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Regulation and dysregulation of 3′UTR-mediated translational control

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Jia, Jie, Yao, Peng, Arif, Abul, Fox, Paul L·2013·Current Opinion in Genetics & Development
DOI 10.1016/j.gde.2012.12.004PMC PMC3644486
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Abstract

Translational control provides numerous advantages in regulation of gene expression including rapid responsiveness, intracellular localization, nondestruction of template mRNA, and coordinated regulation of transcript ensembles. Transcript-selective, translational control is driven by the specific interaction of factor(s) with the 5' or 3' untranslated region (UTR), thereby influencing initiation, elongation, or termination of mRNA translation. The mean length of human 3'UTRs is greater than that of 5'UTR, indicating the expanded potential for motifs, structural elements, and binding sites for trans-acting factors that exert transcript-selective translation control. New and unexpected mechanisms of 3'UTR-mediated translational control and their contributions to disease have received increasing attention during the last decade. Here, we briefly review a few recent and representative discoveries of 3'UTR-mediated translational control, emphasizing the novel aspects of these regulatory mechanisms and their potential pathophysiological significance.

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  1. [1]Sampath P Mazumder B Seshadri V Gerber CA Chavatte L Kinter M Ting SM Dignam JD Kim S Driscoll DM Noncanonical function of glutamyl-prolyl-tRNA synthetase: gene-specific silencing of translation Cell 2004 119 195 208 15479637
  2. [2]Mukhopadhyay R Ray PS Arif A Brady AK Kinter M Fox PL DAPK-ZIPK-L13a axis constitutes a negative-feedback module regulating inflammatory gene expression Mol Cell 2008 32 371 382 18995835 PMC2644327
  3. [3]Arif A Jia J Moodt RA DiCorleto PE Fox PL Phosphorylation of glutamyl-prolyl tRNA synthetase by cyclin-dependent kinase 5 dictates transcript-selective translational control Proc Natl Acad Sci U S A 2011 108 1415 1420 21220307 PMC3029695
  4. [4]Arif A Jia J Mukhopadhyay R Willard B Kinter M Fox PL Two-site phosphorylation of EPRS coordinates multimodal regulation of noncanonical translational control activity Mol Cell 2009 35 164 180 19647514 PMC2752289
  5. Yao P Potdar AA Arif A Ray PS Mukhopadhyay R Willard B Xu Y Yan J Saidel GM Fox PL Coding region polyadenylation generates a truncated tRNA synthetase that counters translation repression Cell 2012 149 88 100 This study reveals a “translational trickle” regulatory mechanism that maintains a basal level of gene expression as well as a novel coding region polyadenylation by which a truncated protein is generated via Tyr-to-stop codon conversion 22386318 PMC3615456
  6. [7]Tammela T Enholm B Alitalo K Paavonen K The biology of vascular endothelial growth factors Cardiovasc Res 2005 65 550 563 15664381
  7. [8]Kamba T McDonald DM Mechanisms of adverse effects of anti-VEGF therapy for cancer Br J Cancer 2007 96 1788 1795 17519900 PMC2359962
  8. [9]Stockmann C Doedens A Weidemann A Zhang N Takeda N Greenberg JI Cheresh DA Johnson RS Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis Nature 2008 456 814 818 18997773 PMC3103772
  9. Ray PS Jia J Yao P Majumder M Hatzoglou M Fox PL A stress-responsive RNA switch regulates VEGFA expression Nature 2009 457 915 919 This study reveals the first protein-dependent RNA switch in human mRNAs. Hypoxia induces a binary conformational change of the VEGF mRNA 3′UTR by altering binding of hnRNP L and GAIT complex to their target RNA elements 19098893 PMC2858559
  10. [11]Jia J Arif A Willard B Smith JD Stuehr DJ Hazen SL Fox PL Protection of Extraribosomal RPL13a by GAPDH and Dysregulation by S-Nitrosylation Mol Cell 2012 PMC3635105 22771119
  11. [12]Djuranovic S Nahvi A Green R miRNA-mediated gene silencing by translational repression followed by mRNA deadenylation and decay Science 2012 336 237 240 22499947 PMC3971879
  12. [13]Khraiwesh B Arif MA Seumel GI Ossowski S Weigel D Reski R Frank W Transcriptional control of gene expression by microRNAs Cell 2010 140 111 122 20085706
  13. [14]Eiring AM Harb JG Neviani P Garton C Oaks JJ Spizzo R Liu S Schwind S Santhanam R Hickey CJ miR-328 functions as an RNA decoy to modulate hnRNP E2 regulation of mRNA translation in leukemic blasts Cell 2010 140 652 665 20211135 PMC2924756
  14. [15]Guo H Ingolia NT Weissman JS Bartel DP Mammalian microRNAs predominantly act to decrease target mRNA levels Nature 2010 466 835 840 20703300 PMC2990499
  15. Poliseno L Salmena L Zhang J Carver B Haveman WJ Pandolfi PP A coding independent function of gene and pseudogene mRNAs regulates tumour biology Nature 2010 465 1033 1038 Reports the first example of a pseudogene acting as an miRNA sponge regulating oncomiRNA activity in tumorigenesis. PTEN1, a PETN pseudogene, binds PTEN-specific oncomiRNAs, and sustains PTEN tumor-suppressor activity 20577206 PMC3206313
  16. [18]Kalyana-Sundaram S Kumar-Sinha C Shankar S Robinson DR Wu YM Cao X Asangani IA Kothari V Prensner JR Lonigro RJ Expressed pseudogenes in the transcriptional landscape of human cancers Cell 2012 149 1622 1634 22726445 PMC3597446
  17. [19]Cazalla D Yario T Steitz JA Down-regulation of a host microRNA by a Herpesvirus saimiri noncoding RNA Science 2010 328 1563 1566 20558719 PMC3075239
  18. [20]Berg MG Singh LN Younis I Liu Q Pinto AM Kaida D Zhang Z Cho S Sherrill-Mix S Wan L U1 snRNP Determines mRNA Length and Regulates Isoform Expression Cell 2012 150 53 64 22770214 PMC3412174
  19. [22]Zhu H Hu F Wang R Zhou X Sze SH Liou LW Barefoot A Dickman M Zhang X Arabidopsis Argonaute10 specifically sequesters miR166/165 to regulate shoot apical meristem development Cell 2011 145 242 256 21496644 PMC4124879
  20. [23]Jafarifar F Yao P Eswarappa SM Fox PL Repression of VEGFA by CA-rich element-binding microRNAs is modulated by hnRNP L EMBO J 2011 30 1324 1334 21343907 PMC3094116
  21. [24]Rayner KJ Esau CC Hussain FN McDaniel AL Marshall SM van Gils JM Ray TD Sheedy FJ Goedeke L Liu X Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides Nature 2011 478 404 407 22012398 PMC3235584
  22. [25]Ventura A Jacks T MicroRNAs and cancer: short RNAs go a long way Cell 2009 136 586 591 19239879 PMC3910108
  23. [26]Weinstein IB Joe A Oncogene addiction Cancer Res 2008 68 3077 3080 discussion 3080 18451130
  24. Medina PP Nolde M Slack FJ OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma Nature 2010 467 86 90 miR21 is the first validated example of “OncomiR addiction” in which a single oncogenic miRNA significantly contributes to tumorigenesis in vivo 20693987
  25. [28]Png KJ Halberg N Yoshida M Tavazoie SF A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells Nature 2012 481 190 194 22170610
  26. [29]Chaudhury A Hussey GS Ray PS Jin G Fox PL Howe PH TGF-beta-mediated phosphorylation of hnRNP E1 induces EMT via transcript-selective translational induction of Dab2 and ILEI Nat Cell Biol 2010 12 286 293 20154680 PMC2830561
  27. [30]Hussey GS Chaudhury A Dawson AE Lindner DJ Knudsen CR Wilce MC Merrick WC Howe PH Identification of an mRNP complex regulating tumorigenesis at the translational elongation step Mol Cell 2011 41 419 431 21329880 PMC3061437
  28. [31]Burns DM D’Ambrogio A Nottrott S Richter JD CPEB and two poly(A) polymerases control miR-122 stability and p53 mRNA translation Nature 2011 473 105 108 21478871 PMC3088779
  29. [32]Chen J Kastan MB 5′-3′-UTR interactions regulate p53 mRNA translation and provide a target for modulating p53 induction after DNA damage Genes Dev 2010 24 2146 2156 20837656 PMC2947767
  30. [33]Chen J Guo K Kastan MB Interactions of nucleolin and ribosomal protein L26 (RPL26) in translational control of human p53 mRNA J Biol Chem 2012 287 16467 16476 22433872 PMC3351294
  31. [34]Yang R Zhan M Nalabothula NR Yang Q Indig FE Carrier F Functional significance for a heterogenous ribonucleoprotein A18 signature RNA motif in the 3′-untranslated region of ataxia telangiectasia mutated and Rad3-related (ATR) transcript J Biol Chem 2010 285 8887 8893 20103595 PMC2838310
  32. [35]Mazumder B Seshadri V Fox PL Translational control by the 3′-UTR: the ends specify the means Trends Biochem Sci 2003 28 91 98 12575997
  33. Sumazin P Yang X Chiu HS Chung WJ Iyer A Llobet-Navas D Rajbhandari P Bansal M Guarnieri P Silva J An extensive microRNA-mediated network of RNA-RNA interactions regulates established oncogenic pathways in glioblastoma Cell 2011 147 370 381 This study describes a comprehensive regulatory network in which a family of miRNAs coordinates expression of target genes in related signaling pathways in response to metabolic and environmental stress in tumorigenesis 22000015 PMC3214599
  34. [37]Ray PS Fox PL A post-transcriptional pathway represses monocyte VEGF-A expression and angiogenic activity EMBO J 2007 26 3360 3372 17611605 PMC1933405
  35. [38]Guttilla IK White BA Coordinate regulation of FOXO1 by miR-27a, miR-96, and miR-182 in breast cancer cells J Biol Chem 2009 284 23204 23216 19574223 PMC2749094

Cited by

Sorted by citations

Authors
Jia, J., Yao, P., Arif, A., & Fox, P. L.
Affiliations
Cleveland Clinic (US)
Corresponding author
Fox, Paul L
ORCID
Venue
Current Opinion in Genetics & Development
Publisher
Elsevier BV
Published
2013-02
Volume
23
Issue
1
Pages
29-34
ISSN
0959-437X (ISSN-L)
DOI
10.1016/j.gde.2012.12.004
PMC
PMC3644486
OpenAlex
W2062021343
Cited by
92
References
3
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2023: 5 · 2022: 7 · 2021: 6 · 2020: 7 · 2019: 4 · 2018: 3 · 2017: 16 · 2016: 13 · 2015: 13 · 2014: 12 · 2013: 3
FWCI
1.28
Type
journal article
Language
en
Open access
Licence
Locations
  • Current Opinion in Genetics & Development (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • NIH (P01 HL029582, P01 HL076491, R01 GM086430)
  • American Heart Association (10SDG3930003)
  • American Heart Association, Great Rivers Affiliate
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Keywords
3' untranslated region, translational regulation, mRNA translation, trans-acting factors, post-transcriptional regulation, 5' untranslated region, disease pathophysiology
MeSH terms
Gene Expression Regulation, Humans, RNA, Messenger, Protein Biosynthesis, Trans-Activators, 5' Untranslated Regions, 3' Untranslated Regions, MicroRNAs

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