Aging Impairs Hippocampal- Dependent Recognition Memory and LTP and Prevents the Associated RyR Up-regulation
Open accessAbstract
Recognition memory comprises recollection judgment and familiarity, two different processes that engage the hippocampus and the perirhinal cortex, respectively. Previous studies have shown that aged rodents display defective recognition memory and alterations in hippocampal synaptic plasticity. We report here that young rats efficiently performed at short-term (5 min) and long-term (24 h) hippocampus-associated object-location tasks and perirhinal cortex-related novel-object recognition tasks. In contrast, aged rats successfully performed the object-location and the novel-object recognition tasks only at short-term. In addition, aged rats displayed defective long-term potentiation (LTP) and enhanced long-term depression (LTD). Successful long-term performance of object-location but not of novel-object recognition tasks increased the protein levels of ryanodine receptor types-2/3 (RyR2/RyR3) and of inositol 1,4,5-trisphosphate receptor type-1 (IP3R1) in young rat hippocampus. Likewise, sustained LTP induction (1 h) significantly increased RyR2, RyR3 and IP3R1 protein levels in hippocampal slices from young rats. In contrast, LTD induction (1 h) did not modify the levels of these three proteins. Naïve (untrained) aged rats displayed higher RyR2/RyR3 hippocampal protein levels but similar IP3R1 protein content relative to young rats; these levels did not change following exposure to either memory recognition task or after LTP or LTD induction. The perirhinal cortex from young or aged rats did not display changes in the protein contents of RyR2, RyR3 and IP3R1 after exposure at long-term (24 h) to the object-location or the novel-object recognition tasks. Naïve aged rats displayed higher RyR2 channel oxidation levels in the hippocampus compared to naïve young rats. The RyR2/RyR3 up-regulation and the increased RyR2 oxidation levels exhibited by aged rat hippocampus are likely to generate anomalous calcium signals, which may contribute to the well-known impairments in hippocampal LTP and spatial memory that take place during aging.
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Research on memory in rodents and monkeys suggests that both spatial (what-where) and temporal (what-when) elements of memory decline alongside typical age-related changes within the brain.
“research on memory in rodents and monkeys, although again not strictly in line with episodic-like memory criteria, suggests that both spatial (what–where) [139–142] and temporal (what–when) [142,143] elements of memory decline alongside typical age-related changes within the brain.”
From Is episodic-like memory <i>like</i> episodic memory? (2024) · cites this paper as [140]
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- Authors
- Arias-Cavieres, A., Adasme, T., Sánchez, G., Muñoz, P., & Hidalgo, C.
- Affiliations
- Universidad Bernardo O'Higgins (CL)
- University of Chile (CL)
- University of Valparaíso (CL)
- Corresponding author
- Hidalgo, Cecilia
- Venue
- Frontiers in Aging Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2017-04-25
- Volume
- 9
- Pages
- 111-111
- ISSN
- 1663-4365 (ISSN-L)
- PMC
- PMC5402473
- OpenAlex
- W2608013985
- Cited by
- 70
- References
- 55
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 10 · 2023: 13 · 2022: 9 · 2021: 8 · 2020: 5 · 2019: 4 · 2018: 7 · 2017: 1
- FWCI
- 2.67
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Aging Neuroscience (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Universidad de Chile (submittedVersion, cc-by-nc-nd)
- Funders
- Fondo Nacional de Desarrollo Científico y Tecnológico (1140545, 11140580)
- Comisión Nacional de Investigación Científica y Tecnológica (21100237)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- aging, hippocampus, recognition memory, long-term potentiation, long-term depression, ryanodine receptor, RyR2, RyR3, IP3R1, calcium signaling, perirhinal cortex, object location task, novel object recognition, synaptic plasticity, spatial memory
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