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Reinterpreting the best biomarker of oxidative stress: The 8-iso-prostaglandin F2α/prostaglandin F2α ratio shows complex origins of lipid peroxidation biomarkers in animal models
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“8-iso-PGF2α (8-isoprostane) is a stable and specific biomarker of oxidative stress and lipid peroxidation, formed when free radicals attack arachidonic acid in cellular lipids, which are vulnerable biological targets of oxidative stress (Van't Erve et al., 2016).”
From Airborne microplastic exposure and urinary oxidative damage biomarkers in populations living in traffic-congested areas (2026) · cites this paper as Van't Erve et al., 2016
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The isoprostanes—25 years later
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Sies, H., Berndt, C., & Jones, D. P. (2017) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-061516-045037 · Cited by 3,520
Liu, Y., Chen, Z., Li, B., Yao, H., Zarka, M., Welch, J., Sachdev, P., Bridge, W., & Braidy, N. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2020.104931 · Cited by 69
Navasumrit, P., Chompoobut, C., Rattanayut, P., Kuntinuguntanon, A., Waeya, S., Kanitwithayanun, J., & Ruchirawat, M. (2026) · Journal of Hazardous Materials Advances · doi:10.1016/j.hazadv.2026.101571
Metadata
- Authors
- van't Erve, T. J., Lih, F. B., Jelsema, C., Deterding, L. J., Eling, T. E., Mason, R. P., & Kadiiska, M. B.
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2016-06
- Volume
- 95
- Pages
- 65-73
- ISSN
- 0891-5849
- PMC
- PMC6626672
- Cited by
- 81
- References
- 1
- Language
- en
- Funders
- National Institute of Environmental Health Sciences
- National Institutes of Health
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- CoChat. (2026). Citation check: Reinterpreting the best biomarker of oxidative stress: The 8-iso-prostaglandin F2α/prostaglandin F2α ratio shows complex origins of lipid peroxidation biomarkers in animal models. https://app.cochat.ai/papers/10.1016/j.freeradbiomed.2016.03.001
- The paper
- van't Erve, T. J., Lih, F. B., Jelsema, C., Deterding, L. J., Eling, T. E., Mason, R. P., & Kadiiska, M. B. (2016). Reinterpreting the best biomarker of oxidative stress: The 8-iso-prostaglandin F2α/prostaglandin F2α ratio shows complex origins of lipid peroxidation biomarkers in animal models. Free Radical Biology and Medicine. https://doi.org/10.1016/j.freeradbiomed.2016.03.001