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Cited by 23Parkinson's Disease Mechanisms and TreatmentsDeep Brain Stimulation and Movement DisordersBalance, Gait, and Falls Prevention

The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.

Beneficial effect of levodopa therapy on stooped posture in Parkinson's disease

Benninger, Felix, Khlebtovsky, Alexander, Roditi, Yaniv, Keret, Ofir, Steiner, Israel, Melamed, Eldad, Djaldetti, Ruth·2015·Gait & Posture
DOI 10.1016/j.gaitpost.2015.05.015
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Abstract

Objective This study was designated to quantitatively evaluate the effect of levodopa on spinal posture in patients with PD using a computer-assisted handheld SpinalMouse device.Methods Prospective case-study involving 48 patients with definite PD. All patients were recruited between September 2011 and September 2013 and included 22 dopa-naïve, evaluated before and 3 months after initiation of treatment, and 26 patients with response fluctuations studied during the "off" and "on" states. The SpinalMouse instrument, a computer-assisted mechanical hand-held device, designed to noninvasively assess the curvature of the spine was guided along the midline of the vertebral column in upright, full flexion, and full extension positions to objectively assess spinal posture.Results In the dopa-naïve patients, spinal incline in the upright position was 12.4±1.2° before and 7.6±1.3° after treatment; p=0.002. Corresponding area-under-the-curve (AUC) values were 131.7±8.0 cm(2) and 87.1±7.3 cm(2); p<0.0001. In the response fluctuations patients, spinal incline was 13.3±1.3° in the "off" and 9.3±1.2° in the "on" period; p=0.015. Corresponding AUC values were 144.6±9.2 cm(2) and 103.1±8.2 cm(2); p<0.0001.Conclusions This is the first study that objectively measured and quantified abnormalities of spinal posture in patients with PD. Findings suggest that levodopa does have a beneficial effect on anterior flexion of the thoracolumbar spine, and thus indicate that the disorder of stooped posture in PD is mediated, at least in part, by dopamine deficiency.

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Crossref · 10.1016/j.gaitpost.2015.05.015

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Metadata

Authors
Benninger, F., Khlebtovsky, A., Roditi, Y., Keret, O., Steiner, I., Melamed, E., & Djaldetti, R.
Affiliations
Tel Aviv University (IL)
Corresponding author
Djaldetti, Ruth
ORCID
Benninger, Felix
Venue
Gait & Posture
Publisher
Elsevier BV
Published
2015-09
Volume
42
Issue
3
Pages
263-268
ISSN
0966-6362 (ISSN-L)
DOI
10.1016/j.gaitpost.2015.05.015
OpenAlex
W1621856726
Cited by
23
References
17
Citations by year
2026: 1 · 2025: 4 · 2024: 3 · 2023: 2 · 2021: 3 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 2
FWCI
1.88
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Gait & Posture (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
  • Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Balance, Gait, and Falls Prevention
Keywords
Parkinson's disease, levodopa therapy, stooped posture, spinal posture, dopamine deficiency, postural assessment
MeSH terms
Aged, Aged, 80 and over, Antiparkinson Agents, Female, Humans, Levodopa, Male, Middle Aged, Parkinson Disease, Posture, Prospective Studies, Range of Motion, Articular, Treatment Outcome

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