Cited by 419Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model OrganismsDietary Effects on Health

Increase in Activity During Calorie Restriction Requires Sirt1

Chen, Danica, Steele, Andrew D., Lindquist, Susan, Guarente, Leonard·2005·Science

Abstract

Sir2 (silent information regulator 2) is a nicotinamide adenine dinucletide‐dependent deacetylase required for longevity due to calorie restriction in yeast and Drosophila. In mammals, calorie restriction induces a complex pattern of physiological and behavioral changes. Here we report that the mammalian Sir2 ortholog, Sirt1, is required for the induction of a phenotype by calorie restriction in mice.

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Crossref · 10.1126/science.1118357

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  • Sirtuins, the Sir2 homologues, mediate certain effects of caloric restriction in flies and mammals.

    “Homologues of Sir2 (called sirtuins) have subsequently been shown to mediate some of the effects of caloric restriction in flies (82) and mammals (83,84).”

    From Neural mechanisms of ageing and cognitive decline (2010) · cites this paper as [84]

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Authors
Chen, D., Steele, A. D., Lindquist, S., & Guarente, L.
Affiliations
Whitehead Institute for Biomedical Research (US)
Corresponding author
Guarente, Leonard
Venue
Science
Published
2005-12-09
Volume
310
Issue
5754
Pages
1641-1641
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2156934560
Cited by
419
References
6
Citations by year
2026: 1 · 2025: 3 · 2024: 5 · 2023: 10 · 2022: 12 · 2021: 18 · 2020: 7 · 2019: 9 · 2018: 20 · 2017: 17 · 2016: 14 · 2015: 17 · 2014: 20 · 2013: 28 · 2012: 29
FWCI
13.53
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Aging (AG11119)
Topics
  • Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Health Sciences › Medicine › Physiology › Dietary Effects on Health
Keywords
SIRT1, Sir2, caloric restriction, longevity, metabolic activity, mice
MeSH terms
Animals, Eating, Motor Activity, Movement, Mice, Knockout, Caloric Restriction, Sirtuins, Mice, Sirtuin 1

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