The isoprostanes—25 years later

A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism.

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Obesity and Systemic Oxidative Stress: Clinical Correlates of Oxidative Stress in The Framingham Study

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Lipid peroxidation: Physiological levels and dual biological effects

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Visceral and Subcutaneous Adipose Tissue Volumes Are Cross-Sectionally Related to Markers of Inflammation and Oxidative Stress

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Biological markers of oxidative stress: Applications to cardiovascular research and practice

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Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans

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Biomarkers of Oxidative Stress Study II: Are oxidation products of lipids, proteins, and DNA markers of CCl4 poisoning?

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Noncyclooxygenase oxidative formation of a series of novel prostaglandins: Analytical ramifications for measurement of eicosanoids

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Quantification of Isoprostanes as Indices of Oxidant Stress and the Risk of Atherosclerosis in Humans

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Oxidative stress and potential interventions to reduce oxidative stress in overweight and obesity

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Formation of Isoprostane-like Compounds (Neuroprostanes) in Vivo from Docosahexaenoic Acid*

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Oxidative Stress Is Associated with Adiposity and Insulin Resistance in Men

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Mass spectrometric quantification of F2-isoprostanes in biological fluids and tissues as measure of oxidant stress

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Increased F ₂ ‐isoprostanes in Alzheimer's disease: evidence for enhanced lipid peroxidation <i>in vivo</i>

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Suggested mechanism for the production of malonaldehyde during the autoxidation of polyunsaturated fatty acids. Nonenzymic production of prostaglandin endoperoxides during autoxidation

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Lipid peroxidation and neurodegenerative disease

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One-month strawberry-rich anthocyanin supplementation ameliorates cardiovascular risk, oxidative stress markers and platelet activation in humans

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Isoprostane Generation and Function

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Isoprostanes as a biomarker of lipid peroxidation in humans: physiology, pharmacology and clinical implications

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Clinical perspective on oxidative stress in sporadic amyotrophic lateral sclerosis

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Formation of novel non-cyclooxygenase-derived prostanoids (F2-isoprostanes) in carbon tetrachloride hepatotoxicity. An animal model of lipid peroxidation.

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Pharmacological ascorbate with gemcitabine for the control of metastatic and node-positive pancreatic cancer (PACMAN): results from a phase I clinical trial

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Free radical-induced generation of isoprostanes in vivo. Evidence for the formation of D-ring and E-ring isoprostanes.

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Biomarkers of lipid peroxidation in clinical material

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F 2 -Isoprostanes in Human Health and Diseases: From Molecular Mechanisms to Clinical Implications

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The relationship between dose of vitamin E and suppression of oxidative stress in humans

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Omega-3 fatty acids, oxidative stress, and leukocyte telomere length: A randomized controlled trial

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The biological relevance and measurement of plasma markers of oxidative stress in diabetes and cardiovascular disease

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Oxidative damage in Parkinson disease: Measurement using accurate biomarkers

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Cerebrospinal fluid F2‐isoprostane levels are increased in Alzheimer's disease

Montine, T., Markesbery, W., Morrow, J., & Roberts, L. (1998) · Annals of Neurology · doi:10.1002/ana.410440322 · Cited by 254 · see citing works

Urinary biomarkers of oxidative status

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Increased CSF F 2 -isoprostane concentration in probable AD

Montine, T. J., Beal, M. F., Cudkowicz, M., O’Donnell, H., Margolin, R. A., McFarland, L. L., Bachrach, A., Zackert, W. E., Roberts, L. J., & Morrow, J. D. (1999) · Neurology · doi:10.1212/wnl.52.3.562 · Cited by 251 · see citing works

Oxidative Stress and Matrix Metalloproteinase-9 in Acute Ischemic Stroke

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Increased excretion of a lipid peroxidation biomarker in autism

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Markers of oxidant stress that are clinically relevant in aging and age-related disease

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Insights into Oxidative Stress: The Isoprostanes

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[16] Mass spectrometry of prostanoids: F2-isoprostanes produced by non-cyclooxygenase free radical-catalyzed mechanism

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Biomarkers of Oxidative Damage and Inflammation in Alzheimer's Disease

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IPF 2α -I: An index of lipid peroxidation in humans

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Discovery of lipid peroxidation products formed in vivo with a substituted tetrahydrofuran ring (isofurans) that are favored by increased oxygen tension

Fessel, J. P., Porter, N. A., Moore, K. P., Sheller, J. R., & Roberts, L. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.252649099 · Cited by 219 · see citing works

Exhaled 8-isoprostane as a new non-invasive biomarker of oxidative stress in cystic fibrosis

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Release of Free F2-isoprostanes from Esterified Phospholipids Is Catalyzed by Intracellular and Plasma Platelet-activating Factor Acetylhydrolases

Stafforini, D. M., Sheller, J. R., Blackwell, T. S., Sapirstein, A., Yull, F. E., McIntyre, T. M., Bonventre, J. V., Prescott, S. M., & Roberts, L. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507340200 · Cited by 212 · see citing works

Human Biochemistry of the Isoprostane Pathway

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A nomenclature system for the isoprostanes

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Using Isoprostanes as Biomarkers of Oxidative Stress: Some Rarely Considered Issues

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Pharmacologic ascorbate synergizes with gemcitabine in preclinical models of pancreatic cancer

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Quantification of F2‐Isoprostanes in Biological Fluids and Tissues as a Measure of Oxidant Stress

Milne, G. L., Yin, H., Brooks, J. D., Sanchez, S. C., Roberts, L. J., & Morrow, J. D. (2007) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(07)33006-1 · Cited by 187 · see citing works

Obesity and Oxidative Stress Predict AKI after Cardiac Surgery

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Brain Regional Quantification of F-Ring and D-/E-Ring Isoprostanes and Neuroprostanes in Alzheimer’s Disease

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Body mass index is associated with reduced exhaled nitric oxide and higher exhaled 8-isoprostanes in asthmatics

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Association Between Cell-Free Hemoglobin, Acetaminophen, and Mortality in Patients With Sepsis: An Observational Study*

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Quantitative high performance liquid chromatography/tandem mass spectrometric analysis of the four classes of F 2 -isoprostanes in human urine

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Postoperative acute kidney injury is associated with hemoglobinemia and an enhanced oxidative stress response

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Identification of non-cyclooxygenase-derived prostanoid (F2-isoprostane) metabolites in human urine and plasma.

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Formation of Reactive Cyclopentenone Compounds in Vivo as Products of the Isoprostane Pathway

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Peripheral F2‐isoprostanes and F4‐neuroprostanes are not increased in Alzheimer's disease

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Pathophysiology of isoprostanes in the cardiovascular system: implications of isoprostane‐mediated thromboxane A 2receptor activation

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Identification of the Major Urinary Metabolite of the F2-isoprostane 8-Iso-prostaglandin F2α in Humans

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F2-isoprostanes as an indicator and risk factor for coronary heart disease

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Quantification of the Major Urinary Metabolite of 15-F2t-Isoprostane (8-iso-PGF2α) by a Stable Isotope Dilution Mass Spectrometric Assay

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Tart Cherry Juice Decreases Oxidative Stress in Healthy Older Men and Women , ,

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Systemic oxidative stress in classic Rett syndrome

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Effect of blueberry ingestion on natural killer cell counts, oxidative stress, and inflammation prior to and after 2.5 h of running

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Bioactive Eicosanoids: Role of Prostaglandin F2α and F2-Isoprostanes in Inflammation and Oxidative Stress Related Pathology

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Nomenclature of Isoprostanes: A Proposal

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Lipidomic analysis of twenty‐seven prostanoids and isoprostanes by liquid chromatography/electrospray tandem mass spectrometry

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Formation of F-ring Isoprostane-like Compounds (F3-Isoprostanes) in Vivo from Eicosapentaenoic Acid

Gao, L., Yin, H., Milne, G. L., Porter, N. A., & Morrow, J. D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601035200 · Cited by 129 · see citing works

Energy Expenditure, Inflammation, and Oxidative Stress in Steady-State Adolescents With Sickle Cell Anemia

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Metabolism of 8‐iso‐prostaglandin F2α

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The effect of vitamins C and E on biomarkers of oxidative stress depends on baseline level

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Measurement of F2- isoprostanes and isofurans using gas chromatography–mass spectrometry

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Recent advances in the biochemistry and clinical relevance of the isoprostane pathway

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Lowering of oxidative stress improves endothelial function in healthy subjects with habitually low intake of fruit and vegetables: A randomized controlled trial of antioxidant- and polyphenol-rich blackcurrant juice

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Nonenzymatic Free Radical-catalyzed Generation of Thromboxane-like Compounds (Isothromboxanes) in Vivo

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Chapter 7: Molecular Epidemiology of Genetic Polymorphisms in Estrogen Metabolizing Enzymes in Human Breast Cancer

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Profiling of oxidative stress in patients with inborn errors of metabolism

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Plasma F2-isoprostanes are elevated in newborns and inversely correlated to gestational age

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Relationship between Urinary 15-F2t-Isoprostane and 8-Oxodeoxyguanosine Levels and Breast Cancer Risk

Rössner, P., Gammon, M. D., Terry, M. B., Agrawal, M., Zhang, F. F., Teitelbaum, S. L., Eng, S. M., Gaudet, M. M., Neugut, A. I., & Santella, R. M. (2006) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-05-0554 · Cited by 107 · see citing works

Oxidative Stress, Obesity, and Breast Cancer Risk: Results From the Shanghai Women's Health Study

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F2-isoprostanes are not just markers of oxidative stress

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F2-isoprostanes mediate high glucose-induced TGF-β synthesis and glomerular proteinuria in experimental type I diabetes

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Liver ergothioneine accumulation in a guinea pig model of non-alcoholic fatty liver disease. A possible mechanism of defence?

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Targeting NRF2–KEAP1 axis by Omega-3 fatty acids and their derivatives: Emerging opportunities against aging and diseases

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Stability of oxylipins during plasma generation and long-term storage

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Genotoxic effect of microplastics and COVID-19: The hidden threat

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Early Detection and Prevention of Alzheimer’s Disease: Role of Oxidative Markers and Natural Antioxidants

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Reformulating Pro-Oxidant Microglia in Neurodegeneration

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Symposium review: Oxylipids and the regulation of bovine mammary inflammatory responses

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Evaluating the stability of three oxidative stress biomarkers under sewer conditions and potential impact for use in wastewater-based epidemiology

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Recent advances in analytical methods of oxidative stress biomarkers induced by environmental pollutant exposure

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Moving forward with isoprostanes, neuroprostanes and phytoprostanes: where are we now?

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Lead exposure and its interactions with oxidative stress polymorphisms on lung function impairment: Results from a longitudinal population-based study

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Effect of DASH diet on oxidative stress parameters: A systematic review and meta-analysis of randomized clinical trials

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Effect of ginger ( Zingiber officinale ) supplementation on oxidative stress parameters: A systematic review and meta‐analysis

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The Yin and Yang of carbon nanomaterials in atherosclerosis

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Oxidative Stress in the Newborn Period: Useful Biomarkers in the Clinical Setting

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Oxidative Stress in Peripheral Arterial Disease (PAD) Mechanism and Biomarkers

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Oxidative Stress and DNA Damage Markers in Colorectal Cancer

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Discovery and horizontal follow-up of an autoantibody signature in human prostate cancer

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Effects of anticoagulants and storage conditions on clinical oxylipid levels in human plasma

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The association between three major physiological stress systems and oxidative DNA and lipid damage

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Short-term supplementation with flavanol-rich cocoa improves lipid profile, antioxidant status and positively influences the AA/EPA ratio in healthy subjects

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Oxidation of Polyunsaturated Fatty Acids as a Promising Area of Research in Infertility

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Oxidative stress and nitric oxide are increased in obese children and correlate with cardiometabolic risk and renal function

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PQQ ameliorates D-galactose induced cognitive impairments by reducing glutamate neurotoxicity via the GSK-3β/Akt signaling pathway in mouse

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Inflammation and Oxidative Stress as Mediators of the Impacts of Environmental Exposures on Human Pregnancy: Evidence from Oxylipins

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Elevated urinary levels of 8-oxo-2′-deoxyguanosine, (5′R)- and (5′S)-8,5′-cyclo-2′-deoxyadenosines, and 8-iso-prostaglandin F2α as potential biomarkers of oxidative stress in patients with prediabetes

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2,4 DNP improves motor function, preserves medium spiny neuronal identity, and reduces oxidative stress in a mouse model of Huntington's disease

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Randomized controlled trial of N -acetylcysteine therapy for RYR1 -related myopathies

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Areca nut components stimulate ADAM17, IL-1α, PGE2 and 8-isoprostane production in oral keratinocyte: role of reactive oxygen species, EGF and JAK signaling

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Oxidative stress, anti-oxidants and the cross-sectional and longitudinal association with depressive symptoms: results from the CARDIA study

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Irritable Bowel Syndrome and Neurological Deficiencies: Is There A Relationship? The Possible Relevance of the Oxidative Stress Status

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Impacts of oxidants and antioxidants on the emergence and progression of Alzheimer's disease

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Oxidative stress in corneal injuries of different origin: Utilization of 3D human corneal epithelial tissue model

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Urine Arsenic and Arsenic Metabolites in U.S. Adults and Biomarkers of Inflammation, Oxidative Stress, and Endothelial Dysfunction: A Cross-Sectional Study

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Oxidative Stress and Natural Antioxidants: Back and Forth in the Neurological Mechanisms of Alzheimer’s Disease

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Biochemical indices of oxidative stress and inflammation in the evaluation of peripheral artery disease.

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Classifying oxidative stress by F2-Isoprostane levels in human disease: The re-imagining of a biomarker

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Fatty Acid Profile and Metabolism Are Related to Human Sperm Parameters and Are Relevant in Idiopathic Infertility and Varicocele

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Lipid peroxidation products as a mediator of toxicity and adaptive response – The regulatory role of selenoprotein and vitamin E

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Dietary Weight Loss, Exercise, and Oxidative Stress in Postmenopausal Women: A Randomized Controlled Trial

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4-hydroxynonenal protein adducts: Key mediator in Rett syndrome oxinflammation

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Relevance of 4-F4t-neuroprostane and 10-F4t-neuroprostane to neurological diseases

Signorini, C., Felice, C. D., Durand, T., Galano, J., Oger, C., Leoncini, S., Ciccoli, L., Carone, M., Ulivelli, M., Manna, C., et al. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.12.009 · Cited by 37 · see citing works

Urinary 8-isoprostane levels and occurrence of lung, colorectal, prostate, breast and overall cancer: Results from a large, population-based cohort study with 14 years of follow-up

Gao, X. Y., Brenner, H., Holleczek, B., Ćuk, K., Zhang, Y., Anusruti, A., Yang, X., Xu, Y., & Schöttker, B. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.05.065 · Cited by 37 · see citing works

Urinary Biomarkers of Inflammation and Oxidative Stress Are Elevated in Obese Children and Correlate with a Marker of Endothelial Dysfunction

Selvaraju, V., Ayine, P., Fadamiro, M., Babu, J. R., Brown, M. D., & Geetha, T. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/9604740 · Cited by 37 · see citing works

Novel free-radical mediated lipid peroxidation biomarkers in newborn plasma

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Clinical blood sampling for oxylipin analysis – effect of storage and pneumatic tube transport of blood on free and total oxylipin profile in human plasma and serum

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Biomarkers of oxidative stress and reproductive complications

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Early metabolic responses to lithium/pilocarpine‐induced status epilepticus in rat brain

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15-F2t-Isoprostane Concentrations and Oxidant Status in Lactating Dairy Cattle with Acute Coliform Mastitis

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Prenatal phthalate exposure and 8-isoprostane among Mexican-American children with high prevalence of obesity

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Effect of long-term vitamin E and selenium supplementation on urine F2-isoprostanes, a biomarker of oxidative stress

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Oxygen Supplementation to Stabilize Preterm Infants in the Fetal to Neonatal Transition: No Satisfactory Answer

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Elevated plasma F2-isoprostane levels in schizophrenia

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Aronia – citrus juice (polyphenol-rich juice) intake and elite triathlon training: a lipidomic approach using representative oxylipins in urine

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Bioactive Oxylipins Profile in Marine Microalgae

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