Human umbilical cord-derived mesenchymal stem cells attenuate liver fibrosis by inhibiting hepatocyte ferroptosis through mitochondrial transfer
Open accessAbstract
Liver fibrosis is a reversible dynamic pathological process induced by chronic liver injury. Without intervention, liver fibrosis can progress to become cirrhosis, liver failure, or hepatocellular carcinoma, thus posing a high global health burden. Therefore, effective therapies for liver fibrosis are urgently required. Although transplantation of mesenchymal stem cells (MSCs) has significant value as a treatment strategy for liver damage, the underlying mechanisms remain unclear. Chronic liver injury progression is significantly influenced by hepatocyte ferroptosis, and targeting ferroptosis is emerging as a potential treatment strategy for liver fibrosis. Here, we showed that the infusion of human umbilical cord-derived MSCs (hUC-MSCs) alleviated TAA-induced liver fibrosis, improved liver functionality, and decreased ferroptosis in mice. hUC-MSCs inhibit ferroptosis-related mitochondrial damage and lipid peroxidation in AML12 cells in vitro . Mechanistically, under oxidative stress, hUC-MSCs transfer healthy mitochondria to damaged hepatocytes through tunneling nanotubes (TNTs). Cytochalasin D (CytoD), an inhibitor of TNT formation, abrogated the protective effects of hUC-MSCs against ferroptosis. This research emphasizes the ability of hUC-MSCs to serve as a promising treatment for liver fibrosis via mitochondrial transfer through TNTs. The graphical abstract illustrates that ferroptosis and mitochondrial dysfunction in hepatocytes play a critical role in the development of liver fibrosis. Furthermore, mesenchymal stem cells (MSCs) have been shown to transfer mitochondria through tunneling nanotubes, restoring mitochondrial homeostasis in hepatocytes, alleviating ferroptosis, and thereby inhibiting the progression of liver fibrosis. • Ferroptosis and mitochondrial dysfunction in hepatocytes are crucial inliver fibrosis. • MSCs transfer mitochondria via tunneling nanotubes, alleviating hepatocytes ferroptosis, and thereby inhibiting liver fibrosis. • The transferred mitochondria restore hepatocytes ferroptosis by regulating the Nrf2/HO-1 signaling pathway.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In a TAA-induced murine model, MSCs alleviate lipid load by transferring mitochondria to ferroptosis hepatocytes via tunneling nanotubes, which enhances oxidative capacity for lipid degradation and utilization, eventually leading to attenuated fibrosis.
“In a TAA-induced murine model, MSCs were observed to alleviate lipid load by transferring Mt to ferroptosis hepatocytes via TNTs, which enhances oxidative capacity for lipid degradation and utilization, eventually leading to attenuated fibrosis [120].”
From Mechanisms, efficacy, and future perspectives of cellular-based therapies for liver fibrosis/cirrhosis: focusing on mesenchymal stromal cells (2025) · cites this paper as [120]
An increasing number of studies support the use of MSCs to treat liver fibrosis by transferring mitochondria.
“An increasing number of studies nowadays support the use of MSCs to treat liver fibrosis by transferring Mt [117, 120, 121].”
From Mechanisms, efficacy, and future perspectives of cellular-based therapies for liver fibrosis/cirrhosis: focusing on mesenchymal stromal cells (2025) · cites this paper as [120]
Cites
Ferroptosis: past, present and future
Li, J., Cao, F., Yin, H.-L., Huang, Z.-J., Lin, Z.-T., Mao, N., Sun, B., & Wang, G. (2020) · Cell Death & Disease · doi:10.1038/s41419-020-2298-2 · Cited by 4,171 · see citing works
Ferroptosis: process and function
Xie, Y., Hou, W., Song, X., Yu, Y., Huang, J., Sun, X., Kang, R., & Tang, D. (2016) · Cell Death & Differentiation · doi:10.1038/cdd.2015.158 · Cited by 3,727 · see citing works
Role of Mitochondria in Ferroptosis
Gao, M., Yi, J., Zhu, J., Minikes, A. M., Monian, P., Thompson, C. B., & Jiang, X. (2019) · Molecular Cell · doi:10.1016/j.molcel.2018.10.042 · Cited by 2,120 · see citing works
Islam, M. N., Das, S. R., Emin, M. T., Wei, M., Sun, L., Westphalen, K., Rowlands, D. J., Quadri, S. K., Bhattacharya, S., & Bhattacharya, J. (2012) · Nature Medicine · doi:10.1038/nm.2736 · Cited by 1,585 · see citing works
Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues
Parola, M., & Pinzani, M. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2018.09.002 · Cited by 1,183 · see citing works
Contemporary Epidemiology of Chronic Liver Disease and Cirrhosis
Moon, A. M., Singal, A. G., & Tapper, E. B. (2019) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2019.07.060 · Cited by 1,154 · see citing works
Mitochondria: master regulators of danger signalling
Galluzzi, L., Kepp, O., & Kroemer, G. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3479 · Cited by 733 · see citing works
The multifaceted role of ferroptosis in liver disease
Chen, J., Li, X., Ge, C., Min, J., & Wang, F. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-00941-0 · Cited by 680 · see citing works
Mitochondrial regulation of ferroptosis
Gan, B. (2021) · The Journal of Cell Biology · doi:10.1083/jcb.202105043 · Cited by 616 · see citing works
Role of Oxidative Stress and Molecular Changes in Liver Fibrosis: A Review
Sánchez-Valle, V., Chávez-Tapia, N. C., Uribe, M., & Méndez‐Sánchez, N. (2012) · Current Medicinal Chemistry · doi:10.2174/092986712803341520 · Cited by 594 · see citing works
Drummen, G. P. C., van Liebergen, L. C. M., Op den Kamp, J. A. F., & Post, J. A. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00848-1 · Cited by 594 · see citing works
Nrf2 and Ferroptosis: A New Research Direction for Neurodegenerative Diseases
Song, X., & Long, D. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00267 · Cited by 575 · see citing works
Stromal cells in the tumor microenvironment: accomplices of tumor progression?
Zhao, Y. F., Shen, M., Wu, L., Yang, H., Yao, Y., Yang, Q., Du, J., Liu, L., Li, Y., & Bai, Y. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06110-6 · Cited by 443 · see citing works
The crosstalk between ferroptosis and mitochondrial dynamic regulatory networks
Li, J., Jia, Y., Ding, Y.-X., Bai, J., Cao, F., & Li, F. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.83348 · Cited by 398 · see citing works
Ferroptosis in Liver Diseases: An Overview
Capelletti, M. M., Manceau, H., Puy, H., & Peoc’h, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144908 · Cited by 365 · see citing works
Marlein, C. R., Zaitseva, L., Piddock, R. E., Robinson, S. D., Edwards, D. R., Shafat, M. S., Zhou, Z., Lawes, M. J., Bowles, K. M., & Rushworth, S. A. (2017) · Blood · doi:10.1182/blood-2017-03-772939 · Cited by 356 · see citing works
Xie, Q., Liu, R., Jiang, J., Peng, J. L., Yang, C., Zhang, W., Wang, S., & Song, J. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-02011-z · Cited by 254 · see citing works
Cell‐to‐cell cross‐talk between mesenchymal stem cells and cardiomyocytes in co‐culture
Plotnikov, E. Y., Khryapenkova, T. G., Vasileva, A. K., Marey, M. V., Galkina, S. I., Исаев, Н. К., Sheval, E. V., Polyakov, V. Y., Sukhikh, G. T., & Zorov, D. B. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2007.00205.x · Cited by 240 · see citing works
Mitochondrial transfer/transplantation: an emerging therapeutic approach for multiple diseases
Liu, Z., Sun, Y., Qi, Z., Cao, L., & Ding, S. (2022) · Cell & Bioscience · doi:10.1186/s13578-022-00805-7 · Cited by 235 · see citing works
The emerging antioxidant paradigm of mesenchymal stem cell therapy
Stavely, R., & Nurgali, K. (2020) · Stem Cells Translational Medicine · doi:10.1002/sctm.19-0446 · Cited by 225 · see citing works
Li, J., Deng, S., Li, J., Li, L., Zhang, F., Zou, Y., Wu, D., & Xu, Y. X. (2022) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-022-00318-8 · Cited by 183 · see citing works
Mitochondrial Transfer and Regulators of Mesenchymal Stromal Cell Function and Therapeutic Efficacy
Mohammadalipour, A., Dumbali, S. P., & Wenzel, P. L. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.603292 · Cited by 176 · see citing works
Peering into tunneling nanotubes—The path forward
Cervantes, D. C., & Zurzolo, C. (2021) · The EMBO Journal · doi:10.15252/embj.2020105789 · Cited by 175 · see citing works
Mitochondrial Transfer in Cancer: A Comprehensive Review
Zampieri, L. X., Silva‐Almeida, C., Rondeau, J. D., & Sonveaux, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063245 · Cited by 173 · see citing works
Yao, S., Pang, M., Wang, Y., Wang, X., Lin, Y., Lv, Y., Xie, Z., Hou, J., Du, C., Qiu, Y., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102871 · Cited by 160 · see citing works
Oxidative Stress–Induced Liver Damage and Remodeling of the Liver Vasculature
Banerjee, P., Gaddam, N., Chandler, V., & Chakraborty, S. (2023) · American Journal Of Pathology · doi:10.1016/j.ajpath.2023.06.002 · Cited by 133 · see citing works
The Functions, Methods, and Mobility of Mitochondrial Transfer Between Cells
Qin, Y., Jiang, X., Yang, Q., Zhao, J., Zhou, Q., & Zhou, Y. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.672781 · Cited by 118 · see citing works
Huang, T., Lin, R., Su, Y., Sun, H., Zheng, X., Zhang, J., Lu, X., Zhao, B.-Q., Jiang, X., Huang, L., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-41529-7 · Cited by 117 · see citing works
Mitochondrial dysfunction: A promising therapeutic target for liver diseases
Chen, P., Yao, L., Yuan, M., Wang, Z., Zhang, Q., Jiang, Y., & Li, L. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2023.101115 · Cited by 114 · see citing works
Self-citationTransferred mitochondria accumulate reactive oxygen species, promoting proliferation
Kidwell, C. U., Casalini, J. R., Pradeep, S., Scherer, S. D., Greiner, D., Bayık, D., Watson, D. C., Olson, G. S., Lathia, J. D., Johnson, J. S., et al. (2023) · eLife · doi:10.7554/elife.85494 · Cited by 111 · see citing works
Luo, Q., Xian, P., Wang, T., Wu, S., Sun, T., Wang, W., Wang, B., Yang, H., Yang, Y., Wang, H., et al. (2021) · Theranostics · doi:10.7150/thno.58632 · Cited by 104 · see citing works
Banerjee, A., Mukherjee, S., & Maji, B. (2021) · Toxicology Reports · doi:10.1016/j.toxrep.2021.04.009 · Cited by 103 · see citing works
Mitochondria-mediated Ferroptosis in Diseases Therapy: From Molecular Mechanisms to Implications
Feng, F., He, S., Li, X., He, J., & Luo, L. (2023) · Aging and Disease · doi:10.14336/ad.2023.0717 · Cited by 89 · see citing works
Emerging Antioxidant Paradigm of Mesenchymal Stem Cell-Derived Exosome Therapy
Xia, C., Dai, Z., Jin, Y., & Chen, P. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.727272 · Cited by 84 · see citing works
Self-citationMechanisms behind therapeutic potentials of mesenchymal stem cell mitochondria transfer/delivery
Malekpour, K., Hazrati, A., Soudi, S., & Hashemi, S. M. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.01.059 · Cited by 84 · see citing works
Current understanding of adipose-derived mesenchymal stem cell-based therapies in liver diseases
Hu, C., Zhao, L., & Li, L. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1310-1 · Cited by 81 · see citing works
Saadh, M. J., Mikhailova, M. V., Rasoolzadegan, S., Falaki, M., Akhavanfar, R., Gonzáles, J. L. A., Rigi, A. M., & Kiasari, B. A. (2023) · European journal of medical research · doi:10.1186/s40001-023-01008-7 · Cited by 77 · see citing works
Park, J.-S., Rustamov, N., & Roh, Y. (2023) · Antioxidants · doi:10.3390/antiox12111928 · Cited by 77 · see citing works
Hepatocytes in liver injury: Victim, bystander, or accomplice in progressive fibrosis?
Tu, T., Calabrò, S., Lee, A., Maczurek, A. E., Budzinska, M. A., Warner, F. J., McLennan, S. V., & Shackel, N. A. (2015) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.13065 · Cited by 70 · see citing works
Role of mitochondria in the regulation of ferroptosis and disease
Fu, C., Cao, N., Zeng, S., Zhu, W., Fu, X., Liu, W., & Fan, S. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1301822 · Cited by 70 · see citing works
Mineral metabolism and ferroptosis in non-alcoholic fatty liver diseases
Ma, C., Li, H., Zhu, Z., Pang, C. H., & Pan, G. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115242 · Cited by 67 · see citing works
Mitochondrial Dysfunction and Chronic Liver Disease
Zhang, C., Zhao, Y., Yu, M., Qin, J., Ye, B., & Wang, Q. (2022) · Current Issues in Molecular Biology · doi:10.3390/cimb44070218 · Cited by 66 · see citing works
The Emerging Role of Ferroptosis in Liver Diseases
Chen, S., Zhu, J., Zang, X., & Zhai, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.801365 · Cited by 63 · see citing works
Mitochondria Transfer in Brain Injury and Disease
Fairley, L. H., Grimm, A., & Eckert, A. (2022) · Cells · doi:10.3390/cells11223603 · Cited by 62 · see citing works
Banerjee, A., Das, D., Paul, R., Roy, S., Das, U. B., Saha, S., Dey, S., Adhikary, A., Mukherjee, S., & Maji, B. K. (2020) · Scientific Reports · doi:10.1038/s41598-020-72076-6 · Cited by 61 · see citing works
Zhao, C., Xiao, C., Feng, S.-Q., & Bai, J. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1177542 · Cited by 58 · see citing works
Banerjee, A., Mukherjee, S., & Maji, B. K. (2021) · Human & Experimental Toxicology · doi:10.1177/09603271211010895 · Cited by 53 · see citing works
Monosodium glutamate causes hepato-cardiac derangement in male rats
Banerjee, A., Mukherjee, S., & Maji, B. K. (2021) · Human & Experimental Toxicology · doi:10.1177/09603271211049550 · Cited by 50 · see citing works
Kumar, R., & Gullapalli, R. R. (2024) · Journal of Visualized Experiments · doi:10.3791/66238 · Cited by 46 · see citing works
Muscle mitochondrial transplantation can rescue and maintain cellular homeostasis
Bhattacharya, D., Slavin, M. B., & Hood, D. A. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00212.2023 · Cited by 45 · see citing works
Ma, B., Ju, A., Zhang, S., An, Q., Xu, S., Liu, J., Yu, L., Fu, Y., & Luo, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01437-0 · Cited by 43 · see citing works
Tsushima, M., Liu, J., Hirao, W., Yamazaki, H., Tomita, H., & Itoh, K. (2019) · Archives of Pharmacal Research · doi:10.1007/s12272-019-01188-z · Cited by 42 · see citing works
Banerjee, A., Das, D., Paul, R., Roy, S., Bhattacharjee, A., Prasad, S. K., Banerjee, O., Mukherjee, S., & Maji, B. K. (2020) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2019-0141 · Cited by 42 · see citing works
Eugenín, E. A., Camporesi, E. M., & Peracchia, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23116133 · Cited by 40 · see citing works
Mesenchymal Stem Cell-Derived Exosomal microRNAs in Cardiac Regeneration
Bhaskara, M. C., Anjorin, O., & Wang, M. (2023) · Cells · doi:10.3390/cells12242815 · Cited by 38 · see citing works
Cell therapy in end-stage liver disease: replace and remodel
Hu, X.-H., Chen, L., Wu, H., Tang, Y., Zheng, Q.-M., Wei, X., Wei, Q., Huang, Q., Chen, J., & Xu, X. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03370-z · Cited by 36 · see citing works
Zhang, L., Liu, Q., Hu, H., Zhao, L., & Zhu, K. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113482 · Cited by 35 · see citing works
Ahmad, T., Mukherjee, S., PATTNAIK, B. R., Kumar, M., Singh, S., Rehman, R., Kumar, M., Jha, A., Wani, M. R., Mabalirajan, U., et al. (2013) · Biophysical Journal · doi:10.1016/j.bpj.2012.11.3638 · Cited by 34 · see citing works
Banerjee, A., Mukherjee, S., & Maji, B. K. (2022) · Journal of Food Biochemistry · doi:10.1111/jfbc.14092 · Cited by 23 · see citing works
Banerjee, A., Das, D., Mukherjee, S., & Maji, B. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112091 · Cited by 20 · see citing works
Ferroptosis: An important mechanism of disease mediated by the gut-liver-brain axis
Yu, X., Wang, S., Ji, Z., Meng, J., Mou, Y., Wu, X., Yang, X., Xiong, P., Li, M., & Guo, Y. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122650 · Cited by 13 · see citing works
Banerjee, A., Das, D., & Maji, B. K. (2024) · Journal of Comprehensive Health · doi:10.25259/jch_7_2023 · Cited by 6 · see citing works
Flagged first, then by citations
1 of the 63 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
From mitochondria to immune networks: new mesenchymal stem cell strategies to treat periodontitis
Wang, X., Wang, C., Ren, M., Shi, Y., Dong, T., Liu, Z., Jiang, J., & Wei, H. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04619-5 · Cited by 13 · see citing works
Song, R., Huang, C., Ma, Y., Zhang, Z., Liu, Y., Chen, B., Zhang, X., Hao, S., Huang, H., Ashrafizadeh, M., et al. (2026) · Science Advances · doi:10.1126/sciadv.adz3266 · Cited by 13 · see citing works
Shi, S., Zhang, M., Zhu, C., Zhu, S., Yu, J., Sui, Q., Xu, J., Ren, J., Zhang, J., Chen, P., et al. (2025) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2025.111586 · Cited by 7 · see citing works
Self-citationZhang, Y., Dou, J., Dai, S., Xie, Y., Wang, H., Chen, Z., Zhuang, H., & Xu, S. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04526-9 · Cited by 7 · see citing works
Ma, L., Yang, X., Huang, X., Guo, H., Li, Z., Fan, S., Qin, H., Meng, F., Liu, P., Wang, X., et al. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03655-w · Cited by 7 · see citing works
Self-citationShuai, Y., Chen, B., Jiang, T., Zhu, L., Su, H., Wei, W., Liu, B., & Jin, L. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03745-9 · Cited by 4 · see citing works
Huang, Y., Cheng, R., Wang, G., Xu, Z., Liu, S., Wan, Y., Hou, X., & Wang, J. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2025.1677021 · Cited by 4 · see citing works
Pan, X., Gao, T., & Wang, B. (2025) · Cell & Bioscience · doi:10.1186/s13578-025-01520-9 · Cited by 2 · see citing works
“In a TAA-induced murine model, MSCs were observed to alleviate lipid load by transferring Mt to ferroptosis hepatocytes via TNTs, which enhances oxidative capacity for lipid degradation and utilization, eventually leading to attenuated fibrosis [120].”
InfluentialEffects and mechanisms of MSCs and MSC-derived exosomes in regulating ferroptosis
Guo, Z., Qu, Z., Zhang, Y., Xu, D., Chu, L., & Cheng, M. (2025) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-025-01136-0 · Cited by 2 · see citing works
Peng, Q., Hao, L., Li, S., Yu, F., Li, N., Luo, X., Yue, J., Luo, Q., Zheng, K., & Hu, X. (2026) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-026-05500-6 · Cited by 2 · see citing works
Emerging importance of ALDH2 in liver diseases and its potential therapeutic role
Wang, S., Xu, S., Xia, G., Wang, X., & Lv, X. (2026) · Biochemical Pharmacology · doi:10.1016/j.bcp.2026.117732 · Cited by 1 · see citing works
Zhang, X., Pu, Z., Ran, C., Zhang, X., Guo, C., Deng, Y., Liu, J., Chen, Y., Feng, J., & Liu, S. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2025.1624817
Fu, J., Deng, Q., Jiao, J., Chen, Y., Yin, X., & Wang, Z. (2026) · Analytical Methods · doi:10.1039/d6ay00703a
Self-citationYu, M., Zhang, Z., Wu, X., Zhang, B., Yang, H., Wei, C., Ran, M., Cao, M., Zhang, J., Ding, X., et al. (2026) · Stem Cells Translational Medicine · doi:10.1093/stcltm/szag086
- Authors
- Xiong, Z., Chen, P., Wang, Z., Yao, L., Yuan, M., Liu, P., Sun, M., Shu, K., & Jiang, Y.
- Affiliations
- Renmin Hospital of Wuhan University (CN)
- Wuhan Union Hospital (CN)
- Corresponding author
- Jiang, Yingan
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2025-04
- Volume
- 231
- Pages
- 163-177
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W4408027369
- Cited by
- 14
- References
- 63
- Citations by year
- 2026: 6 · 2025: 8
- FWCI
- 9.05
- Type
- journal article
- Language
- en
- Update notices
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Free Radical Biology and Medicine (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Renmin Hospital of Wuhan University
- Wuhan University (2002330)
- Topics
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Keywords
- liver fibrosis, human umbilical cord mesenchymal stem cells, ferroptosis, hepatocytes, mitochondrial transfer, tunneling nanotubes, Nrf2/HO-1 pathway, lipid peroxidation, mitochondrial dysfunction, oxidative stress, thioacetamide-induced liver fibrosis, stem cell transplantation
- MeSH terms
- Ferroptosis, Animals, Disease Models, Animal, Humans, Liver Cirrhosis, Male, Mice, Inbred C57BL, Mitochondria, Thioacetamide, Umbilical Cord, Lipid Peroxidation, Oxidative Stress, Hepatocytes, Mesenchymal Stem Cell Transplantation, Mice, Mesenchymal Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
