The DOI matches its Crossref record; 141 of the 141 references it cites were found in a registry or an index.
Hypoxia, oxidative stress and inflammation
Abstract
Inflammatory Arthritis is characterized by synovial proliferation, neovascularization and leukocyte extravasation leading to joint destruction and functional disability. Efficiency of oxygen supply to the synovium is poor due to the highly dysregulated synovial microvasculature. This along with the increased energy demands of activated infiltrating immune cells and inflamed resident cells leads to an hypoxic microenvironment and mitochondrial dysfunction. This favors an increase of reactive oxygen species, leading to oxidative damage which further promotes inflammation. In this adverse microenvironment synovial cells adapt to generate energy and switch their cell metabolism from a resting regulatory state to a highly metabolically active state which allows them to produce essential building blocks to support their proliferation. This metabolic shift results in the accumulation of metabolic intermediates which act as signaling molecules that further dictate the inflammatory response. Understanding the complex interplay between hypoxia-induced signaling pathways, oxidative stress and mitochondrial function will provide better insight into the underlying mechanisms of disease pathogenesis.
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2 retracted
Mitochondrial DNA induces inflammation and increases TLR9/NF-κB expression in lung tissue
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Gu, X., Li, Z., & Su, J. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.116429 · Cited by 91
Wei, S., Xiao, Z., Huang, J., Peng, Z., Zhang, B., & Li, W. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108545 · Cited by 35
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Metadata
- Authors
- McGarry, T., Biniecka, M., Veale, D. J., & Fearon, U.
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2018-09
- Volume
- 125
- Pages
- 15-24
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W2794554845
- Cited by
- 601
- References
- 141
- FWCI
- 26.60
- Type
- journal article
- Language
- en
- Open access
- closed
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- McGarry, T., Biniecka, M., Veale, D. J., & Fearon, U. (2018). Hypoxia, oxidative stress and inflammation. Free Radical Biology and Medicine. https://doi.org/10.1016/j.freeradbiomed.2018.03.042
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
