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A comprehensive exploration of the genetic legacy and forensic features of Afghanistan and Pakistan Mongolian-descent Hazara

He, Guanglin, Adnan, Atif, Rakha, Allah, Yeh, Hui-Yuan, Wang, Mengge, Zou, Xing, Guo, Jianxin, Rehman, Muhammad, Fawad, Abulhasan, Chen, Pengyu, Wang, Chuan-Chao·2019·Forensic Science International: Genetics
DOI 10.1016/j.fsigen.2019.06.018
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Abstract

Afghanistan and Pakistan are rich with a complex landscape of culture, linguistics, ethnicity and genetic legacy at the crossroads between Indian-Subcontinent and Central Asia. Hazara people have historically been suggested to be Mongolian decedents but seldom been genetically studied. To dissect the genetic structure and explore the forensic characteristics of Hazara people, we first genotyped 30 Insertion/deletion (Indel) markers in 468 samples from 2 aboriginal Hazara populations from Afghanistan and Pakistan, and 100 East Asian comparative Bouyei samples using the Investigator® DIPplex kit. Subsequently, we carried out a comprehensive population genetic analysis from four different datasets: 8895 30-Indel genotype data from 51 populations, 15,895 30-Indel allele frequency data from 98 populations, 1048 genotypes of 993 STRs and Indels from 53 HGDP populations and 2068 whole-genomes (621,799 single nucleotide polymorphisms) from 165 worldwide Human origin reference populations, to further unravel the genetic complexity between Hazara and worldwide human populations using various statistical analysis. We find that 30 Indels are in accordance with HWE, and informative and polymorphic in both Central Asians Hazara and East Asian Bouyei populations. The forensic combined probability of exclusion is larger than 0.9943 and the cumulative power of discrimination is larger than 0.99999999999936. These forensic parameters show the high level of diversity, which makes the Indel ampl…

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Metadata

Authors
He, G., Adnan, A., Rakha, A., Yeh, H.-Y., Wang, M., Zou, X., Guo, J., Rehman, M., Fawad, A., Chen, P., & Wang, C.-C.
Venue
Forensic Science International: Genetics
Publisher
Elsevier BV
Published
2019-09
Volume
42
Pages
e1-e12
ISSN
1872-4973
DOI
10.1016/j.fsigen.2019.06.018
Cited by
25
References
1
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Funders
  • National Natural Science Foundation of China (31801040)
  • Nanqiang Outstanding Young Talents Program of Xiamen University (X2123302)
  • Fundamental Research Funds for the Central Universities (ZK1144)

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CoChat. (2026). Citation check: A comprehensive exploration of the genetic legacy and forensic features of Afghanistan and Pakistan Mongolian-descent Hazara. https://app.cochat.ai/papers/10.1016/j.fsigen.2019.06.018
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He, G., Adnan, A., Rakha, A., Yeh, H.-Y., Wang, M., Zou, X., Guo, J., Rehman, M., Fawad, A., Chen, P., & Wang, C.-C. (2019). A comprehensive exploration of the genetic legacy and forensic features of Afghanistan and Pakistan Mongolian-descent Hazara. Forensic Science International: Genetics. https://doi.org/10.1016/j.fsigen.2019.06.018