing works
Bull–Otterson, L., Feng, W., Kirpich, I., Wang, Y., Qin, X., Liu, Y., Gobejishvili, L., Joshi‐Barve, S., Ayvaz, T., Petrosino, J. F., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053028 · Cited by 543 · see citing works
Ji, C., & Kaplowitz, N. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00276-2 · Cited by 539 · see citing works
Autophagy Reduces Acute Ethanol-Induced Hepatotoxicity and Steatosis in Mice
Ding, W., Li, M., Chen, X., Ni, H., Lin, C., Gao, W., Lu, B., Stolz, D. B., Clemens, D. L., & Yin, X. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.07.041 · Cited by 515 · see citing works
Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine.
Pradhan, S. C., & Girish, C. (2006) · PubMed · Cited by 513 · see citing works
Han, J. S., Thompson, P., & Beutler, B. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.172.1.391 · Cited by 508 · see citing works
Iimuro, Y., Gallucci, R. M., Luster, M. I., Kono, H., & Thurman, R. G. (1997) · Hepatology · doi:10.1002/hep.510260621 · Cited by 496 · see citing works
Endotoxemia and gut barrier dysfunction in alcoholic liver disease†
Rao, R. (2009) · Hepatology · doi:10.1002/hep.23009 · Cited by 476 · see citing works
The role of AMP-activated protein kinase in the action of ethanol in the liver
You, M., Matsumoto, M., Pacold, C. M., Cho, W. K., & Crabb, D. W. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.09.049 · Cited by 469 · see citing works
Increased Plasma Tumor Necrosis Factor in Severe Alcoholic Hepatitis
Bird, G. L. A., Sheron, N., Goka, A. K. J., Alexander, G., & Williams, R. L. (1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-112-12-917 · Cited by 457 · see citing works
Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice
Kong, X., Feng, D., Wang, H., Hong, F., Bertola, A., Wang, F.-S., & Gao, B. (2012) · Hepatology · doi:10.1002/hep.25744 · Cited by 448 · see citing works
Multitargeted therapy of cancer by silymarin
Ramasamy, K., & Agarwal, R. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.03.053 · Cited by 443 · see citing works
Ki, S. H., Park, O., Zheng, M., Morales‐Ibanez, O., Kolls, J. K., Bataller, R. A., & Gao, B. (2010) · Hepatology · doi:10.1002/hep.23837 · Cited by 433 · see citing works
Hritz, I., Mandrekar, P., Velayudham, A., Catalano, D., Dolganiuc, A., Kodys, K., Kurt‐Jones, E., & Szabo, G. (2008) · Hepatology · doi:10.1002/hep.22470 · Cited by 415 · see citing works
Palmitic acid induces production of proinflammatory cytokine interleukin-8 from hepatocytes
Joshi‐Barve, S., Barve, S. S., Amancherla, K., Gobejishvili, L., Hill, D. B., Cave, M. C., Hote, P., & McClain, C. J. (2007) · Hepatology · doi:10.1002/hep.21752 · Cited by 406 · see citing works
Wolk, K., Witte, E., Witte, K., Warszawska, K., & Sabat, R. (2010) · Seminars in Immunopathology · doi:10.1007/s00281-009-0188-x · Cited by 395 · see citing works
The interleukin-17 pathway is involved in human alcoholic liver disease # †
Lemmers, A., Moreno, C., Gustot, T., Maréchal, R., Degré, D., Demetter, P., de Nadai, P., Geerts, A., Quertinmont, E., Vercruysse, V., et al. (2009) · Hepatology · doi:10.1002/hep.22680 · Cited by 394 · see citing works
Effects of ethanol on lipid metabolism.
Baraona, E., & Lieber, C. S. (1979) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)40613-3 · Cited by 392 · see citing works
DNA adducts from acetaldehyde: implications for alcohol-related carcinogenesis
Brooks, P. J., & Theruvathu, J. A. (2005) · Alcohol · doi:10.1016/j.alcohol.2005.03.009 · Cited by 382 · see citing works
Effect of alcohol consumption on the gut.
Bode, C., & Christian Bode, J. (2003) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/s1521-6918(03)00034-9 · Cited by 379 · see citing works
Boetticher, N. C., Peine, C. J., Kwo, P. Y., Abrams, G. A., Patel, T. P., Aqel, B. A., Boardman, L., Gores, G. J., Harmsen, W. S., McClain, C. J., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.08.057 · Cited by 338 · see citing works
Toll-like receptors as targets in chronic liver diseases
Mencin, A. M., Kluwe, J., & Schwabe, R. F. (2009) · Gut · doi:10.1136/gut.2008.156307 · Cited by 328 · see citing works
Purohit, V., Bode, J. C., Bode, C., Brenner, D. A., Choudhry, M. A., Hamilton, F., Kang, Y. J., Keshavarzian, A., Rao, R., Sartor, R. B., et al. (2008) · Alcohol · doi:10.1016/j.alcohol.2008.03.131 · Cited by 325 · see citing works
Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice
Lu, Y., Zhuge, J., Wang, X., Bai, J., & Cederbaum, A. I. (2008) · Hepatology · doi:10.1002/hep.22222 · Cited by 310 · see citing works
Pentoxifylline suppression of tumor necrosis factor gene transcription.
Doherty, G. M., Jensen, J. C., Alexander, H. R., Buresh, C. M., & Norton, J. A. (1991) · PubMed · Cited by 306 · see citing works
Casini, A., Ceni, E., Salzano, R., Biondi, P., Parola, M., Galli, A., Foschi, M., Caligiuri, A., Pinzani, M., & Surrenti, C. (1997) · Hepatology · doi:10.1002/hep.510250218 · Cited by 302 · see citing works
Self-citationBailey, S. M., & CUNNINGHAM, C. C. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00769-9 · Cited by 301 · see citing works
THE ROLE OF THE HEPATIC MICROSOMAL ETHANOL OXIDIZING SYSTEM (MEOS) FOR ETHANOL METABOLISM IN VIVO
Lieber, C. S., & DeCarli, L. M. (1972) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)29204-7 · Cited by 298 · see citing works
Plasma Tumor Necrosis Factor α Predicts Decreased Long‐Term Survival in Severe Alcoholic Hepatitis
Felver, M. E., Mezey, E., McGuire, M., Mitchell, M. C., Herlong, H. F., Veech, G. A., & Veech, R. L. (1990) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1990.tb00482.x · Cited by 293 · see citing works
Fischer, M., You, M., Matsumoto, M., & Crabb, D. W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302140200 · Cited by 291 · see citing works
Hypoxia and Hypoxia Inducible Factors: Diverse Roles in Liver Diseases
Nath, B., & Szabó, G. (2011) · Hepatology · doi:10.1002/hep.25497 · Cited by 290 · see citing works
Tang, Y., Banan, A., Forsyth, C. B., Fields, J. Z., Lau, C. K., Zhang, L. J., & Keshavarzian, A. (2007) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2007.00584.x · Cited by 287 · see citing works
Alcohol metabolism and cancer risk.
Seitz, H. K., & Becker, P. B. (2007) · PubMed · Cited by 281 · see citing works
Milani, S., Herbst, H., Schuppan, D., Hahn, E. G., & Stein, H. (1989) · Hepatology · doi:10.1002/hep.1840100117 · Cited by 276 · see citing works
Anglesio, M. S., George, J., Kulbe, H., et al. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-3314 · Cited by 262 · see citing works
Wang, Y., Kirpich, I., Liu, Y., Ma, Z., Barve, S. S., McClain, C. J., & Feng, W. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.08.039 · Cited by 255 · see citing works
Alcohol and genetic polymorphisms: effect on risk of alcohol-related cancer
Druesne‐Pecollo, N., Téhard, B., Mallet, Y., Gerber, M., Norat, T., Herçberg, S., & Latino‐Martel, P. (2009) · The Lancet Oncology · doi:10.1016/s1470-2045(09)70019-1 · Cited by 252 · see citing works
Moshage, H. J., Casini, A., & LIEBER, C. S. (1990) · Hepatology · doi:10.1002/hep.1840120311 · Cited by 251 · see citing works
Tuma, D. J., Thiele, G. M., Xu, D., Klassen, L. W., & Sorrell, M. F. (1996) · Hepatology · doi:10.1002/hep.510230431 · Cited by 245 · see citing works
Differential liver sensitization to Toll-like receptor pathways in mice with alcoholic fatty liver
Gustot, T., Lemmers, A., Moreno, C., Nagy, N., Quertinmont, E., Nicaise, C., Franchimont, D. P., Louis, H., Deviere, J. M., & Moine, O. L. (2006) · Hepatology · doi:10.1002/hep.21138 · Cited by 244 · see citing works
Park, O., Wang, H., Weng, H., Feigenbaum, L., Li, H., Yin, S., Ki, S. H., Yoo, S. H., Dooley, S., Wang, F., et al. (2011) · Hepatology · doi:10.1002/hep.24339 · Cited by 242 · see citing works
Hepatic fibrosis and cirrhosis: The (myo)fibroblastic cell subpopulations involved
Guyot, C., Lepreux, S., Combe, C., Doudnikoff, É., Bioulac‐Sage, P., Balabaud, C. P., & Desmoulière, A. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2005.08.021 · Cited by 241 · see citing works
Dominguez, M., Miquel, R., Colmenero, J., Moreno, M., García–Pagán, J., Bosch, J., Arroyo, V., Ginès, P., Caballería, J., & Bataller, R. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.01.056 · Cited by 238 · see citing works
Gressner, A. M. (1996) · PubMed · Cited by 236 · see citing works
Nagy, L. E. (2003) · Experimental Biology and Medicine · doi:10.1177/153537020322800803 · Cited by 227 · see citing works
Ethanol toxicity and oxidative stress
Bondy, S. C. (1992) · Toxicology Letters · doi:10.1016/0378-4274(92)90086-y · Cited by 227 · see citing works
García-Trevijano, E., Iraburu, M., Fontana, L., Domínguez-Rosales, J., Auster, A., Covarrubias‐Pinedo, A., & Rojkind, M. (1999) · Hepatology · doi:10.1002/hep.510290346 · Cited by 223 · see citing works
PPARγ-mediated insulin sensitization: the importance of fat versus muscle
Kintscher, U., & Law, R. E. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00440.2004 · Cited by 218 · see citing works
Involvement of mammalian sirtuin 1 in the action of ethanol in the liver
You, M., Liang, X., Ajmo, J. M., & Ness, G. C. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00575.2007 · Cited by 214 · see citing works
Nagata, K., Suzuki, H., & Sakaguchi, S. (2007) · The Journal of Toxicological Sciences · doi:10.2131/jts.32.453 · Cited by 212 · see citing works
Tuma, D. J. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00742-0 · Cited by 211 · see citing works
Nieto, N., Friedman, S. L., & Cederbaum, A. I. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110506200 · Cited by 208 · see citing works
Regional distribution of ethanol-inducible cytochrome P450 IIE1 in the rat central nervous system
Hansson, T., Tindberg, N., Ingelman-Sundberg, M., & Ko¨hler, C. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90154-v · Cited by 202 · see citing works
Zintzaras, E., Stefanidis, I., Mauro Santos, A., & Vidal, F. (2006) · Hepatology · doi:10.1002/hep.21023 · Cited by 201 · see citing works
Genetic Factors in Alcohol Metabolism and Alcoholism
BOSRON, W. F., Ehrig, T., & Li, T.-K. (1993) · Seminars in Liver Disease · doi:10.1055/s-2007-1007344 · Cited by 199 · see citing works
Thakur, V., Pritchard, M. T., McMullen, M. R., Wang, Q., & Nagy, L. E. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.1005613 · Cited by 196 · see citing works
Nath, B., Levin, I., Csák, T., Petrasek, J., Mueller, C. A., Kodys, K., Catalano, D. E., Mandrekar, P., & Szabó, G. (2011) · Hepatology · doi:10.1002/hep.24256 · Cited by 189 · see citing works
Casini, A., Cunningham, M., Rojkind, M., & Lieber, C. S. (1991) · Hepatology · doi:10.1002/hep.1840130424 · Cited by 189 · see citing works
Greenwel, P., Domı́nguez-Rosales, J. A., Mavi, G., Rivas-Estilla, A. M., & Rojkind, M. (2000) · Hepatology · doi:10.1002/hep.510310118 · Cited by 189 · see citing works
DNA Damage, DNA Repair, and Alcohol Toxicity--A Review
Brooks, P. J. (1997) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1997.tb04256.x · Cited by 188 · see citing works
Dangerous byproducts of alcohol breakdown--focus on adducts.
(2003) · Europe PMC (PubMed Central) · Cited by 187 · see citing works
Pan, H., Hong, F., Radaeva, S., & Gao, B. (2004) · PubMed · Cited by 186 · see citing works
A randomized placebo controlled trial of vitamin E for alcoholic hepatitis
Mezey, E., Potter, J. J., Rennie-Tankersley, L., Caballería, J., & Parés, A. R. (2003) · Journal of Hepatology · doi:10.1016/s0168-8278(03)00476-8 · Cited by 185 · see citing works
Horiguchi, N., Wang, L., Mukhopadhyay, P., Park, O., Jeong, W.-I., Lafdil, F., Osei-Hyiaman, D., Moh, A., Fu, X.-Y., Pacher, P., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.01.016 · Cited by 185 · see citing works
Reactive oxygen species in tissue injury.
de Groot, H. (1994) · PubMed · Cited by 184 · see citing works
Distribution of ethanol-induced protein adducts in vivo: relationship to tissue injury,
Niemelä, O. J. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00744-4 · Cited by 181 · see citing works
Genetics of Alcoholic Liver Disease and Nonalcoholic Fatty Liver Disease
de Alwis, N. M. W., & Day, C. P. (2007) · Seminars in Liver Disease · doi:10.1055/s-2006-960170 · Cited by 181 · see citing works
MicroRNAs: Master Regulators of Ethanol Abuse and Toxicity?
Miranda, R. C., Pietrzykowski, A. Z., Tang, Y., Sathyan, P., Mayfield, D., Keshavarzian, A., Sampson, W., & Hereld, D. (2010) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.01126.x · Cited by 179 · see citing works
Molecular mechanisms of alcoholic liver disease: Innate immunity and cytokines
Miller, A. M., Horiguchi, N., Jeong, W., Radaeva, S., & Gao, B. (2011) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01399.x · Cited by 176 · see citing works
Inokuchi, S., Tsukamoto, H., Park, E., Liu, Z., Brenner, D. A., & Seki, E. (2011) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2011.01487.x · Cited by 172 · see citing works
Regulation of human metabolism by hypoxia-inducible factor
Formenti, F., Constantin-Teodosiu, D., Emmanuel, Y., Cheeseman, J., Dorrington, K., Edwards, L., Humphreys, S., Lappin, T., McMullin, M., McNamara, C. J., et al. (2010) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1002339107 · Cited by 172 · see citing works
Nlemelä, O., Parkkila, S., Ylä‐Herttuala, S., Villanueva, J. A., Ruebner, B. H., & Halsted, C. H. (1995) · Hepatology · doi:10.1002/hep.1840220428 · Cited by 172 · see citing works
Wang, Y., Liu, Y., Kirpich, I., Ma, Z., Wang, C., Zhang, M., Suttles, J., McClain, C. J., & Feng, W. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.02.001 · Cited by 171 · see citing works
Functions of Autophagy in Hepatic and Pancreatic Physiology and Disease
Czaja, M. J. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.04.038 · Cited by 170 · see citing works
Critical Role of FoxO3a in Alcohol-Induced Autophagy and Hepatotoxicity
Ni, H., Du, K., You, M., & Ding, W. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.08.011 · Cited by 168 · see citing works
Insulin signaling in the transcriptional and posttranscriptional regulation of CYP2E1 expression
Woodcroft, K. J., Hafner, M. S., & NOVAK, R. F. (2002) · Hepatology · doi:10.1053/jhep.2002.30691 · Cited by 164 · see citing works
MicroRNA-217 Promotes Ethanol-induced Fat Accumulation in Hepatocytes by Down-regulating SIRT1
Yin, H., Hu, M., Zhang, R., Shen, Z., Flatow, L., & You, M. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.333534 · Cited by 163 · see citing works
Rolla, R., Vay, D., Mottaran, E., Parodi, M., Traverso, N., Aricò, S., Sartori, M., Bellomo, G., Klassen, L. W., Thiele, G. M., et al. (2000) · Hepatology · doi:10.1053/he.2000.5373 · Cited by 163 · see citing works
IL-22: A critical mediator in mucosal host defense
Aujla, S. J., & Kolls, J. K. (2009) · Journal of Molecular Medicine · doi:10.1007/s00109-009-0448-1 · Cited by 162 · see citing works
Miller, A. M., Wang, H., Bertola, A., Park, O., Horiguchi, N., Ki, S. H., Yin, S., Lafdil, F., & Gao, B. (2011) · Hepatology · doi:10.1002/hep.24517 · Cited by 162 · see citing works
Mechanisms of alcohol‐induced hepatic fibrosis: A summary of the Ron Thurman Symposium†
Purohit, V., & Brenner, D. A. (2006) · Hepatology · doi:10.1002/hep.21107 · Cited by 161 · see citing works
Alcohol induced hepatic fibrosis: Role of acetaldehyde
Mello, T., Ceni, E., Surrenti, C., & Galli, A. (2008) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2007.10.001 · Cited by 160 · see citing works
Self-citationAmelioration of high fat diet induced liver lipogenesis and hepatic steatosis by interleukin-22
Yang, L., Zhang, Y., Wang, L., Fan, F., Zhu, L., Li, Z., Ruan, X., Huang, H., Wang, Z., Huang, Z., et al. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.03.004 · Cited by 157 · see citing works
Glässner, A., Eisenhardt, M., Krämer, B., Körner, C., Coenen, M., Sauerbruch, T., Spengler, U., & Nattermann, J. (2012) · Laboratory Investigation · doi:10.1038/labinvest.2012.54 · Cited by 156 · see citing works
Silymarin Retards the Progression of Alcohol-Induced Hepatic Fibrosis in Baboons
Lieber, C. S., Leo, M. A., Cao, Q., Ren, C., & DeCarli, L. M. (2003) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-200310000-00013 · Cited by 156 · see citing works
Pritchard, M. T., McMullen, M. R., Stavitsky, A. B., Cohen, J. I., Lin, F., Medof, M. E., & Nagy, L. E. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.01.053 · Cited by 155 · see citing works
Neutrophilic infiltration in alcoholic hepatitis
Bautista, A. P. (2002) · Alcohol · doi:10.1016/s0741-8329(02)00206-9 · Cited by 154 · see citing works
Liver Fibrogenesis: A New Role for the Renin–Angiotensin System
Bataller, R. A., Sancho‐Bru, P., Ginès, P., & Brenner, D. A. (2005) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.1346 · Cited by 154 · see citing works
Emerging role of microRNAs in liver diseases
Bala, S., Marcos, M., & Szabó, G. (2009) · World Journal of Gastroenterology · doi:10.3748/wjg.15.5633 · Cited by 154 · see citing works
Copple, B. L., Bai, S., Burgoon, L. D., & Moon, J.-O. (2010) · Liver International · doi:10.1111/j.1478-3231.2010.02347.x · Cited by 153 · see citing works
Jia, J., Bauer, M. W., Cho, J. J., et al. (2001) · Journal of Hepatology · doi:10.1016/s0168-8278(01)00148-9 · Cited by 152 · see citing works
Mandal, P., Park, P., McMullen, M. R., Pratt, B. T., & Nagy, L. E. (2009) · Hepatology · doi:10.1002/hep.23427 · Cited by 150 · see citing works
NIEMELA, O. (1995) · Hepatology · doi:10.1016/0270-9139(95)90630-4 · Cited by 149 · see citing works
Induction of cytochrome P450IIE1 in the obese overfed rat.
Raucy, J. L., Lasker, J. M., Kraner, J. C., Salazar, D. E., Lieber, C. S., & Corcoran, G. B. (1991) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10989-9 · Cited by 148 · see citing works
Lipid peroxidation contributes to immune reactions associated with alcoholic liver disease
Mottaran, E., Stewart, S. F., Rolla, R., Vay, D., Cipriani, V., Moretti, M., Vidali, M., Sartori, M., Rigamonti, C., Day, C. P., et al. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00757-2 · Cited by 145 · see citing works
Crabb, D. W., Galli, A., Fischer, M., & You, M. (2004) · Alcohol · doi:10.1016/j.alcohol.2004.07.005 · Cited by 143 · see citing works
Self-citationRaetsch, C., Jia, J. D., Boigk, G., Bauer, M., Hahn, E. G., Riecken, E.-O., & Schuppan, D. (2002) · Gut · doi:10.1136/gut.50.2.241 · Cited by 143 · see citing works
Cohen, J. I., Roychowdhury, S., McMullen, M. R., Stavitsky, A. B., & Nagy, L. E. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.04.041 · Cited by 138 · see citing works
Effect of chronic alcohol consumption on Hepatic SIRT1 and PGC-1α in rats
Lieber, C. S., Leo, M. A., Wang, X., & DeCarli, L. M. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.03.005 · Cited by 135 · see citing works
Svegliati‐Baroni, G., Ridolfi, F., Sario, A. D., Saccomanno, S., Bendia, E., Benedetti, A., & Greenwel, P. (2001) · Hepatology · doi:10.1053/jhep.2001.23788 · Cited by 134 · see citing works
Basuroy, S., Sheth, P., Mansbach, C. M., & Rao, R. K. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00464.2004 · Cited by 134 · see citing works
Hu, M., Wang, F., Li, X., et al. (2011) · Hepatology · doi:10.1002/hep.24708 · Cited by 132 · see citing works
García-Villafranca, J., Guillén, A., & Castro, J. (2008) · Biochimie · doi:10.1016/j.biochi.2007.09.019 · Cited by 130 · see citing works
Weng, H., Liu, Y., Chen, J., Huang, T., Xu, L., Godoy, P., Hu, J.-H., Zhou, C., Stickel, F., Marx, A., et al. (2009) · Hepatology · doi:10.1002/hep.22934 · Cited by 129 · see citing works
Aldehyde-protein adducts in the liver as a result of ethanol-induced oxidative stress
Niemelä, O. J. (1999) · Frontiers in bioscience · doi:10.2741/niemela · Cited by 124 · see citing works
HIF-1α induction suppresses excessive lipid accumulation in alcoholic fatty liver in mice
Nishiyama, Y., Goda, N., Kanai, M., Niwa, D., Osanai, K., Yamamoto, Y., Senoo‐Matsuda, N., Johnson, R. S., Miura, S., Kabe, Y., et al. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2011.07.024 · Cited by 119 · see citing works
Zhao, X., Dong, Q. D., Bindas, J., Piganelli, J. D., Magill, A., Reiser, J., & Kolls, J. K. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.5.3049 · Cited by 119 · see citing works
Petrášek, J., Dolganiuc, A., Csák, T., Nath, B., Hritz, I., Kodys, K., Catalano, D. E., Kurt‐Jones, E. A., Mandrekar, P., & Szabó, G. (2010) · Hepatology · doi:10.1002/hep.24059 · Cited by 118 · see citing works
Maltby, J. (1996) · Hepatology · doi:10.1053/jhep.1996.v24.pm0008903391 · Cited by 116 · see citing works
The role of hepatic peroxisome proliferator‐activated receptors (PPARs) in health and disease
Everett, L. M., Galli, A., & Crabb, D. W. (2000) · Liver International · doi:10.1034/j.1600-0676.2000.020003191.x · Cited by 114 · see citing works
Self-citationSalaspuro, M. P., Shaw, S., Jayatilleke, E., Ross, W. A., & Lieber, C. S. (1981) · Hepatology · doi:10.1002/hep.1840010106 · Cited by 114 · see citing works
Butura, A., Nilsson, K. C., Morgan, K., Morgan, T. R. M., French, S. W., Johansson, I., Schuppe‐Koistinen, I., & Ingelman‐Sundberg, M. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2008.10.020 · Cited by 113 · see citing works
Role of Alcohol in Liver Carcinogenesis
McKillop, I. H., & Schrum, L. W. (2009) · Seminars in Liver Disease · doi:10.1055/s-0029-1214377 · Cited by 113 · see citing works
The Effect of Ethanol-Induced Cytochrome p4502E1 on the Inhibition of Proteasome Activity by Alcohol
Bardag‐Gorce, F., Yuan, Q. X., Li, J., French, B. A., Fang, C., Ingelman‐Sundberg, M., & French, S. W. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3889 · Cited by 112 · see citing works
Distribution and Kinetics of Ethanol Metabolism in Rat Brain
Zimatkin, S. M., Liopo, A. V., & Deitrich, R. A. (1998) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1998.tb03958.x · Cited by 111 · see citing works
Free radical mechanisms in immune reactions associated with alcoholic liver disease
Albano, E. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00773-0 · Cited by 110 · see citing works
CYP2E1 – Biochemical and Toxicological Aspects and Role in Alcohol-Induced Liver Injury
Cederbaum, A. I. (2008) · Springer eBooks · doi:10.1007/978-0-387-77300-1_6 · Cited by 109 · see citing works
Kong, X., Feng, D., Mathews, S., & Gao, B. (2013) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.12032 · Cited by 108 · see citing works
Nanji, A. A., Dannenberg, A. J., Jokelainen, K., & Bass, N. M. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.064717 · Cited by 107 · see citing works
Niemelä, O., Parkkila, S., Pasanen, M., Limuro, Y., Bradford, B., & Thurman, R. G. (1998) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.1998.tb05925.x · Cited by 107 · see citing works
Autophagy and ethanol-induced liver injury
Donohue, T. M. (2009) · World Journal of Gastroenterology · doi:10.3748/wjg.15.1178 · Cited by 107 · see citing works
Pathological Aspects of Active Oxygens/Free Radicals.
Nakazawa, H. K., Genka, C., & Fujishima, M. (1996) · The Japanese Journal of Physiology · doi:10.2170/jjphysiol.46.15 · Cited by 106 · see citing works
Putative Role of Brain Acetaldehyde in Ethanol Addiction
Deng, X.-S., & Deitrich, R. (2008) · Current Drug Abuse Reviewse · doi:10.2174/1874473710801010003 · Cited by 105 · see citing works
Roychowdhury, S., McMullen, M. R., Pritchard, M. T., Hise, A. G., van Rooijen, N., Medof, E. M., Stavitsky, A. B., & Nagy, L. E. (2008) · Hepatology · doi:10.1002/hep.22776 · Cited by 102 · see citing works
AICAR, an AMPK Activator, Has Protective Effects on Alcohol‐Induced Fatty Liver in Rats
Tomita, K., Tamiya, G., Ando, S., Kitamura, N., Koizumi, H., Kato, S., Horie, Y., Kaneko, T., Azuma, T., Nagata, H., et al. (2005) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000191126.11479.69 · Cited by 102 · see citing works
Galligan, J. J., McCullough, R. L., Shearn, C. T., Fritz, K. S., Backos, D. S., Jiang, H., Franklin, C. C., Orlicky, D. J., Maclean, K. N., & Petersen, D. R. (2012) · Journal of Toxicology · doi:10.1155/2012/207594 · Cited by 101 · see citing works
Autophagy in Alcohol‐Induced Liver Diseases
Dolganiuc, A., Thomes, P. G., Ding, W., Lemasters, J. J., & Donohue, T. M. (2012) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2012.01742.x · Cited by 101 · see citing works
Human and experimental evidence supporting a role for osteopontin in alcoholic hepatitis
Morales‐Ibanez, O., Domínguez, M., Ki, S. H., Marcos, M., Chaves, F. J., Nguyen-Khac, É., Houchi, H., Affò, S., Sancho‐Bru, P., Altamirano, J., et al. (2013) · Hepatology · doi:10.1002/hep.26521 · Cited by 97 · see citing works
Acetaldehyde-induced increase in paracellular permeability in Caco-2 cell monolayer
Rao, R. K. (1998) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.1998.tb03972.x · Cited by 95 · see citing works
Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases
Rambaldi, A., Jacobs, B. P., & Gluud, C. N. (2007) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003620.pub3 · Cited by 95 · see citing works
Alcohol steatosis and cytotoxicity: The role of cytochrome P4502E1 and autophagy
Wu, D., Wang, X., Zhou, R., Yang, L., & Cederbaum, A. I. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.07.005 · Cited by 93 · see citing works
Viitala, K., Israel, Y., Blake, J. E., & Niemelä, O. J. (1997) · Hepatology · doi:10.1002/hep.510250619 · Cited by 92 · see citing works
The Relation of Oxidative Stress and Hyperexcitation to Neurological Disease
Bondy, S. C. (1995) · Experimental Biology and Medicine · doi:10.3181/00379727-208-43862 · Cited by 90 · see citing works
Immunologic Mechanisms of Alcoholic Liver Injury
Thiele, G. M., Freeman, T. L., & Klassen, L. W. (2004) · Seminars in Liver Disease · doi:10.1055/s-2004-832940 · Cited by 89 · see citing works
Inhibition of Proteasome Function Leads to Nf–κB–Independent Il–8 Expression in Human Hepatocytes
Joshi‐Barve, S., Barve, S. S., Butt, W., Klein, J. B., & McClain, C. J. (2003) · Hepatology · doi:10.1053/jhep.2003.50470 · Cited by 88 · see citing works
Osteopontin: Versatile modulator of liver diseases
Nagoshi, S. (2013) · Hepatology Research · doi:10.1111/hepr.12166 · Cited by 87 · see citing works
Acetaldehyde as a substrate for ethanol-inducible cytochrome P450 (CYP2E1)
Terelius, Y., Norsten‐Höög, C., Cronholm, T., & Ingelman‐Sundberg, M. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)91427-e · Cited by 87 · see citing works
Svegliati‐Baroni, G., Inagaki, Y., Rincón‐Sánchez, A. R., Else, C., Saccomanno, S., Benedetti, A., Ramirez, F., & Rojkind, M. (2005) · Hepatology · doi:10.1002/hep.20798 · Cited by 87 · see citing works
Hypoxia‐inducible factor‐dependent production of profibrotic mediators by hypoxic hepatocytes
Copple, B. L., Bustamante, J. J., Welch, T. P., Kim, N. D., & Moon, J. (2009) · Liver International · doi:10.1111/j.1478-3231.2009.02015.x · Cited by 87 · see citing works
Patouraux, S., Bonnafous, S., Voican, C. S., Anty, R., Saint‐Paul, M., Rosenthal‐Allieri, M. A., Agostini, H., Njiké‐Nakseu, M., Barri‐Ova, N., Naveau, S., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035612 · Cited by 86 · see citing works
Cytochrome P4502E1, oxidative stress, JNK, and autophagy in acute alcohol-induced fatty liver
Yang, L., Wu, D., Wang, X., & Cederbaum, A. I. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.06.029 · Cited by 85 · see citing works
Li, C., Nanji, A. A., Siakotos, A. N., & Lin, R. C. (1997) · Hepatology · doi:10.1002/hep.510260317 · Cited by 85 · see citing works
Nepal, S., & Park, P. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.05.013 · Cited by 84 · see citing works
Chen, A., & Davis, B. H. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.8.2818-2826.2000 · Cited by 83 · see citing works
Functional Relevance of Human ADH Polymorphism
Eriksson, C. J. P., Fukunaga, T., Sarkola, T., Chen, W. J., Chen, C., Ju, J. M., Cheng, A. T. A., Yamamoto, H., Kohlenberg-Müller, K., Kimura, M., et al. (2001) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2001.tb02391.x · Cited by 82 · see citing works
Chen, A. (2002) · Biochemical Journal · doi:10.1042/bj20020949 · Cited by 81 · see citing works
Sun, X., Tang, Y., Tan, X., Li, Q., Zhong, W., Sun, X., Jia, W. P., McClain, C. J., & Zhou, Z. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00342.2011 · Cited by 81 · see citing works
The role of acetaldehyde in upper digestive tract cancer in alcoholics
Seitz, H. K., & Meier, P. (2007) · Translational research · doi:10.1016/j.trsl.2006.12.002 · Cited by 80 · see citing works
Holstege, A., Bedossa, P., Poynard, T., Kollinger, M., Chaput, J. C., Houglum, K., & Chojkier, M. (1994) · Hepatology · doi:10.1002/hep.1840190215 · Cited by 80 · see citing works
de Waziers, I., Garlatti, M., Bouguet, J., et al. (1995) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)08567-0 · Cited by 79 · see citing works
Pretranslational activation of cytochrome P450IIE during ketosis induced by a high fat diet.
Yun, Y., Casazza, J. P., Sohn, D. H., et al. (1992) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)08939-4 · Cited by 76 · see citing works
Cubero, F. J., Urtasun, R., & Nieto, N. (2009) · Seminars in Liver Disease · doi:10.1055/s-0029-1214376 · Cited by 76 · see citing works
Fleming, S. D., Toratani, S., Shea‐Donohue, T., Kashiwabara, Y., Vogel, S. N., & Metcalf, E. S. (2001) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2001.tb02253.x · Cited by 75 · see citing works
Hepatic, Metabolic, and Nutritional Disorders of Alcoholism: From Pathogenesis to Therapy
Lieber, C. S. (2000) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360091174312 · Cited by 72 · see citing works
Bell, L. N., Temm, C. J., Saxena, R., Vuppalanchi, R., Schauer, P. R., Rabinovitz, M., Krasinskas, A. M., Chalasani, N., & Mattar, S. G. (2010) · Annals of Surgery · doi:10.1097/sla.0b013e3181dbb572 · Cited by 72 · see citing works
Regulation of Rabbit Cytochrome P450 2E1 Expression in HepG2 Cells by Insulin and Thyroid Hormone
Peng, H., & Coon, M. J. (1998) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)13076-3 · Cited by 70 · see citing works
Crabb, D. W., & Liangpunsakul, S. (2006) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2006.04582.x · Cited by 69 · see citing works
Galli, A., Price, D., & Crabb, D. W. (1999) · Hepatology · doi:10.1002/hep.510290420 · Cited by 69 · see citing works
Self-citationChestovich, P. J., Uchida, Y., Chang, W., et al. (2012) · Transplantation · doi:10.1097/tp.0b013e3182449136 · Cited by 68 · see citing works
Mastelic, B., do Rosário, A. P. F., Veldhoen, M., Renauld, J., Jarra, W., Sponaas, A., Roetynck, S., Stockinger, B., & Langhorne, J. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00085 · Cited by 68 · see citing works
Ethanol oxidizing enzymes: roles in alcohol metabolism and alcoholic liver disease.
Crabb, D. W. (1995) · PubMed · Cited by 67 · see citing works
Anabolic-Androgenic Steroids for Alcoholic Liver Disease: A Cochrane Review
Rambaldi, A., Iaquinto, G., & Gluud, C. N. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05826.x · Cited by 67 · see citing works
PI3K/Akt pathway activation was involved in acute ethanol-induced fatty liver in mice
Zeng, T., Zhang, C., Song, F.-Y., et al. (2012) · Toxicology · doi:10.1016/j.tox.2012.03.005 · Cited by 66 · see citing works
Ge, X., Leung, T., Arriazu, E., Lu, Y., Urtasun, R., Christensen, B., Fiel, M. I., Mochida, S., Sφrensen, E. S., & Nieto, N. (2013) · Hepatology · doi:10.1002/hep.26931 · Cited by 65 · see citing works
Immune mechanisms in alcoholic liver disease
Albano, E., & Vidali, M. (2009) · Genes & Nutrition · doi:10.1007/s12263-009-0151-4 · Cited by 63 · see citing works
Innate immunity and alcoholic liver fibrosis
Jeong, W., & Gao, B. (2008) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2007.05274.x · Cited by 63 · see citing works
CASIN, A., Galli, G., SAIZANO, R., et al. (1994) · Alcohol and Alcoholism · doi:10.1093/oxfordjournals.alcalc.a045537 · Cited by 63 · see citing works
[Treatment of alcoholic hepatitis with silymarin. A double-blind comparative study in 116 patients].
Trinchet, J., Coste, T. C., Vg, L., et al. (1989) · PubMed · Cited by 60 · see citing works
N 2-Ethyldeoxyguanosine as a Potential Biomarker for Assessing Effects of Alcohol Consumption on DNA
Balbo, S., Hashibe, M., Gundy, S., Brennan, P., Canova, C., Simonato, L., Merletti, F., Richiardi, L., Agudo, A., Castellsagué, X., et al. (2008) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-08-0117 · Cited by 60 · see citing works
Role of TLR4 in ethanol effects on innate and adaptive immune responses in peritoneal macrophages
Pascual, M., Fernández‐Lizarbe, S., & Guerri, C. (2011) · Immunology and Cell Biology · doi:10.1038/icb.2010.163 · Cited by 60 · see citing works
Failure of colchicine to improve short-term survival in patients with alcoholic hepatitis
Akriviadis, E. A., Steindel, H., Pinto, P. C., Fong, T., Kanel, G. C., Reynolds, T. B., & Gupta, S. (1990) · Gastroenterology · doi:10.1016/0016-5085(90)90973-5 · Cited by 60 · see citing works
Sharma, P., Kumar, A., Sharma, B. C., et al. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2008.10.024 · Cited by 58 · see citing works
Fadl, A. A., Sha, J., Klimpel, G. R., Olano, J. P., Niesel, D. W., & Chopra, A. K. (2005) · Infection and Immunity · doi:10.1128/iai.73.2.1081-1096.2005 · Cited by 54 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Rungratanawanich, W., Qu, Y., Wang, X., Essa, M. M., & Song, B.-J. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00561-7 · Cited by 411 · see citing works
Pathophysiological Aspects of Alcohol Metabolism in the Liver
Hyun, J., Han, J., Lee, C., Yoon, M., & Jung, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115717 · Cited by 324 · see citing works
LeFort, K. R., Rungratanawanich, W., & Song, B.-J. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-05061-7 · Cited by 202 · see citing works
Alcohol-associated bowel disease: new insights into pathogenesis
Maccioni, L., Fu, Y., Horsmans, Y., Leclercq, I., Stärkel, P., Kunos, G., & Gao, B. (2023) · eGastroenterology · doi:10.1136/egastro-2023-100013 · Cited by 69 · see citing works
Inflammation in Alcohol-Associated Hepatitis: Pathogenesis and Therapeutic Targets
Feng, D., Hwang, S., Guillot, A., Wang, Y., Guan, Y., Chen, C., Maccioni, L., & Gao, B. (2024) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2024.04.009 · Cited by 44 · see citing works
Differential fibrotic phenotypes of hepatic stellate cells within 3D liver organoids
Brovold, M., Keller, D., & Soker, S. (2020) · Biotechnology and Bioengineering · doi:10.1002/bit.27379 · Cited by 21 · see citing works
- Authors
- Ceni, E., Mello, T., & Galli, A.
- Affiliations
- University of Florence (IT)
- Venue
- World Journal of Gastroenterology
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2014-12-21
- Volume
- 20
- Issue
- 47
- Pages
- 17756-17772
- ISSN
- 1007-9327 (ISSN-L)
- PMC
- PMC4273126
- OpenAlex
- W1456504179
- Cited by
- 521
- References
- 245
- Citations by year
- 2026: 42 · 2025: 39 · 2024: 58 · 2023: 75 · 2022: 56 · 2021: 59 · 2020: 47 · 2019: 38 · 2018: 40 · 2017: 21 · 2016: 25 · 2015: 21
- FWCI
- 3.15
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- World Journal of Gastroenterology (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Florence Research (University of Florence) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Keywords
- alcoholic liver disease, acetaldehyde, reactive oxygen species, alcoholic fatty liver, alcoholic hepatitis, liver fibrosis, hepatocellular carcinoma, hepatic stellate cells, collagen synthesis, AMPK, autophagy, lipid peroxidation, lipopolysaccharide translocation, intestinal barrier, Kupffer cells, natural killer cells, innate immunity, adaptive immunity, DNA adducts, DNA methylation
- MeSH terms
- Acetaldehyde, Ethanol, Animals, Humans, Immunity, Innate, Liver, Liver Diseases, Alcoholic, Oxidation-Reduction, Prognosis, Risk Factors, Signal Transduction, Reactive Oxygen Species, Oxidative Stress, Disease Progression, Adaptive Immunity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review