The DOI matches its Crossref record; 232 of the 232 references it cites were found in a registry or an index.
The effects of dietary restriction on oxidative stress in rodents
Open accessAbstract
Oxidative stress is observed during aging and in numerous age-related diseases. Dietary restriction (DR) is a regimen that protects against disease and extends life span in multiple species. However, it is unknown how DR mediates its protective effects. One prominent and consistent effect of DR in a number of systems is the ability to reduce oxidative stress and damage. The purpose of this review is to comprehensively examine the hypothesis that dietary restriction reduces oxidative stress in rodents by decreasing reactive oxygen species (ROS) production and increasing antioxidant enzyme activity, leading to an overall reduction of oxidative damage to macromolecules. The literature reveals that the effects of DR on oxidative stress are complex and likely influenced by a variety of factors, including sex, species, tissue examined, types of ROS and antioxidant enzymes examined, and duration of DR. Here we present a comprehensive review of the existing literature on the effect of DR on mitochondrial ROS generation, antioxidant enzymes, and oxidative damage. In a majority of studies, dietary restriction had little effect on mitochondrial ROS production or antioxidant activity. On the other hand, DR decreased oxidative damage in the majority of cases. Although the effects of DR on endogenous antioxidants are mixed, we find that glutathione levels are the most likely antioxidant to be increased by dietary restriction, which supports the emerging redox-stress hypothesis of aging.
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“However, this is not consistent across studies or across tissues (Hancock et al., 2011; Lanza et al., 2012; Walsh et al., 2014).”
From Mitochondrial (Dys)function and Insulin Resistance: From Pathophysiological Molecular Mechanisms to the Impact of Diet (2019) · cites this paper as Walsh et al., 2014
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“Of note, significant reduction in ROS production was more likely if the duration of the caloric restriction exceeded 20 months.”
From Mitochondrial (Dys)function and Insulin Resistance: From Pathophysiological Molecular Mechanisms to the Impact of Diet (2019) · cites this paper as Walsh et al., 2014
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Metadata
- Authors
- Walsh, M. E., Shi, Y., & Van Remmen, H.
- Affiliations
- The University of Texas at San Antonio Health Science Center (US)
- ORCID
- Shi, Yun
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 66
- Pages
- 88-99
- ISSN
- 0891-5849 (ISSN-L)
- PMC
- PMC4017324
- OpenAlex
- W2001107975
- Cited by
- 181
- References
- 232
- Citations by year
- 2026: 4 · 2025: 14 · 2024: 21 · 2023: 13 · 2022: 10 · 2021: 22 · 2020: 21 · 2019: 16 · 2018: 18 · 2017: 14 · 2016: 8 · 2015: 10 · 2014: 8
- FWCI
- 0.57
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- M.E.W (T32AG021890)
- National Institutes of Health – National Institute on Aging (P01AG20591)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Keywords
- dietary restriction, oxidative stress, reactive oxygen species, antioxidant enzymes, mitochondrial reactive oxygen species, oxidative damage, glutathione, aging, longevity, sex differences, rodents
- MeSH terms
- Aging, Animals, Antioxidants, Catalase, Glutathione Peroxidase, Humans, Oxidation-Reduction, Superoxide Dismutase, Reactive Oxygen Species, Oxidative Stress, Caloric Restriction
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