Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche
Open accessAbstract
Adult hypothalamic neurogenesis has recently been reported, but the cell of origin and the function of these newborn neurons are unknown. Using genetic fate mapping, we found that median eminence tanycytes generate newborn neurons. Blocking this neurogenesis altered the weight and metabolic activity of adult mice. These findings reveal a previously unreported neurogenic niche in the mammalian hypothalamus with important implications for metabolism.
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This corroborates findings indicating the existence of neural stem cells in the OVLT, SFO, ME and AP.
“which corroborates findings indicating the existence of neural stem cells in the OVLT, SFO, ME and AP78–81.”
From A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain (2023) · cites this paper as [80]
The paper’s main text (indexed under Abstract; page unavailable) identifies a neural progenitor pool in the median eminence (ME) and reports that its β2-tanycytes generate newborn neurons. It does not provide findings for neural stem cells in the OVLT, SFO, or AP, so it supports only the ME portion of the cited list. (LLM, conf=0.88)
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- Authors
- Lee, D. A., Bedont, J. L., Pak, T., Wang, H., Song, J., Miranda-Angulo, A., Takiar, V., Charubhumi, V., Balordi, F., Takebayashi, H., Aja, S., Ford, E., Fishell, G., & Blackshaw, S.
- Affiliations
- Johns Hopkins University (US)
- New York University (US)
- Niigata University (JP)
- Corresponding author
- Blackshaw, Seth
- ORCID
- Venue
- Nature Neuroscience
- Published
- 2012-03-25
- Volume
- 15
- Issue
- 5
- Pages
- 700-702
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC3380241
- OpenAlex
- W2035032297
- Cited by
- 502
- References
- 17
- Citations by year
- 2026: 10 · 2025: 24 · 2024: 24 · 2023: 50 · 2022: 23 · 2021: 45 · 2020: 38 · 2019: 29 · 2018: 25 · 2017: 43 · 2016: 41 · 2015: 43 · 2014: 41 · 2013: 42 · 2012: 24
- FWCI
- 16.17
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repository University of Antioquia (University of Antioquia) (publishedVersion, cc-by)
- PubMed Central (acceptedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- Funders
- National Science Foundation
- Johns Hopkins University
- National Alliance for Research on Schizophrenia and Depression
- National Institutes of Health
- Japan Society for the Promotion of Science (23590237)
- National Eye Institute (T32EY017203, T32EY007143)
- National Institute of Neurological Disorders and Stroke (F31NS063550)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- tanycytes, median eminence, hypothalamus, adult neurogenesis, neurogenic niche, high-fat diet, diet-induced obesity, weight gain, locomotor activity, metabolic regulation
- MeSH terms
- Age Factors, Animals, Animals, Newborn, Bacterial Proteins, Body Weight, Bromodeoxyuridine, Cell Count, Female, Histones, Intermediate Filament Proteins, Luminescent Proteins, Median Eminence, Mice, Inbred C57BL, Mice, Transgenic, Nerve Tissue Proteins, Magnetic Resonance Spectroscopy, Pregnancy, Proteins, Radiation, Receptors, Estrogen, Tamoxifen, Gene Expression Regulation, Developmental, RNA, Untranslated, Cell Proliferation, Mice, ELAV Proteins, Stem Cell Niche, Neurogenesis, SOXB1 Transcription Factors, Diet, High-Fat, Nestin
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