The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
AngiomiRs—Key regulators of angiogenesis
Open accessAbstract
Summary The formation of new blood vessels through the process of angiogenesis is critical in vascular development and homeostasis. Aberrant angiogenesis leads to a variety of diseases, such as ischemia and cancer. Recent studies have revealed important roles for miRNAs in regulating endothelial cell (EC) function, especially angiogenesis. Mice with EC-specific deletion of Dicer, a key enzyme for generating miRNAs, display defective postnatal angiogenesis. Specific miRNAs (angiomiRs) have recently been shown to regulate angiogenesis in vivo. miRNA-126, an EC-restricted miRNA, regulates vascular integrity and developmental angiogenesis. miR-378, miR-296, and the miR-17~92 cluster, contribute to tumor angiogenesis. Manipulating angiomiRs in the settings of pathological vascularization represents a new therapeutic approach.
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Cited by
Tumor angiogenesis: molecular pathways and therapeutic targets
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MicroRNA-146a is a therapeutic target and biomarker for peripartum cardiomyopathy
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Bovine milk contains microRNA and messenger RNA that are stable under degradative conditions
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Metadata
- Authors
- Wang, S., & Olson, E. N.
- Venue
- Current Opinion in Genetics & Development
- Publisher
- Elsevier BV
- Published
- 2009-06
- Volume
- 19
- Issue
- 3
- Pages
- 205-211
- ISSN
- 0959-437X (ISSN-L)
- OpenAlex
- W2017358009
- Cited by
- 450
- References
- 53
- FWCI
- 1.68
- Type
- journal article
- Language
- en
- Open access
- green
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