Effects of ionizing radiation on mitochondria

Sequence and organization of the human mitochondrial genome

Anderson, S., Bankier, A. T., Barrell, B. G., de Bruijn, M. H. L., Coulson, A. R., Drouin, J., Eperon, I. C., Nierlich, D. P., Roe, B. A., Sanger, F., et al. (1981) · Nature · doi:10.1038/290457a0 · Cited by 9,740

Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project

The ENCODE Project Consortium (2007) · Nature · doi:10.1038/nature05874 · Cited by 5,223

Mitochondrial formation of reactive oxygen species

Turrens, J. F. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.049478 · Cited by 5,084

Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

Wu, Z., Puigserver, P., Andersson, U., Zhang, C., Adelmant, G., Mootha, V., Troy, A., Cinti, S., Lowell, B., Scarpulla, R. C., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80611-x · Cited by 4,139

Rapid evolution of animal mitochondrial DNA

Brown, W. M., George, M., & Wilson, A. C. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.4.1967 · Cited by 3,439

Untitled work

Fridovich (1978) · doi:10.1126/science.210504 · Cited by 3,329

Mitochondria: More Than Just a Powerhouse

McBride, H. M., Neuspiel, M., & Wasiak, S. (2006) · Current Biology · doi:10.1016/j.cub.2006.06.054 · Cited by 1,985

Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies

Holt, I. J., Harding, A. E., & MORGAN-HUGHES, J. A. (1988) · Nature · doi:10.1038/331717a0 · Cited by 1,860

Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress

Yakes, F. M., & Van Houten, B. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.2.514 · Cited by 1,854

Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation.

Bass, D., Parce, J. W., DeChatelet, L. R., Szejda, P., Seeds, M. C., & Thomas, M. (1983) · The Journal of Immunology · doi:10.4049/jimmunol.130.4.1910 · Cited by 1,811

Effects of Ionizing Radiation on Biological Molecules—Mechanisms of Damage and Emerging Methods of Detection

Reisz, J. A., Bansal, N., Qian, J. X., Zhao, W., & Furdui, C. M. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5489 · Cited by 882

Induction of metastasis, cancer stem cell phenotype, and oncogenic metabolism in cancer cells by ionizing radiation

Lee, S. Y., Jeong, E. K., Ju, M. K., Jeon, H. M., Kim, M. Y., Kim, C. H., Park, H. G., Han, S. I., & Kang, H. S. (2017) · Molecular Cancer · doi:10.1186/s12943-016-0577-4 · Cited by 592

Pathological effects of ionizing radiation: endothelial activation and dysfunction

Baselet, B., Sonveaux, P., Baatout, S., & Aerts, A. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2956-z · Cited by 579

Ferroptosis, radiotherapy, and combination therapeutic strategies

Lei, G., Mao, C., Yan, Y., Zhuang, L., & Gan, B. (2021) · Protein & Cell · doi:10.1007/s13238-021-00841-y · Cited by 539

Cellular Stress Responses in Radiotherapy

Kim, W., Lee, S., Seo, D., Kim, D., Kim, K., Kim, E., Kang, J., Seong, K. M., Youn, H., & Youn, B. (2019) · Cells · doi:10.3390/cells8091105 · Cited by 370

Cancer Stem Cells and Radioresistance: DNA Repair and Beyond

Schulz, A., Meyer, F., Dubrovska, A., & Borgmann, K. (2019) · Cancers · doi:10.3390/cancers11060862 · Cited by 317

Pathophysiology of Radiation-Induced Dysphagia in Head and Neck Cancer

King, S. N., Dunlap, N., Tennant, P., & Pitts, T. E. (2016) · Dysphagia · doi:10.1007/s00455-016-9710-1 · Cited by 251

Biological effects of radiation on cancer cells

Wang, J., Wang, H., & Qian, H. (2018) · Military Medical Research · doi:10.1186/s40779-018-0167-4 · Cited by 247

Role of Mitochondria in Radiation Responses: Epigenetic, Metabolic, and Signaling Impacts

Averbeck, D., & Rodriguez‐Lafrasse, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222011047 · Cited by 262

Ionizing radiation-induced oxidative stress, epigenetic changes and genomic instability: The pivotal role of mitochondria

Szumiel, I. (2014) · International Journal of Radiation Biology · doi:10.3109/09553002.2014.934929 · Cited by 240

Targeted iron oxide nanoparticles for the enhancement of radiation therapy

Hauser, A. K., Mitov, M. I., Daley, E. F., McGarry, R. C., Anderson, K. W., & Hilt, J. Z. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.07.032 · Cited by 202

The impact of high and low dose ionising radiation on the central nervous system

Betlazar, C., Middleton, R. J., Banati, R. B., & Liu, G.-J. (2016) · Redox Biology · doi:10.1016/j.redox.2016.08.002 · Cited by 196

Effect of ionizing radiation on physiological and molecular processes in plants

Gudkov, S. V., Grinberg, M. A., Sukhov, V., & Vodeneev, V. (2019) · Journal of Environmental Radioactivity · doi:10.1016/j.jenvrad.2019.02.001 · Cited by 179

A review of radiation countermeasures focusing on injury-specific medicinals and regulatory approval status: part I. Radiation sub-syndromes, animal models and FDA-approved countermeasures

Singh, V. K., & Seed, T. M. (2017) · International Journal of Radiation Biology · doi:10.1080/09553002.2017.1332438 · Cited by 180

Potential relationship between the biological effects of low-dose irradiation and mitochondrial ROS production

Kawamura, K., Qi, F., & Kobayashi, J. (2018) · Journal of Radiation Research · doi:10.1093/jrr/rrx091 · Cited by 176

Mechanisms of radiation-induced endothelium damage: Emerging models and technologies

Wijerathne, H., Langston, J. C., Yang, Q., Sun, S., Miyamoto, C. T., Kilpatrick, L. E., & Kiani, M. F. (2021) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2021.02.007 · Cited by 194

Molecular targeting of hypoxia in radiotherapy

Rey, S., Schito, L., Koritzinsky, M., & Wouters, B. G. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.10.002 · Cited by 178

Direct Cell Radiolabeling for in Vivo Cell Tracking with PET and SPECT Imaging

Gawne, P. J., Man, F., Blower, P. J., & de Rosales, R. T. M. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00767 · Cited by 168

Targeted and Off-Target (Bystander and Abscopal) Effects of Radiation Therapy: Redox Mechanisms and Risk/Benefit Analysis

Pouget, J., Georgakilas, A. G., & Ravanat, J. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7267 · Cited by 172

Ionizing radiation biomarkers in epidemiological studies – An update

Hall, J. A., Jeggo, P. A., West, C., Gomolka, M., Quintens, R., Badie, C., Laurent, O., Aerts, A., Anastasov, N., Azimzadeh, O., et al. (2017) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2017.01.001 · Cited by 155

Radiation-Induced Chromosomal Aberrations and Immunotherapy: Micronuclei, Cytosolic DNA, and Interferon-Production Pathway

Durante, M., & Formenti, S. C. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00192 · Cited by 156

Redox Paradox: A Novel Approach to Therapeutics-Resistant Cancer

Chaiswing, L., Clair, W. H. S., & Clair, D. K. S. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7485 · Cited by 149

Melatonin as an adjuvant in radiotherapy for radioprotection and radiosensitization

Farhood, B., Goradel, N. H., Mortezaee, K., Khanlarkhani, N., Salehi, E., Nashtaei, M. S., Mirtavoos‐Mahyari, H., Motevaseli, E., Shabeeb, D., Musa, A. E., et al. (2018) · Clinical & Translational Oncology · doi:10.1007/s12094-018-1934-0 · Cited by 144

Ionizing radiation, antioxidant response and oxidative damage: A meta-analysis

Einor, D., Bonisoli‐Alquati, A., Costantini, D., Mousseau, T. A., & Møller, A. P. (2016) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2016.01.027 · Cited by 138

In Response to Precision Medicine: Current Subcellular Targeting Strategies for Cancer Therapy

Li, Z., Zou, J., & Chen, X. S. (2022) · Advanced Materials · doi:10.1002/adma.202209529 · Cited by 133

Metabolomic applications in radiation biodosimetry: exploring radiation effects through small molecules

Pannkuk, E. L., Fornace, A. J., & Laiakis, E. C. (2017) · International Journal of Radiation Biology · doi:10.1080/09553002.2016.1269218 · Cited by 121

Role of Mitochondria in Cancer Immune Evasion and Potential Therapeutic Approaches

Klein, K., He, K., Younes, A. I. A., Barsoumian, H. B., Chen, D., Ozgen, T., Mosaffa, S., Patel, R. R., Gu, M., Novaes, J. A. M. D. O., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.573326 · Cited by 126

Optimizing Boron Neutron Capture Therapy (BNCT) to Treat Cancer: An Updated Review on the Latest Developments on Boron Compounds and Strategies

Hughes, A. M., & Hu, N. (2023) · Cancers · doi:10.3390/cancers15164091 · Cited by 121

Effects of ionizing radiation on the mammalian brain

Hladik, D., & Tapio, S. (2016) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2016.08.003 · Cited by 109

Protection against Radiotherapy-Induced Toxicity

Hall, S., Rudrawar, S., Zunk, M., Bernaitis, N., Arora, D. S., McDermott, C., & Anoopkumar‐Dukie, S. (2016) · Antioxidants · doi:10.3390/antiox5030022 · Cited by 104

Subcellular Targeting of Theranostic Radionuclides

Bavelaar, B. M., Lee, B. Q., Gill, M. R., Falzone, N., & Vallis, K. A. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00996 · Cited by 101

Direct 1O2 optical excitation: A tool for redox biology

Blázquez‐Castro, A. (2017) · Redox Biology · doi:10.1016/j.redox.2017.05.011 · Cited by 98

Topical Formulation Containing Naringenin: Efficacy against Ultraviolet B Irradiation-Induced Skin Inflammation and Oxidative Stress in Mice

Martinez, R. M., Pinho-Ribeiro, F. A., Steffen, V. S., Silva, T. C. C., Caviglione, C. V., Bottura, C., Fonseca, M. J. V., Vicentini, F. T. M. C., Vignoli, J. A., Baracat, M. M., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0146296 · Cited by 96

Normal-Tissue Tolerance to Radiopharmaceutical Therapies, the Knowns and the Unknowns

Wahl, R. L., Sgouros, G., Iravani, A., Jacene, H., Pryma, D., Saboury, B., Capala, J., & Graves, S. A. (2021) · Journal of Nuclear Medicine · doi:10.2967/jnumed.121.262751 · Cited by 95

Low-Dose Irradiation Promotes Persistent Oxidative Stress and Decreases Self-Renewal in Hematopoietic Stem Cells

Rodrigues-Moreira, S., Moreno, S. G., Ghinatti, G., Lewandowski, D., Hoffschir, F., Ferri, F., Gallouët, A.-S., Gay, D. L., Motohashi, H., Yamamoto, M. P., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.09.013 · Cited by 99

Radiation-Induced Bystander Effect is Mediated by Mitochondrial DNA in Exosome-Like Vesicles

Ariyoshi, K., Miura, T., Kasai, K., Fujishima, Y., Nakata, A., & Yoshida, M. A. (2019) · Scientific Reports · doi:10.1038/s41598-019-45669-z · Cited by 91

Targeting cancer-cell mitochondria and metabolism to improve radiotherapy response

McCann, E., O'Sullivan, J. N., & Marcone, S. (2020) · Translational Oncology · doi:10.1016/j.tranon.2020.100905 · Cited by 89

Effects of Gamma Radiation on Crop Production

Ali, H., Ghori, Z., Sheikh, S., & Gul, A. (2015) · Springer eBooks · doi:10.1007/978-3-319-23162-4_2 · Cited by 91

Silver Nanoparticles Induce Mitochondrial Protein Oxidation in Lung Cells Impacting Cell Cycle and Proliferation

Holmila, R. J., Vance, S. A., King, S. B., Tsang, A. W., Singh, R. N., & Furdui, C. M. (2019) · Antioxidants · doi:10.3390/antiox8110552 · Cited by 84

Radiation-Induced Immunity and Toxicities: The Versatility of the cGAS-STING Pathway

Constanzo, J., Faget, J., Ursino, C., Badie, C., & Pouget, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.680503 · Cited by 85

Targeting of cellular redox metabolism for mitigation of radiation injury

Farhood, B., Ashrafizadeh, M., Khodamoradi, E., Hoseini‐Ghahfarokhi, M., Afrashi, S., Musa, A. E., & Najafi, M. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117570 · Cited by 78

Radiation induces apoptosis primarily through the intrinsic pathway in mammalian cells

Cao, X., Wen, P., Fu, Y., Gao, Y., Qi, X., Chen, B., Tao, Y., Wu, L., Xu, A., Lü, H., et al. (2019) · Cellular Signalling · doi:10.1016/j.cellsig.2019.06.002 · Cited by 76

A comprehensive review of sensors of radiation‐induced damage, radiation‐induced proximal events, and cell death

Saini, S., & Gurung, P. (2024) · Immunological Reviews · doi:10.1111/imr.13409 · Cited by 84

Repair characteristics and time-dependent effects in Saccharomyces cerevisiae cells after X-ray irradiation

Guo, X., Zhang, M., Liu, R., Gao, Y., Yang, Y., Li, W., & Lü, D. (2018) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-018-2566-9 · Cited by 71

Radiation induces progenitor cell death, microglia activation, and blood-brain barrier damage in the juvenile rat cerebellum

Zhou, K., Boström, M., Ek, C. J., Li, T., Xie, C., Xu, Y., Sun, Y., Blomgren, K., & Zhu, C. (2017) · Scientific Reports · doi:10.1038/srep46181 · Cited by 68

Radioprotective Effect of Flavonoids on Ionizing Radiation-Induced Brain Damage

Wang, Q., Xie, C., Xi, S.-J., Qian, F., Peng, X., Huang, J., & Tang, F.-R. (2020) · Molecules · doi:10.3390/molecules25235719 · Cited by 73

Ionizing radiation and heart risks

Bhattacharya, S., & Asaithamby, A. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.01.045 · Cited by 67

Ameliorating mitochondrial dysfunction restores carbon ion-induced cognitive deficits via co-activation of NRF2 and PINK1 signaling pathway

Liu, Y., Yan, J., Sun, C., Guo, L., Li, S., Zhang, L., Di, C., Gan, L., Wang, Y., Zhou, R., et al. (2018) · Redox Biology · doi:10.1016/j.redox.2018.04.012 · Cited by 68

Brain Damage and Patterns of Neurovascular Disorder after Ionizing Irradiation. Complications in Radiotherapy and Radiation Combined Injury

Gorbunov, N. V., & Kiang, J. G. (2021) · Radiation Research · doi:10.1667/rade-20-00147.1 · Cited by 69

Reactive Oxygen Species: Angels and Demons in the Life of a Neuron

Biswas, K., Alexander, K. D., & Francis, M. M. (2022) · NeuroSci · doi:10.3390/neurosci3010011 · Cited by 74

Reprogramming of Energy Metabolism in Response to Radiotherapy in Head and Neck Squamous Cell Carcinoma

Cruz‐Gregorio, A., Martínez-Ramírez, I., Pedraza‐Chaverrí, J., & Lizano, M. (2019) · Cancers · doi:10.3390/cancers11020182 · Cited by 67

Age-related effects of X-ray irradiation on mouse hippocampus

Casciati, A., Dobos, K., Antonelli, F., Benedek, A., Kempf, S. J., Bellés, M., Balogh, A., Tanori, M., Heredia, L., Atkinson, M. J., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.8575 · Cited by 66

The Protective Roles of ROS‐Mediated Mitophagy on 125I Seeds Radiation Induced Cell Death in HCT116 Cells

Hu, L., Wang, H., Huang, L., Zhao, Y. L., & Wang, J. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/9460462 · Cited by 66

Live cell imaging of mitochondria following targeted irradiation in situ reveals rapid and highly localized loss of membrane potential

Walsh, D. W. M., Siebenwirth, C., Greubel, C., Ilicic, K., Reindl, J., Girst, S., Muggiolu, G., Simon, M., Barberet, P., Seznec, H., et al. (2017) · Scientific Reports · doi:10.1038/srep46684 · Cited by 66

Fasting, Fats, and Physics: Combining Ketogenic and Radiation Therapy against Cancer

Klement, R. J. (2017) · Complementary Medicine Research · doi:10.1159/000484045 · Cited by 66

Cdk5-mediated Drp1 phosphorylation drives mitochondrial defects and neuronal apoptosis in radiation-induced optic neuropathy

Rong, R., Xia, X., Peng, H., Li, H., You, M., Liang, Z., Yao, F., Yao, X., Xiong, K., Huang, J., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-02922-y · Cited by 66

Mitochondrial Signaling Pathways Associated with DNA Damage Responses

Shimura, T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076128 · Cited by 71

Magnetite and bismuth sulfide Janus heterostructures as radiosensitizers for in vivo enhanced radiotherapy in breast cancer

Nosrati, H., Ghaffarlou, M., Salehiabar, M., Mousazadeh, N., Abhari, F., Barsbay, M., Ertas, Y. N., Rashidzadeh, H., Mohammadi, A., Nasehi, L., et al. (2022) · Biomaterials Advances · doi:10.1016/j.bioadv.2022.213090 · Cited by 60

The role of radiation induced oxidative stress as a regulator of radio-adaptive responses

Sisakht, M., Darabian, M., Mahmoodzadeh, A., Bazı, A., Shafiee, S. M., Mokarram, P., & Khoshdel, Z. (2020) · International Journal of Radiation Biology · doi:10.1080/09553002.2020.1721597 · Cited by 60

Control of Neuroinflammation through Radiation-Induced Microglial Changes

Boyd, A., Byrne, S., Middleton, R. J., Banati, R. B., & Liu, G. J. (2021) · Cells · doi:10.3390/cells10092381 · Cited by 65

Crosstalk between autophagy and intracellular radiation response (Review)

Hu, L., Wang, H., Huang, L., Zhao, Y. L., & Wang, J. (2016) · International Journal of Oncology · doi:10.3892/ijo.2016.3719 · Cited by 58

Severe mitochondrial damage associated with low-dose radiation sensitivity in ATM- and NBS1-deficient cells

Shimura, T., Kobayashi, J., Komatsu, K., & Kunugita, N. (2016) · Cell Cycle · doi:10.1080/15384101.2016.1156276 · Cited by 55

FLASH Radiotherapy: Expectations, Challenges, and Current Knowledge

Borghini, A., Labate, L. U., Piccinini, S., Panaino, C. M. V., Andreassi, M. G., & Gizzi, L. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052546 · Cited by 55

Roles of Sulfur Metabolism and Rhodanese in Detoxification and Anti-Oxidative Stress Functions in the Liver: Responses to Radiation Exposure

Nakajima, T. (2015) · Medical Science Monitor · doi:10.12659/msm.893234 · Cited by 55

Antioxidant marine algae phlorotannins and radioprotection: A review of experimental evidence

Shin, T., Ahn, M., Hyun, J. W., Kim, S. H., & Moon, C. (2014) · Acta Histochemica · doi:10.1016/j.acthis.2014.03.008 · Cited by 55

Targeting mitochondria in cancer cells using gold nanoparticle‐enhanced radiotherapy: A Monte Carlo study

Kirkby, C., & Ghasroddashti, E. (2015) · Medical Physics · doi:10.1118/1.4906192 · Cited by 55

Dose enhancement effects to the nucleus and mitochondria from gold nanoparticles in the cytosol

McNamara, A. L., Kam, W. W.-Y., Scales, N., McMahon, S. J., Bennett, J. W., Byrne, H. L., Schuemann, J., Paganetti, H., Banati, R. B., & Kuncic, Z. (2016) · Physics in Medicine and Biology · doi:10.1088/0031-9155/61/16/5993 · Cited by 54

The influence of ketogenic therapy on the 5 R’s of radiobiology

Klement, R. J. (2017) · International Journal of Radiation Biology · doi:10.1080/09553002.2017.1380330 · Cited by 54

Chronic Ionizing Radiation of Plants: An Evolutionary Factor from Direct Damage to Non-Target Effects

Duarte, G. T., Volkova, P., Pérez, F. F., & Horemans, N. (2023) · Plants · doi:10.3390/plants12051178 · Cited by 56

Early Disruption of the Microbiome Leading to Decreased Antioxidant Capacity and Epigenetic Changes: Implications for the Rise in Autism

Eshraghi, R. S., Deth, R. C., Mittal, R., Aranke, M., Kay, S.-I. S., Moshiree, B., & Eshraghi, A. A. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00256 · Cited by 58

MitoQ ameliorates testicular damage induced by gamma irradiation in rats: Modulation of mitochondrial apoptosis and steroidogenesis

Ibrahim, A. A., Karam, H. M., Shaaban, E. A., Safar, M. M., & El-Yamany, M. F. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116655 · Cited by 51

Integrative assessment of low-dose gamma radiation effects on Daphnia magna reproduction: Toxicity pathway assembly and AOP development

Song, Y., Xie, L., Lee, Y., Brede, D. A., Lyne, F. M., Kassaye, Y. A., Thaulow, J., Caldwell, G. S., Salbu, B., & Tollefsen, K. E. (2019) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2019.135912 · Cited by 52

Radiation-induced liver disease: beyond DNA damage

Zhou, Y. J., Tang, Y., Liu, S. J., Zeng, P. H., Qu, L., Jing, Q., & Yin, W. J. (2022) · Cell Cycle · doi:10.1080/15384101.2022.2131163 · Cited by 50

Enhanced cytotoxic and genotoxic effects of gadolinium-doped ZnO nanoparticles on irradiated lung cancer cells at megavoltage radiation energies

Zangeneh, M., Nedaei, H. A., Mozdarani, H., Mahmoudzadeh, A., & Salimi, M. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.109739 · Cited by 49

Geometrical structures for radiation biology research as implemented in the TOPAS-nBio toolkit

McNamara, A. L., Ramos‐Méndez, J., Perl, J., Held, K. D., Dominguez, N., Moreno, E., Henthorn, N. T., Kirkby, K. J., Meylan, S., Villagrasa, C., et al. (2018) · Physics in Medicine and Biology · doi:10.1088/1361-6560/aad8eb · Cited by 48

The effect of radiation dose on mouse skeletal muscle remodeling

Hardee, J. P., Puppa, M., Fix, D. K., Gao, S., Hetzler, K. L., Bateman, T. A., & Carson, J. A. (2014) · Radiology and Oncology · doi:10.2478/raon-2014-0025 · Cited by 47

Mild mitochondrial uncoupling protects from ionizing radiation induced cell death by attenuating oxidative stress and mitochondrial damage

Rai, Y., Anita, A., Kumari, N., Singh, S., Kalra, N., Soni, R., & Bhatt, A. N. (2020) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2020.148325 · Cited by 45

Metformin mitigates gastrointestinal radiotoxicity and radiosensitises P53 mutation colorectal tumours via optimising autophagy

Chen, L., Liao, F., Jiang, Z., Zhang, C., Wang, Z., Luo, P., Jiang, Q., Wu, J., Wang, Q., Luo, M., et al. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15149 · Cited by 45

Exposure to environmental radionuclides is associated with altered metabolic and immunity pathways in a wild rodent

Kesäniemi, J., Jernfors, T., Lavrinienko, A., Kivisaari, K., Kiljunen, M., Mappes, T., & Watts, P. C. (2019) · Molecular Ecology · doi:10.1111/mec.15241 · Cited by 44

Cancer stem cells (CSCs): key player of radiotherapy resistance and its clinical significance

Hoque, S., Dhar, R., Kar, R., Mukherjee, S., Mukherjee, D., Mukerjee, N., Nag, S., Tomar, N., & Mallik, S. (2022) · Biomarkers · doi:10.1080/1354750x.2022.2157875 · Cited by 43

In vivo assessment of reactive oxygen species production and oxidative stress effects induced by chronic exposure to gamma radiation in Caenorhabditis elegans

Maremonti, E., Eide, D. M., Rossbach, L. M., Lind, O. C., Salbu, B., & Brede, D. A. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.11.037 · Cited by 43

Mitochondrial reactive oxygen species-mediated genomic instability in low-dose irradiated human cells through nuclear retention of cyclin D1

Shimura, T., & Kunugita, N. (2016) · Cell Cycle · doi:10.1080/15384101.2016.1170271 · Cited by 42

Repurposing DNA repair factors to eradicate tumor cells upon radiotherapy

Bhattacharya, S., & Asaithamby, A. (2017) · Translational Cancer Research · doi:10.21037/tcr.2017.05.22 · Cited by 44

Gamma radiation induces dose-dependent oxidative stress and transcriptional alterations in the freshwater crustacean Daphnia magna

Gomes, T., Song, Y., Brede, D. A., Xie, L., Gützkow, K. B., Salbu, B., & Tollefsen, K. E. (2018) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2018.02.039 · Cited by 42

NOBF4-Functionalized Au–Fe3O4 Nanoheterodimers for Radiation Therapy: Synergy Effect Due to Simultaneous Reactive Oxygen and Nitrogen Species Formation

Klein, S., Harreiß, C., Menter, C., Hümmer, J., Distel, L. V., Meyer, K., Hock, R., & Kryschi, C. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b03660 · Cited by 42

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Cha, M., Seo, J., Kim, H. J., Kim, M. H., Yoon, H.-S., Jo, S. W., Oh, S., & Chang, J. H. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.120.019072 · Cited by 42

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Chien, L., Chen, W.-K., Liu, S.-T., Chang, C., Kao, M., Chen, K., Chiu, S.-C., Hsu, M.-L., Hsiang, I.-C., Chen, Y.-J., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.5790 · Cited by 41

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Cuccurullo, V., Stasio, G. D. D., Cascini, G. L., Gatta, G., & Bianco, C. (2019) · Diagnostics · doi:10.3390/diagnostics9040127 · Cited by 40

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Foglietta, F., Serpe, L., & Canaparo, R. (2023) · Discover Nano · doi:10.1186/s11671-023-03939-w · Cited by 41

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Ueta, K., Yamamoto, J., Tanaka, T., Nakano, Y., Kitagawa, T., & Nishizawa, S. (2016) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2016.2841 · Cited by 41

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Baulch, J. E. (2018) · International Journal of Radiation Biology · doi:10.1080/09553002.2018.1549757 · Cited by 37

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