Increase in Activity During Calorie Restriction Requires Sirt1
Abstract
Sir2 (silent information regulator 2) is a nicotinamide adenine dinucletide‐dependent deacetylase required for longevity due to calorie restriction in yeast and Drosophila. In mammals, calorie restriction induces a complex pattern of physiological and behavioral changes. Here we report that the mammalian Sir2 ortholog, Sirt1, is required for the induction of a phenotype by calorie restriction in mice.
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Sirtuins, the Sir2 homologues, mediate certain effects of caloric restriction in flies and mammals.
“Homologues of Sir2 (called sirtuins) have subsequently been shown to mediate some of the effects of caloric restriction in flies (82) and mammals (83,84).”
From Neural mechanisms of ageing and cognitive decline (2010) · cites this paper as [84]
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Self-citation
- Authors
- Chen, D., Steele, A. D., Lindquist, S., & Guarente, L.
- Affiliations
- Whitehead Institute for Biomedical Research (US)
- Corresponding author
- Guarente, Leonard
- Venue
- Science
- Published
- 2005-12-09
- Volume
- 310
- Issue
- 5754
- Pages
- 1641-1641
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2156934560
- Cited by
- 419
- References
- 6
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 10 · 2022: 12 · 2021: 18 · 2020: 7 · 2019: 9 · 2018: 20 · 2017: 17 · 2016: 14 · 2015: 17 · 2014: 20 · 2013: 28 · 2012: 29
- FWCI
- 13.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG11119)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Keywords
- SIRT1, Sir2, caloric restriction, longevity, metabolic activity, mice
- MeSH terms
- Animals, Eating, Motor Activity, Movement, Mice, Knockout, Caloric Restriction, Sirtuins, Mice, Sirtuin 1
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