Protein carbonylation after traumatic brain injury: cell specificity, regional susceptibility, and gender differences
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Protein carbonylation is a well-documented and quantifiable consequence of oxidative stress in several neuropathologies, including multiple sclerosis, Alzheimer׳s disease, and Parkinson׳s disease. Although oxidative stress is a hallmark of traumatic brain injury (TBI), little work has explored the specific neural regions and cell types in which protein carbonylation occurs. Furthermore, the effect of gender on protein carbonylation after TBI has not been studied. The present investigation was designed to determine the regional and cell specificity of TBI-induced protein carbonylation and how this response to injury is affected by gender. Immunohistochemistry was used to visualize protein carbonylation in the brains of adult male and female Sprague-Dawley rats subjected to controlled cortical impact (CCI) as an injury model of TBI. Cell-specific markers were used to colocalize the presence of carbonylated proteins in specific cell types, including astrocytes, neurons, microglia, and oligodendrocytes. Results also indicated that the injury lesion site, ventral portion of the dorsal third ventricle, and ventricular lining above the median eminence showed dramatic increases in protein carbonylation after injury. Specifically, astrocytes and limited regions of ependymal cells adjacent to the dorsal third ventricle and the median eminence were most susceptible to postinjury protein carbonylation. However, these patterns of differential susceptibility to protein carbonylation were gender dependent, with males showing significantly greater protein carbonylation at sites distant from the lesion. Proteomic analyses were also conducted and determined that the proteins most affected by carbonylation in response to TBI include glial fibrillary acidic protein, dihydropyrimidase-related protein 2, fructose-bisphosphate aldolase C, and fructose-bisphosphate aldolase A. Many other proteins, however, were not carbonylated by CCI. These findings indicate that there is both regional and protein specificity in protein carbonylation after TBI. The marked increase in carbonylation seen in ependymal layers distant from the lesion suggests a mechanism involving the transmission of a cerebral spinal fluid-borne factor to these sites. Furthermore, this process is affected by gender, suggesting that hormonal mechanisms may serve a protective role against oxidative stress.
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Protein carbonylation, a marker of oxidative damage, was lower in the brains of female rats compared with males post-TBI.
“Protein carbonylation, a marker of oxidative damage, was also lower in the brains of female rats compared with males post-TBI.”
From Sex Differences in Traumatic Brain Injury: What We Know and What We Should Know (2019) · cites this paper as [130]
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Astrocytes: Biology and pathology
Sofroniew, M. V., & Vinters, H. V. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0619-8 · Cited by 5,196 · see citing works
Pathophysiology of traumatic brain injury
Werner, C., & Engelhard, K. (2007) · British Journal of Anaesthesia · doi:10.1093/bja/aem131 · Cited by 1,712 · see citing works
Chen, Y., & Swanson, R. A. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000044631.80210.3c · Cited by 895 · see citing works
Protein carbonylation, cellular dysfunction, and disease progression
Dalle‐Donne, I., Aldini, G., Carini, M., Colombo, R., Rossi, R., & Milzani, A. (2006) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2006.tb00407.x · Cited by 836 · see citing works
Devi, L., Prabhu, B. M., Galati, D. F., Avadhani, N. G., & Anandatheerthavarada, H. K. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1469-06.2006 · Cited by 792 · see citing works
Mitochondrial Dysfunction Is a Primary Event in Glutamate Neurotoxicity
Schinder, A. F., Olson, E. C., Spitzer, N. C., & Montal, M. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-19-06125.1996 · Cited by 770 · see citing works
Eng, L. F. (1985) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(85)80063-1 · Cited by 737 · see citing works
Castegna, A., Aksenov, M. Y., Thongboonkerd, V., Klein, J. B., Pierce, W. M. J., Booze, R. M., Markesbery, W. R., & Butterfield, D. A. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01103.x · Cited by 581 · see citing works
Astrocytes protect neurons from hydrogen peroxide toxicity
Desagher, S., Glowinski, J., & Prémont, J. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-08-02553.1996 · Cited by 543 · see citing works
Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche
Lee, D. A., Bedont, J. L., Pak, T., Wang, H., Song, J., Miranda-Angulo, A., Takiar, V., Charubhumi, V., Balordi, F., Takebayashi, H., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3079 · Cited by 502 · see citing works
Hypothalamic tanycytes: a key component of brain-endocrine interaction
RODRIGUEZ, E., BLAZQUEZ, J., PASTOR, F., PELAEZ, B., PENA, P., PERUZZO, B., & AMAT, P. (2005) · International review of cytology · doi:10.1016/s0074-7696(05)47003-5 · Cited by 475 · see citing works
Ependymal cells: biology and pathology
Bigio, M. R. D. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0624-y · Cited by 381 · see citing works
Mitochondrial calcium and oxidative stress as mediators of ischemic brain injury
Starkov, A. A., Chinopoulos, C., & Fiskum, G. M. (2004) · Cell Calcium · doi:10.1016/j.ceca.2004.02.012 · Cited by 339 · see citing works
Increased lipid peroxidation in sera of ALS patients
Simpson, E. P., Henry, Y. K., Henkel-Tigges, J., Smith, R. G., & Appel, S. H. (2004) · Neurology · doi:10.1212/wnl.62.10.1758 · Cited by 328 · see citing works
Role of Oxidative Stress in the Progression of Alzheimer's Disease
Rukhsana Sultana, A., & Butterfield, D. A. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1222 · Cited by 327 · see citing works
Progesterone protects against lipid peroxidation following traumatic brain injury in rats
Roof, R. L., Hoffman, S. W., & Stein, D. G. (1997) · Molecular and Chemical Neuropathology · doi:10.1007/bf02815156 · Cited by 317 · see citing works
Readnower, R. D., Chavko, M., Adeeb, S., Conroy, M. D., Pauly, J. R., McCarron, R. M., & Sullivan, P. G. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22510 · Cited by 313 · see citing works
Progesterone and Estrogen Regulate Oxidative Metabolism in Brain Mitochondria
Irwin, R. W., Yao, J., Hamilton, R. T., Cadenas, E., Brinton, R. D., & Nilsen, J. (2008) · Endocrinology · doi:10.1210/en.2007-1227 · Cited by 289 · see citing works
Oxidative Stress in Traumatic Brain Injury
Rodríguez-Rodríguez, A., Egea-Guerrero, J. J., Murillo-Cabezas, F., & Carrillo‐Vico, A. (2014) · Current Medicinal Chemistry · doi:10.2174/0929867321666131217153310 · Cited by 266 · see citing works
Oxidative Stress Following Traumatic Brain Injury in Rats
Tyurin, V. A., Tyurina, Y. Y., Borisenko, G. G., Соколова, Т. В., Ritov, V. B., Quinn, P. J., Rose, M. E., Kochanek, P. M., Graham, S. H., & Kagan, V. E. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0752178.x · Cited by 249 · see citing works
Faul, M., Xu, L., Wald, M. M., Coronado, V. G., & Dellinger, A. M. (2010) · Injury Prevention · doi:10.1136/ip.2010.029215.951 · Cited by 240 · see citing works
Roof, R. L., & Hall, E. D. (2000) · Journal of Neurotrauma · doi:10.1089/neu.2000.17.1155 · Cited by 233 · see citing works
Chen, Y., & Swanson, R. A. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200302000-00001 · Cited by 228 · see citing works
Neuroprotection by resveratrol against traumatic brain injury in rats
Ateş, Ö., Cayli, S. R., Altınöz, E., Gürses, İ., Yücel, N., Sener, M., Koçak, A., & Yoloğlu, S. (2006) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-006-9253-0 · Cited by 219 · see citing works
Female TBI patients recover better than males
Groswasser, Z., Cohen, M., & Keren, O. (1998) · Brain Injury · doi:10.1080/026990598122197 · Cited by 216 · see citing works
(E)-4-Hydroxy-2-Nonenal May be Involved in the Pathogenesis of Parkinson’s Disease
Selley, M. L. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00021-5 · Cited by 215 · see citing works
The Effect of Gender on Patients With Moderate to Severe Head Injuries
Berry, C., Ley, E. J., Tillou, A., Cryer, G., Margulies, D. R., & Salim, A. (2009) · Journal of Trauma: Injury, Infection & Critical Care · doi:10.1097/ta.0b013e3181ba3354 · Cited by 197 · see citing works
Marked Gender Effect on Lipid Peroxidation after Severe Traumatic Brain Injury in Adult Patients
Bayir, H., Marion, D. W., Puccio, A. M., Wisniewski, S. R., Janesko, K. L., Clark, R. S. B., & Kochanek, P. M. (2004) · Journal of Neurotrauma · doi:10.1089/089771504772695896 · Cited by 194 · see citing works
Redox Proteomics in Selected Neurodegenerative Disorders: From Its Infancy to Future Applications
Butterfield, D. A., Marzia Perluigi, A., Reed, T. T., Muharib, T., Hughes, C. P., Robinson, R. A. S., & Rukhsana Sultana, A. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4109 · Cited by 167 · see citing works
Opii, W. O., Nukala, V. N., Rukhsana Sultana, A., Pandya, J. D., Day, K. M., Merchant, M. L., Klein, J. B., Sullivan, P. G., & Butterfield, D. A. (2007) · Journal of Neurotrauma · doi:10.1089/neu.2006.0229 · Cited by 160 · see citing works
Peuchen, S., Bolaños, J. P., Heales, S., Almeida, Á., Duchen, M. R., & Clark, J. B. (1997) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00010-5 · Cited by 160 · see citing works
Does Progesterone Have Neuroprotective Properties?
Stein, D. G., Wright, D. W., & Kellermann, A. L. (2007) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2007.05.001 · Cited by 148 · see citing works
Beschorner, R., Adjodah, D., Schwab, J. M., Mittelbronn, M. G. A., Pedal, I., Mattern, R., Schluesener, H. J., & Meyermann, R. (2000) · Acta Neuropathologica · doi:10.1007/s004010000202 · Cited by 141 · see citing works
Tryptophan metabolism and oxidative stress in patients with chronic brain injury
Mackay, G., Forrest, C. M., Stoy, N. S., Christofides, J. A., Egerton, M., Stone, T. W., & Darlington, L. G. (2006) · European Journal of Neurology · doi:10.1111/j.1468-1331.2006.01220.x · Cited by 126 · see citing works
Bizzozero, O. A., DeJesus, G., Callahan, K., & Pastuszyn, A. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20587 · Cited by 124 · see citing works
Oxidative stress in head trauma in aging
Shao, C., Roberts, K. N., Markesbery, W. R., Scheff, S. W., & Lovell, M. A. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.03.007 · Cited by 111 · see citing works
Barrett, P., Ivanova, E., Graham, E. S., Ross, A., Wilson, D., Plé, H., Mercer, J. G., Ebling, F. J. P., Schuhler, S., Dupré, S. M., et al. (2006) · Journal of Endocrinology · doi:10.1677/joe.1.06929 · Cited by 111 · see citing works
The Distributional Nexus of Choroid Plexus to Cerebrospinal Fluid, Ependyma and Brain
Johanson, C. E., Stopa, E. G., McMillan, P. N., Roth, D. R., Funk, J., & Krinke, G. J. (2010) · Toxicologic Pathology · doi:10.1177/0192623310394214 · Cited by 105 · see citing works
Rapid proteomic remodeling of cardiac tissue caused by total body ionizing radiation
Azimzadeh, O., Scherthan, H., Sarioglu, H., Barjaktarović, Ž., Conrad, M., Vogt, A., Calzada‐Wack, J., Neff, F., Aubele, M. M., Buske, C., et al. (2011) · PROTEOMICS · doi:10.1002/pmic.201100178 · Cited by 101 · see citing works
Oxidative Stress - Molecular Mechanisms and Biological Effects
Lushchak, V. I., & Semchyshyn, H. M. (2012) · InTech eBooks · doi:10.5772/2333 · Cited by 90 · see citing works
Aldolase directly interacts with ARNO and modulates cell morphology and acidic vesicle distribution
Merkulova, M., Hurtado‐Lorenzo, A., Hosokawa, H., Zhuang, Z., Brown, D., Ausiello, D. A., & Marshansky, V. N. (2011) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00076.2010 · Cited by 80 · see citing works
Suzuki, Y., Nakagomi, S., Namikawa, K., Kiryu‐Seo, S., Inagaki, N., Kaibuchi, K., Aizawa, H., Kikuchi, K., & Kiyama, H. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01920.x · Cited by 79 · see citing works
Polarized endocytosis and transcytosis in the hypothalamic tanycytes of the rat
Peruzzo, B., Pastor, F., Bl�zquez, J., Amat, P., & Rodr�guez, E. (2004) · Cell and Tissue Research · doi:10.1007/s00441-004-0899-1 · Cited by 78 · see citing works
Luoma, J. I., Kelley, B. G., & Mermelstein, P. G. (2011) · Steroids · doi:10.1016/j.steroids.2011.02.013 · Cited by 76 · see citing works
Astrocytes and catalase prevent the toxicity of catecholamines to oligodendrocytes
Noble, P. G., Antel, J. P., & Yong, V. W. (1994) · Brain Research · doi:10.1016/0006-8993(94)91525-3 · Cited by 70 · see citing works
Papadopoulos, M. C., Koumenis, I. L., Yuan, T. Y., & Giffard, R. G. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00320-5 · Cited by 69 · see citing works
Progesterone inhibits superoxide radical production by mononuclear phagocytes in pseudopregnant rats
Sugino, N., 嶋村, 勝., Tamura, H., Ono, M., Nakamura, Y., Ogino, K., & Kato, H. (1996) · Endocrinology · doi:10.1210/endo.137.2.8593826 · Cited by 68 · see citing works
Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications
Aldini, G., Yeum, K., Niki, E., & Russell, R. M. (2010) · Wiley eBooks · doi:10.1002/9780813814438 · Cited by 68 · see citing works
Unique Post-Translational Modifications in Specialized Microtubule Architecture
Ikegami, K., & Setou, M. (2010) · Cell Structure and Function · doi:10.1247/csf.09027 · Cited by 66 · see citing works
Piao, C.-S., Loane, D. J., Stoica, B. A., Li, S., Hanscom, M., Cabatbat, R. M., Blomgren, K., & Faden, A. I. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.03.018 · Cited by 63 · see citing works
Zheng, J., & Bizzozero, O. A. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22488 · Cited by 61 · see citing works
Vink, R., & van den Heuvel, C. (2004) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.13.10.1263 · Cited by 61 · see citing works
Nanomedicine in Health and Disease
(2011) · CRC Press eBooks · doi:10.1201/b11076 · Cited by 53 · see citing works
Post-electrophoretic identification of oxidized proteins
Conrad, C. C., Talent, J. M., Malakowsky, C. A., & Gracy, R. W. (1999) · Biological Procedures Online · doi:10.1251/bpo17 · Cited by 42 · see citing works
Mechanism of Aldolase Control of Sorting Nexin 9 Function in Endocytosis
Rangarajan, E. S., Park, H., Fortin, E., SYGUSCH, J., & Izard, T. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.092049 · Cited by 35 · see citing works
Kernt, M., Arend, N., Buerger, A., Mann, T., Haritoglou, C., ULBIG, M. W., Kampik, A., & Hirneiß, C. (2013) · Journal of Glaucoma · doi:10.1097/ijg.0b013e31824caf90 · Cited by 28 · see citing works
Halyna, M., & Volodymyr, I. (2012) · InTech eBooks · doi:10.5772/35949 · Cited by 25 · see citing works
Oikawa, S., Kobayashi, H., Kitamura, Y., Zhu, H., Obata, K., Minabe, Y., Dazortsava, M., Ohashi, K., Tada‐Oikawa, S., Takahashi, H., et al. (2014) · Free Radical Research · doi:10.3109/10715762.2014.901509 · Cited by 19 · see citing works
Oxidative stress in isolated blunt traumatic brain injury
Kavaklı, H. Ş., Erel, Ö., Karakayalı, O., Neşeli̇oğlu, S., Tanrıverdi, F., Coşkun, F., & Kahraman, A. F. (2010) · doi:10.5897/sre.9000708 · Cited by 11 · see citing works
Rzigalinski, B. A., Meehan, K., Whiting, M., Dillon, C., Hockey, K., & Brewer, M. (2011) · Science Publishers eBooks · doi:10.1201/b11076-7 · Cited by 11 · see citing works
Delayed Cell Death after Traumatic Brain Injury : Role of Reactive Oxygen Species
Clausen, F. (2004) · Uppsala University Publications (Uppsala University) · Cited by 7 · see citing works
Carini, M., & Orioli, M. (2010) · doi:10.1002/9780813814438.ch11 · Cited by 4 · see citing works
Navarro, A., Tolivia, J., & Alvarez‐Uría, M. (1995) · PubMed · Cited by 4 · see citing works
Bosken, J. M., Wang, J. A., & Hall, E. D. (2012) · Springer protocols handbooks/Springer protocols · doi:10.1007/978-1-61779-782-8_32 · Cited by 2 · see citing works
Flagged first, then by citations
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Sorted by citations
Sex Differences in Traumatic Brain Injury: What We Know and What We Should Know
Gupte, R. P., Brooks, W. M., Vukas, R. R., Pierce, J. D., & Harris, J. L. (2019) · Journal of Neurotrauma · doi:10.1089/neu.2018.6171 · Cited by 533 · see citing works
Osier, N. D., & Dixon, C. E. (2016) · Frontiers in Neurology · doi:10.3389/fneur.2016.00134 · Cited by 173 · see citing works
Yauger, Y. J., Bermudez, S., Moritz, K. E., Glaser, E. P., Stoica, B. A., & Byrnes, K. R. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1430-7 · Cited by 125 · see citing works
Sex Differences in Animal Models of Traumatic Brain Injury
Rubin, T. G., & Lipton, M. L. (2019) · Journal of Experimental Neuroscience · doi:10.1177/1179069519844020 · Cited by 117 · see citing works
Oxidized phospholipid signaling in traumatic brain injury
Anthonymuthu, T. S., Kenny, E., Lamade, A. M., Kagan, V. E., & Bayır, H. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.06.031 · Cited by 99 · see citing works
von Leden, R. E., Yauger, Y. J., Khayrullina, G., & Byrnes, K. R. (2016) · Journal of Neurotrauma · doi:10.1089/neu.2016.4486 · Cited by 90 · see citing works
Demarest, T. G., Schuh, R. A., Waddell, J., McKenna, M. C., & Fiskum, G. M. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13590 · Cited by 86 · see citing works
Phytochemical-induced nucleolar stress results in the inhibition of breast cancer cell proliferation
Lewińska, A., Bednarz, D., Adamczyk‐Grochala, J., & Wnuk, M. (2017) · Redox Biology · doi:10.1016/j.redox.2017.03.014 · Cited by 69 · see citing works
Abou‐Abbass, H., Abou‐El‐Hassan, H., Bahmad, H. F., Zibara, K., Zebian, A., Youssef, R., Ismail, J. N., Zhu, R., Zhou, S., Dong, X., et al. (2016) · Electrophoresis · doi:10.1002/elps.201500585 · Cited by 68 · see citing works
Epigenetics in acute kidney injury
Tang, J., & Zhuang, S. (2015) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000140 · Cited by 61 · see citing works
Amorini, A. M., Lazzarino, G., Pietro, V. D., Signoretti, S., Lazzarino, G., Belli, A., & Tavazzi, B. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.01.023 · Cited by 60 · see citing works
Astrocyte‐mediated mechanisms contribute to traumatic brain injury pathology
Muñoz‐Ballester, C., & Robel, S. (2023) · WIREs Mechanisms of Disease · doi:10.1002/wsbm.1622 · Cited by 53 · see citing works
Sex-Specific Differences in Redox Homeostasis in Brain Norm and Disease
Ruszkiewicz, J. A., Miranda‐Vizuete, A., Tinkov, A. A., Геннадиевна, С. М., Skalny, A. V., Tsatsakis, A. M., & Aschner, M. (2019) · Journal of Molecular Neuroscience · doi:10.1007/s12031-018-1241-9 · Cited by 47 · see citing works
Acosta, G., Race, N. S., Herr, S., Fernandez, J., TANG, J. C. Y., Rogers, E. A., & Shi, R. (2019) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2019.06.004 · Cited by 43 · see citing works
Pandya, J. D., Musyaju, S., Modi, H. R., Cao, Y. J., Flerlage, W. J., Huynh, L., Kociuba, B., Visavadiya, N. P., Kobeissy, F. H., Wang, K., et al. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.02.001 · Cited by 42 · see citing works
Fluorescence labeling of carbonylated lipids and proteins in cells using coumarin-hydrazide
Vemula, V., Ni, Z., & Fedorova, M. (2015) · Redox Biology · doi:10.1016/j.redox.2015.04.006 · Cited by 42 · see citing works
RETRACTED ARTICLE: The Na/K-ATPase Oxidant Amplification Loop Regulates Aging
Sodhi, K., Nichols, A., Mallick, A., Klug, R. L., Liu, J., Wang, X., Srikanthan, K., Goguet-Rubio, P., Nawab, A., Pratt, R. D., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-26768-9 · Cited by 32 · see citing works
RetractedMulti-Mechanistic Approaches to the Treatment of Traumatic Brain Injury: A Review
Lynch, D. G., Narayan, R. K., & Li, C. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12062179 · Cited by 32 · see citing works
Protein Citrullination: A Proposed Mechanism for Pathology in Traumatic Brain Injury
Lazarus, R. C., Buonora, J. E., Flora, M. N., Freedy, J. G., Holstein, G. R., Martinelli, G. P., Jacobowitz, D. M., & Mueller, G. P. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00204 · Cited by 29 · see citing works
Self-citationKobeissy, F. H., Kobaisi, A., Peng, W., Barsa, C., Goli, M., Sibahi, A., Hayek, S. E., Abdelhady, S., Haidar, M. A., Sabra, M., et al. (2022) · Cells · doi:10.3390/cells11030581 · Cited by 28 · see citing works
Sex-based differences of antioxidant enzyme nanoparticle effects following traumatic brain injury
Tarudji, A. W., Miller, H. A., Curtis, E. T., Porter, C. L., Madsen, G. L., & Kievit, F. M. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.01.065 · Cited by 28 · see citing works
Butterfield, D. A., & Reed, T. T. (2016) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201600003 · Cited by 27 · see citing works
Kobeissy, F. H., Goli, M., Yadikar, H., Shakkour, Z., Kurup, M., Haidar, M. A., Alroumi, S., Mondello, S., Wang, K., & Mechref, Y. S. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1288740 · Cited by 27 · see citing works
Gender proteomics I. Which proteins in non-sexual organs
Gianazza, E., Miller, I., Guerrini, U., Palazzolo, L., Parravicini, C., & Eberini, I. (2017) · Journal of Proteomics · doi:10.1016/j.jprot.2017.10.002 · Cited by 23 · see citing works
Alaaeddine, R. A., Fayad, M., Nehme, E., Bahmad, H. F., & Kobeissy, F. H. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-60733-7_4 · Cited by 20 · see citing works
Genetic analysis of the glyoxalase system in schizophrenia
Bangel, F. N., Yamada, K., Arai, M., Iwayama, Y., Balan, S., Toyota, T., Iwata, Y., Suzuki, K., Kikuchi, M., Hashimoto, T., et al. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.01.014 · Cited by 18 · see citing works
Kuzmić, M., Javot, H., Bonzom, J., Lecomte-Pradines, C., Radman, M., Garnier‐Laplace, J., & Frelon, S. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.11.004 · Cited by 18 · see citing works
Adamczyk, J., Deręgowska, A., Skoneczny, M., Skoneczna, A., Kwiatkowska, A., Potocki, L., Rawska, E., Pabian, S., Kaplan, J., Lewińska, A., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.8673 · Cited by 16 · see citing works
Zhang, Z., Li, X., Zhang, Y., Zhou, J., Chen, Y., Li, Y., & Ren, D. (2024) · Plant Science · doi:10.1016/j.plantsci.2024.112311 · Cited by 13 · see citing works
N-acetylcysteine reduces brain injury after delayed hypoxemia following traumatic brain injury
Celorrio, M., Rhodes, J., Vadivelu, S., Davies, M., & Friess, S. H. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113507 · Cited by 13 · see citing works
Moigne, T. L., Sarti, E., Nourisson, A., Zaffagnini, M., Carbone, A., Lemaire, S. D., & Henri, J. (2021) · Journal of Structural Biology · doi:10.1016/j.jsb.2022.107873 · Cited by 11 · see citing works
Oyagbemi, A. A., Adebayo, A. K., Adebiyi, O. E., Adigun, K. O., Folarin, O. R., Esan, O. O., Ajibade, T. O., Ogunpolu, B. S., Falayi, O. O., Ogunmiluyi, I. O., et al. (2023) · Biomarkers · doi:10.1080/1354750x.2022.2164354 · Cited by 10 · see citing works
Zhang, X., Li, Z., Zhang, Q., Chen, L., Huang, X., Zhang, Y., Liu, X., Liu, W., & Li, W. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000491975 · Cited by 10 · see citing works
Liu, X., Huang, Y., Zhang, Y., Li, X., Liu, C., Huang, S. C., Xu, D., Wu, Y., & Liu, X. (2016) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-015-0290-7 · Cited by 10 · see citing works
Diversity of Protein Carbonylation Pathways
Fedorova, M. (2017) · Wiley eBooks · doi:10.1002/9781119374947.ch3 · Cited by 10 · see citing works
Neuroprotection or Sex Bias: A Protective Response to Traumatic Brain Injury in the Females
Yatoo, M. I., Bahader, G. A., Beigh, S. A., Khan, A. M., James, A. W., Asmi, M. R., & Shah, Z. A. (2023) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527323666230817102125 · Cited by 9 · see citing works
Furukawa, A., Kakita, A., Chiba, Y., Kitaura, H., Fujii, Y., Fukuda, M., Kameyama, S., & Shimada, A. (2020) · Epilepsy Research · doi:10.1016/j.eplepsyres.2020.106502 · Cited by 8 · see citing works
Gowthami, N., Pursotham, N., Dey, G., Ghose, V., Sathe, G. J., Pruthi, N., Shukla, D. P., Gayathri, N., Santhoshkumar, R., Padmanabhan, B., et al. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15953 · Cited by 7 · see citing works
Effects of Sex Steroids on Damaged Neural Systems
Stein, D. G. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803592-4.00110-3 · Cited by 7 · see citing works
Bratu, T., Rogobete, A. F., Săndesc, D., Bedreag, O. H., Tanasescu, S. A., Nitu, R., Popovici, S. E., & Crăiniceanu, Z. P. (2016) · Biochemical Genetics · doi:10.1007/s10528-016-9763-8 · Cited by 7 · see citing works
Karisetty, B. C., Duscharla, D., Vijay, V., Patel, S., Soren, K., Kumar, A., Ummanni, R., & Chakravarty, S. (2024) · Journal of Proteins and Proteomics · doi:10.1007/s42485-024-00145-9 · Cited by 6 · see citing works
Moreno, F. J., Méndez, L., Raner, A., Miralles‐Pérez, B., Romeu, M., Ramos‐Romero, S., Torres, J. L., & Medina, I. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115708 · Cited by 6 · see citing works
Rajendram, R., Rajendram, R., & Preedy, V. R. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800213-1.00051-1 · Cited by 5 · see citing works
Koza, L. A., Grossberg, A. N., Bishop, M., Prusmack, C. J., & Linseman, D. A. (2024) · Advances in Redox Research · doi:10.1016/j.arres.2024.100097 · Cited by 5 · see citing works
Zhao, J., Xing, W., Ji, C., Hu, H., Zhang, Y., Wang, Z., & Liu, J. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.115019 · Cited by 4 · see citing works
Lazarus, R. C., Buonora, J. E., Kamnaksh, A., Flora, M. N., Freedy, J. G., Holstein, G. R., Martinelli, G. P., Jacobowitz, D. M., Agoston, D. V., & Mueller, G. P. (2017) · Springer eBooks · doi:10.1007/978-3-319-58244-3_16 · Cited by 3 · see citing works
Self-citationGowthami, N., & Bharath, M. M. S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-19084-1.00017-x · Cited by 2 · see citing works
Moreno, F. J., Méndez, L., Raner, A., Miralles‐Pérez, B., Romeu, M., Ramos‐Romero, S., Torres, J. L., & Medina, I. (2024) · Antioxidants · doi:10.3390/antiox13010103 · Cited by 2 · see citing works
Alarcón‐Aguilar, A., Luna‐López, A., López‐Díazguerrero, N. E., & Königsberg, M. (2018) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-018-0643-0 · Cited by 1 · see citing works
The implications of sex and gender in traumatic brain injury
Mollayeva, T., Mollayeva, S., & Colantonio, A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823036-7.00043-8
Theranostic Nanomaterials for Brain Injury
Miller, H. A., & Kievit, F. M. (2022) · Springer eBooks · doi:10.1007/978-3-031-11409-0_8
- Authors
- Lazarus, R. C., Buonora, J. E., Jacobowitz, D. M., & Mueller, G. P.
- Affiliations
- Uniformed Services University of the Health Sciences (US)
- Corresponding author
- Mueller, Gregory P.
- ORCID
- Mueller, Gregory P.
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2015-01
- Volume
- 78
- Pages
- 89-100
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W2066093115
- Cited by
- 53
- References
- 63
- Citations by year
- 2024: 5 · 2023: 10 · 2022: 3 · 2021: 1 · 2020: 3 · 2019: 5 · 2018: 4 · 2017: 6 · 2016: 12 · 2015: 4
- FWCI
- 4.78
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Free Radical Biology and Medicine (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Uniformed Services University of the Health Sciences (R07028414, T0702554)
- Topics
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- protein carbonylation, traumatic brain injury, oxidative stress, gender differences, controlled cortical impact, astrocytes, ependymal cells, median eminence, cell specificity, glial fibrillary acidic protein, fructose-1,6-bisphosphate aldolase, cerebrospinal fluid
- MeSH terms
- Animals, Astrocytes, Brain Injuries, Cells, Cultured, Ependyma, Female, Fructose-Bisphosphate Aldolase, Glial Fibrillary Acidic Protein, Immunoenzyme Techniques, Male, Nerve Tissue Proteins, Neurons, Sex Characteristics, Blotting, Western, Rats, Sprague-Dawley, Microglia, Oxidative Stress, Intercellular Signaling Peptides and Proteins, Proteomics, Protein Carbonylation, Rats
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